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소나무로부터 배출되는 모노테르펜 구성비의 수령별 특성 연구
김조천,홍지형,주명칠,전진,김기준 동신대학교 환경연구소 2002 환경연구 Vol.7 No.1
소나무로부터 직접 배출되는 주요한 모노테르펜 물질로 α-pinene, camphene, myrcene, β -pinene, α-phellandrene, α-terpinene, d-limonene, p-cymene, β-phellandrene 등이 확인되었다. 7년생 소나무에서 직접 배출되는 모노테르펜 물질의 구성비를 분석한 결과 β-pinene이 67.0%로 가장 높았고, 22년생 소나무 경우에 β-phellanone이 37.4%로 가장 높았으며, 32년생 소나무는 α-pinene 구성비가 약 42.9%로 가장 높았다. 소나무는 수령에 따라서 구성비에 큰 차이를 보였으며, 소나무 수령이 높을수록 α-pinene이 구성비가 높았다. 소나무의 수령별 α-pinene과 β-pinene의 비율(α-pinene/β-pinene)을 비교한 결과, 7년생 소나무의 경우 0.16~l.15 범위로 나타났고, 22년생 소나무의 경우 0.64~2.47로 나타났으며, 32년생 소나무의 경우 0.50~18.47 범위로 나타났다. α-pinene과 β-pinene의 비는 수령이 높아질수록 좀 더 높은 값을 보였고, 동일한 수령일지라도 나무에 따라서 차이를 보였다. The major monoterpenes emitted from the Pinus densiflora were α-pinene, camphene, myrcene, β-pinene, α-phellandrene, α-terpinene, d-limonene, p-cymene and β-phellandrene. As a result of comparison of monoterpene composition by tree age for P. densiflora, it was found that β-pinene was a dominant monoterpene for 7-year-old pine(67%). β-Phellandrene(37.4%) and α-pinene(46.1%) were most abound for 22-year-old pine and 32-year-old pine respectively. The ratio of monoterpene composition varied considerably with tree age for the pine, and the percentage of α-pinene composition increased with tree age. The ratio of α-pinene and β-pinene(α-pinene/β-pinene) increased with tree age, and varied tree to tree.
최강원,오명돈,배현주,백경란,박선양,김병국,신완식,강문원,진종률,박종원,김춘추,김동집,한지숙,민유홍,이선주,고윤웅 대한화학요법학회 1993 대한화학요법학회지 Vol.11 No.2
Fluconazole의 진균 감염증 예방 효과와 안전성에 관하여 3개 대학병원에서 관해유도화학요법을 받는 급성 백혈병환자를 대상으로 무작위 배정법과 너도나도 누가림법에 의하여 연구하였다. 모두 62명의 환자에게 fluconazole(100㎎ bid) 또는 nystatin(1,000,000IU/day)을 무작위로 투여하였다. 투약은 관해유도화학요법과 같은 날짜에 시작하여 호중구수가 1,000㎣이상으로 회복되거나 진균 감염증이 확인되거나 의심되어 Amphotericin-B를 시작하거나, 약과 관련된 부작용이 나타날 때까지 계속하였다. 진균 colonization은 fluconazole군에서 감소하였으나 nystqatin군에서는 증가하였다, 표재성 진균감염증으로 nystatin군에서 C. albicans 진균혈증 1례와 C.parasilosis 진균혈중 1례가 발생하였다. 경험적 항진균요법으로 Amphotericin-B를 투여한 경우는 fluconazolerns 34명중 7례(21%), nystatinrns 28명중 10례(36%)였다(p<0.05). Fluconazole군과 nystatin군 사이에 부작용이나 사망률에 차이는 없었다. 결론적으로, fluconazole은 관해유도화학요법을 받는 급성 백혈병환자에서 진균의 colonization을 줄이는데 효과적이고 안전한 항진균제이다. We made a randomized, double-blind, multicenter trial to compare the efficacy and safety of fluconazole with nystatin for prevention of fungal infections in patients with acute leukemia. Sixty-two adult undergoing remission induction chemotherapy for cute leukemia were enrolled. Patients were randomly assigned to receive either fluconazole (100㎎ bid) or nystatin(1,000,000IU×6/day) with corresponding placebo. The study drug was started in initiation of chemotherapy and continued until recovery of neutrophil counts(>1,000/㎣), development of proven or suspected invasive fungal infection, or the occurrence of drug-related toxicity. Fungal colonization decreased in fluconazole(F) group, however increased in nystain(n) group. Superficial fungal infection occurred in 1 of 34 F group, whereas invasive fungal infection developed in 3 of 28 N group. Empirical amphotericin-B therapy was given in 7 of 34(21%) F group and 10 of 28(36%) N group(p>0.05). The incidence of drug-related side effects and overall moratlity were similar in both study groups.
차미선,손홍주,이건,고명선,이상준,이종근 부산대학교 환경문제연구소 1996 環境硏究報 Vol.14 No.1
Microorganisms producing bioemulsifier were isolated from the sea water in Pusan costal aera. The isolated strain which had the highest emulsification activity and stability was identified as the genus Acinetobacter from the results of morphological, cultural and biochemical tests and named Acinetobacter sp. EL-C6 for convinience. The compositions of optimum medium for emulsification of crude oil by Acinetobacter sp. EL-C6 were crude oil 2%, NH_4NO_3 0.2%, K_2HPO_4 0.01%, MgSO_4·7H_2O 1%, CaCl_2·2H_2O 0.1%, NaCl 3% and the initial pH 7.5. The cultivation for emulsification of crude oil was carried out in 500m1 shaking flask containing 100m1 of the optimum medium at 30℃. The highest emulsification was observed after 5 days. The utilization on the various hydrocarbon of the Acinetobacter sp. EL-C6 was showed that the utilization of n-alkane compounds were better than that of aromatic compounds. Among the petroleum compounds, by Acinetobacter sp. EL-06.
칼슘길항제와 혐수성 산소 라디칼 제거물질이 백서 피부판 생존에 미치는 영향
양정열,임홍철,이명주,서재홍 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2
Regulation of Ca^++ channels across cell menbranes can be dramatically altered by ischemic states, and such agents relates to cytotoxic effect. The genration of free radicals in ischemic tssue is detrimental to survive of that tissue. If intracellular calcium increasement and free radical production can be blocked or scavenged, tissue damage should be minimized. In the concept of above theory, the author studied the effect of nifedipine. α-tocopherol known as a calcium channel blocker and hydrohobic scavenger on the random pattern skin flap survical of white rats . Sprague-Dawley rats(N-60) were divided into four groups of control(no medication) , nifedipine(10㎎/ ㎏ /day, I.M.), α-tocopherol(20㎎/㎏/day, I.M.). nifedipine plus α-tocopherol. All of medications were given for 11days from 4days before flap elevation and contnued for 7days after flap elevation. When flap survival rates were measured. Flap tissue was obsered by gross, light microscooc and electron microscopic levels. The results were obtained as follows. 1. Groups treated with nifedipine. α-tocopherol. nifedipine +α-tocopherol showed significant increase of the area of flap survival compared with that of the control group.(P<0.001 in nifedipine group and α-tocopherol, and P<0.01 in nifedipine plus α-tocopherol group.) 2. The flap survival was best improved in the α-tocopherol group. (P>0.05). 3. Skin including dermis after 3 days of Nifedipine plus α-tocopherol group disclosed marked proliferation and dilatations of vessels in the deeper part. 4. Electron micrograph of endothelial cells after 3 and 5 days of Nifedipine and α-tocopherol groups disclosed intact basement membrane, swelling of endoplasmic reticulum and mitochondria. Following the above results. It is suggested that calcium channel blocker and α-tocopherol seem to play a important role which incerase survival of the skin flap.
자발성 세균성 복막염을 일으킨 그람음성간균의 3세대 세팔로스포린 내성률 변화
방지환,송경호,박주경,박완범,김성한,김홍빈,김남중,오명돈,김의종,이효석,최강원 대한감염학회 2007 감염과 화학요법 Vol.39 No.3
The third generation cephalosporin is widely used in treatment of spontaneous bacterial peritonitis (SBP). Resistance to the third generation cephalosporin was associated with poor outcome in patients with SBP. Thus it is necessary to know the changes in resistance rate. We planned to investigate retrospectively on resistance rate of the third generation cephalosporin of gram negative bacteria isolated in patients with SBP, who visited Seoul National University Hospital between 1998 and 2006. The Clinical and Laboratory Standards Institute guidelines were applied for antibiotic susceptibility test. A total of 269 consecutive episodes of clinically and microbiologically proven SBP was identified during the study period and 209 cases were caused by gram negative organisms. Among 209 isolates, 22 (10.5%) showed resistance to the third generation cephalosporin. The prevalence of resistance was decreasing during the study period (P=0.014).
Lee, Myoung Jin,Jin, Seonghoon,Baek, Chang-Ki,Hong, Sung-Min,Park, Soo-Young,Park, Hong-Hyun,Lee, Sang-Don,Chung, Sung-Woong,Jeong, Jae-Goan,Hong, Sung-Joo,Park, Sung-Wook,Chung, In-Young,Park, Young IEEE 2007 IEEE transactions on electron devices Vol.54 No.12
<P> We have experimentally analyzed the leakage mechanism and device degradations caused by the Fowler–Nordheim (F–N) and hot carrier stresses for the recently developed dynamic random-access memory cell transistors with deeply recessed channels. We have identified the important differences in the leakage mechanism between saddle fin (S-Fin) and recess channel array transistor (RCAT). These devices have their own respective structural benefits with regard to leakage current. Therefore, we suggest guidelines with respect to the optimal device structures such that they have the advantages of both S-Fin and RCAT structures. With these guidelines, we propose a new recess-FinFET structure that can be realized by feasible manufacturing process steps. The structure has the side-gate form only in the bottom channel region. This enhances the characteristics of the threshold voltage (<TEX>$V_{\rm TH}$</TEX>), <SMALL>ON</SMALL>/<SMALL>OFF</SMALL> currents, and the retention time distributions compared with the S-Fin structure introduced recently. </P>