‘임상간호연구’ 학술지 게재논문(1995-2008년)의 연구동향 분석

최명애,정재심,임경춘,김주현,김금순,권정순,김성재,김경희,곽찬영,박광옥,이경은,김을순,이경숙 병원간호사회 2010 임상간호연구 Vol.16 No.2

Purpose: The purpose of this study was to identify the research trend of 341 studies published in Journal of Korean Clinical Nursing Research from 1995 to 2008. Methods: This study was conducted from May to November, 2009. The tool for analysis developed through literature reviews and discussions of researchers consisted of 7 categories such as characteristics of researchers, research designs, subjects, data collection methods, ethical consideration, nursing interventions, and dependent variables. Data were analyzed by frequency and percentage. Results: The mean number of author per study was 4.7, and clinical nurses were the most frequent as the first author (79.7%) and as a corresponding author (67.1%). Quantitative study was 97.6% and nonexperimental study was 51.7%. The most frequently used research designs were quasi-experimental study (73.9%) among experimental studies and survey study (79.1%) among nonexperimental studies. Patients were the most frequent subjects for studies (55.8%). 46.1% of studies gathered data with questionnaire, 57.7% of studies had consent from patients, and 44.3% of studies used nursing skills for nursing interventions, and 60.0% of studies used clinical end points for dependent variables. Conclusion: The research trend of clinical nursing studies shows that clinical nurses mostly perform quasi-experimental researches to solve patients' problem and frequently use nursing skills for nursing intervention and explore the effect of nursing interventions on clinical end points.

신성고혈압쥐에서 혈관내피층이 Phorbol Ester에 의한 수축에 미치는 영향

정수아,김형,차경훈,전제열,윤평진,염철호,박진,조남수,홍순표 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.11

골관절염 환자에서 관절내 Sodium Hyaluronate(Hyruan®)의 투여가 슬관절통에 미치는 영향

김훈정,임경준,위상우,정종달,유벙식,안태훈,소금영 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Background : Sodium Hyaluronate has been found to be deficient in the synovial fluid of patients with osteoarthritis. We evaluate the effect of intraarticular Sodium Hyaluronate(Hyruan®) on the knee joint pain in patients with osteoarthritis. Method : Ten patients with osteoarthritis of the knee were participated in this study. Sodium Hyaluronate was injected into knee joints weekly for 5 weeks consecutively. Clinical evaluations were performed using visual analogue scale(VAS) for pain, tenderness and swollen joint counts weekly for the first 5 weeks and at 10 weeks postinjection. Result : VAS, tenderness and swollen joint were all significantly improved from 2 weeks to 10 weeks. There was no complication, except pain on injection site in two patients. Conclusion : Intraarticular injection of Sodium Hyaluronate has been shown to be effective on the treatment of patients with osteoarthritis of the knee.

인종주의(Racism)에 대한 흑인 현대 무용가들의 반기

김경남,박정훈 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1

Race has been classified in physiological, pathological, psychological, and biochemical characteristics as well as the characteristics of the body for a long time. Achieving political, social, and economical rights and interests has become important national goals in capitalistic society, and genetic characteristics between races began to be abused. The case of blacks in America is a typical example, and they lived a special life as slaves based on genetic inferiority. Even after they were freed from slavery, racial discrimination has been maintained by the white people thinking they are superior. In the 20th century, discriminating blacks appeared even in modern dance. So, this study investigated how the black modern dancers have overcome the racism in the dance area by what activities. The summary is as follows. 1. In the tradition of Europe, the black modern dancers did activities to demonstrate their own intelligence and ability, and to make themselves serious creative artists. 2. They demonstrated their pride on their black ancestors and Afro-American's rich culture heritage, implanting the black's identity into the world over. 3. Escaping from Jim Crow stereotype which had been imposed to the black ever since Minstrels age, they embodied various role and image. 4. In the dance area which was severely closed to the black, the black modern dancers established lots of dance schools and dance companies, providing more opportunities to stand on stage. 5. Creating universal dance movements useful not only to the black but also to the white, the black modern dancers provided a 'cultural variety'. 6. Developing and keeping a political community through Protest Dance, they challenged toward the political, social, and economic racism, and showed integrated power by artificially revealing the black culture. Black-discriminating views in today's dance and other fields are being strongly challenged. However, there is a trend that the white people in a Dance field thinking of their superiority still see relationship between the white and black as domination and subordination, and superiority and inferiority. I think there should be a lot of work to define the history and value of black modern dancers based on right recognition on the black and their modern dance, and I believe this study will help understand black modern dance and American modern dance and suggest a direction to find things in common between the two.

Molindone: 약물학적 특성과 임상적 적용 : Molindone: A Review of Pharmacological Properties and Clinical Use

곽경필,정성훈 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.1

새로운 비전형적 항정신병약물은 전형적 약물에 비해 효능과 부작용 측면에서 많은 이점을 가지고 있으나, 비전형적 약물 역시 체중증가라는 부작용을 보인다. 체중증가는 치료의 순응도 뿐만 아니라 신체적 건강 그 자체에도 중요한 의미를 가진다. 항정신병약물 중 molindone만이 체중변화가 거의 없고 일부 환자에서는 체중감소가 보고된 바 있다. 그래서 본 논문에서는 molindone의 약동학적, 약력학적 특성, 치료적 효능 및 부작용에 대해 검토해 보았다. Molindone은 다른 항정신병약물과 여러 면에서 많은 유사성을 가지지만, 구조적 차이와 D1, D2, M, H1, α 수용체의 친화력에서 차이를 보인다. 약동학적 면에서도 매우 짧은 반감기, 낮은 지용성 등이 다른 항정신병약물과 차이를 가지고 있다. 정신분열병에 있어 molindone의 치료적 효능은 다른 항정신병약물과 차이가 없다. 약동학적, 약력학적 특성으로 노인, 내과적 질환이 병합된 환자, 임신부에게 안정성과 적은 부작용을 고려할 때 molindone이 선택될 수 있다고 제안되고 있다. 중추신경계와 기타 부작용 역시 전형적 항정신병약물과 유사한 경향을 가지나, 체중변화와 경련 유발에는 기타 항정신병약물에 비해 우수하다고 할 수 있겠다. 1980년대 말까지 molindone은 독특한 약동학적 특성으로 비전형적이라 분류되기도 하였지만, 현재의 비전형적 약물 즉 세로토닌-도파민 길항제가 소개되면서 molindone에 대한 임상연구는 거의 찾아보기 힘들다. 그러나 비전형적 항정신병약물이 과거처럼 전형적인 항정신병약물에 반응을 보이지 않거나 부작용이 심각한 환자에게만 사용되는 것이 아니라, 모든 정신병적 증상의 일차 치료제로 선택되는 현 시점에서 과도한 체중증가가 문제가 되는 환자들 중 일부는 molindone으로 교체하여 증상호전의 유지 및 체중감소를 동시에 얻을 수 있는 군이 있을 가능성이 높다. 다만 국내 및 국외에서 최근 molindone의 임상연구가 부족한 편이기 때문에 molindone으로 교체가능한 환자군에 대한 지침을 얻을 수 없어 임상의의 경험에 의존할 수밖에 없다는 문제점이 있다. 그래서 향후 항정신병약물에 의한 체중증가 부작용에 대한 잘 계획된 연구들이 필요할 것으로 생각된다. Although the side effect profiles of the new atypical antipsychotics are more advantageous than those of the conventional neuroleptics, the atypical antipsychotics have also been associated with weight gain. Weight gain is common and troublesome side effect and may have a significant effect on compliance as well as physical health. Several reports suggest that molindone is less harmful in this respect and alleviates the obesity of some patients. So, the authors review literatures concerning the pharmacodynamics, pharmacokinetics, therapeutic effects, and side effects of molindone.Molindone, an indole derivative dopamine antagonist, is structurally distinct from other classes of neuroleptics. Molindone exhibits many similarities to other neuroleptics, including dopamine receptor blockade, antipsychotic efficacy, and extrapyramidal side effects. Despite these similarities, molindone also has different properties. Molindone has very little affinity to bind centrally to either the D1 or D2 receptor site and has the lowest affinity for cholinergic, noradrenergic and histaminic receptors. Molindone also inhibits the enzyme monoamine oxidase in vitro and in vivo. Molindone is unlike any other neuroleptic agent with respect to its pharmacokinetic parameters. Tmax of molindone is very short and is less lipophilic than other neuroleptics. Although the elimination half-life of molindone is approximately 2 hours, the clinical duration of action of molindone is at least 24 hours.Molindone appears to be comparable in efficacy to conventional antipsychotics in schizophrenia and to be both effective and well-tolerated in geriatric and medically ill patients. Molindone does not appear to have the same propensity to induce side effects as other neuroleptic agents. But, clinically, molindone has a tendency to cause weight loss than conventional antipsychotic agents. The mechanism producing this weight loss is uncertain. A wide range of studies is still needed before we can fully appreciate the usefulness of molindone.

GIS 및 RS기법을 활용한 산사태 취약성 평가

김경태,정성관,박경훈,오정학 한국지리정보학회 2005 한국지리정보학회지 Vol.8 No.1

본 연구는 금호강 유역을 대상으로 GIS와 윈격탐사기법을 활용하여 산사태 취약성의 예측과 지도화를 수행하자 한다. 산사태 영향인자인 사면경사, 사면방4향, 지질, 토지이용도, 식생지수(NDVI)의 공간데이터베이스는 30m×30m 해상도로 구축하였다. 산사태 취약성은 중첩분석과 한산평가 매트릭스 방법으로 예측하였고, 6개 범주(안정, 매우 낮음, 낮음, 중간, 높음, 매우 높음)로 구분한 산사태 취약성 지도를 제작하였다. 분석결과에 따르면, 산사태 취약성이 '매우높은' 지역은 전체 대상지의 약 0.3% 정도를 차지하며, 이들 지역은 주로 높은 경사TA와 낮은 식생지수를 가지는 산림지역에 분포하는 것으로 나타났다. This study aims at predicting and mapping of the landslide susceptibility in the Geumho river watershed using GIS and Remote Sensing techniques. We constructed the spatial database of affecting factors such as slope angle, slope aspect, lithology, landuse, and vegetation index (NDVI) at a 30mx30m resolution. The landslide susceptibility of the study area was predicted through overlay analysis and adding up estimation matrix, and the predicted map of landslide susceptibility with six categories (stable, very low, low, moderate, high, very high) was constructed. As the results, it showed that the very high susceptibility zones made up approximately 0.3% of the total study area, and these zones were mainly distributed in the forest area with the high slope angle and low vegetation index.

인공 치아우식 발생 모델에서 디지털 방사선 공제술을 이용한 인접면 치아우식증의 진단

박정훈,최용석,황의환,이기자,최삼진,박영호,김경숙,진현석,홍경원,오범석,박헌국 대한구강악안면방사선학회 2009 Imaging Science in Dentistry Vol.39 No.1

Purpose : The purpose of the experiment was to evaluating the diagnostic ability of dental caries detection using digital subtraction in the artificial caries activity model. Materials and Methods : Digital radiographies of five teeth with 8 proximal surfaces were obtained by CCD sensor (Kodak RVG 6100 using a size #2). The digital radiographic images and subtraction images from artificial proximal caries were examined and interpreted. In this study, we proposed novel caries detection method which could diagnose the dental proximal caries from single digital radiographic image. Results : In artificial caries activity model, the range of lesional depth was 572-1,374 μm and the range of lesional area was 36.95-138.52mm². The lesional depth and the area were significantly increased with demineralization time (p<0.001). Furthermore, the proximal caries detection using digital subtraction radiography showed high detection rate compared to the proximal caries examination using simple digital radiograph. Conclusion : The results demonstrated that the digital subtraction radiography from single radiographic image of artificial caries was highly efficient in the detection of dental caries compared to the data from simple digital radiograph.

방사선 조사를 받은 흰쥐 신경뇌하수체 관문의 미세구조 : 관문의 새로운 개념설정 Establishment of a New Concept on the Barrier

이헌용,안의태,양남길,고정식,박경호 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

신경뇌하수체는 뇌의 일부지만 뇌실둘레기관(circumventricular organ)으로서 전형적인 혈액-뇌관문이 없으므로 혈관 안팎의 물질이동이 자유로운 신경내분비기관이다. 이 실험에서는 심한 방사선 조사시에 혈액-신경뇌하수체관문의 형태적 대응을-연구함으로써, 관문의 특성을 분석했으며, 관문의 구성을 구체적으로 설정하여 이를 개념화 할 것을 제안하였다. 체중 200-250g의 숫흰쥐를 sodium thiopenthal 로 마취시킨 후 Mitsubishi선형가속기로 방사선 조사를 시켰다. 조사조건은 거리 80cm, 조사구역 30 X 30cm, 조사깊이 1.2cm, 조사속도 분당 200 rads로 하여 실험군에 따라 3,000 rads 또는 6,000 rads가 되도록 했다. 조사후 6시간, 2일, 6일후에 각군의 동물을 도살 하여 신경뇌하수체를 떼어냈다. 떼어낸 조직은 1% glutaradehyde- 1% paraformaldehyde액에 1차 고정하고, 1% osmium tetroxide액에 2차 고정하였고, araldine혼합액에 포매된 조직은 절편을 만들어 uranyl acetate와 lead citrate액으로 염색해서 전자현미경으로 관찰하였다. 주로 모세혈관주위공간에서 관문구조를 중심으로 관찰한 결과 3,000 rads 조사군과 6,000 rads조사군 모두가 비슷하게 심한 변화를 보였고, 변화의 정도가 2일군에서 가장 심했으며 6일군에서는 약간 안정되는 모습이었으나 변화의 양상은 모든 실험군을 통해서 비슷하였다. 가장 두드러진 변화는 모세혈관주위공간에서 나타났는데 공간의 확장, 큰포식세포의 증가와 활성화, 신경뇌하수체세포속에 들어 있던 신경종말들의 이탈, 먼지 같은 물질의 증가 등을 들 수 있었다. 특히 큰 포식세포의 변화는 매우 특징적이어서 넓은 세포질관(판상족, lamellipoda)을 형성하여 모세혈관과 신경뇌하수체세포사이를 차단시킬 뿐아니라 왕성한 포식작용으로 공간내의 축삭종말들을 용해시켰다. 큰포식세포의 세포질안에는 과립형질내세망들이 매우 발달하였고, 세포질 영역이 매우 넓어진 것으로 볼 때, 이들이 기동타격대로서 활발히 움직이는 매우 효율적인 관문의 구성성분으로 생각되었다. 특히 신경뇌하수체는 전형적인 혈액-뇌관문이 없으므로 신경내분비기능의 수행에는 유리하나 면역활성물질이나 독성물질등 뇌에 해로운 물질의 왕래를 차단하여 제거하거나, 과다하게 분비된 신경호르몬을 조절하는 일이 중요하다고 볼 때, 큰포식세포가 이같은 역할에 적합한 구성성분이라는 결론을 얻었다. 이 실험에서는 효율성이 높은 관문으로서 혈액-신경뇌하수체관문이 구성성분을 차례로 기재하고 이를 개념화 할 것을 제안한다. 모세혈관과 축삭종말사이에 형성되어 있는 혈액-신경뇌하수체관문이 구성을 차례로 표기하면 다음과 같다 (그림 9,10). 1. 유창모세혈관 내피 2. 모세혈관 내피의 기저판 3. 혈관주위세포와 기저판("이차방어선", 한정된 범위내에서 움직일 수 있다). 4. 큰포식세포, 필요에 따라 판상족(lamellipoda)을 넓게 뻗는다.("삼차방어선", 모세혈관 주위공간 속을 이동해 다니는 "기동타격대") 5. 신경뇌하수체세포의 기저판 6. 신경뇌하수체세포의 세포질돌기(호르몬분비 조절) To study the morphological characteristics of the blood-neurohypophysis barrier system in a severely altered situation, the heads of rats were exposed to heavy X-irradiation. Rats weighing 200-250 g each were anesthetized with sodium thiopenthal, and placed on the table of Mitsubishi linear accelerator ML-4MV. Only heads of rats were placed within the exposure area of 30 cm X 30 cm. Irradiation was processed at the distance of 80 cm, with the speed of 200 rads/min in the radiation depth of 1.2cm. Total doses were 3,000 rads or 6,000 rads according to the animals of the different experimental groups. Rats were sacrificed on 6 hours, 2 days or 6 days following radiations. Tissue blocks of neurohypophyses were fixed in the 1% glutaraldehyde-1% paraformaldehyde solution, and they were refixed in the 1% osmium tetroxide solution. Ultrathin sections were contrasted with uranyl acetate and lead citrate solutions. Electron micrographs exhibited dramatic changes within the perivascular space of neurohypopysis. The perivascular space was greatly enlarged, and it contained many macrophages, floating axonal endings and plentiful flocculent materials. The enlargement was largest in the 2 day-group animals. Many macrophages are activated, and it showed tremendous cytoplasmic lamellipoda. Wide plate of macrophagic cytoplasm usually engulfed the floating axon terminals, and are located between the cappillary and the pituicytes. The situation gave the impression that macrophages prevent, filter and/or retrieve the excessive materials transported between the capillary and the axonal endings. Since the perivascular microenvironment of neurohypophysis is more vulnerable as compared with those brain areas equipped with blood-brain barrier, the functional barrier system by macrophages in the neurohypophysis should have important role. The concept of blood-neurohypophyseal barrier with the following components is proposed. The components of the barrier system from the blood pool to the hormonal pool are 1. Endothelium of fenestrated capillary 2. BAsal lamina of endothelium 3. Pericyte("second line of defense". mobile in a limited area) 4. Macrophage, extending its wide cytoplasmic plate(the lamelipoda) in need("third line of defense". freely movable in the perivascular space, "active surveillance system") 5. Basal lamina of pituicyte 6. Cytoplasmic processes of pituicyte

MPEG을 이용한 저전송률 화상회의 시스템

장경훈,이정훈,최연성,김장형 濟州大學校 産業技術硏究所 1998 산업기술연구소논문집 Vol.9 No.2

In this paper. we implement ITU-T Recommendation H.323 that is multimedia communication system. Video conferencing system is implemented software using RTP. MPEG and G.721 by Visual C++ 6.0 language in Windows-98. Also Video post-office box is implemented. We should prove the result of H.323 through experiment.

금호강 유역 산림의 경관생태적 패턴분석

박경훈,정성관,이현택,오정학,김경태 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.3

산림의 단편화와 같은 인위적 교란은 유역생태계의 지속성에 영향을 미치기 때문에, 본 연구는 각종 개발사업에 따른 산림의 단편화를 사전에 예방하기 위해서 경관지수와 GIS를 이용하여 금호강 유역에 분포하는 산림구조를 정략화하였다. 소유역 단위의 경관지수값은 인자분석에 의해 전체분산을 또% 정도 설명하는 3개의 공통인자를 단순화하였다. 산림단편화 정도는 소유역별 인자점수를 토대로 계산하였고, 이는 도시지역 면적률(r=0.827, p<0.01, R2=0.685), 고도(r=-0.637, p<0.01)그리고 경사도(r=-0.593, p<0.01)와 상호관련성이 있는 것으로 나타났다. 이상과 같이 본 연구는 금호강 유역관리를 위한 산림경관의 건전성 및 구조적 패턴을 평가하기 위한 방법론과 경관지수값을 제시하였다. 향후에는 경관패턴 및 그 변화가 유역환경의 건전성에 미치는 영향을 규명하기 위한연구가 필요할 것이다. An artificial disturbance like fragmentation in watershed forest has impacted a sustainability of watershed ecosystem, therefore this research quantified the landscape structure in the Geumho river watershed using landscape indices and GIS. Landscape indices were calculated from the forest distributed maps for 24 subwatersheds. Three common factors, which explained about 85% of the variation in the original data, were extracted by a factor analysis. The fragmentation gradient in forest landscape, which was calculated from the factor scores, was correlated with proportion of urban land (rte. 827, p<0.01, R²=0.685). elevation (r=-0.637, p<0. 01) and slope gradient (r=-0.593, p<0. 01) . The result of the study presented that the methodology and the values of landscape indices to assess the structural patterns of forest landscape for the Geumho river watershed management. Future research will be directed towards the detection of impacts of landscape patterns and their changes on the integrity of watershed environments.