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군 복무 중 발병한 공황장애 환자에 대한 한의 복합치료 및 한방정신요법 기반 노출치료 병행 1례 보고
이경은,위민지,김근우 대한한방신경정신과학회 2025 동의신경정신과학회지 Vol.36 No.2
Objectives: The objective of this study was to observe changes in clinical symptoms and autonomic nervous system indices following a combination of Korean medical treatments and exposure therapy based on traditional Korean psychotherapy for a patient with panic disorder and agoraphobia that developed during military service who had a history of childhood trauma due to school bullying. Methods: A 23-year-old male diagnosed with panic disorder according to DSM-5 criteria received a combination of herbal medicine, acupuncture, and relaxation therapy. Starting on the 7th day of hospitalization, exposure therapy sessions based on Korean psychotherapy were conducted two to three times per week. Psychological assessments including BDI-II, BAI, STAI, PAS, and SCL-90-R were performed before and after treatment, along with Heart Rate Variability (HRV) measurements such as RMSSD. Results: Significant reductions were observed in major psychological assessment scores (BDI, BAI, STAI, PAS), with improvements in anxiety, frequency of panic attacks, and physical symptoms. During exposure therapy, HRV assessments including RMSSD showed a tendency of increase in variability after relaxation training, which was interpreted as reflecting a relaxation response of the autonomic nervous system. Conclusions: Korean medical treatment combined with traditional psychotherapy-based exposure therapy appears to be effective in alleviating symptoms of panic disorder and promoting psychological stability. HRV assessment might serve as a useful physiological marker for tracking treatment response. Further studies are warranted to develop systematic clinical protocols based on these findings.
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부모의 사회경제적 지위와 아동의 자아존중감과의 관계에서 부모양육행동과 가정폭력의 매개역할
이경은,이주리 한국아동심리재활학회 2008 놀이치료연구 Vol.12 No.3
The purpose of this longitudinal study was to examine the influences of parental socioeconomic status on self-esteem of children and the mediating effects of parenting behavior and domestic violence. For analysis, the 2004-2005 panel 2 data of Korea Youth Panel Survey were used. Participants were 844 4th graders(time 1, 2004) and 5th graders(time 2, 2005) in elementary schools. The results were analysed using structural equation modeling with AMOS 7.0. This study finding indicated that (1) After Controlling time 1 self-esteem of children, time 1(2004) parental socioeconomic status influenced time 2(2005) self-esteem of children directly. (2) Parenting behavior and domestic violence mediated the associations between time 1(2004) parental socioeconomic status and time 2(2005) self-esteem of children, After controlling time 1 self-esteem of children. 본 연구는 종단 자료를 활용하여 부모양육행동과 가정폭력이 부모의 사회경제적 지위와 아동의 자아존중감 간 관계를 매개하는지 검증하였다. 이를 위해, 한국청소년패널조사(KYPS)의 초 4 패널 자료중 2004년~2005년 데이터를 사용하였다. 연구대상은 총 844명으로, 조사시작 시점인 2004년도에 초등학교 4학년생들이었다. 구조방정식 모형 분석 결과, 연구 결과는 다음과 같이 나타났다. 첫째, 시기 1(2004년)의 아동의 자아존중감을 통제한 후, 시기 1(2004년)의 부모의 사회경제적 지위는 시기 2(2005년)의 아동의 자아존중감에 영향을 미쳤다. 둘째, 시기 1(2004년)의 아동의 자아존중감을 통제한 후, 부모양육행동(2004년)과 가정폭력(2004년)은 시기 1의 부모의 사회경제적 지위(2004년)와 시기 2의 아동의 자아존중감(2005년) 간 관계를 완전매개 하였다.
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Ephedrine이 뇌내 Biogenic Amine 함량에 미치는 영향
이경은,Lee, Kyung-Eun 대한약리학회 1995 대한약리학잡지 Vol.31 No.2
Sympathomimetic amines, especially ephedrine, are a major ingredient in proprietary medications for symptomatic treatment of upper respiratory infections. Their frequent uses can lead to occasional instances of abuse and habituation. The clinical symptoms of ephedrine abuse are similar to that of amphetamine psychosis and resemble closely that of schizophrenia. Because both amphetamine psychosis and schizophrenia are thought to be mediated primarily through the action on catecholamines, ephedrine-induced changes of the biogenic amines can be suspected. However, there were few studies about the central effects of ephedrine because of the milder central action than peripheral. Therefore, the present investigation was undertaken to elucidate the relations between the effects of single or repeated administration of ephedrine on the regional levels of biogenic amines in rat brain and ephedrine-induced CNS stimulation. The male Sprague-Dawley rats weighing $100{\sim}200\;g$ were used. After single or repeated administrations of ephedrine, blocks of tissue were obtained from frontal cortex, corpus striatum, hippocampus, thalamus, hypothalamus, substantia nigra and cerebellum. The concentration of biogenic amines(norepinephrine, epinephrine, dopamine, 5-hydroxytryptamine(5-HT)) and their metabolites (3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid(HVA), 5-hydroxyindoleacetic acid(5-HIAA)) were measured by means of high performance liquid chromatography-electrochemical detector(HPLC-ECD). The results obtained were as follows: 1) In the normal rat, the concentration of norepinephrine was the highest in hypothalamus. Dopamine, DOPAC and HVA were highest in corpus striatum, and 5-HT and 5-HIAA were highest in substantia nigra. Epinephrine was not detectable in any part of the brain tissue. 2) In a single administration of ephedrine, the concentration of DOPAC was decreased in corpus striatum. However, the other biogenic amines and their metabolites were not changed. 3) In repeated administration of ephedrine, the concentration of norepinephrine was decreased in all brain region checked. Dopamine was decreased in corpus striatum and substantia nigra and, increased in hypothalamus, and HVA was decreased in corpus striatum. 5-HT was decreased in all brain region except cerebellum and, 5-HIAA was decreased only in frontal cortex. The ratio of 5-HIAA/5-HT was increased in corpus striatum, thalamus, hypothalamus and substantia nigra. These data indicated that, although a single administration of ephedrine did not change the central neurotransmitters, repeated administration of ephedrine caused the decreases of norepinephrine and 5-HT in the most regions of brain, which may be responsible for the emergence of abnormal behavioral effect after ephedrine abuse.
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