회맹장 및 대장을 침범한 장 결핵에 있어서 바륨을 이용한 방사선 이중조영촬영 소견에 대한 연구

진용현,전혜정,이용근,강철호,조성범,김윤환,박철민,차상훈,김일영,이혜경 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

To determine the characteristic double contrast barium enema findings of ileo-cecal and colonic tuberculosis and to make differential diagnosis from other bowel inflammatory disease. Sixty-seven patients confirmed as ileo-cecal and/or colonic-tuberculosis in six hospitals were evaluated retrospectively. The diagnosis was proven by endoscopic biopsy, surgery, and clinical follow up. Nine of 67 patients were excluded because radiologic findings were normal though endocopic biopsy examinations resulted in tuberculosis. Histopathological diagnosis were madein 58 cases as follows: endoscopic biopsy(n=29), operation(n=12), follow up examination(n=14), tissue culture(n=1), laparoscopic biopsy(n=2). There were 30 men and 28 females. The mean age were 36 yrs(range:16-67), 34 patients were in the second and third decade. The distribution of lesions, morphological characteristics, mucosal changes, ulcer shape and depth, associated with other tuberculous lesion, multiplicity were retrospectively analyzed in the findngs of double contrast barim enema. The commonest clinical symptoms were abdominal pain(n=35, 60%) and diarrhea(n=18, 31%). The chest radiography revealed association of pulmonary tuberculosis in 39 cases. Tuberculous lesions of other organs except chest were present in five cases. Double contrast barium enema findings showed a thickening and irregularity of intestinal mucosal fold(n=29, 50%), bowel contraction and/or shortening(n=26, 45%). There were small, nodular, superficial ulcers in the case of ulcer depth less than 2 mm in the depth. As many as 39 cases(67%) in this series had two or more lesions in the intestinal tuberculosis. The involved segment revealed symmetrical feature(n=21, 36%). Inflammatory pseudopolypoid lesions were noted in 30 cases(52%). The ileo-cecal region was involved in 38 cases(66%). The ascending colon(n=25, 43%) was the second commonest site with or without contiguous cecal involvement. Lesions in terminal ileum, ileo-cecal valve, transverse colon, descending colon and appendix were seen in 19, 18, 18, 12 and seven cases, respectively. Among 18 cases of ileo-cecal valve lesions, there were incompetency in nine cases(16%) and wide gapping in four cases(7%). In 14 cases, tuberculous enterocolitis was diagnosed by clinical follow-up and double contrast barium enema study. 12 out of 14 cases, the findings of double contrast barium enema of tuberculous enterocolitis were normalized after anti-tuberculous medication. However, two cases showed more aggravated state than before due to inappropriate treatment. Double contrast barium enema plays an important role in the diagnosis of tuberculous enterocolitis, determines the type, site and extent of the involvement and helps in treatment guide by using sequential studies.

대학생의 성별, 학년별, 전공별 스트레스에 관한 연구

김보혜,안윤정,정민영,차지영,최경원,김지현,김수지,이자형 이화여자대학교 간호과학대학 2004 이화간호학회지 Vol.- No.38

The purpose of this study was to investigate the level and effect of stress on physical and mental health. Based on that result, we offer the basic research to lessen students' stress and make a program to promote health condition effectively. Subjects were 526 university students. (male: 232(44.1%) female: 294(55.9%). composed of 7 majors: human studies&social science, management, Science&technology, education. law, medicine, entertainment. freshman 108(20.5%), sophomore 140(26.6%) junior 148(28.1%), senior 130(24.7%)) Subjects were filled with 127 questionnaires. T test and ANOVA were used to evaluate each stress levels. The .05 level of significance was the critical for this research. Also used the correlation to know the relation between stress levels and effects. The result of the study were as follows: 1. According to gender, male students got 2.37, female students got 2.46 on the stress level(p=.05). And also the belonging items showed female students got higher stresses than male students. 2. According to grade, the average score of stress level was 2.42. sophomores got the highest stress and freshmen got the lowest stress level. But that was not meaningful difference. freshman and sophomore got higher stress on studying. and except the freshman, all grades got severe stress on employment. 3. According to major, there were differences on university life and surroundings. On university life, the students who majored management got highest stress and the students who majored Education got the least stress. And on surroundings, the students who majored Law got highest stress. 4. According to gender, female students suffered from more stress effects than male students.(male 2.3725 female 2.4657 t:-1.968 p:.050) 5. According to grade, the average score of stress was 2.2285. sophomore got 2.3042 and junior got 2.2148 on stress effects. 6. According to major, The students who major in law got more stress effects caused by family than any other students. The students who major in entertainment and gymnastics got more stress effects than any other students in surroundings. 7. There were significant correlations between the stress level and effects(r.=847, p=.000).

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

중학생의 역사 드라마 시청이 역사의식에 미치는 영향

장희흥,차경호,구혜진 大邱大學校 師範大學 附設 敎育硏究所 2010 學校敎育硏究 Vol.5 No.2

This study is aimed at proposing the specific plans to use history drama lessons through the study on the relations between reality, fascination and involvement that are sub-variables of history drama viewing and middles school students’ historical consciousness, and to raise their historical consciousness by using history drama lessons. In order to accomplish such a goal, the study selected respective 250 middle school students in Daegue and Gumi, Gyeongsangbuk-do as its subjects, and the surveyed and analyzed findings are obtained as follows. First, it is the result obtained by dividing the subjects’ general characteristics. Fascination and involvement among reality, fascination, and involvement that were sub-variables had a difference in the division by sex. Fascination was shown to be higher in female students while involvement was higher in male students. In addition, as to the region, history drama viewing had no difference in middle school students of Daegue and Gyeongsangbuk-do. Historical consciousness was higher in middle school students of Daegue that those of Gyeongsangbuk-do, while regarding the grade there was no difference in history drama viewing and historical consciousness. Second, it was the result regarding how reality, fascination, and involvement that were sub-variables of history dram viewing affected historical consciousness. With regards to types of history dram viewing, fascination, reality, and involvement significantly affected historical consciousness in order. According to the gender, male students’ reality, involvement, and fascination gave a significant effect on historical consciousness while female students’ involvement didn’t affect historical consciousness, and fascination and reality gave an effect on historical consciousness in order. As to the grade, the first graders’ reality, fascination, and involvement were not related to historical consciousness while the second graders’ reality and fascination except for involvement affected in order. Besides, the third graders’ fascination only affected historical consciousness. Regarding the region, fascination and reality of middle school students in Daegu affected historical consciousness in order while fascination, involvement, and reality of middle school students in Gyeongsangbuk-do influenced historical consciousness. Like this, there was a little difference in the gender, grade, and region, but reality, fascination, and involvement that were sub-variables related to history drama viewing affected historical consciousness, and the higher sub-variables related to history drama viewing were, the higher historical consciousness was. Due to the fact that history dramas had a fictional element, there was a discussion on educational efficiency. However, this study verified the fact that history dramas can be educationally used, instead of deciding whether history drams were true or not. Based on the findings of the study, the effective utilization methods of history dramas in history lessons are suggested as follows. First, the study of historical figures using history dramas is possible. Students can understand properties of characters through re-enactment and empathy, and approach various figures that don’t appear in textbooks. Second, they can raise critical view that is able to divide false and fact of history dramas and use it to the fact learning. Third, it is possible to learn historical terms. By learning unfamiliar and difficult historical terms in advance, they can increase interest in history lessons. Fourth, storytelling of historical materials is possible. Students can make their own new interpretation by constructing various historical materials in a way of history dramas. Fifth, they can use a decoration making of history dramas, a visiting of the set, and a clipping of TV screen capture in various manufacturing studies as materials. Sixth, they can have a mock trial and a role-playing lesson regarding behaviors decisions of history drama figures. Seventh, they can study the public life history through history dramas. 이 논문은 중학생의 역사 드라마 시청이 역사의식에 미치는 영향에 대한 것이다. 역사 드라마 시청과 관련된 하위변인인 현실감, 심취도, 관여도는 성별, 학년, 지역에 따른 차이는 있지만, 역사의식에 분명 히 영향을 미치고 있다. 영향력의 크기는 심취도, 현실감, 관여도 순으로 나타났다. 그렇기에 역사 드라 마 시청과 관련한 역사 수업은 중학생의 역사의식 향상에 도움을 줄 수 있을 것으로 보인다. 역사 드라마를 시청하려는 의도와 시청하는 동안의 관여도 정도는 남학생의 경우 역사의식에 유의한 영향을 미쳤지만, 여학생의 경우 유의한 영향을 미치지 않는 것으로 나왔다. 학년별로 결과를 살펴보면 모든 학년에서 관여도는 역사의식에 통계적으로 유의한 영향을 주지 않는 것으로 나타났고, 제일 고학 년인 3학년에서 심취도만이 영향을 주는 것으로 보아 역사 드라마를 시청함에 있어 역사적 사실과 허구를 구별하는 능력이 아래 학년보다 발달하여 현실감의 영향을 덜 받은 것으로 보인다. 역사의식은 대구광역시 중학생이 경상북도 중학생보다 다소 높다. 그리고 실제 사극의 선호도는 퓨전 이나 판타지를 선호하지만 실제 전통사극이 역사의식에 더 높은 영향을 미쳤다. 이것은 현장 교사의 경 험담과 일치한다.

관상정맥동과의 연결이 없는 좌상대정맥의 CT 소견 : 1예 보고 case report

백상현,박재성,이혜경,홍현숙,김대호,조준희,박성진,차장규 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

A persistent left superior vena cava (PLSVC) is the most common thoracic venous anomaly. It is a persistent remnant of a vessel that is present as a counterpart of normal right-sided superior vena cava(SVC) in early embryological development but normally disappears later. Its diagnosis can be confirmed by many noninvasive and invasive tests, or it is incidentally diagnosed at insertion into the left subclavian or jugular vein or thoracic surgery. If it is not associated with other congenital cardiac anomalies, it is usually asymptomatic and hemodynamically insignificant. We describe the chest radiograph and CT findings of bilateral SVC with drainage to left superior intercostal vein, hemiazygos, azygos vein and right SVC, and no connection of coronary sinus.

Receptor Binding Affinities of Synthetic Cannabinoids Determined by Non-Isotopic Receptor Binding Assay

Cha, Hye Jin,Song, Yun Jeong,Lee, Da Eun,Kim, Young-Hoon,Shin, Jisoon,Jang, Choon-Gon,Suh, Soo Kyung,Kim, Sung Jin,Yun, Jaesuk Korean Society of ToxicologyKorea Environmental Mu 2019 Toxicological Research Vol.35 No.1

A major predictor of the efficacy of natural or synthetic cannabinoids is their binding affinity to the cannabinoid type I receptor ($CB_1$) in the central nervous system, as the main psychological effects of cannabinoids are achieved via binding to this receptor. Conventionally, receptor binding assays have been performed using isotopes, which are inconvenient owing to the effects of radioactivity. In the present study, the binding affinities of five cannabinoids for purified $CB_1$ were measured using a surface plasmon resonance (SPR) technique as a putative non-isotopic receptor binding assay. Results were compared with those of a radio-isotope-labeled receptor binding assay. The representative natural cannabinoid ${\Delta}^9$-tetrahydrocannabinol and four synthetic cannabinoids, JWH-015, JWH-210, RCS-4, and JWH-250, were assessed using both the SPR biosensor assay and the conventional isotopic receptor binding assay. The binding affinities of the test substances to $CB_1$ were determined to be (from highest to lowest) $9.52{\times}10^{-3}M$ (JWH-210), $6.54{\times}10^{-12}M$ (JWH-250), $1.56{\times}10^{-11}M$ (${\Delta}^9$-tetrahydrocannabinol), $2.75{\times}10^{-11}M$ (RCS-4), and $6.80{\times}10^{-11}M$ (JWH-015) using the non-isotopic method. Using the conventional isotopic receptor binding assay, the same order of affinities was observed. In conclusion, our results support the use of kinetic analysis via SPR in place of the isotopic receptor binding assay. To replace the receptor binding affinity assay with SPR techniques in routine assays, further studies for method validation will be needed in the future.

Receptor Binding Affinities of Synthetic Cannabinoids Determined by Non-Isotopic Receptor Binding Assay

Hye Jin Cha,Yun Jeong Song,Da Eun Lee,Young-Hoon Kim,Jisoon Shin,Choon-Gon Jang,Soo Kyung Suh,Sung Jin Kim,Jaesuk Yun 한국독성학회 2019 Toxicological Research Vol.35 No.1

A major predictor of the efficacy of natural or synthetic cannabinoids is their binding affinity to the cannabinoid type I receptor (CB₁) in the central nervous system, as the main psychological effects of cannabinoids are achieved via binding to this receptor. Conventionally, receptor binding assays have been performed using isotopes, which are inconvenient owing to the effects of radioactivity. In the present study, the binding affinities of five cannabinoids for purified CB₁ were measured using a surface plasmon resonance (SPR) technique as a putative non-isotopic receptor binding assay. Results were compared with those of a radio-isotope-labeled receptor binding assay. The representative natural cannabinoid Δ<SUP>9</SUP>-tetrahydrocannabinol and four synthetic cannabinoids, JWH-015, JWH-210, RCS-4, and JWH-250, were assessed using both the SPR biosensor assay and the conventional isotopic receptor binding assay. The binding affinities of the test substances to CB₁ were determined to be (from highest to lowest) 9.52 × 10<SUP>−13</SUP> M (JWH-210), 6.54 × 10<SUP>−12</SUP><SUP></SUP> M (JWH-250), 1.56 × 10<SUP>−11</SUP> M (Δ<SUP>9</SUP>-tetrahydrocannabinol), 2.75 × 10<SUP>−11</SUP> M (RCS-4), and 6.80 ×10−11 M (JWH-015) using the non-isotopic method. Using the conventional isotopic receptor binding assay, the same order of affinities was observed. In conclusion, our results support the use of kinetic analysis via SPR in place of the isotopic receptor binding assay. To replace the receptor binding affinity assay with SPR techniques in routine assays, further studies for method validation will be needed in the future.

A Case of ALK-Rearranged Adenocarcinoma with Small Cell Carcinoma-Like Transformation and Resistance to Crizotinib

Cha, Yoon Jin,Cho, Byoung Chul,Kim, Hye Ryun,Lee, Hye-Jeong,Shim, Hyo Sup Elsevier 2016 JOURNAL OF THORACIC ONCOLOGY Vol.11 No.5

Identification of classifier genes for hepatotoxicity prediction in non steroidal anti inflammatory drugs

Cha, Hye-Jin,Ko, Moon-Jung,Ahn, Soo-Mi,Ahn, Joon-Ik,Shin, Hee-Jung,Jeong, Ho-Sang,Kim, Hye-Soo,Choi, Sun-Ok,Kim, Eun-Jung The Korean Society of Toxicogenomics and Toxicopro 2010 Molecular & cellular toxicology Vol.6 No.3

Toxicogenomics has the potential to be used for the regulatory decision making to predict toxicity in developing new drugs. We have identified the classifiers for hepatotoxicity prediction in nonsteroidal anti inflammatory drugs (NSAIDs) through analyzing differential gene expression profiles of hepatotoxic and nonhepatotoxic compounds using HepG2 cell. $100\;{\mu}M$ of 8 hepatotoxic and 8 nonhepatotoxic NSAIDs were treated to HepG2 cell and the analysis of gene expression changes after 24 hallowed a set of genes to be identified differentiating hepatotoxicants from nonhepatotoxicants by statistical method. The hepatotoxicity prediction model was built using the selected 77 genes. These genes and pathways, commonly regulated by hepatotoxicants, may be indicative of the early characterization of hepatotoxicity and possibly predictive of later hepatotoxicity onset. 4 test compounds including hepatotoxic and nonhepatotoxic NSAIDs were used for validating the prediction model and the accuracy was 100%. Given that the specificity and sensitivity showed 100%, these are the most precise classifiers identified until now.

Dependence Potential of Tramadol: Behavioral Pharmacology in Rodents

( Hye Jin Cha ),( Min Ji Song ),( Kwang Wook Lee ),( Eun Jung Kim ),( Young Hoon Kim ),( Yun Je Lee ),( Won Keun Seong ),( Sa Ik Hong ),( Choon Gon Jang ),( Han Sang Yoo ),( Ho Sang Jeong ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.6

Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.