Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

머리염색이 인체에 미치는 영향

윤형식,황성호,이현륭,김수호,박연석,권낙현,정호진,김동훈,노현주,홍성호,박병찬,이관,정해관 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

일상생활에서 모발염색은 흔히 접할 수 있는 미용의 한 종류로 특히 젊은층을 중심으로 폭발적으로 유행하고 있다. 염색을 위항 사용하는 약제는 표백제와 발색제 등 각종 화학약품이 사용되고 있으나 이로 인한 건강장해에 대한 연구는 그리 많지 않다. 저자들은 염색이 인체의 모발건강에 미치는 영향을 파악하기 위하여 염색과 관련된 주관적 증상과 모발의 변화에 대한 실험적 연구를 시행하였다. 동국대학교 경주 캠퍼스 재학생 80명을 대상으로 설문조사를 시행하여 염색 유 ·무 및 염색 후에 경험한 증상에 대해 설문 조사하였고, 의과대학 재학생 46명을 대상으로 피부 반응 테스트를 실시하였다. 또한 염색 전후의 모발 탄성도를 측정하였고 모발의 상태를 파악하기 위해 전자 현미경검사를 실시하였다. 설문조사 결과 염색 전에 비하여 염색 후 안구혼탁, 안구건조, 시력저하, 발진 및 접촉성 피부염, 모발손상, 모근손상 등의 증상을 더 많이 경험한다고 호소하였다(p<0.05). 모발손상과 모근손상은 헤어드라이어 사용 빈도에 따라 증가하는 것으로 조사되었다(p<0.05). 피부반응검사에서 가려움증이 가장 많은 증상이었으며 이는 여성보다는 남성에서 높은 것으로 조사되었다. 염색 전후의 모발장력은 염색 전 134.5±10.37g, 염색 128.0±30.69g, 염색 이틀 후 112.5±19.69g으로 나타났다. 염색 전후의 모발의 전자현미경 케라틴 층이 현저히 감소하고 모발이 가늘어지는 차이를 보였다. 염색은 모발손상, 모발 케라틴 손상 및 모근 손상, 발진 및 접촉성 피부반응, 안구혼탁, 안구건조, 시력 저하를 유발한다. 따라서 염색약으로 인한 손상에 대한 주의와 예방이 필요하다고 생각한다. 예방대책으로 염색 전 피부테스트를 통한 적합성 여부를 판단하는 것이 필요하며 가급적 염색을 피하는 것이 좋을 것이다. 염색약에 발암물질이 포함되어있다는 보고도 있어 염색 제조사의 철저한 실험과 염색 물질의 선별이 염색으로 인한 부작용을 최소화하는데 중요한 역할을 할 것이다. Hair coloring has became one of the most popular cosmetic activities to younger generations during last decade. However, there are few studies on the health effect of widespread use of chemical dyes. This study was conducted to study the effects of hair coloring dye on hair and other systems. We conducted a questionnaire survey of 80 persons in Kyongju campus, Dongguk University. We have done open patch skin test on 46 medical students. We also conducted scanning electron microscopy to examine the hair strength and structure before and after hair coloring process. Injury of hair and hair bulb, contact dermatitis, turbid eyes, xerophthalmia, and poor visual acuity were the main symptoms complained after hair coloring (p<0.05). Injury of hair and hair bulb were increased by frequency of hair-dryer use(p<0.05). In open patch test, pruritus was complanined by more than half of the subjects. Mean strength of hairs before and after hair coloring was as follows; 134.5 (SD 10.37)g before hair coloring, 128.0 (SD 30.69)g immediately after hair coloring, and 112.5 (SD 19.69)g after two days. The scanning electron microscopic findings of hair surface before and after hair coloring showed decreased keratin layer and thinning of the hair. Hair coloring induces injury to hair, its keratin layer, and hair bulb as well as contact dermatitis, turbid eyes, xerophthalmia, and poor visual acuity. Therefore, we think that precaution is needed in use of hair coloring dye. To prevent complications induced by hair coloring dye, it is necessary, especially to those with allergy or skin disorders, to perform skin test before action and avoid hair coloring whenever possible. Longterm health effects of hairdye should be studied and manufacturing companies should try to minimize complications induced by hair coloring dye.

실용음악 전공 학생들의 발성치료 전후 성대 및 음성 특성 비교

황연신,심미란,김철준,최용석,김상연,최찬호,선동일,Hwang, Yeon Shin,Shim, Mi Ran,Kim, Chul Jun,Choi, Yong Suk,Kim, Sang Yeon,Choi, Chan Ho,Sun, Dong Il 대한후두음성언어의학회 2016 대한후두음성언어의학회지 Vol.27 No.2

Background and Objectives : Many students major in applied music singing have various difficulties in phonation when they sing or perform. But the studies about this cause are lack. The purpose of this study is whether singing voice therapy based on vocal music is effective or not to applied music singing students that have difficulties in phonation. Materials and Methods : Singing voice therapy program had been done to 8 students major in applied music singing during 7 weeks. We did laryngeal stroboscope, perceptual, acoustic and aerodynamic examination before and after singing voice therapy to this students. And we studied post examination results have differences or improvements compared to pre examination results. Results : Four male students don't have effective improvement after singing voice therapy but they shows slight improvement in aerodynamic examination values compared to pre examination values. Four female students shows improvement in aerodynamic examination values and pitch range increasing. Above all, one student's vocal nodules disappeared after singing voice therapy. Conclusion : Singing voice therapy based on music singing is very effective to the students major in applied music singing. Above all, their curriculum in applied music singing should include phonation training based on music singing before training perform and technic practices.

스포츠와 정치에 관한 이론적 고찰

성영호,이석영,노덕선,권지윤 龍仁大學校 體育科學硏究所 1997 體育科學硏究論叢 Vol.7 No.1

An attempt of indicating al perspective for the systematic arrangement of studies on sports and politics was made examining the contents and method of preceding studies conies concerned. Main results are as follow; 1. The concrete domains of the study on sports and politics are classified into such five categories as sports policy sports and political ideology, political functions of sports, sports and social regime, and sports international relations. After indicating the problems to be solved in terms of the systematic arrangement of the studies in each category, they are mutually related and a guideline for the systematization of studies on sports and politics is presented. 2. Politics can basically be understood as policy which has a certain logical relation with public interests and power, for the analysis of mutual relation between sports and politics standing on the basic of policy it is inevitable to clarify the meaning of in fluence relation and function Especially logical improvement of the method of functional analysis is indispensable.

후방 도달 척추 절제술을 이용한 강직성 요천추 변형의 치료

석세일,정의룡,이정희,김진혁,김성수,이지호,최원기,박용원 대한척추외과학회 2004 대한척추외과학회지 Vol.11 No.2

고속 주행 모드에서 자동차 디퓨저의 스트레이크 개수와 배치에 따른 공기저항 유동해석

이진호,박성하,최동석,한영진,곽나영,이상욱 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

This study proposes an optimized diffuser strake design that can improve driving performance for cars in high-speed driving mode. The speed of the vehicle is set to 160km/h, and the number of strake is set to 4, 6 and 8, and the angle of the diffuser is set to 4, 5 and 6 degrees. The arrangement of the strake is centered, edged and equally arranged. The optimized diffuser design induced with the Ansys Fluent analysis shows a drag coefficient of 16% less than the basic diffuser-free model at a diffuser angle of 6 degree, 8 strakes, and equal arrangement.

소아에서 발생한 전완부의 섬유종증

문상호,김정란,강석 동국대학교 의학연구소 1998 東國醫學 Vol.5 No.-

섬유종증 혹은 유건종은 드문 비전이성 섬유성 종양으로 국소적으로 침습하고 수술적 제거술 후에도 자주 재발하는 것으로 알려져 있다. 섬유종증의 해부학적 호발부위는 견관절, 대퇴부, 상완부, 흉부 후면 그리고 둔부이다. 20세에서 40세에 주로 나타나며 주로 장골의 간단부에 호발하는 것이 특징이다. 광범위 절제술이 성공적인 치료 방법이 될 수 있으며 병변내 혹은 변연 절제술은 재발이 빈번하다. 저자들은 7세 남아에서 전완부 척골 간부(diaphysis)에 발생한 섬유종증을 치료한 예를 경험한 바 있어 문헌고찰과 함께 보고한다. Fibromatosis or desmoid tumor is rare nonmetastasizing fibrous tumor that tends to invade locally and frequently recurs after surgical excision. The anatomical distribution of the tumors reveals that the shoulders, thighs, arms, posterior part of the thorax and buttocks are the principal sites of involvement. The lesion frequently occurs between 20 and 40 years of age and most of them are located within the metaphyseal regions of long bones. Wide excision is the most successful treatment, while marginal and intralesional excisions are consistently associated with recurrence. We report a case of extra-abdominal desmoid tumor, which was located in ulnar diaphyseal region in a 7 year-old boy.

한국인 정신분열병과 양극성 기분장애에서 Ciliary Neurotrophic Factor(CNTF)유전자 변이에 관하여

이충숙,신석철,지익성,왕성근,이영호 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4

정신분열병과 양극성 기분장애 같은 주요 정신질환의 발병에서 유전적 요인이 중요하게 작용한다. 최 근 정신분열병과 양극성 기분장애의 원인을 신경병리학적 연구와 신경영상학적 연구를 통하여 신경발달 학인 면에서 이해하려고 시도하고 있다. Ciliary neurotrophic factor(CNTF)는 해마신경원와 내측 중 격신경원을 포함한 다양한 신경세포의 강력한 생명 유지인자로 작용하여 중추신경계의 발달과 유지와 관련이 있는 것으로 여겨지면서, 주요 정신질환의 원인적인 요인으로 제시되고 있지만 이에 대한 연구결 과는 일치되지 못한 상태이다. 이에 저자 등은 한국인 정신분열병 환자 112명과 양극성 기분장애 환자 81명 그리고 정상 대조군 125명을 대상을 CNTF 유전자 변이와 연관성을 알아보고자 본 연구를 시행하여 다음과 같은 결론을 얻었다. CNTF의 유전자형은 정신분열병 환자군에서 N/N 80(70.4%), N/M 32(28.6%), M/M 0(0.0%)이 었고, 양극성 기분장애 환자군에서 N/N 58(71.6%), N/M 23(28.4%), M/M 0(0.0%)이었으며, 정상 대조군에서는 N/N 94(75.2%), N/M 30(24.0%), M/M 1(0.8%)이었다. 대립유전자의 빈도는 정신분 열병 환자군에서 N 192(85.7%), M 32(14.3%)이었고, 양극성 기분장애 환자군에서는 N139(85.8%), M 23(14.2%)이었으며, 정상 대조군에서는 N 218(87.2%), M 32(12.8%)이었다. 3군간의 유전자형과 대립유전자에서 유의한 차이가 없었다. 이러한 연구결과 한국인 정신분열병과 양극성 기분장애에서 CNTF 유전자의 변이가 원인적 요인으 로 작용할 것이라고 볼 수 없었다. Genetic factors play an important role in the development of schizophrenia and bipolar disorder, and recently the neural maldevelopment hypothesis is suggested by neuropathological and neuroimaging studies. Neurotrophic factors, including ciliary neurotrophic factor(CNTF), play a central role in the regulation of neural development. This study was designed to investigate the association between the null mutation of CNTF gene and schizophrenia and bipolar disorder in a Korean population. The CNTF gene were typed with polymerase chain reaction in 112 patients with schizo-phrenia, 81 with bipolar disorders and in 125 healthy controls. The distributions of the CNTF genotype in schizophrenic patients with N/N, N/M, M/M were 80(71.4%), 32(28.6%), 0(0%), in bipolar disorders were 58(71.6%), 23(28.4%), 0(0%) and in the controls were 94(75.2%), 30(24.0%), 1(0.8%). The allele frequencies of the CNTF gene in schizophrenic patients with N and M were 192(85.7%), 32(14.3%), in bipolar disorders were 139(85.8%), 23(14.2%), and in the control were 218(87.2%), 32(12.8%). There were no differences in the genotype distributions and the allele frequencies of CNTF gene null mutation among the 3 groups. These results suggest CNTF gene null mutation is not causally related to the development of schizophrenia and bipolar disorder in Korea.

初期發熱患者에 대한 防風解毒湯의 經時的 解熱效果

정우상,문상관,조기호,김영석,배형섭,이경섭 경희대학교 1997 慶熙醫學 Vol.13 No.4

Carbamazepine으로 인한 무과립성 백혈구증 1례

박성수,이정호,오석환 인제대학교 1986 仁濟醫學 Vol.7 No.3

발작성 이상 뇌파 소견을 지닌 정신분열증 환자에서 Carbamazepine 사용후 임상 증상과 말초 혈액 소견상 무과립성 백혈구증을 보인 증례를 치험하였기에 문헌적 고찰과 함께 이를 보고한다. Recently Carbamazepine use has been increased in psychiatry. Especially Carbamazepine has been proposed as an alternative therapy in manic-depressive illness when lithium is ineffective or cannot be used because of side effect. As Carbamazepine use is increasing in psychiatry, the psychiatric community become familiar with the adverse effects associated with Carbamazepine's side effects vary widly including a potential irreversible agranulocytosis. We experienced and treated a case of agranulocrtosis in a patient who was given Carbamazepine for schizophrenic disorder with abnormal E. E. G. finding. The it is important to undergo the regular hematological monitoring because of the Carbamazepine administration. Therefore it is important to undergo the regular hematological monitoring because of the severity of the hematological adverse effect, though it is rare. And it is also important to discontinue the medication immediately and to treat intensively agranulocytosis.