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선동일,황성재,김홍래,김민식,Sun Dong-Il,Hwang Sung-Jae,Kim Hong-Rae,Kim Min-Sik 대한기관식도과학회 2005 大韓氣管食道科學會誌 Vol.11 No.1
Granular cell tumors are relatively uncommon benign laryngeal lesions thought to originate form Schwann cells. The granular cell tumor occurs everywhere in the body, especially in the head and neck. The larynx is relatively an uncommon location, accounting for approximately 3 to $10\%$ of all reported cases. Typically the most common presenting symptom is hoarseness, with some patients also presenting stridor, hemoptysis, dysphagia, and otlagia. But the tumor may be asymptomatic and discovered only incidentally during a routine examination. The diagnosis of granular cell honor can be confirmed by histopathologically and immunocytochemical staining fer S-100 antigen. Treatment of a granular cell tumor consists of a wide local excision by the endoscopic, transoral or laryngofissure methods. Recently, CO2 laser has been used to remove granular cell tumor with clear resection margin. This article describes one such case in a 62-year-old man, followed by a brief review of the literature on this subject.
두경부 종양에서 TIG1 유전자의 Hypermethylation
선동일,김민식,조광재,방충일,유영화,배민영,조승호 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.2
Background and Objectives:Decreased expression and growth suppression of Tazarotene-Induced Gene 1 (TIG1) were reported in prostate cancer. In this study, we examined the possibility of TIG1 transcriptional silencing by hypermethylation in head and neck cancer. Subjects and Method:We extracted DNA and total RNA from five head and neck cell lines (O11, O12, O19, O22 and O28), and three prostate cell lines (PC3, LNCap and DU145). We checked the methylation status of TIG1 by methylation-specific PCR (MSP) and RT-PCR. We also examined primary cancer tissues of 32 head and neck cancer, 31 prostate cancer and 10 normal samples. Results:We found that all of five head and neck (100%) cell lines and two of three prostate (66.7%) cell lines were methylated. RT-PCR analysis confirmed the absence of TIG1 expression in six cell lines with methylation. We checked primary cancer by MSP and found TIG1 methylation in 16 of 32 (50%) head and neck cancers, and 17 of 31 (54.8%) prostate cancers. Normal head and neck and prostate tissues were free of methylation. Conclusion:Our results support the notion that methylation might be an important mechanism of TIG1 inactivation and a target event in head and neck cancer. (Korean J Otolaryngol 2005;48:247-52)
선동일,김범수,정소령,안국진,김민식 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.1
Objective: To evaluate the postoperative laryngeal CT findings of neoarytenoid soft tissue at an arytenoidectomy site during a supracricoid partial laryngectomy, and to compare its thickness to the mucosa over the spared arytenoid cartilage. Materials and Methods: Thirty-one patients underwent a supracricoid partial laryngectomy with (n = 14) or without (n = 17) an arytenoidectomy. A postoperative laryngeal CT examination was performed to statistically compare the thickness of the neoarytenoid soft tissue to the mucosa over the spared arytenoids. Results: The neoarytenoid soft tissue revealed an eccentric prominence in all 14 arytenoidectomy sites. Further, the neoarytenoid soft tissue was consistently thicker than the mucosa over spared arytenoids cartilage (p < 0.01), however did not exceed 11 mm. Conclusion: The eccentric prominence of neoarytenoid soft tissue at the arytenoidectomy site during a supracricoid partial laryngectomy should be identified and distinguished from a recurrent mass when compared to spared arytenoid cartilage on a postoperative laryngeal CT. Objective: To evaluate the postoperative laryngeal CT findings of neoarytenoid soft tissue at an arytenoidectomy site during a supracricoid partial laryngectomy, and to compare its thickness to the mucosa over the spared arytenoid cartilage. Materials and Methods: Thirty-one patients underwent a supracricoid partial laryngectomy with (n = 14) or without (n = 17) an arytenoidectomy. A postoperative laryngeal CT examination was performed to statistically compare the thickness of the neoarytenoid soft tissue to the mucosa over the spared arytenoids. Results: The neoarytenoid soft tissue revealed an eccentric prominence in all 14 arytenoidectomy sites. Further, the neoarytenoid soft tissue was consistently thicker than the mucosa over spared arytenoids cartilage (p < 0.01), however did not exceed 11 mm. Conclusion: The eccentric prominence of neoarytenoid soft tissue at the arytenoidectomy site during a supracricoid partial laryngectomy should be identified and distinguished from a recurrent mass when compared to spared arytenoid cartilage on a postoperative laryngeal CT.
선동일,조광재,홍정훈,김민식 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.8
Esophageal foreign bodies in infants are frequently obscured because of the non-specific symptoms and signs and the lack of historical clues. Infants in such cases often present vomiting, odynophagia, dysphagia or ptyalism without a history of foreign body ingestion. Recently we encountered a case of the vocal cord palsy caused by an esophageal foreign body which was found when studying the vocal cord palsy in an infant. We report this case with review of literature.
선동일,김민식,김준형,조광재,조승호 대한기관식도과학회 2000 大韓氣管食道科學會誌 Vol.6 No.2
The goals of lip reconstruction are to provide oral competence, adequate support for the lower lip, contour restoration, adequate lip sulcus, and adequate oral aperture. The composite radial forearm palmaris longus free flap is thin enough that it can be folded onto itself without a significant increase in bulk. The flap is easy to dissect, the pedicle contains long vessels of large diameter, and the skin is a good color and texture match for the perioral region. Moreover, the vascularized tendon can be used for lower lip reconstruction. This makes the flap ideally suited for total lower lip reconstruction. We experienced the case of total lower lip excision and reconstruction with the radial forearm free flap including palmaris longus tendon, so we reported that case with literature. The patient has a lower lip squamous carcinoma(T3NIM0), and performed a total lower lip excision with right modified radical neck dissection and left extended supraomohyoid neck dissection, and a reconstruction with radial forearm free flap includng palmaris longus tendon. The oral competence and masticatory function were nearly normalized and cosmetical result was very acceptable.
선동일,김민식,이정학,조승호,Sun, Dong-Il,Kim, Min-Sik,Lee, Jeong-Hak,Cho, Seung-Ho 대한기관식도과학회 2000 大韓氣管食道科學會誌 Vol.6 No.1
A neurilemmoma of the facial nerve presenting as a parotid mass is a rare neoplasm and has been reported infrequently in the surgical literature. Diagnosis is usually by tissue biopsy intraoperatively and treatment is surgical with preservetion of facial function. This is a case of a solitary neurilemmoma involving the main trunk of the facial nerve in the posterior part of parotid gland continuing up to vertical segment of the facial nerve, in which the facial nerve had to be sacrificed and free autogenous nerve grafting was done.
이하선에 발생한 Catsleman's Disease 1례
선동일,김민식,이주형,박영학,조승호 대한기관식도과학회 2000 大韓氣管食道科學會誌 Vol.6 No.2
Catsleman's disease is a type of angiofolliculr lymph node hyperplasia and its etiology is not known yet. It usually presents with the mediastinal mass but rarely with the parotid mass. There are only five cases previously reported in the literatures. It has two pathologic types, which are hyaline vascular type and plasma cell type. Plasma cell type is frequently associated with systemic menifestations. Diagnosis is based on the histopatholgic findings. Treatment is surgical excision. A case of Catsleman's disease involving the parotid lymph node is presented and literatures are reviewed.