별렬컴퓨터의 사용자 정의 뷰 생성도구 설계

장경성,방상원,박경우 木浦大學校 情報産業硏究所 1995 情報産業硏究誌 Vol.3 No.-

Parallel Program Visualization has been successfully applied to alleviate the complexities of parallel software development. However, those program visualization tools which utilize the more advanced visualization techniques tend to be too complex and special purpose to be generally useful. The use of tools can be applied to simplify the use of complex environments, but the tools for program visualization can still require extensive specification for views and information processing details. This paper provides a model for program visualization for parallel software that user programmed with his or her defined views. It suggests the dynamic multiprocessing by providing the object code came from dynamic linker.

아메바성 대장염과 연관된 Henoch-Scho¨nlein Purpura 1예

장재현,원경준,이준,변유미,이재광,김영훈,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Henoch-SchonIein purpura is a common form of vasculitis primarily involving the skin, the gastrointestinal tract, the joints, the kidneys, and the nervous system. The etiological investigations are essential, because triggering factors are found in approximately half the patients such as viral, bacterial and parasitic infections, drugs, toxins, systemic diseases and cancer. But it's the correlation between Henoch-SchonIein purpura and Entamoeba histolytica has been rarely reported. We report a 29-years-old woman with Henoch-SchoIein purpura complicated by the lower gastrointestinal bleeding caused by the amoebic colitis. She complained of cramping abdominal pain, lower extremity purpura and hematochezia. Cysts and trophozoites of Entamoeba histolytica were detected in her stool. Skin biopsy demonstrated the leukocytoclastic vasculitis. She was administered metronidazole 1,500㎎ a day for the treatment of amebic colitis. Her hematochezia was improved, but the abdominal pain and purpura were not. The subsequent corticosteroid therapy improved her symptoms.

아급성 Ethanol 중독시 고뇨산혈증에 미치는 Pyrazinamide의 영향

장윤경,강우규,김동훈,최종원 慶星大學校 環境問題硏究所 1992 環境硏報 Vol.2 No.1

Ethanol 투여후 pyrazinamide 처리로 유도되어지는고 뇨산혈증의 발생 기전과 규명하고자 ethanol을 rat에 아급성적으로 투여하고 pyrazinoic acid의 대사 과정, 뇨산의 혈증 농도, 뇨산의 생합성 및 분해과정에 관여하는 효소의 활성 변화를 비교검토하였을 때 pyrazina-mide의 대사산물인 pyazinoic acid의 생성과정은 증가되었으나 pyrazinoic acid의 분해과정은 영향이 없었다. Ethanol 아급성 중독상태에 pyrazinamide를 투여하였을 때 혈액중의 뇨산 농도는 대조군에 비해 약 123% 정도현저히 증가되었다. 뇨산의 분해 효소인 urixase의 활성변화와 생합성에 관여하는 adenosine deaminase, purine nucleoside phos-phorylase 및 guanine deaminase의 활성변화에는 별다른 관련성이 없었으며 선책적으로 xanthine oxidase 활성만이 유도되어 나타나는 결과였다. In the present work, the purpose was to onbserve the effect of subacute ethanol intoxication on the changes of purine metabnolic pathway after pyraxzinamide administration in rats. In vitro test, it was observed that pyrazinamide deaminasing-enzyme activity was significantly increased and pyrazinoic acid oxidizing-enzyme activity was not affected by ethanol-administrated rat's cytosolic liver. When uric acid level in blood was estimated after pyrazinamide treatment, the blood level was increased in comparison to control group of subacute ethanol intoxication. Ethanol administration did not affect activities of guanine deaminase, adenosine deaminase, purine nucleoside phosphorylase and uricase, on the other hand, xanthing oxidase activity was significantly increased as compared with control. These results suggest that hyperuricemia incuced by the administration of pyrazinamide after subacute ethanol intoxication may be result from the selective increase of xanthine oxidase activity.

녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

저전력형 부탄가스 감지소자의 제조 및 그 특성

장경훈,임준우,강봉휘,이덕동 경북대학교 센서기술연구소 1995 센서技術學術大會論文集 Vol.6 No.1

Low power consuming butane gas sensors were fabricated using mica substrate which is a thin and elastic insulator. To increase the sensitivity and the stability, various catalyst layers were formed on SnO_(2) thin layer. Among them, SnO_(2) /Pt(17Å)/Pd(30Å) and SnO_(2) /Pt(8Å )/Pd(30Å) thin layer showed good characteristics in stability and dependance of temperature and humidity. The size of fabricated sensors was 1 x 3 mm^(2) and the consumed power was lower than 100 mW at operating temperature(250℃). For 2000 ppm butane concentration, the response time and the recovery time were about 5 seconds and 15 seconds respectively. The sensitivity of the sensors was about 80 % for 5000 ppm butane concentration.

브라켓 재생시 표면 처리 방법에 따른 전단 접착 강도에 관한 연구

임장빈,이진우,차경석 대한치과교정학회 1996 대한치과교정학회지 Vol.26 No.5

본 연구는 현재 브라켓의 개발 양상이 tip, torque 등이 브라켓 내에 내재되어 있는 straight wire appliance의 도입으로, 브라켓의 디자인은 더욱 세밀하고, 복잡해져 점차 고가화 되어 재사용의 요구가 증가하는 점에 맞추어 계획되었다. 본 연구의 목적으로는 재생과정의 목표에 부합하는 브라켓 접착면의 재처리 방법을 찾는 것이다. 실험 방법은 금속 브라켓, 도재 브라켓 각 5개씩 5군으로 나누어 브라켓 기저부에 재처리과정을 시행한 후, 이를 치아에 접착하고 만능 시험기(universal testing machine)을 사용하여 치아에서 브라켓이 탈락하는 시점의 최대 전단접착강도를 채득하였으며, 그 후 치아의 법랑질 표면을 입체 현미경으로 관찰하여 파절면의 접착제 잔류지수를 구하였다. 또한 입체 현미경 (stereoscopic microscope)과 주사전자현미경 (SEM) 화상으로 재처리된 브라켓의 접착면을 관찰하였다. 이와 같은 실험으로 다음과 같은 결론을 얻었다. 1. 금속 브라켓에서 접착 강도가 가장 높은 재처리 방법은 sandblasting을 8초간 시행한 군이었으며, 이는 제조회사에서 제작된 원래 상태인 대조군의 접착강도보다도 오히려 높았다. 2. 세라믹 브라켓에서 접착 강도가 높은 재처리 방법은 8초간 sandblasting한 군이었으나, 대조군의 접착강도 보다는 낮았다. 3. Sandblasting 시간을 4초에서 8초로 증가시킨 경우 금속 브라켓의 접착강도는 급격히 증가하는데 비해 도재 브라켓의 접착강도는 별 차이가 없었다. 그 이유는 도재 브라켓의 경우 브라켓 접착부의 표면적 증가에도 불구하고, 금속 브라켓과는 달리 브라켓 자체의 물성 차이로 인해 도재 브라켓에서의 접착력을 좌우하는 거대 기계적 결합부위의 파손이 일어나 접착력의 약화를 가져왔기 때문이다. The purpose of this study is to find the optimal reconditioning method for a debonded bracket base. In this study, metal brackets and ceramic brackets are used. There are devided into five groups by reconditioning methods (A : control(new bracket). B : heat treated, C : grinded with green stone, D : sandblasting for four seconds, E : sandblasting for eight seconds). Each reconditioned brackets were bonded and shear bond strength was measured by universal testing machine. After debonding, enamel surfaces were examined under stereoscopic microscope to determine the adhesive remnant index. The Microstructure of reconditioned bracket were examined by SEM (JSM 5200, Japan) and stereoscopic microscope (SZ-ST, Japan). 1. In metal bracket groups, sandblasting for eight seconds revealed the greatest shear bonding strength and its strength was above that of control group. 2. In ceramic bracket groups, sandblasting for eight seconds revealed the greatest shear bonding strength but its strength was below that of control group. 3. As sandblasting time was increased, shear bonding strength of metal bracket was increased very much, but in ceramic brackets, shear bonding strength exhibited limited increase. This difference was caused by macro-mechanical retentive areas of ceramic brackets were broken for their brittle characteristics of material.

이중구조 촉매전극을 이용한 알칼리 연료전지에 관한 연구

노용우,이태희,설용건,장의종,김경림 연세대학교 산업기술연구소 1990 논문집 Vol.22 No.1

An experimental low-temperature low-pressure hydrogen-oxygen alkali fuel cell was constructed and its performance was tested for various operating conditions. Hydrogen was used for fuel and oxygen was used for oxidant and KOH solution was used for electrolyte. Both electrodes for hydrogen and oxygen were prepared by the same method and the materials used were carbonyl nickel and ammonium bicarbonate. Experimental results show that maximum current density of 8.91 mA/㎠ was obtained at 40℃ wt% KOH solution and optimum power was 1.74 mW/㎠ at 6.43 mA/㎠ current density.

3D 온라인 슈팅 게임 개발 : "3D 포트리스"

金敬植,崔勝寬,寓昔珍,申一卿,朴勝浩,李東熙,李東建,張孝善 호서대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.19 No.-

In this paper, features and efficiencies of the 3D engine are described which has been developed through the research of 3D real time rendering techniques. And an on-line shooting game "3D Fortress" which has been developed using this 3D engine with server technologies is introduced for the techniques and methodology applied in the process of development of the game as well as the features and discussions of its implementation.

관상동맥질환 환자들에서 스트레스지각과 대응전략간의 관계

김장우,고경봉 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적 : 본 연구의 목적은 138명의 관상동맥질환자들을 대상으로 환자들의 스트레스인자 및 스트레스반응 지각과 대응전략 간의 관계를 조사하여 이들 환자에서 효과적 혹은 비효과적인 대응전략을 발견함으로써 이를 나중에 이런 환자들의 정신사회적 치료에 응용하고자 하는데 있다. 방법: 스트레스인자 및 스트레스반응에 대한 지각은 각각 스트레스인자 지각 척도(Global Assessment of Recent Stress Scale) 및 스트레스반응 지각척도(Perceived Stress Response Inventory)를, 대응전략은 대응척도(Coping Scales)를 이용하여 평가하였다. 결과: 일 및 직장, 대인관계, 대인관계의 변화, 질병 및 상해, 경제적인 문제, 비일상적인 사건, 일상생활 변화의 유무, 전반적인 스트레스인자 지각 점수는 도피-회피와, 질병 및 상해, 경제적인 문제, 전반적인스트레스지각 점수는 책임수용과, 경제적인 문제와 관련된 스트레스 지각점수는 계획적 문제해결 및 긍정적 재평가와 양성 상관성을 보였다. 도피-회피는 부정적 감정반응, 인지기능저하 및 일반적 부정적 사고, 자기비하적 사고, 충동공격적 사고, 일반적 신체증산, 특정신체증상, 수동반응적 및 부주의 행동,충동공격적 행동과 같은 모든 스트레스반응 항목들과 유의한 양성 상관성을 보였다. 그 다음으로 거리감 유지는 부정적 감정반응, 인지기능저하 및 일반적 부정적 사고, 일반적 신체증산, 수동반응적 및 부주의 행동과 양성 상관성을 보였다. 남자가 여자보다 직면, 자기통제, 사회적 지지추구, 책임수용, 계획적 문제해결, 긍정적 재평가를 유의하게 더 많이 사용하는 것으로 밝혀졌다. 교육수준은 직면, 자기통제, 사회적 지지추구, 책임수용, 계획적 문제해결, 긍정적 재평가와 같은 대응전략과 양성상관성을 보였다. 결론: 이상의 결과는 관상동맥질환 환자들이 사용하는 대응전략이 스트레스인자의 종류, 성별, 교육수준에 따라 달라지고 있고 대응전략 중 도피-회피 및 거리감유지가 가장 비교화적일 가능성을 시사해준다. Objectives: The objective of this study was to investigate the relationship between perceived stress and coping strategies in 138 patients with coronary artery diseases. Methods: Global assessment of recent stress(GARS) scale and perceived stress response inventory(PSRI) were used to measure perception for stressors and stress responses. Coping scale was used to measure coping strategies. Results: Scores of perceived stress related to work, job, interpersonal area, changes in relationship, sickness or injury, financial area, and overall global areas showed significant positive correlations with escape-avoidance. Also scores of perceived stress related to sickness or injury, financial problems, overall global areas showed significant correlations with accepting responsibility. Scores related to financial area showed significant positive correlation with planful problem solving and positive reappraisal. Escape-avoidance had a significantly positive correlation with negative emotional response, lowered cognitive function and general negative thinking, self-depreciative thinking, impulsive - aggressive thinking, general somatic symptoms, specific somatic symptoms, passive-responsive careless behavior and impulsive-aggressive behavior. Distancing had a significantly positive correlation with negative emotional response, lowered cognitive function and general negative thinking, general somatic symptoms and passive-responsive careless behavior. Confrontive coping, self-control, seeking social support, accpting responsibility, planful problem solving, and positive reappraisal were more frequently used in men than in women. Education had a significantly positive correlation with confrontive coping, self-control, seeking social support, accepting responsibility, planful problem solving, and positive reappraisal. Conclusions: The above results suggest that coping strategies of patients with coronary artery disease may be affected by types of perceived stressors, sex, and level of education, and that escape-avoidance and distancing may be the most ineffective coping strategies used in these patients.

대전에서 연중 태양광선의 UVA와 UVB양에 대한 조사 (예비보고)

박장규,김경훈,이우재,서기범 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Ultraviolet A(355 nm) and ultraviolet B(290 nm) doses were measured at Taejon from March to September, 1993, on four different weather conditions(clear, relatively clear, relatively cloudy and cloudy). And the results were compared with the doses of Kongju area measured in 1985. The followings were the summary of the findings. 1. UVA(1.98± 0.35 × 10 exp(-3) w/㎠) and UVB(17.62+ 5.72 X 10 exp(-6) w/㎠ doses were peak at noon on clear weather. 2. Average doses of UVA(2.36±0.70 × exp(-3) w/㎠) and UVB(24.28±8.83 × exp(-3) w/㎠) were peak at noon in August on clear weather. 3. The doses of UVA and UVB were influenced by yellow sand, fog and other pollutants. 4. The doses of UVA on clear weather in Daejoen were lower than Kongju about 40%, in contrast those of UVB were not different in statistical values.