Succinylcholine으로 유발된 Fasciculation과 Myalgia에 대한 Diazepam과 d-tubocurarine 전처치의 비교효과

최세진,길기진,이정은 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

Succinylcholine-induced muscle pain well documented. It is common to use subparalyzing dose of a non-depolarizing muscle relaxant before succinylcholine and accepted in clinical practice forpreventing of succinylcholine-induced fasciculation and it's associated sequalae. But it is needed to give large dose of succinylchcline to offer adeguate relaxation for tracheal intubation in these pretreated cases. This present study was undertaken to compare the effect of diazepam with d-tubocurarine on succinylcholine induced side effects. Sixty cases were studied if four different groups. In 1st group : no pretreatment, 2nd group : diazepam(0.05mg./kg.), 3rd group : diazepam(0.1 mg./kg.), 4th group : d-Tc.(0.05mg./kg.). The following results were obtained : 1. Diazepam pretreatment groups had no significant changes for the prevention of muscle fasciculation following succinylcholine compare to control group, but prevention of muscle fasciculation by d-Tc. pretreatment were significant. 2. Conditions for intubation were excellent in all groups. 3. In the prevention of muscle pain, there was no significant difference between the control and diazepam pretreatment group but significant difference between the control and d-Tc. prtreatment. 4) There was no specific relationship between muscle fasciculation and muscle pain.

위암에서 장화생 발생 양상에 대한 연구

최은정,강상균,김창진 순천향대학교 1994 논문집 Vol.17 No.4

The pathogenic mechanisms of gastric carcinoma, which is the most common malignant tumor in Korea, have not been completely revealed, but several lines of evidence suggest that intestinal metaplasia contributes in some way to the gastric carcinogenesis. Histologically, the gastric carcinoma can be classified into two main types, the expanding type and the infiltrative type. Intestinal metaplasia can be classified into 3 types : type Ⅰ which is complete metaplasia, type Ⅱ and type Ⅲ which are incomplete metaplasia secreting sulphomucin. The expanding type has some correlations with incomplete sulphomucin secreting metaplasia. To investigate the relationship between patterns of intestinal metaplasia, especially sulphomucin producing metaplasia, and histologic types of gastric carcinoma, 80 cases of gastric carcinoma and 10 cases of gastric ulcer were studied histochemically with hematoxylin-eosin, periodic acid-Schiff alcian blue(PAS-AB : pH2.5) and high iron diamine alcian blue (HID-AB : pH2.5) stains. The results were as follows : 1. Of a total of 80 cases of gastric carcinoma, 21 cases(26%) were expanding type and 59 cases(74%) were infiltrative type. 2. Of 21 cases of expanding type, 6 cases(28%), 4 cases(19%) and 5 cases(25%) were type Ⅰ, type Ⅱ and type Ⅲ intestinal, which is higher rate than that of nonsulphomucin secreting type Ⅰ intestinal metaplasia. 3. Of 59 cases of infiltrative type, 18 cases(30%), 8 cases(14%) and 12 cases(20%) were type Ⅰ, type Ⅱ and type Ⅲ intestinal metaplasia respectively. Twenty cases(34%) were sulphomucin secreting type Ⅱ and typeⅢ metaplasia, which is slightly higher rate than that of nonsulphomucin secreting type Ⅰ metaplasia. 4. Non-metaplasia was found in 28% of expanding type, and in 36% of infiltrative type, which suggests that, compared to the expanding type, infiltrative type tends to be associated with non-metaplasia 5. Of 10 cases of gastric ulcer, 6 cases(60%), 2 cases(20%) and 1 case(10%) were type Ⅰ, type Ⅱ and type Ⅲ intestinal metaplasia respectively. Above results suggest that sulphomucin secreting type Ⅱ and Ⅲ intestinal metaplasia have some relationship with gastric carcinogenesis, and that infiltrative type is more frequently associated with non-metaplasia, while non-tumorous gastric lesion as peptic ulcer has frequently associated with type Ⅰ complete intestinal metaplasia. However, further studies on the profiles of mucins secreted by epithelial cells should be done to elucidate the relationships between intestinal metaplasia and gastric carcinogenesis.

피조개 발의 점액질에 대한 조직화학적 연구

최병태,조기진,홍말숙,정권순,조운복 釜山大學校 師範大學 1995 교사교육연구 Vol.31 No.-

피조개 발의 조직학적 구조는 hematoxylin-eosin염색 및 Weigert iron hematoxylin염색을, 점액질 성상을 검색하기 위하여 PAS반응, diastase 침지 후 PAS반응, alcian blue pH 2.5염색, alcian blue pH 1.0염색, alcian blue pH 2.5-PAS염색, alcian blue pH 1.0-PAS염색, aldehyde fuchsin pH 1.7-alcian blue pH 2.5염색 및 0.25% toluidine blue염색을 실시하였다. 피조개의 발은 상피, 상피하결합조직 및 근층으로 이루어져 있었으며 상피는 단층섬모원주세포로 되어 있었다. 상피하결합조직 및 근층에 다세포성 점액선인 발선이 발달되어 있었고 도관은 결합조직과 상피세포를 거쳐 개구되어 있었다. 근층은 종주근, 수직근 및 횡근섬유로 구성되어 있었다. 점액질의 조성을 보면 상피세포섬모에는 sialomucin만을, 상피세포는 중성점액질만 함유하고 있었다. 상피세포 및 결합조직내 점액도관에는 산성과 중성점액질의 혼합성인 것과 산성점액질만 함유한 것이 혼재하나 전자가 더 많았다. 산성점액질의 성상으로 보아 대부분이 강 sulfomucin을 가지며 일부는 약 sulfomucin과 sialomucin의 혼합성이었다. 대부분 발선의 점액선포에 대한 점액질 조성은 점액도관과 유사하였으나 일부 상부발선의 점액선포는 중성점액질만을, 하부발선의 점액선포는 sialomucin만을 함유하였다. This study was performed to investigate the histological structure and the histochemical properties of the mucosubstances in the foot of Anadara broughonii. For the histological structure, hematoxylin-eosin and Weigert iron hematoxylin staining were used. The mucosubstances stained with PAS, PAS-diastase, 0.25% toluidine blue, alcian blue pH 2.5, alcian blue pH 1.0, alcian blue pH 2.5-PAS, alcian blue pH 1.0-PAS, aldehyde fuchsin pH 1.7-alcian blue pH 2.5 methods. The foot was composed basically of three layers: epithelium, subepithelial connective tissue and muscular layers. The foot was lined by simple ciliated columnar epithelial cell. Foot glands consisted of multicelluear mucous acini were present in the subepithelial connective tissue and muscular layer. The mucous duct of foot glands was distributed from connective tissue to epithelial cells, and open onto the surface of the foot. The foot muscle traveled in three planes as longitudinal, transverse and vertical muscle fiber. About the properties of mucosubstances on the foot, cilia of epithelial cell contained sialomucin only and epithelial cell neutral mucosubstances only. Most of mucous duct within epithelial cells and connective tissue showed a mixture of acidic and neutral mucosubstances, while a few mucous ducts were contained acidic ones only. Among acidic mucosubstances, notable strong sulfomucin were found in most mucous cell of duct, and a mixture of weak sulfomucin and sialomucin appeared in a few cells. The properties of mucosubstances in the food glands were similiar to those of mucous duct. But a few mucous acini contained neutral mucosubstances and sialomucin only in upper and lower portion of foot gland, respectively.

그람양성구균에 대한 Teicoplanin과 Vancomycin의 시험관내 항균력

최태열,김경숙,전용관,서일혜,김정욱,이웅수,안정열,김홍석,정재용,최효선,김덕언,유진우 대한감염학회 1994 감염 Vol.26 No.1

An increasing frequency of methicillin resistant S. aureus(MRSA), methicillin resistant coagulase negative staphylococci(MRCNS) and Enterococcal infection have been observed in recent years. Teicoplanin is a new glycopeptide antibiotic obstained from the Actinoplanes teicomycetius. The molecular structure and spectrum of antimicrobial activity of teicoplanin is simillar to those of vancomycin, and has been reported to have an excellent in vitro and in vivo effect against various gram-positive infections. Therefore, we evaluated the in vitor susceptibility of gram positive cocci, such as, S. aureus, coagulase negative Staphylococci(CNS), and Enterococci to teicoplanin and vancomycin. The total 253 strains consisted of MSSA(40), MRSA(53), MSCNS(47), MRCNS(48), and Enterococci(65). They were assayed by disc diffusion and agar dilution. During the study, 57% of S. aureus and 49% of CNS showed resistance to methicillin. The inhibitory diameter of teicoplanin was 15-20mm in MSSA, 12-19mm in MRSA, 13-24mm in MSCNS, 11-23mm in MRCNS, and 15-22mm in Enterococci respectively, and showed sensitivity in all but 8 strains(3.2%). The range of the minimum inhibitory concentration (MIC) of teicoplanin to MSSA, MRSA, MSCNS, MRCNS and Enterococci were 9.12-2.0㎍/ml, 0.25-2.0㎍/ml, & 0.25-32㎍/ml, 0.12-1.0㎍/ml respectively. One case of S. haemolyticus was resistant to teicoplanin (32㎍/ml) by the agar dilution method. Eight minor (3.2%) and one major(0.4%) error was observed when the MIC and disk diffusion data were correlated with teicoplanin. As for vancomycin the inhibitory diameter was 17-21mm in MSSA, 15-21mm in MRSA, 18-26mm in MSCNS, 18-25mm in MRCNS, and 16-22mm in Enterococci respectively. The range of the MIC of vancomycin to MSSA, MRSA, MSCNS, MRCNS, and Enterococci were 0.25-1.0㎍/ml, 0.25-4.0㎍/ml, 0.5-2.0㎍/ml and 0.5-2.0㎍/ml respectively. One minor error (0.4%) was seen with the vancomycin disk. The MIC90 of MSSA and MRSA exhibited the same results in teicoplanin (1.0㎍/ml, 1.0㎍/ml), and vancomycin(2.0㎍/ml, 2.0㎍/ml). MSCNS and MRCNS exhibited greater MIC90 with teicoplanin(4.0㎍/ml, 8.0㎍/ml) than vancomycin(2.0㎍/ml, 2.0㎍/ml). Incontrase Enterococci were more susceptible to teicoplanin(0.5㎍/ml) than to vancomucin (2.0㎍/ml). Results from this analysis indicated that both teicoplanin and vancomycin were very excellent for gram positive infections, especially those resistant to methicillin.

당뇨병성 신증 환자 20예에서 복합한약전탕액이 신기능에 미치는 영향

최우정,김동웅,신선호,이언정,최진영,신학수,조권일,이광석 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.2

Diabetic Nephropathy is one of the major causes of chronic renal failure. It is a common microvascular complication and clinically defined as the presence of persistent Proteinuria. We studied the effects and change of the renal function of Complex Herbal medication of the 20Diabetic Nephropathy patients. We measured the initial levels of Total Protein, Creatinine Clearance Rate(Ccr), Serum Creatinine(Serum-Cr), Urine Creatinine(Urine-Cr) and HbA1C on admission and followed up the level changes of Total Protein, Ccr, Serum-Cr and Urine-Cr on discharge. The results are following : Complex Herbal Medication does not cause the renal toxicity. The longer hypertension period is, the higher Serum-Cr level and Urine-Cr level. In an older age group, Urine-Cr is lower. 4.From the "Deficiency in Origin and Excess in Superficiality(本虛表實)“points of view, Complex Herbal Medication improves the Serum-Cr in Diabetic Nephropathy patients. According to this results, it could be suggested that Complex Herbal Medication does not cause the renal toxicity in Diabetic Nephropathy patients and intensive controls of blood sugar, blood pressure and Complex Herbal Medication prevent the renal failure in Diabetic Nephropathy patients with early stage of Microalbumiuria.

임신중 산전 초음파로 진단된 자궁근종의 임상적 고찰

서정호,김윤숙,김대원,이동운,최규연,이정재,이임순 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Objectives: To study the clinical manifestations; time, mode of delivery, size of myomas and outcome of pregnancy in cases of myomas that were detected prior to pregnancy or during the antenatal care and after delivery. Methods: We statistically analyzed 76 patients with uterine myomas in pregnancy admitted to Soonchunhyang Seoul Hospital during the period of Jan. 1999 and Dec. 2001. Results: The results are as follows. 1. The mean age of patients in the detected group and undetected group were 32.9 years and 32.3 years, respectively. There was no difference in the proportion of primarity between the detected group(98.2%) and the undetected group(79.6%) 2. The most common type of uterine myoma in both groups was intramural myoma (detected group 94.1% vs undetected group 81.3%). The uterine myomas were most commonly located in the anterior portion and fundus(detected group 52.9% and 23.5% respectively vs undetected group 47.4% and 23.7% respectively) and the proportion was not significantly different between the two groups. Uterine myomas with a diameter of 3cm or more in the detected group were detected by clinical examination and ultrasonogram. Rate of uterine myomas with a diameter of 3cm or more in the detected group is 76.5% and less than 3cm is 54.2% which detected incidentally at delivery. 3. The proportion of term infants were detected group 88.2% vs undetected group 91.5%. 4. The most common indications for cesarean section in both groups were cephalopelvic disproportion and repeated cesarean section (detected group 41.2% and 45.8% respectively vs undetected group 11.8% and 18.6% respectively) and there was no significant difference between the two groups. 5. Secondary pathologic changes in the all myomectomy specimens were degeneration in both groups but there was no necrosis or sarcomatous change. 6. Antenatal complications were preterm labor, premature repture of membranes, spontaneous abortion, malpresentation, and placenta previa. Intrauterine growth retardation and placental abruption were not seen in both groups. Conclusion: Myoma detected by ultrasonogram before or during pregnancy is not a significant implication of pregnancy outcome.

Chlamydia trachomatis에서 분리된 Cryptic plasmid DNA의 클로닝

유정한,김덕언,박일규,강정옥,최태열 대한임상병리학회 1996 대한임상병리학회지 Vol.16 No.5

경막외마취 환자에서 10% Pentastarch 용액의 혈장확장효과

이정은,박병룡,김은경,김만수,최세진 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

In order to compare the effect of 10 % pentastarch solution with Ringer's lactate solution on plasma volume expansion in thirty epidural anesthetic patients, systolic arterial blood pressure (SABP), diastolic arterial blood pressure(DABP), heart rate(HR), central venous pressure(CVP), cardiac output(CO) and changes of hemoglobin(Hb) were measured. The patients were devided into three groups Group Ⅰ (n=10) ; Epidural anesthesia was performed without fluid infusion previously(control) Group Ⅱ (n=10) ; 500 ml of Ringer's lactate solution was rapid infused intravenously before epidural anesthesia Group Ⅲ (n=10) ; 500 ml of 10% pentastarch solution was rapid infused intravenously before epidural anesthesia All data were collected before fluid infusion, at 15 min, at 30 min, at 45 min, at 60 min, at 120 min and at 180 min after epidural local anesthetic injection. The results are as follows. 1. SABP, DABP, HR, CVP and CO were decreased significantly (p<0.05) at 30, 45 minute after local epidural anesthetic injection in Group Ⅰ and Group Ⅱ. There was no any significant differences between two groups. 2. SABP, DABP, HR and CO were not changed significantly, Besides CVP was increased significantly (p<0.05) after 10% pentastarch solution infusion in group Ⅲ. 3. Changes of Hb were increased in group Ⅲ.

금속-도재관의 제작에 이용되는 치과용 저융도재의 이축굽힘강도 평가

소정모,최운재 대한치과기재학회 2001 대한치과재료학회지 Vol.28 No.2

This study was performed to evaluate the biaxial flexure strength of dental metal-bonding porcelains. Three kinds of commercially available low-fusing porcelains of Ceramco (CC), Vintage (VT) and Omega 900 (ON) and three kinds of ultra low-fusing porcelains of Carmen (CM), Carrara (CR) and finess (FN) were selected as experimental materials. Disc specimens were prepared to the final dimensions of 12㎜ in diameter and 1㎜ in thickness. Specimens were polished sequentially from #800 to #2000 emery papers, and the final surface finishing on the tensile side was received an additional polishing sequence through 0.3㎛ alumina paste. The biaxial flexure test was conducted using the ball-on-three-ball method at a crosshead speed of 0.5mm/min. The highest Weibull modulus value of 17.5 was observed in the VT group and the lowest value of 8.7 was observed in the ON group. However, the highest characteristic strength value of 107.0 MPa was observed in the ON group and the lowest value of 54.1 MPa was observed in the CM group. The highest biaxial flexure strength value of 101.4 MPa was obtained in the ON group and the lowest value of 54.1 MPa was obtained in the CM group. Results of Tukey test showed that an overall significant difference was indicated except the CM and CR and the FN and VT groups (p<0.05). The fracture surfaces showed that the cracks were propagated into the conical shape from the maximum tensile stress region. The higher the fracture strength values are, the rougher the fracture surface becomes. There was no significant relation between strength and porosity in fracture surfaces.

한랭작업 근로자들의 건강위해에 관한 연구

박호추,정설미,문덕환,이종태,김대환,김정호,최재일,황용식,이용희,이채언 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.1

In order to evaluate the status of cold exposure and its health hazards of workers at cold storage workplaces and to provide basic data for effective health care, the author measured core temperature and also observed clinical symptoms and signs, past and present history, and general health examination data on 99 cold exposed workers for exposure group and 96 non-exposed workers for control group working at 2 food refrigerating companies in Pusan area from January 6, 1998 to February 24, 1998. The results were as follows: 1. There was statistically significant difference in water intake between the exposure and control group and increased urine volume, urine frequency in exposure group without statistically significant difference. 2. Past and present illness in exposure group were hypertension (18.2%), hepatopathy (8.1%), gastro-intestinal disease(7.1%), arthritis (4.0%), intervertebral disc herniation(4.0%), and so on, and hypertension, arthritis was statistically significant difference compared to control group. 3. Symptoms in exposure group were fatigue(89.9%), headache (64.6%). drowsy(63.6%), neck stiffness(59.6%), excessive food intake(59.6%). general weakness(58.6%), hunger(58.6%), numbness(54.5%), and so on, and there was statistically significant difference between the exposure and control group except fatigue, drowsy. 4. As results of clinical test abnormality rate of the systolic, diastolic blood pressure and electrocardiogram were significantly higher in exposed group than control. 5. Core temperature in exposure group was statistically significantly lower than control group and the highest statistically significant inverse correlation with the working hours and working frequency of daily mean cold storage. As above results, the author suggested that the further studies should be conducted to evaluate the health status of workers about chronic health effects in cold workplaces and to establish effective health care methods for them.