혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

위 종양조직내 c-myc, c-H-ras, p53단백 표현에 대한 면역조직화학적 연구

정성욱,김철환,염범우,이대일 고려대학교 의과대학 1994 고려대 의대 잡지 Vol.31 No.1

Activation of oncogenes, mutated genes, and inactivation of suppressor genes were the maj or genetic abnormalities in carcinogenesis. Oncogene-related proteins can be detected by an immunohistochemical staining or other techniques in molecular biology. Accumulation of abnormal protein encoded from mutated p53 can be detected in cancer cells, on the contrary of wild-type p53 immunoreactivity is usually not seen in normal cells because the protein has a very short half-life. Using monoclonal and polyclonal antibodies against from c-myc, H-ras, and p53 related proteins, the author has performed an experiment on the normal, dysplastic, and malignant gastric mucosa. The results obtained were as follows; 1. c-myc showed no expression on all the gastric mucosa used. 2. H-ras showed expression on the normal glandular epithelium, especially parietal cells, peripheral to the dysplastic and neoplastic glands. And a few cases(29%) show cytoplasmic expression in signet-ring cells of gastric adenocarcinomas. 3. p53 showed nuclear expression in 7% of dysplastic mucosa, and 50% of gasric adenocarcinomas. However, there is no relationship with the expression and between the histologic differentiation and depth of tumor invasion. With the above results, p53 alterations occur relatively tate in carcinogenic process and there is different molecular biology between the gastric and the colorectal adenocarcinomas in which Ki-ras and p53 were frequenly expressed.

일개 지방자치단체의 건강진전도 평가

고광욱,김윤지,송성은,김정민 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Background: Healthy and sustainable community is essential component of development. But there has been no systematic reporting about healthy municipality in specific city, although economic development results in considerable progress. Method: According to the Ontario progress monitoring tool partial monitoring has been done. Survey to the stakeholder including public officers were done and analyzed. Result: Economic area were most lowly reported area. By specific item, direction of improvement were induced in each area including social environment and human health area. Green space, waste treatment, traffic problem, small health service benefit were major agenda among the stockholders. Conclusion: According to the Ontario progress reporting, we got good picture about healthiness of one municipality and concrete direction of improvement.

腎皮質 電氣 燒灼法에 의한 白鼠 慢性 腎不全症 모델 誘導에 관한 硏究

정민수,김성숙,이강욱,신영태 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

An animal model with experimental uremia is an a important research tool for the study of sequence of pathological events taking place in uremic syndrome. A number of animal models and methods for the induction of chronic uremia have been published. The present study is designed to estabilish usefullness of a new method for the induction of chronic uremia in the rat. This method consist of unilateral destruction of most of the renal cortex by burns and contralateral nephrectomy. To investigate the results of massive renal ablation by this method, we measured serially blood pressure, body weight, BUN, serum creatinine, creatinine clearance, rate and examined renal histology. The results were as follows : 1) Surgical mortality rate was 5% and postoperative mortality of experimental group was 30.8% during 15 weeks of postoperative period. 2) Blood pressure of experimental group was significantly higher than control group after renal ablation(p<0.01). 3) Experimental group showed lower body weight gain than control group(p<0.01). 4) BUN and serum creatinine values increased continuously after renal ablation. However, those of control group were not changed. 5) Creatinine clearence rate of experimental group decreased significantly after renal ablation(p<0.01). 6) Weight of remnant kidney in experimental group was significantly higher than left kidney of control group(p<0.01). 7) Histologically, focal and segmental glomerular sclerosis, mesangeal proliferation, interstitial fibrosis and tubular atrophy appeared in the kidney of most experimental group 15 weeks after renal ablation. In conclusion, experimental rat group shows remarkable uremic appearance 7-11 weeks after renal ablation. This suggests that the unilateral renal cortical electrocoagulation and contralateral nephrectomy was a useful method for inducing experimental CRF rat model.

유한요소법에 의한 용접잔류응력의 해석

김정호,조성욱,유봉준 중앙대학교 생산공학연구소 1999 생산공학연구소 논문집 Vol.8 No.1

대형구조물의 용접시 잔류변형과 잔류응력은 구 구조물의 모양과 크기, 그리고 구속조건에 따라 크게 달라진다. 따라서, 대형구조물의 잔류응력에 대한 정확한 해석을 위해 용접 잔류응력 및 용접 잔류변형을 정확히 예측할 수 있는 적절한 유한요소해석 절차의구현이 필요하다. 본 연구에서는 용접 잔류응력과 변형률의 존재를 예측할 수 있는 열전달 해석 및 열탄소성 해석과 같은 적절한 유한요소해석 과정을 찾고자 한다. 해석을 위해 아크의 열원에 대한 가우시안 분포를 가정하고 용접부의 상변화에 대한 엔탈피모델을 선정한다. 그리고, 대형구조물의 열전달해석을 위해 Remeshing기법을 이용한 유한요소모델의 생성이 필요하다. 끝으로, 개발된 해석과정은 단순맞대기 용접에 대해 적용해 보았고, Remeshing 기법은 컴퓨터 자원에 대한 절약 측면에서 상당한 효과를 나타내었다. Welded structures experience changes in shape, size and constraint conditions after favirication due to internal residual stresses. For the accurate simulation of the typical welding procedure, transient heat transfer analysis as well as thermal-elasti-plastec analysis should be employed. In this paper, appropriate finite element analysis procedures that can predict welding residual stresses and strains are presented. Gaussian distribution of arc heat source is assumed andenthalpy model is employed for phase change of the welding zone. Finally for the purpose of applying the developed technique to large scale structrues, remeshing techniques by successive generation of finite element model are given for that transfer analysis. The developed analysis procedure are tested for the simple butt welding which gives reliable results. Remeshing techniques are also tested against the existing mesh pattern which showed considerable reduction in computational resources.

부산지역 산성강우의 특성과 주영향인자 해석에 관한 연구

황성욱,유수영,조정구,박정호,최금찬 동아대학교 환경문제연구소 2003 硏究報告 Vol.25 No.2

Acid rain was strongly raised in regional air pollution problems. All of researchs have been focused in plt tendency in a limited area. But, chemical composition data are important because of the control strategy are also necessary to reduce source emission from various air pollution sources. Longtime may be helpful to evaluate acid rain effect to regional area for a long time. We have accumulated acid data from Sep. 1993 to Jan. 2003. In this study, data which was given from Sept., 1993 to 2000 is measured pH and EC, analyzed cations anions by ion chromatography. All of analyzed data were calculated to fit average and standard by SAS package.

고혈압과 당뇨병이 허혈성 뇌혈관질환의 위험인지로서의 Lipoprotein(a)에 미치는 영향

박정욱,박성경,이정욱,김영인,김용재,이광수,김범생 대한신경과학회 1996 대한신경과학회지 Vol.14 No.1

연직말뚝의 경사도에 대한 연구

장정욱,박춘식,최차석 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

This Paper studied the effects of inclination of piles on pile behaviors. The following are the conclusions of this study. (1) When all the piles are inclined to a same direction, the piles reaction, maximum moment and horizontal displacement of footing increase as the angle of inclination increases. (2) when the piles of each opposite side are inclined symmetrically, the vertical reaction either increases or decreases in proportion to the angle of inclination. In this case, the vertical reaction of inclined piles decreases but the vertical reaction of non-inclined piles increase.

식도를 포함한 전위장관을 침범한 전이성 악성 흑색종 1예

최정영,김준기,신성하,고영춘,조상욱,서강석,강명원,임연근,여향순,김경수 全南大醫大 2001 전남의대학술지 Vol.37 No.1

특발성 경련질환으로 오인된 원발성 부갑상선기능저하증 1례

신성하,최정영,김준기,고영춘,조상욱,김순호,임중규 全南大醫大 2001 전남의대학술지 Vol.37 No.1