간내 담석과 동반된 간내 담도암에서의 p53과 Ki-ras의 발현

김명환,이성구,서동완,이승규,남승우,박능화,민영일,김연석,심기남,공경엽 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5

Background/Aims: Hepatolithiasis or primary intrahepatic stones may be accompanied later by intrahepatic cholangiocarcinoma. This cancerous lesion is frequently associated with atypical hyperplastic epithelium that was suspected of being precancerous. To investigate the Ki-ras or p53 mutation may play a role in carcinogenesis, and to determine whether atypical hyperplastic epithelium may be precancerous, this study was performed in intrahepatic cholangiocarcinomas associated with hepatolithiasis. Methods: We examined 12 patients with intrahepatic cholangiocarcinomas associated with hepatolithiasis. Ki-ras point mutations were assessed by direct DNA sequencing. Expressions of p53 protein were immunohistochemically assessed. The overexpression of p53 and point mutation of Ki-ras were examined in normal, hyperplastic, atypical hyperplastic, and can- cerous tissues separately. Results: The expressions of p53 protein were detected in 4 (33%) of 12 cholangiocarcinomas and Ki-ras point mutations at codon 12 were found in 2 (17%) of 12 cholangiocarcinomas. In those two carcinoma cases which contained the mutant sequence of Ki-ras, the same point mutation from wild type GGT (glycine) to GAT (aspartic acid) was. found in the associated atypical hyperplastic epithelium. However, none of the normal and hyperplastic epithelium harbored Ki-ras or p53 mutations. Conclusions: The overexpression of p53 may play a part in the carcinogenesis of some intrahepatic cholangiocarcinomas associated with hepatolithiasis, whereas the role of Ki-ras mutations in those cases is dubious. However, Ki-ras point mutation at codon 12 may be responsible for either cancer or atypical hyperplastic epithelium associated with hepatolithiasis in certain cases, suggesting atypical hyperplastic epithelium may give rise to carcinoma.

조혈모세포이식환자에서 조혈기능의 회복과 관련된 인자들에 관한 연구

정기주,강명수,권기두,김경하,이상철,김현정,배상병,김찬규,이남수,이규택,원종호,홍대식,박희숙 순천향대학교 의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

성격유형에 따른 복식문양 이미지 평가에 관한 연구

남기선,한명숙 服飾文化學會 2004 服飾文化硏究 Vol.12 No.1

The objectives of this study were to investigate the perceptions of Korean female university students for clothing pattern tendency and structural element of clothing pattern image dimension and to find how individual personality type influence the preferred clothing pattern characteristics. For this study, a questionnaire was designed and sent to 600 female university students of Daejeon, Seoul and metropolitan area. The tool used in this study was MBTI(The Myers-Briggs Type Indicator) Form G Korean version and for the analysis of data SPSS 10.0 package were used. 10 representative patterns for this study were floral, dot, stripe, check, animal, abstract & artistic, geometric, vegetable & leaf, paisely, patchwork pattern. The data were analyzed by factor analysis, arithmetic mean, One-Way ANOVA, χ^(2)-test. The major findings were as follows: Clothing pattern image dimension perceived by Korean female university students for 10 representative patterns were basic form, deluxe, specialty, and cultral dimension. Among them, basic form and deluxe dimension were major dimensions. In basic form dimension, dot pattern score was high indicating female students perceive it as light, comfortable, clean, cool and simple pattern image. In deluxe dimension, floral pattern scored high and in specialty dimension, abstract and artistic pattern scored high among other pattern image. In cultural dimension, geometric pattern and check pattern scored high. Based on other detailed analysis results, It is concluded that the personality type greatly influence clothing pattern evaluation. For example, in case of color combination of patchwork pattern, there was a difference in color preference depend on a personality type such as sensing(S) or intuition(N). Therefore, sensing personality type preferred adjacent color combination than contrast color combination. Detailed marketing strategy is necessary in planning textile design of merchandise plan.

제2형 당뇨병 남성 환자에서 유리 테스토스테론과 성호르몬 결합 글로블린 농도

남기덕,김영설,박철영,오승준,김덕윤,우정택,김성운,양인명,김진우,최영길 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.6

연구배경:인슐린저항성은 제2형 당뇨병과 심혈관질환의 주요한 위험 인자로 성호르몬과 상호 관계가 있다고 알려져 있다. 그러나 여성과는 달리 남성에서는 연령과 인슐린저항성에 따른 유리 테스토스테론과 성호르몬 결합 글로블린 농도의 변화에 대한 연구가 부족한 실정이다. 그러므로, 본 저자등은 제2형 당뇨병 남성 환자에서 정산인과 비교해서 유리 테스토스테론과 성호르몬 결합 글로블린 농도를 측정하고 연령에 따른 변화 정도를 알아보고자 하였다. 방법:대상 환자 모두에서 연령과 체질량지수, 총 콜레스테롤, 중성지방, 공복혈당과 인슐린 농도를 측정하였다. 혈중 유리 테스토스테론 농도는 방사면역측정법(radioimmunoassay)을 이용해서 측정하였고, 혈중 성호르몬 결합글로불린은 면역방사계측측정법(immunoradiometric assay)을 이용해서 측정하였다(Diagnostic System Laoratories, Wbster, TX, USA). 결과:1)제2형 당뇨병 남성 환자에서 정상 대조군 남성에 비해 성호르몬 결합글로불린은 104.1±35.0 vs 25.7±3.5 mole×10??로 의미 있게 높았으나(p<0.001), 유리 테스토스테론은 13.7±9.5 vs 13.6±6.5 ng/dL로 차이가 없었다. 2)연령과 성호르몬 결합 글로블린 사이의 상관 계수는 제2형 당뇨병 남성 환자에서 0.40로 중등고의 양의 상관 관계를 보였고(p<0.001), 정상 대조군 남성에서 0.11로 유의한 상관 관계를 보이지 않았다. 연령과 유리 테스토스테론 사이의 상관 계수는 제2형 당뇨병 남성 환자에서 0.08, 정상 대조군 남성에서-0.17로 모두에서 유의한 상관 관계를 보이지 않았다. 3)연령과 체질량지수를 보정한 후에 제2형 당뇨병 남성 환자와 정상 대조군 남성에서 혈중 인슐린 농도, 유리 테스토스테론과 성호르몬 결합 글로블린 사이에는 상관 관계가 없었다. 결론:제2형 당뇨병 남성 환자에서 정상 남성에 비해 성호르몬 결합 글로블린 농도가 증가되어 있었으며, 유리 테스토스테론은 차이가 없었다. 연령이 증가함에 따라 성호르몬 결합 글로블린이 제2형 당뇨병 남성 환자에서 정상 남성에 비해 증가 폭이 의미있게 컸으며, 유리 테스토스테론은 변화가 없었다. Background: Insulin resistance is a risk factor for cardiovascular disease and type 2 diabetes mellitus. There are many previous studies indicating that insulin lowers serum sex hormone-binding globulin levels, and there is inverse correlation between insulin resistance and serum sex hormone-binding globulin levels in women. However, in men, a limited number of studies are available to explain the effect of sex hormone on age and insulin. Therefore, the present study was undertaken to investigate the relationship among free testosterone, hormone-binding globulin and age in type 2 diabetic men and control subjects. Method: Age, body mass index, total cholesterol, triglyceride, fasting blood sugar, and insulin concentrations were examined on 89 type 2 diabetic men and 47 control subjects. The free testosterone level was measured by commercially available double-antibody system (Radioimmunoassay). The sex hormone-binding globulin level was also measured by commercially available double-antibody system(Immunoradiometric assay). Results: 1) Sex hormone-binding globulin level was significantly increased in patients with type 2 diabetes. However, there was no significantly difference in free testosterone level between the two groups. 2) Sex hormone-binding globulin was positively correlated with age (r=0.4, p <0.001) in patients with type 2 diabetes. Sex hormone-binding globulin and free testosterone were not correlated with age in control sujects. 3) Free testosterone and sex hormone-binding globulin concentrations were not significantly related to serum insulin concentration after adjusting for age and body mass index. Conclusions: We observed increased sex hormone-binding globulin concentration in diabetes man, and was a positively related to age. Further studies are needed to understand the relationships between age, insulin resistance, testosterone, and sex hormone-binding globulin concentrations(J Kor Diabetes Asso 24:699~707,2000).

쌀보리를 기질로 한 알코올발효의 최적 액화효소

남기두,김운식,최명호,박완 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

증자시 높은 점성이 문제되는 쌀보리를 기질로 알콜발효를 행할 경우, 기질의 점성문제를 해결하여 발효조건을 개선하면서 생산수율을 올릴 수 있는 상업용 액화효소를 검토하였다. 쌀보리 증자액화시 BAN을 사용한 경우 기절의 점도는 T120L의 1/3 정도로 떨어졌으며 최종 알콜수율도 T120L에 비해 원료 Ton 당 4 ℓ 정도 더 높게 나왔다. 알콜의 수율은 사용한 당화효소의 종류에 의해서도 영향을 받았다. 산업 규모에서 BAN을 사용한 쌀보리의저온증자가 가능하였으며 고온증자에 비해 알콜수율도 388.4에서 390.4 ℓ/Ton으로 약간 증가하였다. 또 이때 사용한 기질의 전분가를 분석하였는데, 산가수분해 및 효소가수분해법에 의한 쌀의 전분가 분석치는 큰 차이를 보이지 않았으나 쌀 보리의 경우는 효소가수분해법에 의한 값이 산가수분해법에 비해 10% 정도 낮게 나타났다. 이때 BAN은 T120L에 비해 전분가가 약 1% 높게 나왔다. Various treatments of naked barley with commercial liquefying enzymes have been employed to reduce high viscosity of naked barley in cooking as a raw material for alcohol production and to increase alcohol yield. The enzyme BAN used for cooking and liquefaction of naked barley was able to make a reduction of one third of viscosity and to enhance alcohol yield of 4 l/Ton of raw material than the T120L was. Of course, alcohol yield depended in part on the applied saccharifying enzymes. The low temperature cooking of naked barley with BAN was favorable compared with high temperature cooking of both of reducing viscosity (210 vs. 237 cp) and final alcohol yield (Yp/so; 0.397 vs. 0.395 g/g) in industrial scale.

打設式 管井의 Developing工法에 關한 硏究

權武男,李基明,金照雄 慶北大學校 1975 論文集 Vol.20 No.-

The purpose of this study is to develop the economic and effective Developing machine and method for the maintenance of function and development of tube wells. The results studied in these experiments are as follows: 1. The ability from various Developing instruments, Sand-Excluding(Dry Weight), is more than 2 times to compare air compressor and surge plunger method with hand pump method. 2. The thickness of the formed filter layer influenced largely on the ability of concentrating water is about 7 centimeters under the methods of the Developing and the gravel packing. 3. The possible pumping rates and the draw down of water table on the same pumping rates (100tons/day) equal to the Developing and gravel packing method.

에디전트 기법을 이용한 BBS의 불건전 기사 검색 시스템의 설계 및 구현

손봉기,남기범,이건명 충북대학교 컴퓨터 정보통신 연구소 1999 컴퓨터정보통신연구 Vol.7 No.1

BBS(Bulletin Board System)의 사용이 대중화되면서 건전하고 유용한 정보뿐만 아니라 음란물 및 불법 소프트웨어의 복제 판매 등과 같은 불건전하고 불법적인 정보가 전파될 수 있다. 특히 BBS 상의 음란물은 청소년에게 정서적으로 나쁜 영향을 줄 수 있고, 불법판매 행위는 소프트웨어 관련업계에 경제적인 피해를 줄 수 있다. 현재 BBS 서비스 업체 및 기관에서는 게시판, 자료실 등에 대해 담당직원을 두어 수 작업으로 불건전 기사를 제재하고 있는데, 이 방법은 제재하는데 한계가 있고 인력과 시간의 부담이 따른다. 본 논문에서는 에이전트 기법을 이용해 BBS 내에서의 불건전 정보를 자동으로 검색하는 시스템을 설계하여 제안한다. 이 시스템은 인력과 시간의 절약은 물론 불건전 정보가 BBS를 통해 유통되는 것을 방지하는데 크게 기여할 것이라 기대된다. As the information exchanges in BBS(Bulletin Board System) become popular, unsound and illegal information like lascivious things, illegal reproduction selling of softwares as well as sound and useful information might be prevailing. Especially lascivious things in BBS exert a harmful influence upon juveniles. At present BBS service companies and the police squad manually take sanctions against unsound articles by completely charged staff monitoring BBS. This method has limitations in thoroughly monitoring BBS and requires many human resources and long retrieval time. In this paper, we design and propose a system that automatically retrieves unsound articles in BBS by using agent technology. We expect that this system can have the advantages of saving retrieval time, reducing human resources and restraining unsound information from being distributed over BBS.

섬록암폐석을 이용한 폴리머 콘크리트의 특성 및 제품 개발

김기락,최동순,연규석,주명기,김남길 강원대학교 석재복합신소재제품연구센터 1997 석재연 논문집 Vol.2 No.-

우리나라에서는 각종 광산으로 부터 폐석이 다량으로 발생되고 있다. 이와같은 폐석의 부가가치를 높일 수 있는 방안의 모색이 절실한 실정이다. 따라서 본 연구에서는 강원도 춘천지역의 섬록암 광산에서 다량으로 발생되고 있는 폐석을 활용하여 고강도이며, 내구성이 우수한 폴리머 콘크리트를 제조하고, 이에 대한 물리·역학적 특성을 실험적으로 구명하였다. 또한 섬록암 폐석을 이용한 폴리머 콘크리트를 사용하여 플륨, 경계석, 보도블럭, 기와 등과 같은 공장제품을 제조하여 이에 대한 효율적 활용 방안을 제시하였다. Large amount of mine waste have been produced and acumulated from various mining works in korea. Mine wastes causes many adverse invironmental impacts and it is urgently required t develop methods to increase its value by resuing in construction materials and other products. The dbjectives of the study were to develop a high strength and durable high quality polymer concrete by using Diorite mine wastes that are produced from mines in Chunchon area, and to experimentally test the physical and mechanical properties of the concrete. Also, effective reuse methods for the Diorite mine wastes were suggested by developing flumes, curb stones, foot path blocks and roof tiles with the polymer concrete.

裁植密度가 靑刈豌豆의 主要形質 및 收量에 미치는 影響

趙南棋,韓英明,朴良門,姜奉均 濟州大學校 亞熱帶農業硏究所 1998 亞熱帶農業硏究 Vol.15 No.-

ABSTRACT Two pea cultivars, 'Cheju local pea' and 'Sparkle', were planted on 3 March at Cheju at 5 plant densities(10x 10, 15x15, 20x20, 25x25, 30x30cm) to determine the optimum plant population. Days to flowering decreased as planting density was increased. Days to flowering of Cheju local pea was greater than Sparkle that of. The broader planting density, the higher plant height. Cheju local pea was taller than Sparkle. As planting density increased, stem diameter and number of nodes per plant of two cultivars increased. Fresh forage yields of Cheju local pea (3,585kg/10a) and Sparkle(3.787kg/10a) were greatest at 10X 10cm planting. Plant height for each cultivar was positively correlated with fresh forage yield.