발열을 동반한 호중구감소증에서 Cefepime 단독투여와 Ceftazidime 및 Tobramycin 병합투여의 효능비교

정현욱,채제욱,강미라,양정채,문치숙,기현균,장현하,오원섭,김기현,백경란,이남용,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 국내에서 발열을 동반한 호중구감소증이 있는 악성 종양환자에게 경험적 항생제로 베타락탐계 항생제와 아미노배당체의 병합요법의 사용이 일반적이다. Cefepime은 광범위 항균 작용을 가지고 있어, 그람 음성균 뿐만 아니라 그람 양성균에 대해서도 우수한 효과를 나타낸다. 재료 및 방법: 발열을 동반한 호중구감소증이 있는 악성 종양환자를 대상으로 무작위, 공개, 비교 연구를 시행하였다. 대상 환자를 무작위로 cefepime 단독요법군과 ceftazidime 및 tobramycin 병합요법군으로 나누어 투여하고 각각의 임상적 효능과 안전성을 비교하였다. 구강및 인후 점막염이 있는 환자에서 분리된 녹색 연쇄알 구균에 대한 항생제 내성 정도를 조사하였다. 결과 : 대상환자 89명 중 CA 투여군이 48예(53.9%), CT 투여군이 41예(46.1%)이었다. 발열의 유형별로 MDI는 18예(20.2%), CDI는 9예(10.1%), UF는 62예(69.7%)로 두 군 간에 차이가 없었다. CA 투여군과 CT 투여군의 임상적 호전률은 시험약 투여 후 2-4일째 각각 91.7%, 85.4% (P=0.31), 치료 종료 시 각각 91.7%, 100% (P=0.15)로 두 군간에 유의한 차이가 없었다. 치료 종료 시 CA 투여군과 CT 투여군의 세균학적 소실률은 모두 100%로 두 군간의 유의한 차이가 없었다(P=0.78). 점막염이 있는 환자로부터 녹색 연쇄알 구균이 분리된 경우는 25예(28.1%)이었으며, 분리된 녹색 연쇄알 구균은 penicillin, ceftriaxone, cefepime, vancomycin에 모두 감수성을 보였다. 약제 관련 이상 반응의 발생 빈도도 두 군간에 유의한 차이가 없었다. 결론 : 발열을 동반한 호중구감소증이 있는 악성 종양환자의 경험적 항생제로서 cefepime 단독요법은 ceftazidime 및 아미노배당체의 병합요법만큼 효과적이고 안전하였다. Background : Broad-spectrum antibiotic therapy has been recommended as an empirical regimen in cancer patients with febrile neutropenia. Cefepime is a fourth generation cephalosporin with good activity against both gram-positive cocci and gram-negative bacilli. Materials and Methods : To compare the efficacy and safety of cefepime alone with ceftazidime plus tobramycin as empirical regimen for adult cancer patients with febrile neutropenia, a randomized, open label, comparative trial was performed. If the patient showed clinical improvent 72 hours, antibiotic could be changed to oral ciprofloxacin. Clinical and microbiological responses were determined at 72 hours and at the end of therapy. To investigate the antimicrobial resistance of viridans streptococci, swab cultures were obtained from throat in all enrolled patients and antimicrobial susceptibility tests were performed by using microdilution method according to the NCCLS. Results : A total of 89 patients were enrolled. Forty-eight patients received cefepime alone (CA), and 41 patients received ceftazidime plus tobramycin (CT). Demographic and baseline clinical characteristics were similar in both groups (P>0.05). The initial clinical success rate at day 2-4 in group CA (91.7%) was similar with that in CT group (85.4%) (P=0.31). At the end of therapy, the final clinical success rate in CA group (91.7%) was similar to that in CT group (100%) (P=0.15). In 18 patients, with microbiologically defined infections, the eradication rate was 100% in both groups. Adverse events including liver dysfunction (21.3%) and renal dysfunction (2.2%), were similar in both groups (P=0.87). Viridans streptococci were isolated from the throat cultures in 25 cases, and all of these strains were susceptible to penicillin (MIC_(90) 0.12 ㎍/mL), cefepime (1 ㎍/mL), and vancomycin (0.12 ㎍/mL). Conclusion : Efficacy and safety of cefepime monotherapy was comparable to the combination of ceftazidime and tobramycin. It could be used as an alternative empirical regimen for treating cancer patients with febrile neutropenia.

Pisolithus tinctorius菌에 의해 형성된 소나무류 外生菌根의 形態的 比較

文美蘭,吳光仁,鄭南澈 全南大學校 農業科學技術硏究所 1999 農業科學技術硏究 Vol.34 No.-

Pisolithus tinctorius菌을 곰솔(Pinus thunbergii), 소나무(P. densifora), 리기다소나무(P. rigida), 테에다소나무(P. taeda), 리기테다소나무(P. rigitaeda), 버지니아소나무(P. virginiana)에 人工接種하여 수종간 균근의 發達, 菌根型의 特異性, 外部形態的 特徵을 調査하였다. P. tinctorius菌이 接種된 소나무류의 菌根型은 線型(linear type), 頂端型(apical type), 棍棒型(clavate type), 塊根型(nodular type), 二次分枝型(dichotomy type), 念珠型(bead type), 長二次分枝型(long dichotomy type), 不均衡 二次分枝型(unbalanced dichotomy type), 二重二次分枝型(double dichotomy type), 不均衡二重二次分枝型(unbalanced double dichotomy type), 不均衡半二重二次分枝型(unbalanced semi-double dichotomy type), 珊瑚型(coralloid type)으로 識別되었다. 곰솔, 리기테다소나무의 均套표면은 노란색 Felt 형의 뚜렷한 菌套를 형성하였다. 그러나 리기다소나무, 소나무, 테다소나무, 버지니아소나무의 菌套表面은 부착 菌絲의 형성이 전혀 없는 매끄럽고 윤기있어 보이는 황갈색 velvety형 均套를 나타냈다. 소나무, 리기다소나무, 테다소나무, 버지니아소나무는 線型, 頂端型, 二次分枝型, 念珠型, 長二次分枝型들과 같은 단순한 형태들이 주로 나타났지만, 곰솔과 리기테다소나무는 二次分枝型, 變形들인 長二次分枝型, 不均衡二次分枝型, 二重二次分枝型, 不均衡二重二次分枝型, 不均衡半二重二次分枝型들이 많이 나타났고 안정형인 珊瑚型으로 發達하였다. The morphological characteristics of ectomycorrhizae in the seedlings of 6 different pines(Pinus. thunbergii, P. densiflora, P. rigida, P. teada, P. rigiteada and P. virginiana), inoculated with ectomycorrhizal fungi, Pisolithus tinctorius(Pers.) Coker & Couch, were analyzed. The types of ectomycorrhizal short roots among 6 pines could be categorized into 12 types; linear, apical, clavate, nodular, dichotomy, bead, long dichotomy, unbalanced dichotomy, double dichotomy, unbalanced double dichotomy, unbalanced semi-double dichotomy, and coralloid types. Whereas the sheaths of seedlings of P. thunbergii and P. rigiteada were covered with a mycellium bed of light yellowish white, those of the other pines were covered with the smooth and blight bed of yellowish brown without attached mycellium. The five major types(i.e, linear, apical, dichotomy, bead, and long dichotomy types) of the 12 types classified in this study were for P.densiflora, P.rigida,P.teada,and P.virginiana,respectively. However, P. thunbergii, and P. rigiteada of long dichotomy, unbalanced dichotomy, double dichotomy, unbalanced double dichotomy, and unbalanced semi-double dichotomy types were the major types, which were developed into a stable type such as coralloid type.

흰쥐의 비장에서 분리한 림프구를 이용한 형광백혈구 안저촬영술

정미란,이숙희,황정용,양연식 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Background: The study on retinal blood flow has been continuously pursued and recently new methods such as targeted dye delivery, fluorescent vesicle system, laser Doppler velocimetry and acridine orange staining method has been presented. The authors developed a new method, fluorescein leukocyte angiography using a scanning laser ophthalmoscope which include external staining of leukocyte with fluorescein dye and reintroducing this fluorescent leukocyte into the blood flow. However, visualization of the leukocytes was limited since the leukocytes used were from the peripheral blood in a small animal. Methods: The authors removed leukocytes from the spleen and stained these leukocytes which were reintroduced into the blood flow to observe the retinal and choroidal blood circulation. In four pair of rats, one group was injected with the leukocytes of another rat's spleen and the other group were injected with the leukocytes of each own's individual spleen and all underwent angiography. Results: There were only few lymphocytes visualized in the group of rats which eceived allo-injection of leukocytes and in the other group the lymphocytes were numerous and also had a longer existence. Conclusions: In small animals like rats the visualization of the lymphocytes used from the spleen was better than the those from the peripheral blood and lymphocytes from one own's spleen was useful for longer periods of visualization.

서울과 경기지역 성인여성의 타우린 섭취량과 배설량 및 혈장 타우린 농도

임미형,양혜란,정진일,김을상 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.1

The purpose of this study was to investigate dietary taurine intakes, plasma taurine levels and urinary taurine excretions of women in Seoul(Kangbuk-ku) and Kyunggi(Yeoju) area, Korea. Seventy married women aged 39.7±8.9 have volunteered for this study: 36 from Seoul area and 34 from Kyunggi area. Diet samples were collected from the participants and the samples included three meals (breakfast, lunch and supper), snacks, drinks and whatever the participants had eaten for 24 hours. The plasma was obtained by allowing a 5 ml fasting blood sample to be in a heparinized tube for 30 min and centrifuging it at 11,000 × g for 20 min. The collected diets were blended, centrifuged and deproteinized. Taurine levels in the diet and plasma were determined as the dabsyl derivative using HPLC with Rf-detector. The intake of taurine ranged from 6.8 to 837.8 ㎎/day and its mean value was 145.5±64.0 ㎎/day (mean±SD). The 90th, 50th and 10th percentile values of the taurine intake were 280.0, 94.3 and 26.8 ㎎/day, respectively. There was a significant difference between two groups: 202.0±204.9 for Seoul area and 85.5±7.2 ㎎/day for Kyunggi area(p<0.001). The taurine level in plasma ranged from 42.1 to 201.9 μmol/L and its mean value was 74.9±22.8 μmol/L. The 90th, 50th and 10th percentile values of the plasma taurine were 101.1, 70.7 and 54.6 μmol/L, respectively. There was no significant difference between Seoul area and Kyunggi area in plasma taurine level.

유아교육기관 원장의 수업지도성에 관한 연구

신은미,이정란 경복대학 2002 京福論叢 Vol.6 No.-

본 연구는 유아교육기관 원장의 수업지도성에 대한 현황을 분석함으로써, 교사양성과정 및 현직교육을 위한 기초자료를 제공하는데 그 목적을 두었다. 이를 위해 25명의 유치원 및 어린이집 원장과 36명의 유치원 및 어린이집 교사들을 대상으로 설문 조사를 하였다. 연구결과, 첫째, 유치원 원장은 어린이집 원장에 비해 수업지도성에 대해 높게 인식하고 있었다. 둘째, 어린이집 교사는 유치원 교사에 비해 원장의 수업지도성에 대해 높게 인식하고 있었다. 셋째, 원장의 수업지도성에 대해 가장 큰 차이는 유치원 원장과 유치원 교사간에 나타났다. The purpose of this study is to analyzes early chidhood center director's instructional leadership and to provides primary informations for early childhood teacher preparation and in-services. A questionaire examined to 25 early childhood center directors and 36 early childhood center teachers. The findings of this study are as follows: First, there are no significant differences between the kindergarten directors and chidcare center directors. But kindergarten directors were highly perceived of instructional leadership than childcare center directors. Second, there are no significant differences between the kindergarten teachers and chidcare center teachers. But childcare center teachers were highly perceived of instructional leadership than kindergarten teachers. Third, there is a largely significant difference between the kindergarten directors and kindergarten teachers.

동국의대에서 실시한 2002년 전염병관리실무과정에 대한 평가

방미란,임현술,정해관,한영란,정철 대한보건협회 2003 대한보건연구 Vol.29 No.1

Communicable diseases have recently reemerged, with new communicable diseases continually breakmg out on a global scale; threaten the health and economics of populations. The Korean National Institute of Health carries out Field Management Training Prcgrams (FMTP) to address this problem The objectives of this study were the evaluation of the understanding and satisfaction for this program, and recommendation for improvement strategies. We conducted a questionnaire survey of 80 persons who completed the FMTP, at Dongguk University, between March 1 and November 30, 2002. The data collected was analyzed by Student s t-statistics. The understanding of the curriculum was Well in 42 (52.5%) and Moderate in 24 persons (30.0%). The satisfaction with the curriculum was Moderate in 38 (47.5%) and Good in 30 persons (37.5%). The satisfaction for the period of education was Bad for 31 persons (38.7%), which accounted for the majority of cases. The mean scores, by Likert s scale, for the understanding and satisfaction of the curriculum were 3.70 (±0.71) and 3.32 (i0.721, respectively. The mean score for the epidemiological survey was the highest for satisfaction with the course, at 3.78 (±0.62). The mean value of satisfaction for curriculum in education of period was significantly higher in health department group than in nursing department group (P<0.05). From this survey it appears the respondents were satisfied with this program. The FMTP will be systematically revised for curriculums, and effort will be required to develop controls for communicable disease, both by the government and the university.

ATHB12, an ABA-lnducible Homeodomain-Leucine Zipper (HD-Zip) Protein of Arabidopsis, Negatively Regulates the Growth of the Inflorescence Stem by Decreasing the Expression of a Gibberellin 20-Oxidase Gene

Ora Son,허윤선,김윤경,이현정,김성한,김미란,남경희,이명석,김부용,박종범,박정안,이석찬,Atsushi Hanada,Shinjiro Yamaguchi,이인정,김승기,윤대진,Eva So¨derman,천충일 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

ATHB12, an ABA-lnducible Homeodomain-Leucine Zipper (HD-Zip) Protein of Arabidopsis, Negatively Regulates the Growth of the Inflorescence Stem by Decreasing the Expression of a Gibberellin 20-Oxidase Gene

Ora Son,허윤선,김윤경,이현정,김성한,김미란,남경희,이명석,김부용,박종범,박정안,이석찬,Atsushi Hanada,Shinjiro Yamaguchi,이인정,김승기,윤대진,Eva So¨derman,천충일 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

과민성 장 증후군의 증상 경감을 위한 비약물적 접근 고찰

최명애,김금순,안경주,채영란,최정안,홍해숙,박미정,이경숙,신기수,정재심 대한기초간호자연과학회 2005 Journal of korean biological nursing science Vol.7 No.2

There have been many trials of clinical efficacy of multicomponent and single component treatments for irritable bowel syndrome(IBS). We reviewed effects of non phamacological treatments in the IBS. Though the efficacy of multi-component approaches was unclear, several results suggest that cognitive behavioral therapy was effective in improving gastrointestinal symptoms of IBS. As a single component, cognitive therapy and relaxation with or without biofeedback could improve the symptoms and psychological health of IBS patients. Yoga, meditation, self-help information and hypnotherapy could be applicable to IBS.

일부 부인과 양성 질환자의 지방조직 및 혈청의 PCBs와 DDE 농도

박성균,이강숙,노영만,구정완,민선영,한진구,고원경,김미란,정재근,이종승,김진홍 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 연구는 지방조직과 혈청의 PCBs와 DDE 농도를 측정하고, 이에 영향을 미치는 것으로 알려진 요인들과의 관련성을 평가하고자 하였다. 방법 : 유방암, 자궁내막증 등 유기염소계 화합물의 영향이 있는 것으로 알려진 호르몬 관련 질병을 제외한 부인과 환자 52명을 대상으로 지방조직과 혈청을 분석하였으며, 설문조사를 통하여 연령, 교육수준, 직업, 비만도, 흡연과 음주, 출산력, 수유력등을 조사하였다. 지방조직과 혈청의 PCBs와 DDE 농도는 가스크로마토그래피를 사용하여 측정하였다. 결과 : 지방조직의 경우, 13개 PCBs congeners 농도의 합은 중앙값이 48.29 ng/g, 기하평균값이 56.78 ng/g이었고, DDE 농도는 중앙값이 142.89ng/g, 기하평균값이 117.06 ng/g이었으며, 혈청의 경우는 PCBs congeners 농도의 합은 중앙값이 4.67 ㎍/L, 기하평균값이 4.85 ㎍/L이었고, DDE 농도는 중앙값이 1.75 ㎍/L, 기하평균값이 2.09 ㎍/L로 나타났다. 지방조직과 혈청의 DDE 농도 사이는 높은 상관성을 보였으나(r²=0.310, p=0,0002), PCBs는 상관성이 약한 것으로 나타났다(r²=0.029, p=0.2582). 영향요인을 범주화한 후 로그변환 시킨 지방조직과 혈청의 PCBs, DDE 평균의 차이를 분석한 결과, 지방조직의 DDE만이 출산자녀수(p=0.015), 초산연령 (p=0.014), 비만지수(p=0.035)와 연관성이 발견되었다 다중회귀분석의 결과 지방조직의 DDE는 출산자녀수가 적을수록, 초산연령이 늦을수록 증가하는 경향을 보였다. 결론 : 출산자녀수와 초산연령, 비만도가 지방조직의 DDE와 관련성을 보였으며, 또한 유기염소계 화합물의 장기간의 노출에 의한 영향을 평가하는데 있어서 혈청보다 지방조직이 더 유용한 생물지표임을 알 수 있었다. Objectives : This study was purposed to determine the levels of PCBs and DDE in adipose tissue and serum and to evaluate the relations with factors affecting these levels. Methods : We analyzed adipose tissues and sera from 52 gynecologic benign disease patients aged 27-78 years, except hormonal diseases such as breast cancer and endometriosis. We also surveyed age, education, occupation, body mass index (BMI), smoking, drinking, number of children, and duration of breastfeeding by questionnaires. Tissue and serum levels of PCBs and DDE were measured using gas chromatography. Results : The median and geometric mean levels of PCBs were 48.29 ng/g, 56.78 ng/g for adipose tissue and 4.67 ㎍/L, 4.85 ㎍/L for serum, and those of DDE were 142.89 ng/g, 117.06 ng/g for adipose tissue and 1.75 ㎍/L, 2.09 ㎍/L for serum, respectively. Adipose tissue and serum levels for DDE showed high correlation (r²=0.310, p=0.0002), but those of PCBs didn't (r²=0.029, p=0.2582). In analyses of the differences of the means of log transformed adipose tissue and serum PCBs and DDE levels for groups of potential covariates, only adipose tissue DDE levels were significantly associated with number of children (p=0.015), age at first birth (p=0.074) and BMI (p=0.035). In multiple regression analysis, adipose tissue DDE levels were significantly increased with decreasing number of children and increasing age at first birth. Conclusions : This study suggested that parity and adiposity were associated with levels of DDE in adipose tissue, and adipose tissue is a better biomarker than serum for evaluating the long-term exposure of organochlorines.