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      • SCIESCOPUSKCI등재
      • KCI등재SCOPUS

        간세포암과 하대정맥 막성폐쇄의 치료 후 호전된 백혈구파괴혈관염 1예

        이준엽 ( Jun Yeob Lee1 ),이주원 ( Ju Won Lee1 ),이진욱 ( Jin Wook Lee ),박현준 ( Hyun Joon Park ),장국환 ( Gook Hwan Jang ),김다정 ( Da Jung Kim ),김선민 ( Sun Min Kim ),한병훈 ( Byung Hoon Han ),정규식 ( Gyoo Sik Jung ),김근태 ( 대한류마티스학회 2015 대한류마티스학회지 Vol.22 No.5

        Vasculitis is a heterogeneous group of diseases that destroy blood vessel walls by inflammation. Approximately half of vasculitis cases are idiopathic, but sometimes associated with genetic factors, medicines, chronic infection, autoimmune diseases, and malignancies. Although the mechanism remains unclear, vasculitis secondary to malignancy, also known as paraneoplastic vasculitis, has been reported. It is generally associated with hematologic malignancies rather than solid malignancies and commonly presents as leukocytoclastic vasculitis or polyarteritis nodosa. We experienced a case of leukocytoclastic vasculitis in a patient with hepatocellular carcinoma and membranous obstruction of the inferior vena cava. Here, we report this case with a brief review of literature. (J Rheum Dis 2015;22:322-326)

      • KCI등재

        한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

        조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

        Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

      • KCI등재

        새로운 유사 원자층 증착 방법에 의한 산화막의 형성 및 터널링 자기 접합에의 응용

        한신희,정원철,이장식,김병동,주승기 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.1

        The tunneling barrier is crucial to the overall performance in magnetic tunnel junction. We have suggested a new formation method for the tunnel barrier, which has utilized pseudo atomic layer deposition with sputtering (PALDS). As is well known, all metallic thin films oxidize more or less under atmospheric conditions. With using this property of metallic thin films, we have prepared tunnel barrier by sputtering metallic thin film and exposing it to the oxygen ambience. From transmission electron microscopy (TEM) observation, the formed tunnel barrier has been confirmed to have clear and good interface between magnetic layers and tunnel barrier. From atomic force microscopy (AFM) observation, it has been also confirmed to have low surface roughness. The TMR MRAM cell manufactured using PALDS method has been shown to exhibit typical tunnel resistance of 86 KΩ·μm^2 and TMR ratio of about 40%. The 40% of MR is quite large. It is considered that this value is geometrically enhanced magnetoresistance due to the low junction resistance of MTJ.

      • PGE_2와 DBcAMP가 골조직 세포의 생리적 활성에 미치는 영향

        이준기,채한정,강장숙,김형룡 원광대학교 생체재료·매식연구소 1998 원광생체재료·매식 Vol.7 No.2

        One of the primary functions for which bones have evolved is to act as structural support. To achieve this goal, bones are remodeling throughout life so that their structure remains optimal for the prevailing mechanical environment. Bone remodeling consists of an initial phase of osteoclastic bone resorption followed by a bone formation period. Prostaglandins are potent regulators of bone formation and bone resorption that can have both stimulatory and inhibitory effects. Elevation of intracellular cAMP is an important intracellular signaling mechanism involved in the regulation of the expression of many proteins. In this study, the author examined whether PGE_2 or DBcAMP affected osteoblastic activation or osteoclastic differentiation in mouse bone marrow cells and osteosarcoma ROS 17/2.8 cells. The effect of PGE_2 and DBcAMP on the cell proliferation was measured by the incorporation of [^3H]-thymidine into DNA. From the result, PGE_2( 0.5-1 ㎍/ml ) and DBcAMP(0.1-0.5 mM) inhibited the [^3H]-thymidine incorporation into DNA. The effect of PGE_2 and DBcAMP on the induction of alkaline phosphatase(ALP) was investigated in ROS 17/2.8 cells cultured in medium containing 0.4% fetal bovine serum. PGE_2 and DBcAMP stimulated ALP activity in the cells. PGE_2 also increased the intracellular cAMPs contents with a maximal effect at 0.5 ㎍/ml. ROS 17/2.8 cells released nitric oxide upon stimulation of PGE2 or DBcAMP with interferon-γ. PGE_2 and DBcAMP increase the phosphorylation level of CREB(cAMP response element binding protein) without any change on the amount of CREB protein. Also, PGE_2 (10^-6 M) and DBcAMP (10^-4 M) significantly increase the generation of osteoclast-like cell in mouse bone marrow cell culture system. In conclusion, the results of this study suggested that PGE_2 and cAMP should appear to be an important regulatory molecule in the processes of bone formation and resorption.

      • KCI등재

        공동주택 최상층과 지상1층 차별화계획의 효과 및 개선방안 연구

        장한두,이규인,제해성 대한건축학회 2003 대한건축학회논문집 Vol.19 No.10

        The purpose of this research is to analyze various types of the additional design alternatives of apartment housing units at ground and top floors which is recently supplied by developers in Korea, and to find out their effects on residents and to suggest design enhancements. For this research, first, eleven apartment housing estates are selected through literature review and field survey, and types of design alternatives are categorized. Second, the effects of the design alternatives on the residents are analyzed based upon survey. Third, a direction of design enhancement is suggested through analyzing residents' behavior and needs. The results of this study are (1)to verify the seven types of the design alternatives. They are ⅰ)attic at top floor unit, ⅱ)rooftop terrace at top floor unit, ⅲ)living room enlarged floor height at top floor unit, ⅳ)duplex unit at top floor, ⅴ)private garden at ground floor unit, ⅵ)private accessibility at ground floor unit, ⅶ)underground storeroom at ground floor unit, (2)to analyze the effects of design alternatives on the residents, which are composed of the spacial feasibilities of ⅰ)connection to ground, ⅱ)exposition to open air, ⅲ)diversity of composing interior space, ⅳ)flexibility of various usage and ⅴ)openness of interior space, and (3)to suggest a direction of design enhancement of the alternatives at ground and top floors for higher performance.

      • Integrated Human-Robot Ergonomics의 일환으로써 TOES/WCS에 의한 로보트의 동작제어개선에 관한 연구

        이순요,한장희,김태원 한국경영과학회 1989 한국경영과학회 학술대회논문집 Vol.- No.1

        The purpose of this study, as a part of an intergrated human-robot ergonomics, is to improve robot motion control in a teaching and operating expert system / world coordinate system (TOES / WCS) constructed in the previous study. The major contribution of this study reduces the inaccuracy in coordinate reading and the movement time of robots in macro motion control. This study also reduces undesirable teaching time required by using a unit control (UC) and micro unit control (MUC) in micro motion control.

      • 압출성형에 의한 국산 무연탄 활성탄의 세공구조 변화

        이송우,문장천,김도한,이창한,최동훈,류동춘,송승구 부산대학교 환경문제연구소 2000 環境硏究報 Vol.18 No.-

        The purpose of this study is to investigate the variation of pore size distribution of the coal-based extruded activated carbon. The extruded activated carbon was prepared by extruding the mixture of coal powder and coal tar. Pore size distribution of the extruded activated carbon was compared with that of the extruded coal and the extruded char. Also it was compared with that of the crushed activated carbon, raw coal and char. The extruded coal had coarser surface than that of raw coal. Macropores of the extruded coal were funned near 10,000Å in diameter during carbonization process and steam penetrated easily between particles and were growing between 3,000Å and 20,000Å in diameter during activation process.

      • 계층화분석법을 이용한 노후 공동주택의 재건축과 리모델링 의사결정방법

        이태영,장한두,제해성 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(계획계)

        In this study, it is tried to establish a integrated evaluation method composed of functional criteria, economical criteria and characteristic criteria of apartment housing, the latter is additional consideration. Functional and economical criteria is similarly effected in decision making to respectively apartment housings with different characteristics by functional evaluation and profit analysis. There is necessity for recognizing that decision making between reconstruction and remodeling of apartment housing must be performed as not single development project but consideration of residential environment to improve the quality of residents' environment in long-range insight. Therefore, meaning of this study is to find out the possibility of application about characteristics of apartment housing as criteria than to make a practical evaluation method.

      • 참깨 立枯性 病原菌에 관한 硏究

        李斗珩,梁壯錫,韓東旭 서울市立大學校 1986 論文集 Vol.20 No.2

        Damping-off and wilting diseases in sesame plant(Sesamum indicum L.) occurring severely in Korea have been studied for incidences of disease from seeds, diseased plants and soils. Alternaria longissima, A. tenuis, Aspergillus. spp, Cephalosporium sp., Cuvuaria lunata, Drechslera sp.,sp., Fusarium equiseti, F. moniliforme, F. semitectum, F. solani, Mucor sp., Myrothecium roridum Penicillium spp., Phoma sp., Rhizopus sp., were saprophytic fungi and Alternaria sesami, A. sesamicola, Macrophomina phaseolina, Rhizoctonia solani were pathogenic fungi detected from 66 seed samples of sesame. Initial symptoms caused by pathogenic fungi on seedlings from naturally infected seed by the test tube agar method have been described and discussed. Except Alternaria sesamicola, A. tenuis and Macrophomina phaseolina, all fungi were completey wiped out the infection by pretreatment with Benlate-T. The pathogenic fungi isolated from sesame soil were Fusarium oxysporum and Rhizoctonia solani. F.oxysporum occurred less frequently in upland rice and ground nut soils than in sesame soil, but R. solani not decreased by upland rice and ground nut soils. The differences of the isolation frequency of F.oxysporum and the incidence of the wilting plants were found among the fields which varied in their cropping histories. F.oxysporum isolated most frequently from stems and roots of wilting sesame plants followed by R. solani. Nematodes also isolated from the wilting sesame plants.

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