프리미돈의 한국인에서의 생체이용율시험

권광일,윤민혁,윤희열,박희찬,권준택,심희옥,김동출 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-

A reversed phase HPLC method was developed and validated for the determination of primidone in human plasma. Propylthiouracil was used as an internal standard. Calibration curves were linear in the concentration range of 10-120 ng/㎖. The coefficient of variation of the intra- and inter-day precision were below 15%. The coefficient of variation of the accuracy were below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Twenty four healthy human male volunteers were orally administered 20 mg of primidone. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(LAST) was 85.0±17.7 ㎍ hr/㎖, C_(max) was 4.22±1.04 ㎍/㎖, T_(max) was 1.85±1.13 hr, t_(1/2) was 17.7±2.4 hr. The pharmacokinetic parameters and the HPLC method can be used for the desigm of bioequivalence study of primidone.

형상문법이론에 따른 피터 아이젠만의 평면구성원리에 관한 연구 : 주택작품을 중심으로

권영숙,이광희 대한건축학회 2005 대한건축학회논문집 Vol.21 No.1

The purpose of this study is to analyze the architectural characteristics of plan composition by using shape grammar theory and to examine It's possibility for computerization of the process The study selected Peter Eisenman's House series for the analyses and verified he used some kind of formal composition rules Which were based on the theory The study found out four rules Rule 1 is the folding of quadrangle Rule 2 is the adding of two Quadrangles toward the wing shape Rule 3 isi also adding of quadrangle along X axis of every quadrangle, while rule 4 is adding along X axis of the quadrangle The study simulated the process of plan compositions by using ObjectARX In AutoCAD, and proved that It was so effective to create various alternatives with repetitive usages In the design works

줄넘기 운동이 고등학교 비만 남학생의 건강체력 및 비만 스트레스 해소에 미치는 영향

권봉안,장희수,정순광 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6

This study is to understand the effect of rope jumping on health related physical strength and obesity stress of high school obese students. The subject of this study was 40 1st and 2nd grade obese male students attending at P high school located in Goyang-City, Kyunggi-province as of the 1st semester, 2003 school year. As the study instrument, a questionnaire of physical strength items and obesity stress was used. To analyze the effect of rope jumping on health related physical strength, physical strength items were adopted, and to analyze the effect of rope jumping on the relief of obesity stress, the questionnaire was used. The questionnaire was asked to answer questions by Self-administration method to 20 subjects of the experiment group participating at rope jumping. As the questionnaire, health related pre-physical strength test was performed along with the 1st survey and the 2nd survey was carried after exercise, then health related physical strength test was carried out. The collected data were analyzed using SPSS/Windows 10.0 statistical program, and average and standard deviation by the sub-factor of each factor was calculated and to understand differences using groups and periods, 2x3 2-way variance analysis(ANOVA) by repeated measurement was carried out. In case interaction of two factors, that is, character and school year, post-verification using Duncan's multiple range test was made, when significance level will be set at α=.05. Based on the above research procedure and data analysis, following conclusion is as follow. 1) In the change of health physical strength by exercise participation of high school obese male students, there was no significant difference, but muscular endurance and body fat were different. 2) In the change of health physical strength by exercise participation of high school obese male students, there was no significant difference before and after exercise, but difference after exercise. 3) In the individual difference by rope jumping participation of high school obese male students, there was no significant difference in school year and character, but difference in obesity. 4) In the exercise programs by rope jumping participation of high school obese male students, there was no significant difference in school year and character, but difference in obesity.

퀴니딘 정제의 건강한 한국인에 대한 약물동태

박희찬,윤민혁,김동출,권준택,권광일 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-

The purpose of this study was to estimate the pharmacokinetics of quinidine sulfate in healthy Korean The parameters were examined on 16 volunteers who received a oral single dose(200mg quinidine sulfate). After dosing. blood samples were collected for a period of 24 hours. Plasma samples were analyzed for quinidine sulfate and DL-propranolol hydrochloride(internal standard) by HPLC/UV. The pharmacokinetic parameters (AUC_(0-24hr), AUC_(inf). C_(max), T_(max), K_(a), K_(el), t_(1/2), Vd/F and Cl/F) were calculated from the plasma quinidine sulfate concentration-time data of each volunteer. The computer program "WinNonlin" was used for compartmental analysis. One compartment model with first order input, first order output was chosen as the appropriate pharmacokinetic model. The pharmacokinetic parameters(AUC_(0-24hr). AUC_(inf). C_(max), T_(max), K_(a), K_(el), T_(1/2), Vd/F and Cl/F) calculated 9.47±2.24 ㎍·hr·㎖^(-1), 10.95±2.62 ㎍·hr·㎖^(-1), 0.93±0.16 ㎍/㎖, 1.56±0.45 hr, 1.10±0.36 hr^(-1), 5.17+0.90 hr, 162.38±33.36 L and 22.27±5.35 L/hr, respectively.

Tabes Dorsalis의 핵자기공명영상 및 전기생리학적 소견

권기한,김성민,권석범,이병철,조광호,주정희 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

PC기반의 4채널 컴퓨터 비전 및 통신 시스템의 설계와 구현

이수형,이상혁 위덕대학교 산업기술연구소 2001 산업기술연구소 논문집 Vol.5 No.1

본 논문에서는 개인용 컴퓨터의 기반에서 작동되는 영상획득 보드를 설계하고 이를 이용하여 DVR 시스템을 구현하였다. 제작된 영상획득 보드는 다양한 분야에 쉽게 적용할 수 있도록 하드웨어 드라이버를 제작하고 이를 기반으로 하는 소프트웨어 개발 환경 및 응용프로그램 등을 구축하였다. 또한 이를 바탕으로 디지털 감시분야에 많이 사용되는 DVR 시스템을 구현하여 기존의 아날로그 방식의 CCTV 시스템을 대체하며 영상 입력 이외에도 다양한 센서입력을 이용하도록 제작하였다. 인터넷을 통한 영상전송 시스템에는 웹을 기반으로 하는 ActiveX 컨트롤을 사용함으로써 일반 사용자 들이 쉽게 영상을 확인할 수 있도록 하였다. In this paper, we designed personal computer based video acquisition board and implemented digital video record system. We made the board driver, software development environment and application software for the video acquisition board to adapt easily for various fields. And DVR(digital video recorder) system which substituted for conventional CCTV in security area, was implemented using not only video input data but also various type of sensors. Finally, video communication system makes users veew the video through the internet using ActiveX control based on the web browser.

특발성 확장성 심근증 환자의 임상적 소견의 관찰 : 남녀 성별에 따른 차이를 중심으로 Comparison of Sex difference

이광희,김철현,최태명,이성우,김성구,권영주,변재호 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

특발성 확장성 심근증에 대한 진단 및 연구는 이전에 주로 관혈적인 좌심실조영술이나 부검에 의해 이루어져 연구가 많이 않았으나 최근 심초음파도의 보편적인 이용으로 진단이 용이하여 이에 대한 임상적 연구가 증가되고 있다. 그러나 남녀 성별에 따른 임상적 소견의 차이에 대한보고는 많지 않았다. 대상 및 방법 : 특발성 확장성 심근증으로 진단받은 환자 68명(남자 37명, 여자 31명)을 대상으로 임상적 소견과 심전도 및 심초음파 검사소견등을 남녀간에 비교 분석하였다. 결 과 1. 유병기간은 여자가 남자보다 유의하게 길었고(p<0.05), 호흡곤란, 심계항진 및 심부전의 빈도는 여자에서 더 많은 경향을 보였으나 통계적으로 유의한 차이는 없었다. 2. 심초음파도상 좌심실 이완기말 내경계수, 심실중격 두께 계수, 좌심실 후벽 계수, 좌심방 내경 계수는 여자가 남자보다 유의하게 컸으나(p<0.01), 분획단축(fractional shorting)은 양군간에 유의한 차이가 없었다. 3. 심전도상 QRS 기간이 여자가 남자보다 긴 경향이 있었으나(p<0.08) 기타 소견은 양군간에 유의한 차이가 없었다. 결 론 : 특별성 확장성 심근증의 임상적 소견 및 검사 소견의 성별에 따른 분석에서 여자에서 질병의 정도가 더 심한 것으로 나타나는 소견이 있었으나 추후에 더 많은 연구및 원인 분석이 필요할 것으로 사료된다. Background : Idiopathic dilated cardiomyopathy(IDC) is a well recognized condition both clinically and morphologically. Despite the relatively frequency of this condition, few studies focusing on sex difference have been reported. Method : A total of 68 patients with IDC(37 men, 31 women)were studied retrospectively. Certain clinical and laboratory findings were analyzed and compared between men and women. Results 1. The women had a significantly(p<0.05) longer mean duration of chronic congestive heart failure than men. 2. Of the echocardiographic findings, index of left ventricular end-diastolic diameter, interventricular septal thickness, left ventricular posterior wall thicknes and left atrial dimension were significantly higher in women than in men. 3. Duration of QRS complex in ECG was longer in women(p<0.08) conclusion Some of clinical and laboratory findins are more advanced phase in women in IDC.

초등학생의 과외체육활동이 학교 체육수업 선호도에 미치는 영향

이종희,한광령,권형진 경희대학교 체육대학 한국체육과학연구소 2004 體育學論文集 Vol.32 No.-

The purpose of this study was to examine the present state of elementary school students in extracurricular physical programs and its effect on their preference in school P.E and to provide research materials which can be used to increase teaching efficiency. For this purpose, a questionnaire was completed by 410 fifth and sixth grades in 4 different school districts(Kang-nam, Kang-buk, Kang-dong and Kang-seo)in Seoul. The questionnaire was developed on the basis of the study and adjusted for the purpose of this study. The results of the questionnaire were analyzed by SPSS. The general characteristics of the subjects of the survey were presented through frequency analysis. The correlations between the subjects' preference in the sub-fields of P.E. and the participation in the extracurricular physical program and gender were analyzed by x² verification. In addition, the t-test was executed to see the differences of preference in the sub-fields of P.E. The results were as follows. 1) The students who were not involved in extracurricular physical activity (Non-EC Group) outnumbered the student who participated in it(EC Group), In addition more boys than girls were in the extracurricular physical programs. 2) In the EC Group, boys did Taekwondo most. And it was followed by swimming soccer, basketball and Kendo. Girls also chose Taekwondo most. It preceded swimming dance, sports dance and Kindo. Unlike boys, girls rather positively participated in expressive activities like dance and sports dance. 3) With respect to the correlations between subjects' attitudes towards P.E and the participation in the extracurricular physical programs and sex, EC Group and boys showed more preference, interest and positiveness than Non-EC Group and girls(p<.001). 4) With respect to the correlations between subjects' preferences in the sub-fields of P.E. and the participation in the extracurricular physical programs and gender, first, EC Group showed more preference for gymnastics than Non EC Group(p<.05). In addition, in the sub-fields of gymnastics, boys and girls liked mat activities (37.8%) and vaulting horse activities(22.7%) most respectively(p<.01). Secondly, in the tract, there was no significant differences in the preferences between groups. Both boys and girls chose "relay" as their favorite activity. Thirdly, in the sub-field of game, soccer-related game was followed by skating and skiing. Whereas the soccer-related game was favored by both EC Group and Non-EC Group, the participation variable was significant in skiing and Taekwondo. The former was favored by EC Group. Moreover, gender affected the preference in the events of game activity. While 57.5% of the boys favored for the soccer-related game, 27.3% of the girls said "skating" was their favorite event. Preference in physical strength events differed according to participation variable as well as gender variable. Fourthly, the sub-field of expressive activity was least favoured by every group. Fifthly, in the sub-field of physical strength, "Exciting physical activity" was most popular. It showed that the participation in the extracurricular physical program and gender were analyzed as following. 5) The correlations between the elementary school student' preferences in the sub-fields of P.E and the ① Compared to The Non-EC Group, the EC Group showed significant preference in the sub-field of gymnastics, game, tract, physical strength activity. Therefore, it is proved that extracurricular physical programs can increase students' interest in these four sub-fields. ② Based on the gender variable, it was found that both boys and girls were most interested in the game activity. In case of boys, it was followed by track activity, physical strength activity, and gymnastics. In case of girls, it was followed by track activity, physical strength activity. In conclusion elementary school students' participation in extracurricular physical program affected their attitudes towards P.E. Therefore, it is essential to proceed the further research on continuity between elementary school P.E. and community sports as well as need analysis on elementary school students' P.E.

마이크로센서 응용을 위한 실리콘 미세가공 기술

고희선,김영민,권대혁,도양희,이광만 제주대학교 산업기술연구소 1999 尖端技術硏究所論文集 Vol.10 No.2

Silicon micromachining technology can be used to build microsensors and actuators by using tools derived from standard IC processing. For the silicon micromachining the etching characteristics of tetramethyl ammonium hydroxide (TMAH) by dissolving silicon powder or silicic acid have been studied. The 3, 5 and 10wt.% TMAH solutions, with dissolved silicon powder (6g/l) or with dissolved silicic acid(Si(OH)4, 16g/l) were used. And ammonium peroxydisulfate (APODS, 2g/l) dissolved in the solutions were also used. The etch rates of silicon and the etched surface roughness were observed with various etching conditions. The crystallographical aspect on the crystal orientation of silicon have been studied. With sufficiently fresh solutions, these TMAH concentration and combination of etchants, provide repeatable etch properties, does not attack exposed aluminum or silicon dioxode, and provide smooth (100) silicon surfaces.

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5