정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Tetrahydroisoquinoline Alkaloids가 쥐의 동맥과 뇌균등질의 α-Adrenoceptors에 미치는 영향

이현석,백선하,황수현,박인성,김은상,정진명,한종우,장기철,장기철 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.1

국내기업의 팀제 도입에 따른 효율적 운영방안에 관한 연구

한기수,윤광심 대불대학교 1999 論文集 Vol.5 No.1

In this study, team organizational effectiveness and effectiveness and efficiency of team was analyzed and how to grade it in company K was suggested. First, definition, purpose, precondition and management method of teams organization was explained, and then theatrical consideration was made on putting the team organization management into practices. Second, problems was explained based on that analysis. Third, methods were suggested how to cope with the situation. Major finding and some suggestion of the study in the field of management of team in company K as follws : Teams develop direction, momentum, and commitment by working to shape a meaningful purpose. Management is responsible for clarifying the charter, retionale, and leave enough flexibility for the term to develop commitment around its own spin on that purpose, set of specific goals, timing, and approach. Effective teams develop strong commitment to a common approach, that is to how they will work together to accomplish their purpose. team members must agree on how will do particular jobs, how schedules will be set and adhered to, what skills need to be developed, how continuing membership in the team is to be earned, and how the group will make and modify decisions.

근로자의 경영 참가제도에 관한 연구

한기수 대불대학교 1998 論文集 Vol.4 No.1

The purpose of this study is to analysis problems of management participation and to draw out system appropriate for Korean business by investigating actual conditions and recent trends of the existing management participation system in Korean business, carrying out empirical study and literature study. First, It is absolutely needed that the management should consider labor unions as "Harmony" rather than as "power" Second, government should develop systems suitable for our environments and assist enterprisers in enforcing suitable management participation respectively. The third, Positive, continuous enlightening education is needed to make labor unions and the management perceive the good effect of the management participation system. The forth, The current labor-management cooperation system of the labor laws should be revised to adjust to the changing environment.

組織의 效率的 管理를 위한 狀況理論에 대한 硏究

한기수 대불대학교 2002 論文集 Vol.8 No.1

Contingency theory focuses on how an organization has relations with a given environment and how the relations impact on the organization. Today's organization theory has changed differently from the past from a micro viewpoint analysing an organization only by the structure and process of the inside to a macro one focussing on peculiarity and diversity in market and technical system included in outer environment. On this study, as such mainstreams of modern organization research, both of the System Viewpoint and the Contingency Viewpoint would be the object to apply respectively to individual, group, organization and synthetic model of such viewpoints would be suggested.

기업가와 기업가정신에 관한연구

한기수 대불대학교 2001 論文集 Vol.7 No.1

Activity and role of enterprisers in the society of capitalism is very important, and it is hoped that enterprisers should play a role and take a responsibility on community members and state societies. It means that they should have responsibility on business operation because they were developed by members in the state society thought the commencement of business were established by individuals. thus entrepreneurial spirit of presidents who started enterprises and objective of establishment are important. The enterprisers are supposed to be able to explain the objective of establishment and their management philosophy clearly to anyone since it is their responsibility and role.

근로시간 단축에 관한 연구

한기수 대불대학교 1999 論文集 Vol.5 No.1

The reduction of working hour would have direct effects on the korean industries, According to the study results, working hour per week is 48 hours which include 44 legal working hours and extended working hours. As a result, korean working hours is even higher than advanced countries. If the working hour is reduced to the hour of the advanced countries. real cost of labor increases would be lager than capital intensive industries. The results show that large damage would come from trading with Japan and the US. According to results. The reduction of working hour would affect increasing cost of labor and be a burden on the korean industries. Therefore, a more aggressive labor policies from government are needed in order to lower the burden.

목표관리에 의한 기업의 업적평가에 관한 연구

한기수 대불대학교 2000 論文集 Vol.6 No.1

The purpose of this thesis in diagnosing the problem of Company's performance appraisal system through comparing with other rival company. To the result of this research, problem of company performance appraisal system ahs been identified as follow; 1. Each departmental specific objectives were not consistent with overall organization mission and objectives. 2. Relative importance among evaluation criteria could not be able to differentiate one from another because of too aomong evaluation indexes. 3. Irrationality of giving an extra wiight value on each evaluation index without considering the contribution lever of each criterion on performance. 4. Difficulty of measuring efficiency and effectiveness of management function dut to too simple and absolute appraisal method. 5. inadequate current reward system that has lack of employee's expectancy and valence, and insufficient performance review and feedback to employee letting him know the levels the levels of achievement.

更年期, 老年期精神病의 原因 및 診斷

韓璂洙 대한의학협회 1962 대한의학협회지 Vol.5 No.5

교육훈련 제도에 관한 연구

한기수 대불대학교 2002 大佛大學校大學院 硏究論文集 Vol.- No.1