2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

직무몰입, 조직시민행동에 대한 성과지향적 보상체계의 효과 : 영업직을 중심으로 the Study of Stock Brokers

고수일,한주희 한국생산성학회 2001 生産性論集 Vol.15 No.3

본 연구는 성과-보상의 연계성으로 유발된 직무동기가 직무몰입 및 조직시민행동에 미치는 영향에 대하여 증권회사의 영업직을 대상으로 실증 분석하였다. 성과-보상의 연계성은 성과-승진의 연계성, 성과-급여의 연계성 그리고 성과-평가의 연계성의 하위개념으로 구분하여 고찰하였다. 연구 결과를 요약하면 다음과 같다. 첫째, 연구변수들에 대한 상관관계 분석결과, 성과-급여의 연계성과 성과-평가의 연계성은 정의 상관성을 나타내고 있다. 또한 성과-급여의 연계성은 직무동기, 직무몰입, 의사소통 및 이타성 변수 등과 모두 정의 상관성을 보이고 있었다. 한편 성과-평가의 연계성은 직무동기 및 의사소통과 정의 상관성을 나타내고 있음을 확인할 수 있다. 직무동기는 직무몰입, 의사소통 및 이타성과 모두 정의 상관성을 나타내고 있다. 둘째, 자신의 업무영역이 분명하고 업무 성과에 대한 측정이 가능한 영업직 구성원의 경우에는 성과-급여 및 성과-평가의 연계성을 높이는 제도를 도입하는 경우 직무동기가 높아진다는 것이다. 영업직 구성원은 성과-승진의 연계성을 통하여 동기부여되지 않으며, 또한 승진과 급여를 별개로 인식하고 있음을 알 수 있다. 셋째, 성과지향적 보상체계를 설계하는 인사관리자들은 성과-평가의 연계성을 제고할 수 있는 방안을 찾아야 할 것이다. 본 연구 결과는 성과와 급여의 연계에 집중되어 왔던 기존의 관점에서 성과와 평가의 연계성에 대한 관점으로 확대 또는 전환되어야 할 필요성을 시사하고 있다. This research investigated the relationship of reward for performance, work motivation, job involvement, and organizational citizenship behaviors. With 251 employees in stock brokerage, it was found that (1) pay for performance and evaluation for performance were related positively to employees' work motivation while promotion for performance was not, (2) work motivation showed positive relationship with job involvement and organizational citizenship behaviors such as communication and altruism. thus, (3) reward for performance encouraged in-role and extra-role behaviors at the same time. Some implications of these results were discussed.

Maillard 反應에 關한 硏究 : Ⅴ. 反應溫度 및 時間이 skim milk의 Maillard reaction에 미치는 영향 Ⅴ. Effects of reaction temperature and time on the Maillard reaction by heating skim milk

李乙熙,朴玉潤,徐珠銖,高鏡畢 진주산업대학교 농업기술연구소 1993 農業技術硏究所報 Vol.6 No.-

The color intersities of melanoidins and the contents of HMF in skim milk by heat treatment. The contents of HMF in skim milk were detected in all heat-treated skim milk by colormetrical method and HPLC method. The color intensities of melanoidins showed significant dependence on reaction temperature and time. The contents of HMF in skim milk were detected in all heat treated skim milk by colormetrical method. While they were not detected by HPLC method when skim milk was heated at the temperature 70℃ for 30, 50 and 70 minutes. It showed significant dependence of reaction temperature and time.

패션산업의 신속대응(Quick Response)시스템 도입현황 및 도입사례에 관한 연구

강희정,고은주 창원대학교 생활과학연구소 1997 생활과학연구 Vol.- No.1

Environmental changes (e.g., threat of imports, rivalry among existing competitiors) have increased the difficulties in operating an apparel business. To manage the environmental changes, Quick Response System (QRS) has been proposed. QRS is defined as a business strategy to speed up the information and product between business partners for maximizing consumer satisfaction by information technologies(e.g., EDI, Bar code) and partnership (Ko, 96, VICS, 1989). The purpose of this study are to review the current development of QRS(i.e., background, concepts, benefits, adoption problems), to analyze two cases (in Japan and Korean), and to suggest the future directions for the new adopters of QRS. The information from this study can be used when apparel companies do strategic planning and evaluate the adoption of QRS. Informed decision are critical when companies do make a decision for the best choice.

Ba_2Ti_9O_20 유전체 재료의 저온소결 첨가제에 의한 소결 거동 및 고주파 특성

최명호,이주희,박명진,고영철,김남철 국립7개대학공동논문집간행위원회 2001 공업기술연구 Vol.1 No.-

Sintering characteristics and microwave dielectric properties of the Ba_2Ti_9O_20 ceramics added with lithium-boro-silicate glass frit were investigated. Sintering experiments showed that the densification occurred at lower firing temperatures down to 900℃ as the addition of glass frit was increased up to 10wt%. The bulk density and shrinkage of ceramics were strongly dependent on the amount of the glass frit. The microstructures of the ceramics were found to become skeletal-like structures as increase of glass frit. The monoclinic crystal structure of the Ba_2Ti_9O_20, however, was found not to be affected by the addition of glass frit up to 10wt%. Microwave dielectric constants of the glass frit added ceramics were relatively consistent of 35 with over 15% shrunk and densified ceramics. However, the quality factor (Qf) and the temperature constant (TCP) was found to be significantly affected by the additions of glass frit.

Outcomes of empirical treatment with intravenous immunoglobulin G (IVIG) combined with low dose aspirin in women with unexplained recurrent pregnancy loss

( Ju Hee Kim ),( Sung Hoon Kim ),( Nu Ri Yang ),( Yu Ri Ko ),( Sa Ra Lee ),( Hee Dong Chae ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: To evaluate whether administration of intravenous immunoglobulin G (IVIG) combined with low dose aspirin in women with unexplained recurrent pregnancy loss has clinical efficacy. Methods: We retrospectively analyzed the medical records of 113 patients diagnosed with unexplained recurrent pregnancy loss and treated with IVIG and low-dose aspirin between January 1998 and March 2020. We evaluated the characteristics and live birth rate of patients, and compared the pregnancy outcomes in natural pregnancies and pregnancies assisted reproductive technologies (ART). In addition, patients who checked percentage of natural killer (NK) cells were analyzed. Results: In the study population, the rate of total live birth was 79% (89/113), and there was no significant difference in the rate of live birth between natural pregnancy (81%) and ART (74%, P = .46). Most of the patients delivered at term (90%, n = 80); nine patients delivered preterm, seven of whom were ART cases. None of the newborns had an identifiable congenital anomaly. A total of 25 patients were checked percentage of NK cells, with an average of 13.76 ± 6.9 % (range, 1.0 - 28.4%). The relationship between the increase in percentage of NK cells and the miscarriage was not significant (Odds ratio, 0.81; 95% confidence interval, 0.61-1.06; P = .13). Conclusion: IVIG combined with low-dose aspirin showed good outcomes in both natural pregnancies and those assisted by ART, and was safe for treating unexplained recurrent pregnancy loss. Moreover, the treatment was effective regardless of the percentage of NK cells.

Purification and Characterization of An Exo-type β-N-acetylglucosaminidase from Pseudomonas fluorescens JK-0412

Ju Hee Ko,Jae Kweon Park,Woo Jung Kim,Hang Soo Jo,Yong Il Park 한국당과학회 2010 한국당과학회 학술대회 Vol.2010 No.1

A chitinolytic enzyme from the culture filtrates of Pseudomonas fluorescens was purified to apparent homogeneity and its kinetic properties were characterized. The molecular weight of the purified enzyme (NagA) was estimated by SDS–PAGE to be approximately 50 kDa. The optimum pH, temperature, and pH stability of NagA on synthetic substrate pNP-GlcNAc were determined to be pH 6.5, 37oC and pH 6–9, respectively. Its kinetic parameters on pNP-GlcNAc and pNP-(GlcNAc)2 were Km = 0.13 mM and 0.82 mM, and Vmax = 245 and 40 pmol/㎍/min, respectively. Chitinolytic activity of the purified NagA toward natural substrates (GlcNAc)n, n=2-5 was also determined by high performance anion-exchange chromatography with pulsed electrochemical detection (HPAEC-PED). The results suggest that NagA is an exo-type β-N-acetylglucosaminidase yielding GlcNAc as the final product from the chitooligosaccharides. Taken together, this is the first report of an exo-type chitinolytic enzyme based on the comparison of its peptide sequence from other chitinolytic enzyme produced by other microorganisms.

운동강도가 ICV STZ 투여로 유발된 기억력 손상희쥐에서 해마 신경세포생성과 BDNF 발현에 미치는 영향

이희혁 ( Hee Hyuk Lee ),윤진환 ( Jin Hwan Yoon ),정일규 ( Il Gyu Jeong ),김승희 ( Seung Hee Kim ),김보균 ( Bo Kyun Kim ),신말순 ( Mal Soon Shin ),고일규 ( Il Gyu Ko ),성윤희 ( Yun Hee Sung ),김창주 ( Chang Ju Kim ) 한국운동생리학회 2009 운동과학 Vol.18 No.4

Semi-quantitative Measurement of a Specific Glycoform Using a DNA-tagged Antibody and Lectin Affinity Chromatography for Glyco-biomarker Development

Lee, Ju Hee,Cho, Chang Hee,Kim, Sun Hee,Kang, Jeong Gu,Yoo, Jong Shin,Chang, Chulhun Ludgerus,Ko, Jeong-Heon,Kim, Yong-Sam American Society for Biochemistry and Molecular Bi 2015 Molecular and Cellular Proteomics Vol.14 No.3

<P>Aberrant glycosylation-targeted disease biomarker development is based on cumulative evidence that certain glycoforms are mass-produced in a disease-specific manner. However, the development process has been hampered by the absence of an efficient validation method based on a sensitive and multiplexed platform. In particular, ELISA-based analytical tools are not adequate for this purpose, mainly because of the presence of a pair of N-glycans of IgG-type antibodies. To overcome the associated hurdles in this study, antibodies were tagged with oligonucleotides with T7 promoter and then allowed to form a complex with corresponding antigens. An antibody-bound specific glycoform was isolated by lectin chromatography and quantitatively measured on a DNA microarray chip following production of fluorescent RNA by T7-trascription. This tool ensured measurement of targeted glycoforms of multiple biomarkers with high sensitivity and multiplexity. This analytical method was applied to an <I>in vitro</I> diagnostic multivariate index assay where a panel of hepatocellular carcinoma (HCC) biomarkers comprising alpha-fetoprotein, hemopexin, and alpha-2-macroglobulin (A2M) was examined in terms of the serum level and their fuco-fractions. The results indicated that the tests using the multiplexed fuco-biomarkers provided improved discriminatory power between non- hepatocellular carcinoma and hepatocellular carcinoma subjects compared with the alpha-fetoprotein level or fuco-alpha-fetoprotein test alone. The developed method is expected to facilitate the validation of disease-specific glycan biomarker candidates.</P>

The lived experience of ethical dilemma of ICU nurses

Sung-Hee Ko(고성희),Seon-Hee Yoo(유선희),Young-Ju Yun(윤영주),Sung-Hee Lee(이성희) 질적연구학회 2006 질적연구학회 학술대회 자료집 Vol.2006 No.-