補中益氣湯 투여가 장거리 달리기 선수의 에너지 및 전해질 대사에 미치는 영향 : changes in the energy and electrolyte metabolism among long distance runners

송순기,금동호,오재근,이명종 동국대학교 한의학연구소 1998 東國韓醫學硏究所論文集 Vol.7 No.1

스포츠 과학 분야에서는 운동 선수들의 경기력 향상과 운동 피로의 신속한 회복을 도모하기 위하여 한약을 복용하고 그 효과와 유의성에 대하여 연구가 활발히 이루어지고 있다. 격심한 운동을 수행할 때 나타나는 Glucose 등 에너지원의 고갈, Lactate 등 대사 산물의 축적, 전해질의 불균형 등의 여러 제반 증상이 氣虛로 인하여 나타나는 전신의 증후와 유사하다고 생각하여 補中益氣湯을 투여한 후 인체의 대사 변화를 관찰함으로서 운동수행능력에 미치는 영향과 유의성을 평가하고자 하였다. 본 연구는 장거리 달리기 선수를 대상으로 2주간의 補中益氣湯의 투여가 에너지 대사 및 전해질대사에 미치는 영향을 규명하기 위하여 최대심박수의 70% 강도의 운동을 실시한 후 운동전 안정시, 운동 직후, 휴식 후 10분, 휴식 후 30분, 휴식 후 1시간으로 나누어 혈액검사를 하였을 때 나타나는 각종 변인의 반응 양상을 비교 분석하여 유의한 결과를 얻었다. 혈중 에너지 대사에서는 free fatty acid와 Lactate 반응에서 유의성 있는 차이가 나타났고, 전해질대사에서도 Na^(+), Cl-와 K^(+) 반응에서 모누 유의성 있는 차이를 나타냈다. 그러므로 補中益氣湯은 에너지 및 전해질 대사에서 유의성있는 변화를 나타내었으며 운동수행능력의 향상에 유효하였다. Objective This experimental study was designed to investigate effects of Bo-joong-ik-gi-tang administration among long distance runners on changes of the energy and electrolyte metabolism. Materials and Methods All subjects were divided randomly with two groups, Bo-joong-ik-gi-tang Group (N=4) and control group (N=4) and performed to run the 400m track with 70% of HR max about 1 hour. The blood samples were collected from antecubital vein by 5㎖ syringes at before exercise, immediateIy after exercise, recovering- 10 min, recovering-30 min, recovering-1 hour. These sampie were used to analyze for the factors of the changes on metabolic responses. Firest, the primary factors on the changes of the energy metabolism were checked ; Glucose, Free fatty acid, Lactate, LDH. Second, the primary factors on the changes of the electroIyte metabolisrn were checked ; Na^(+), Cl^(-), K^(+). Results 1. The change of the energy metabolism 1) Glucose response was not shown significant difference between two groups. 2) Free fatty acid response in Bo-joong-ik-gi-tang group was significantly increased at recover-10 min. 3) Lactate response in Bo-joong-ik-gi-tang group was significantly decreased at immediately after exercise, recover-10 min, recover-30 min. 4) LDH response was not shown significant difference between two groups. 2. The change of the electrolyte metabolism 1) Na^(+) response in Bo-joong-ik-gi-tang group was shown significant difference between two groups at before exercise. 2) C^(-) response in Bo-joong-ik-gi-tang group was significantly increased at before exercise, immediately after exercise. 3) K^(+) response in Bo-joong-ik-gi-tang group was significantly increased at recover-10 min. Conclusion According to the above results, it was shown that Bo-joong-ik-gi-tang had the positive effects on changes of the energy and electrolyte metabolism for the long distance runners.

에탄올이 백서의 해마에서 Neuropeptide Y 발현에 미치는 영향

정홍경,이기철,이정호,이희제,정주호,이주영 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.1

에탄올을 장기간 섭취한 백서에서 Acamprosate 투여가 Nitric Oxide Synthase 발현에 미치는 영향

정홍경,이기철,이정호,이승휘,이희제,정주호 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.1

한국해안으로부터 Purple, Non-Sulfur Photosynthetic Bacterium, Rhodobacter sp. EGH-24의 분리 및 특성

차미선,김기한,조순자,이나은,이정은,이재동,이상준,박재림 한국환경과학회 2003 한국환경과학회지 Vol.12 No.12

A species of facultative photo-organotrophic, purple, non-sulfur bacterium was isolated from the 47 point at west and south coast of Korea in September 2001. Separated 13 samples of changes with red color under 28~32 ℃, 3000 lux, anaerobe conditions for 7 days cultivated in basal medium. For pure isolation from 13 samples, we used agar-shake tube method (0.4 % agar) and separated 5 strains through 13-repetition test. EGH-24 and EGH-30 was identified as the same strain through the RAPD(Random Amplified Polymorphic DNA)-PCR of strain EGH-9, EGH-13, EGH-23, EGH-24, EGH-30. Four isolates cultivated in synthesis wastewater for wastewater biodegradation test. EGH-24 was selected with efficient wastwater treating strain. Based on the results obtained from morphology, nutrient requirements, major bacteriochlorophyll content, 16S-rDNA phylogenetic analysis, EGH-24 strain may be identified as a new strain of the genus Rhodobacter and named Rhodobacter sp. EGH-24.

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

Clozapine이 백서의 Schedule-Induced Polydipsia에 미치는 영향

이기철,정홍경,이정호,홍승범,최영민,전성일,정재현,하준명 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.2

Object : This study was designed to evaluate the effects of clozapine which is one of most useful atypical antipsychotics in the schedule-induced polydipsic rat which is an animal model of obsessive-compulsive disorder. Methods : Spraque-Dawley rats were placed in automatic cage where a pellet dispenser automatically dispensed 90mg pellets on a fixed-time 60 seconds(FT- 60s) feeding schedule over 150-minute test session for 4 weeks. After 4 weeks of daily exposure to the FT-60s feeding schedule, experimental rats met a predetermined criterion for polydipsic behavior(greater than 3 times of water per session on average). Rats were stratified into clozapine(0.34mg/kg,i.p.), clozapine(14.63mg/kg,i.p.), clomlpramine(5mg/kg,i .p.), and vehicle (1cc/kg,i.p.) group and treated with each drugs for 3 weeks. To identify the non-polydipsic food-deprived rats, a separate group of rats(N=8) were individually housed and given a single bolus(14.5gm) of food per day which maintained them at their average body weight. Results : The results were as follows ; 1)After 4 weeks of scheduled feeding procedure, the experimental group showed significant differences than bolus control in the amount of water consumption as compared with their baseline of water intakes for 4 weeks. At the same periods, there were no differences between the experimental group and bolus control in the borty weight. 2)The clomipramine group, the clozapine 0.34mg group and the clozapine 14.63mg group showed significant decrease in the amount of water intake for at 2nd & 3rd week of drug treatment as compared with their baseline of polydipsic water intakes. But, the vehicle control group showed no changes of amounts of water intake for 3 weeks of treatment as compared with their baseline of polydipsic water intakes. Conclusion : Above findings suggest that the fixed time feeding Procedure for Schedule induced polydipsia as an animal model of obsessive compulsive disorder was effective to the evaluation of pharmacological challenge study. In clinical situation, the authors suggest that atypical antipsychotic drugs which act as serotonin and dopamine receptor antagonist may be helpful to improve the symptoms of the patients with treatment refractory obsessive-compulsive disorder.

돌나물(Sedum sarmentosum Bunge)의 자생지 서식환경과 생장특성에 관한 연구

이중기,황재문 안동대학교 농업과학기술연구소 2000 農業科學技術 硏究論文集 Vol.7 No.-

돌나물(Sedum sarmentosum)은 산 또는 들에 널리 분포하며, 특히 경사지나 바위 위에서도 이끼류와 공생하고 있었다. 자생지 토양은 수분함량의 범위가 넓었고 유기들이나 치환성 양이온 등의 함량은 재배작물의 평균치와 비슷한 수준이었다 돌나물은 월동 후 2월말부터 싹을 틔우며, 3월초부터 성장하여 5월 중순에 채취할 정도(약 30cm)로 자란다. 5월 중순에 줄기의 5∼6마디에서 1∼4차례 꽃가지가 갈라져 노란색 꽃을 피우며, 11월말부터 생장이 정지되어 잎이 말라 떨어지고 줄기와 뿌리가 일부 남아 월동한다. 돌나물은 25℃에서 생육 상태가 가장 양호하였고 생장량도 많았다. 그리고 자연광의 50%차광처리에서 생체중이 가장 높았고 자연광에서보다 개화도 10여일 지연되었다. 토양수분의 함량이 22%±1.0정도(1일 관수량 1.5mm 수준)에서 생체량이 가장 많았으나 자생지 들나물에 비해 절간장이 길었으며, 12%±1.0(1일 관수량 1.0mm 수준)에서 상품가치가 양호하였다. This study was conducted to survey the habitat environment at natives of Sedum sarmentosum and to elucidate growing conditions of S. sarmentosum. In native areas of S. sarmentosum, Digitaria microbachne, Artermisia mongolica and mosses were dominant species and S. sarmentosum grown on the slope and rock fences symbiosed with mosses. S. sarmentosum might lave wide adaptability on the dry or wet soil and sunny or shaded place. The organic content of the habitat soil was almost same level of the average upland soil, but the available phosporous and calcium content were low level. The growth stage was different by topography of S. sarmentosum. This plant was sprouted from late Febuary, grown continuously until mid of May, then formed flowering branches, flowered from late May and stopped growth in early November. The optimum growth temperature of S. sarmentosum seemed to be about 25℃, however, it showed slow growth even at 1.5℃. The shading 30 to 50 % of natural sun light was good for growth but delayed the flowering time compared to the natural condition, and the wet soil(irrigatiing 1.5mm a day) resulted more vigorous growth than dry conditions(irrigating below 1.0mm a day) in S. sarmentosum.

1994학년도 신입생 성격검사 결과분석

이근재,한기백 釜山敎育大學校 學生生活硏究所 1994 學生指導硏究 Vol.14 No.-

안동호 상류 운곡천의 이화학적 수질특성과 식물플랑크톤 군집 특성

이중복,이희무,이건주,박정원,박재충,김동걸,권기석 7개 국립대학교 환경연구 논문집 공동발행 위원회 2002 환경연구논문집 Vol.2 No.1

This investigation is about the characteristics of phytoplankton community and physciochemical water quality of specific 6-point the Woon-kog stream system in upsteam of the Andong Lake. DO value was showed over 8.1㎎/L at each site and COD_Mn, BOD, T-N, T-P tend to increase as they stream down and that the existence and dominance of phytoplankton was low and it was difficult to conclude the definite correlation of water quality and phytoplankton community. Finally, it seemed to be desirable that alternatives for pollutional reduction should be made and performed on the basis of the continuous monitoring of the inflow to preserve the Andong Lake.

카드뮴의 血液內 ALAD 活性沮害作用에 對한 마늘의 抑制效果에 關한 試驗管內實驗

李東基,閔在基,車喆煥 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.1

It has been already reported through animal(albino rat) experiments that Korean garlic containing abundant amount of thiol compounds such as -SH and -S-S- radicals, has the effects of reducing heavy metals and consequently improving the histopathological changes 'in some organs in case of heavy metal poisoning with cadmium and mercury. However, the mechanism of such effects produced in human body by the garlic has yet to be revealed. The hypothesis of this study is that garlic may bind with cadmium and render cadmium inactive before producing toxic effects in tissues. Therefore. to examine the binding action of garlic with the heavy metal, cadmium, garlic extracts and garlic ingredient, allyldisulfide, were first mixed prior to reacting the mixture with various concentrations of cadmium in human blood specimens, in vitro, and activities of ALAD in blood were observed. The same procedure was done with penicillamine, a chelating agent used to treat heavy metal poisoning clinically, to compare with the effect of garlic. The results are as follows: 1. While the ALAD activities of 0.01, 0.05, 0.1 mMoles of cadmium in blood were 17~33% of the normal one, those of cadmium reacted with garlic extract were 33~68% of the normal one. Consequently, the latter showed 15~35% increase of activity. The data shows the possibility that some part of cadmium was inactivated by garlic, by the fact that the ALAD activity of 0.01 mMole cadmium and that of 0.1 mMole cadmium with garlic extract were nearly the same. 2. In case of allyldisulfide, the suppressive effect in the inhibitory action of cadmium on the ALAD activity in blood was also observed; the potency of effect was lower than that of garlic extract. 3. Compared with penicillamine, the effect of garlic was 1.2 times that of penicillamine, and that of allyldisulfide was similar to that of penicillamine.