편측관상봉합 조기유합증 환자에서 컴퓨터단층촬영을 이용한 두개 기저부의 술후 변화 예측

김영석,김진형,김용욱,유선국,이혜연,김기덕,박병윤 大韓成形外科學會 2004 Archives of Plastic Surgery Vol.31 No.2

사립체 DNA 뉴클레오타이드 3243 A→G 돌연변이 [MTTL1^*MELAS3243G]에 의한 MELAS 증후군

박기형,김승현,이영주,김희태,김주한,김명호,박성섭 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

高成果 企業의 生産體制 特性

김형기 慶北大學校 經濟經營硏究所 2002 經商論集 Vol.30 No.1

정신분열병 환자에서 자기공명영상 구획화를 이용한 전두엽 하위구조와 구조적 이상 관찰

김재진,권준수,강도형,윤탁,한문희,장기현 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 정신분열병 환자를 대상으로 한 구조적 뇌영상 연구들은 국소적 전두피질(prefrontal cortex)의 이상에 대하여 상당히 다양한 결과들을 보고하였다. 본 연구는 정확한 해부학적 구획화를 바탕으로 한 관심영역 체계를 통해 정신분열병에서 전두피질의 구조적 이상 유무를 탐색하고자 시행되었다. 방 법 : 12명의 정신분열병 환자와 12명의 나이 및 성별 분포가 동일한 정상인들을 대상으로 뇌 자기공명 영상을 획득한 후, 지형학적 표지물을 이용하여 8개의 전두엽 하위구조 구획 작업을 실시하였다. 구획된 전두엽 하위구조들의 용적을 측정하여 두 군간에 차이가 있는가 관찰하였고, 하위구조 용적과 정신분열 증상의 심각도 간의 상관관계를 살펴보았다. 결 과 : 상당 수의 전두엽 하위구조들의 용적이 정상인에 비해 정신분열병 환자들에서 작은 경향을 보였고, 특히 우측 부운동영역(supplementary motor area)이 통계적으로 유의하게 작은 용적을 보였다(p<0.003). 또 이러한 전두엽 하위구조들의 용적 감소는 정신분열병 음성 증상의 심각도와 밀접한 상관성을 보였고, 이러한 현상은 우측 상전두이랑(superior frontal gyrus)에서 가장 대표적이었다(γ=-0.704, p=0.01). 결 론 : 이러한 결과는 정신분열병에서 전두엽기능저하의 바탕이 되는 구조적 결함의 존재 가능성을 시사한다. 이러한 전두피질의 구조적 결함은 정신분열병에서의 인지기능결핍과 신경회로의 장애 소견과 연결될 수 있다. Objectives : Although most of the functional and structural neuroimaging studies have reported the association of the that cognitive deficits in patients with schizophrenia with the pathophysiology of the prefrontal cortex, their findings vary considerably. Based on the precise parcellation methods, this study was designed to investigate substructural abnormalities of the prefrontal cortex in patients with schizophrenia. Methods : The subjects consisted of twelve patients with schizophrenia and 12 age- and sex-matched normal volunteers. Magnetic resonance images were obtained in all subjects, and parceled into 8 frontal substructures using the topographic landmarks. The frontal substructural volumes were compared between the two groups, and their correlations with the schizophrenic symptom severity were analysed in the patient group. Results : In the comparison of substructural volumes, most frontal substructures of the patient group tended to be smaller than those of the normal comparison group ; particularly the right supplementary motor area was significantly smaller(p<0.003). Negative symptoms tended to be inversely correlated with the frontal substructural volumes, particularly with the right superior frontal gyral volume(γ=-0.70, p=0.01). Conclusion : These findings suggest the possibility of structural defects related to 'hypofrontality' in schizophrenia. These frontal structural defects may be the basis of neurocognitive deficits and neural circuital dysfunction in schizophrenia.

알코올성 췌장염 환자에서 CYP2E1 유전자형의 다형성

김일환,염윤기,채석,권준택,김형기,박상흠 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Cytochrome P4502E1(CYP2E1) is inducible by ethyl alcohol and activates procarcinogenic N-nitrosodimethylamine(NDMA), benzene, urethane and other lower molecular weight compound. CYP2E1 is also involved in metabolism of certain drugs, for example, alcohol, acetaminophen, tamoxifen, theophylline, flouorinated anesthetics, and chlorozoxazone. CYP2E1 activity was shown to be polymorphically distributed in humans and has been suggested to play a role in hepatocellular carcinoma and alcoholic related disorders. Although genetic predispodition to alcoholism and alcoholic liver disease has been reported, genetic susceptibility to alcoholic pancreatitis is still a matter of debate. The aims of this study were to investigate the allelic frequency of CYP2E1 Rsa I polymorphism in Koreans with alcoholic pancreatitis patients. We investigated the frequency distribution of CYP2E1 Rsa I polymorphism in 212 unrelated healthy Koreans and 64 alcoholic pancreatitis patients. Detection of the CYP2E1 alleles was performed by polymerase chain reaction and restriction fragment length analysis. The genomic DNA was isolated from peripheral blood with conventional phenol: chloroforn extraction method. The allelic frequencies of c1 and c2 in healty volunteers were 0.85 and 0.15, respectively. The allelic frequencies of c1 and c2 in alcoholic pancreatitis patients were 0.8 and 0.2, respectively. The rare type (c2/c2) of CYP2E1 Rsa I polymorphism was 0.005 and 0.031 (p<0.001) in healthy volunteers and alcoholic pancreatitis patients, respectively. However, the CYP2E1 genotype showed no significant relation to the alcoholic pancreatitis patients. It was suggested that the risk of alcoholic pancreatitis diagnosed clinically seem to be not associated with the CYP2E1 genotype.

肝吸蟲症 治療前後에 있어서 血淸 및 尿의 抗體價變動에 관한 比較硏究

金亨東,嚴基善,林漢鍾 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.3

The changes of IgG levels of sera and urine were observed with the enzyme-linked immunosorbent assay (ELISA) at before and after medication in human clonorchiasis. Sera and urine from 68 cases of confirmed clonorchiasis were tested at before and at 9 and 18 month after treatment with Distocide® (praziquantel). Group I (n=22) was cured after first medication and then followed up for 18 months. And Group Ⅲ (n=24) of patients with eggs in their feces after first medication showed egg reduction rate of 90%. Thirteen normal controls were parasite free healthy persons for clonorchiasis in non-endemic area. The antigen used was saline extract of crude Clonorchis sinensis adult worm with the protein concentration of 14.3㎍/㎖ and the results obtained were as follows: 1. When a serum dilution of 1:400 was used, the absorbance values (488 nm) were 1.122, 1.373 and 1.632 in groups Ⅰ,Ⅱ,Ⅲ respectively before medication. Antibody level decreased significantly at 9 months after medication showed 0.572, 0.749 and 1.155 in the respective group. Then the levels decreased slightly to 0.464, 0.516 and 1.107 at 18 months after medication. But the control group showed relatively constant absorbance values of 0.291 at before 0.301 and 0.286 respecively at 6 and 18 months. 2. Urine showed absorbance values of 0.484, 0.629 and 0.849 in groups Ⅰ, Ⅱ, Ⅲ respectively before medication. Then the values decreased about a half level revealed 0.261, 0.226 and 0.467 in the respective group at 18 months after medication. Control group showed relatively constant absorbance values 0.232 at before and 0.252 at 18 months. 3. The diameter of wheal size (mm) by intradermal test did not show substantial changes, i.e. 11.7, 13.3 and 12.7 in groups Ⅰ, Ⅱ, Ⅲ respectively before medication; 11.7, 12.9, and 11.4 in the respective group at 18 months after medication. 4. The relation of the absorbance values between sera (y) and urine (x) made the regression equation: y=0.707X+0.908, and showed relatively high correlation (r=0.619, n=68, p<0.001) before medication; y=0.760X+0.387 with some correlation (r=0.582, n=68, p<0.001) at 18 months after medication. 5. The relation between the absorbance values of urine and log EPG (eggs per gram of feces)/100 revealed more or less irregular correlations, i.e.r=0.566(p<0.01), 0.661(p<0.001)and 0.384(p<0.10)in groups Ⅰ, Ⅱ, Ⅲ respectively before medication. 6. The relation between the absorbance values of urine and the wheal size (mm) by intradermal test showed low correlation, i,e, r=0.416(p<0.10), 0.416(p<0.10)and 0.421(p<0.05)in groups Ⅰ, Ⅱ, Ⅲ respectively before medication.

유한요소법을 이용한 판 구조물의 동적거동 해석 연구

김영권,이기형,박태원,정인성 全北大學校 1995 論文集 Vol.39 No.-

This study discusses the finite element approximation and the choice of elements is dictated by the need to perform accuate for both thin and thick shells and by the complexity of the sensitivity calculations. A number of very accurate plate and shell elements exist for which the sensitivity computation become hopelessly complex. On the other hand, most very simple elements, which would lend themselves to compact and efficient sensitivity computation, do not posses sufficient accuracy for routine use.

혈장 중 theophyline 분석법 확립 및 약동학적 연구

김형기,권준택,염윤기 순천향대학교 의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

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'인사동 거리소리판'의 성격과 문화적 의의

김기형 우리어문학회 2003 우리어문연구 Vol.20 No.-

Today, Pansori, which is the core of the national culture, is starting to ensure the foundation of its autogenous transmissional power. However, the problem is that the repertories of the Pansori are not yet various much. What can we do so that the Pansori may take hold upon the current context of reality? There have been some movements to activate and disseminate Pansori with a critical awareness of the current problems. Such efforts have been led by young Pansori singers. For example, Kyu Ho Lee concentrates on transforming the difficult narrations of Pansori into easy and familiar narrations for general audiences. Many Pansori singer also shows his great interests in the creative popularization of Pansori. Pansori will be a successful performance when the literary narrations and the artistic expressions of the great singers are skillfully combined. It will also be helpful to activate Pansori when more great writers become interested in writing the narrations of the Pansori. 'Torangkangdae Contest' or 'Insadong Street Soripan' which has very experimental characterizations emphasize the prestige of the Pansori. The institutional system for the intangible cultural assets give the positive impact of Pansori as it is passed down readily to the next generations. On the other hand, the system gives us some negative effects and a feeling that Pansori has become very standardized without any variations. It reduces the vitality of Pansori which is one of the main characteristics of Pansori. Nowadays, interest in Pansori and its traditional culture has been increasing greatly because the spirit of the times emphasizes the identity of the national culture. However, we have lost the true nature of Pansori which contains keen satire and which evokes insights into life with an awareness of realistic problems about life. Therefore Pansori becomes just a kind of high culture. If we want to revive Pansori as a real art form, it is necessary to find the true nature of the Pansori. The future of the Pansori will be very bright when young critical Pansori singers bloom in their spirit of experimentalism.

經濟統計 프로그램 再使用 시스템의 設計

奇宇傑,金亨泰 조선대학교 경영경제연구소 1995 經營經濟硏究 = Management and economics research Vol.18 No.1

Software development of large scale program such as Operating System is lengthy and costly process. In order to reduce cost, time and risk, there is currently general acceptance of the need for Software Reuse System during the whole development cycles. In this paper, the problem of existing reuse system methodology is analyzed. Also using this method Economy Statistics Program Reuse System(ESPRS) which supports all phase of software life cycles is designed. It appears that this ESPRS reduces considerably communication error of requirement specification between system-analyst and end-user.