파킨슨병과 진행성 핵상마비에서의$^1H$자기공명분광법:예비 연구

장기현,전범석,송인찬,김동성,민관홍,한문희,강사욱,민병구,한만청 대한영상의학회 1996 대한영상의학회지 Vol.34 No.6

Purpose : To determine whether 1H magnetic resonance spectroscopy (MRS) is useful in differentiatingidiopathic Parkinson's disease (IPD) from progressive supranuclear palsy (PSP), based on metabolite ratios.Materials and Methods : Using a 1.5 T MR Unit, single voxel 1H MRS using STEAM with a TR of 2000ms and a TE of135ms was performed in seven PD and eight PSP patients. Five age-matched volunteers(mean age, 63 years) andanother five younger healthy volunteers(mean age, 30 years) were studied as normal controls. The regions ofinterest were the putamen and pallidum, with a size of 2 X 2 X 2cm. After measuring the spectral intensities ofeach metabolite (N-acetylaspartate=NAA, choline=Cho, creatine=Cr and lactate), relative peak height ratios ofNAA/Cr, Cho/Cr and Naa/Cho, and lactate levels among four groups were compared. Results : NAA/Cho and NAA/Crratios were statistically lower in the PSP group than the IPD group (1.21 $\pm$ 0.26 versus 1.45 $\pm$ 0.20, and 1.26 $\pm$0.23 versus 1.38 $\pm$ 0.19, respectively : p<0.05). NAA/Cho and NAA/Cr ratios were significantly lower inage-matched controls than in younger normal controls (1.39 $\pm$ 0.21 versus 1.76 $\pm$ 0.15, and 1.36 $\pm$ 0.13 versus1.79 $\pm$ 0.17, respectively : p<0.05). However, NAA/Cho and NAA/Cr ratios between age-matched controls and IPD werenot significantly different (p>0.05). Cho/Cr ratios were not different among four groups. Lactate was not detectedin any patients. Conclusion : NAA/Cho and NAA/Cr ratios in the corpus striatum were significantly lower in the PSPgroup than in the age-matched control and IPD groups. These results suggest that loss of neuron cells in thecorpus striatum is more prominent in PSP than in IPD, and that NAA/Cho and NAA/Cr ratios may help in differentialdiagnosis of IPD and PSP.

후두개와종양의 전산화단층촬영 소견에 대한 고찰 -혈관조영 및 전산화단층촬영 소견의 비교

장기현 대한영상의학회 1980 대한영상의학회지 Vol.16 No.1

Authors present 16 cases of posterior fossa tumors in which both vertebral angiography and computed tomography were performed and pathologic diagnosis verified at Seoul National University Hospital form January, 1978 through December, 1979. The radiographic finding are analyzed with emphasis on abnormal vascularity on angiography and computed tomographic findings. The purpose of this study is to understand the correlation between angiographic vascularityand contrast enhancement on post-contrast scan. The results are as follows : 1. The C.T.scan of all the cases show contrast enhancement , whereas only 6 cases show abnomal vascularity on angiogrpahy. 2. Angiographic abnormal vasculatures influence onstrong contrast enhancement on C.T. but the converse is not necessarily true. 3. The vertebral angiography appears to be of less diagnostic value for cases with slight contrast enhancement on C.T. than for cases with strong enhancement on C.T.

터키안 및 그 주위종양의 전산화단층촬영 소견

장기현 대한영상의학회 1980 대한영상의학회지 Vol.16 No.2

A total of 42 cases of sellar and parasellar tumors are verified at Seoul National University Hospital from December 1978 through July 1980. They are composed of 25 pituitary adenomas, 5 meningiomas, 4 craniopharyngiomas, 1 astrocytoma, 1 germinoma, 1 teratoma, 1 epidermoid, 1 arachnoid cyst, 1 chondroma, 1 sphenoid mucocele and 1 chronic epidural hematoma. Authors analyzed and described the computed tomographic findings of them.

VLSI 기술발전과 전망

장기현 대한전자공학회 1980 電子工學會雜誌 Vol.7 No.4

뇌경막외 및 뇌경막하혈종의 방사선학적 고찰

장기현 대한영상의학회 1975 대한영상의학회지 Vol.11 No.2

It is recognized that the differential diagnosis between an epidural hematoma and a subdural hematoma may be difficult and sometimes impossible. The purpose of this paper is to review and analize the radiographic findings of 23 epidural and 45 subdural hematomas, which were surgically proven at S.N.U. Hospital during the period from July 1972 through July 1975, with emphasis on differential diagonstic aspects. Roentgen analysis is based on incidence of skull farcture, shape of avasular zone and various characteristic angiograhic signs. The results are as follows: 1. Simple skull roentgenograms reveal fractures in 19 cases out of 23 epidural hematomas and in 18 cases out or 45 subdural hematomas. None of 8 chronic subdural hematomas shows skull farcture. 2. On cerebral angiography, epidural hematomas reveal typical lentiform avascular zone in 10 cases, semilunar shape in 2 cases and crescent shape in 3 cases, while subdural hematomas reveal crescent avascular zone in 18 cases, emilunar avascular zone in 4 cases and lentiform in 3 cases. 3 lentiform avascular zones of subdural hematoma are all found in cases of chronic stage and over 40 years of age. 3. In epidural hematomas, extravasation of contrast media (7 cases), displacement of dural sinus from inner tables(5 cases), medial displacement of middle meningeal artery (3 cases), amputation of middle meningeal artery (1 case) and pseudoaneurysm of middle meningeal artery (1 case) were observed, while only one case of extravasation of contrast media was observed in subdural hematomas.

뇌질환의 자기공명영상

장기현 대한의학협회 1990 대한의학협회지 Vol.33 No.7

單純腹部 및 上部胃腸管 撮影의 X - 線 判讀

張基賢 대한가정의학회 1981 Korean Journal of Family Medicine Vol.2 No.7

폐기형종 일례보고

장기현 대한영상의학회 1974 대한영상의학회지 Vol.10 No.2

The majority of intrathoracic teratoma are found in the mediastinum and those which occur in the lung are among the rarest of tumors. A case of intrapulmonary teratoma in a young Korean woman is reported, with brief review of the literatures. the teratoma presented radiologically in the right middle lobe as a well defined mass shadow which contained crescent shaped air and multiple nodularities with calcification.

잠행성 뇌혈관기형: 고자장(2. OT)자기공명영상 및 전산화단층촬영술과의 비교

장기현 대한영상의학회 1989 대한영상의학회지 Vol.25 No.1

저자들은 잠행성 뇌혈관기형으로 진단받은 환자중 전산화단층촬영술 (CT) 혈관조영 술, 및 조자장(2 OT) 자기공명영상 (MR) 검사를 모두 시행한 14명의 환자에서 발견된 20례 의 병변을 역행적으로 분석하였다. 3명의 환자에서는 수술로 확진되었으며 나머지는 전형적 임상소견 및 특징직방사선학적 소견으로 진단하였다. MR로는 모든 병변을 국한성 출혈성 병소로 찾을수 있었다. 잠행성 뇌혈관기형의 특징적 MR소견은 T2 강조 영상에서 병변의 주변부를 따라 hemosiderin 침착을 나타낸는 두꺼운 저강도륜과 함께 중심부에는 여러단계 의 혈종이 있음을시사하는 다양한 신호강도를 보이는 것으로 큰혈종이 동반되는 않은 경우 에는 부종이나 종괴효과가 경미하였다. 이중 2례에서능 소량의 반복출혈로 형성되는 특이한 포도송이 모양을 관찰할술 있었다. 그러나 병변이 1cm 이하로 작은 경우메는 원형 또는 난 형의 균질한 저강도 결절로 보였고(8례) 비전형적 소견을 보이는 경우도 2례 있었다. 잠행성 뇌혈관기형의 가능성을 강력히 시사하는 부수적 MR소견으로 비정상적 혈관에 의한 신호소 실이 4례에서 주위 뇌실질의 위축이나 백질연화가 2례에서 각각 관찰되었다. 병변의 호발부 위는 대뇌피질하부나 (8례) 뇌실주위(6례) 였다. CT로서는 20례중 4례의 작은 뇌혈관기형을 찾지 못하였으며 대분분의 경우 CT만으로는 뇌혈관기형의 진단응 내리기는 어려웠다 CT에 서 발견된 16례중 그정도나 모양의 차이는 있으나 15례에서 고 밀도 음영을 보이는 부위를 관찰할수 있었다. 그중 주변부의 고밀도 음영은 MR에서 hemosiderin 침착부위와 일치하였 도 중심부위에 국한된 고 밀도 음영은 급성혈종의 MR소견을 보였으며 CT상 저밀도 음영 인 부위는 MR에서 T1 및 T2강조영상에서 모두 고강도음영을 보여 액화된 아급성 출혈병 소임을 알수있었다. We retrospectively analyzed 20 lesions of occult cerebral vascular malformation (OCVM) examined by CT, angiography and high-field (2.0T) MR in 14 patients. All lesions were angiographically occult. Diagnosis was based on the typical clinical history and characteristic radiologic findings in all patients and confirmed by surgery in 3 patients. MR demonstrated all lesions as hemorrhagic foci. The most common and typical MR finding of OCVM was circumscribed thick hypointense rim on T2-weighted images (T2-Wls) representing hemosiderin deposit with various central intensities suggesting the presence of hematomas in different stages (11 lesions). Among these, the recurrent hemorrhage in small amount produced the characteristic "a bunch of grape" appearance. But, small OCVM less than 1 em in diameter was identified as a small homogeneous hypointense nodule on T2-Wls with sharp (6 lesions) or fade-out (1 lesion) border. There were 2 lesions showing atypical findings such as dense hemosiderin rim with central lacuna or bilobed subacute hematoma. As the associated MR findings which strongly suggest the diagnosis of OCVM signal void due to feeding or draining vessels was found in 4, lesions and the surrounding focal cortical atrophy or leukomalacia in 2 lesions. The predilection site of OCVM was subcortical (8 lesions) and periventricular (6 lesions) location. CT depicted 16 of the 20 lesions, but missed 4 lesions of small OCVM. CT alone did not permit definitive diagnosis of OCVM in most cases. Fifteen lesions demonstrated on CT contained somewhat hyperdense area in central or peripheral location Peripheral hyperdense area corresponded to the dense hemosiderin deposit on MR and central one to the hematoma formed by recent hemorrhage. Low density area on CT usually corresponded to liquefif.1 subacute hematoma on MR.

Radiation 손상에 기인한 실리콘 특성변화

장기현 대한전자공학회 1978 전자공학회지 Vol.15 No.4

실리콘 태양전지의 수명을 예측하기 위하여 1 MeV electron radiation으로 인한 실리콘 손상을 조사 연구하였다. 그 결과 흑형 실리콘에 있어서는 거의 안정상태의 손상에 이르렀음을 보았다. For a long life photovoltaic cell the degradation of the device characteristics with 1 MeV electron radiation must be known so as to be able to predict the life of the cell. Hence, a study was made of radiation damage effects on the bulk properties of the silicon crystal. From the results of the data, it is concluded that there appeared to be a steads rotate damage level reached in f type material.