Clomiphene citrate에 의한 배란유도 후의 임신율에 관한 연구

임춘근,이민용,권경익,박세출,이두룡,남동호,양숙경 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3

From March 1990 to February 1993, we evaluated completely follow-uped 68 cases of amenorrhea, oligomenorrhea, infertility(anovulation). The ratio of primary to secondary is 31: 37. Ovulation rate and pregnancy rate of 68 cases which were completely treated with clomphene citrate is 72%, 71.8% respectively. Among these 23 pregnat cases, 19 cases were full term delivered, 1 case is ongoing pregnant, and 3 cases were spontaneously aborted. No one of multiple pregnancy and congenital abnormality was noted.

액체크로마토그래피/질량분석법을 이용한 랫트 혈장내의 Surfactin C의 정량법에 관한 연구

임종환,김명석,이동연,이상훈,백경진,김태원,정두순,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Surfactin isolated from Bacillus subtilis has a strong surface tension-lowering activity, together with antiviral, antitumor, fibrinolytic and hypocholesterolemic activities. LC/MS is a simple, rapid and effective technique for the determination of surfactin C in rat serum. The separation of surfactin was achieved on reverse phase column. The mobile phase consisted of 0.1% trifluoracetic acid in water (A) and acetonitrile (B). As a result of analysis of blank rat serum samples, matrix interference was not shown. The values of precision and accuracy were satisfied w the guideline. A newly developed LC/MS method for the determination of surfactin C was successfully applied in its pharmacokinetic analysis.

단백뇨를 보이는 사구체 질환 및 당뇨병성 신병증에서의 Lp(a)

권태환,김준홍,조성,김석재,김용림,조동규,백미영 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1

Background: Recently there has been evidences that serum Lp(a), an independent risk factor to atherosclerotic cardiovascular diseases, were increased in proteinuric disorders such as nephrotic syndrome and diabetic nephropathy. Methods: We intended to search of altered concentrations of Lp(a) in proteinuric disorder measuring serum Lp(a) concentrations with ELISA in 44 glomerulonephritic patients(25 nephrotic syndrome(NS), 19 non-nephrotic range proteinuric glomerulonephritis(GN), 25 diabetic nephropathy patients(DN), and 31 healthy controls(HC). Also, we compared Lp(a) concentration between glomerulonephritis patients and diabetic nephropathy patients with proteinuria of similar degree. Results: 1) There were significantly increased levels of total choesterol, triglyceride, and LDL-cholesterol in Ns compared to GN, DN, HC. 2) There were significantly increased concentrations of serum Lp(a) in NS compared to HC, but no signiicant difference in serum Lp(a) among NS, GN, and DN. 3) There was no significant difference in serum Lp(a) concentrations between NS & DN with 24 hour urine protein greater than 3.0g. 4) There was no significant difference in serum Lp(a) concentration between GN with 24 hour urine protein greater than 0.5g and less than 1.5g and DN with proteinuria of simial degree. 5) In glomerulonephritis patients, there was negative correlation between serum Lp(a) concentration and serum albumin level but correlation with 24 hour urinary protein, total cholesterol, Ldl-cholesterol, and HDL-cholesterol was not shown. In diabetic nephropathy, there was no significant correlation among serum Lp(a) concentration and all parameters including serum albumin, 24 hour urinary protein, and other lipid profiles. Conclusion: The present study confirmed that patients with nephrotic syndrome of diverse etiologies have makedly increased plasma level of Lp(a), in conjunction with other lipid abnormalities. However, this study shows no difference in Lp(a) concentrations between diabetic nephropathy and glomerulonephritis with similar degree of proteinuria.

STRESS DISTRIBUTION OF ENDODONTICALLY TREATED MAXILLARY SECOND PREMOLARS RESTORED WITH DIFFERENT METHODS : THREE-DIMENSIONAL FINITE ELEMENT ANALYSIS

임동열,김현철,허복,김광훈,손권,박정길 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.1

본 연구의 목적은 근관치료 된 치아를 구조와 물성이 다른 post와 core 그리고 전장관으로 수복한 후 과도한 교합하중을 가했을 때 치아에 나타나는 응력분포를 조사하기 위함이다. 발치 된 상악 제2소구치를 micro-CT로 단층촬영하고 3D Doctor로 윤곽선을 추출한 다음 HyperMesh Ver. 6으로 삼차원 치아모형을 만들고 다음과 같은 세 가지 방볍으로 수복한 유한요소모형을 제작하였다. 1) 스테인레스 스틸 포스트와 복합레진 코어 그리고 도재소부전장금관으로 수복한 모형 2) fiber 포스트와 복합레전 코어 그리고 전부도재관으로 수복한 모형 . 3)포스트, 코어와 전장관이 일체형인 간접복합레진 EndoCrown으로 수복한 모형. 형성된 모형의 협측 또는 설측교두에 500N의 하중을 가하였으며 하중의 방향은 치아 장축에 대해 45도 이었다. 치관부와 치근부의 von Mises 응력을 ANSYS 9.0 프로그램으로 분석한 결과 포스트와 코어의 형태보다는 전장관 재료의 탄성계수가 근관치료된 상악 소구치의 응력분포를 좌우하였다. 치관부에서는 재료의 탄성계수가 높은 전장관으로 수복한 모형이 낮은 응력분포를 보였다. 치근부에서는 재료의 탄성계수가 낮은 전장관으로 수복한 모형이 낮은 응력분포를 보였다 The purpose of this study was to evaluate the influence of elastic modulus of restorative materials and the number of interfaces of post and core systems on the stress distribution of three differently restored endodontically treatcd maxillary second premolars using 3D FE analysis Model 1, 2 was restored with a stainless steel or glass fiber post and direct composite resin. A PFG or a sintered alumina crown was considered. Model 3 was restored by EndoCrown. An obliquc 500 N was applied on thc buccal (Load A) and palatal (Load B) cusp. The von Mises stresses in the coronal and root structure of each model were analyzed using ANSYS. The elastic modulus of the definitive restorations rather than the type of post and core system was thc primary factor that influenced the stress distribution of endodontically treated maxillary premolars. The stress concentration at thc coronal structure could be lowered through the use of definitive restoration of high elastic modulus The stress concentration at the root structure could be lowered through the use of definitive restoration of low elastic modulus.

民謠와 說話의 交涉

任東權 中央大學校 人文科學硏究所 1977 人文學硏究 Vol.4-5 No.-

민요는 서민의 시가이다. 형식이 짧고 시율이 있고 서정적인 경우가 많다. 그리고 특정된 개인의 노래가 아니라 집단의 공감에 의하여 성립되고 전파되고 전승되어 왔다. 설화는 이야기가 있고 형식이 길며 구화되고 설명적이며 서사적이다. 따라서 여러 사건과 주제를 담을 수가 있고 과장하고 흥미를 가지게 된다. 민요와 설화는 서로의 차이점이 있음에도 그 이질성을 극복하고 서로 교섭을 가지고 성장해 왔다. 민요와 설화의 이와같은 현상에 대하여 관심을 가지고 양자의 교섭을 구명함에 있어 여기에서는 민요와 설화의 개념을 우선 다음과 같이 설정하고자 한다.

자연 동굴 토양 방선균의 속 다양성 분포

임채영,권오성,김판경,박동진,이동희,김창진 한국산업미생물학회 1996 한국미생물·생명공학회지 Vol.24 No.5

국내에 소재 하는 자연 동굴 중 충청북도의 고수굴, 천둥굴, 노동굴, 강원도의 고씨굴, 경상북도의 성류굴, 제주도의 협재굴, 쌍용굴, 만장굴 등 8개 동굴의 내부에 존재하는 토양 방선균 분포를 조사하였다. 그 결과 전체적인 속 수준의 분포로서는 Streptomyces가 52.5%, Micromonospora가 16.3%, Nocardioform 22.8% 정도 분포하고 있었으며 Kineosporia, Actinomadura, Nocardiopsis, Streptosporangium의 순서로 방선균이 0.3~1.4% 정도 분포하고 있었다. 지금까지 보고된 일반적인 방선균 분포와 비교해 볼 때 특히 Streptomyces의 분포 비율이 낮고 상대적으로 Micromonospora, Nocardioform이 많이 분포하고 있었다. 한편 노동굴 지역을 대상으로 동굴 내부와 외부로 나누어 방선균 분포를 비교해 보았다. 그 결과 동굴의 내부에는 Streptomyces가 52.0%, Micromonospora가 16.8%, Nocardia가 32.0% 정도 분포하였고 외부에서는 Streptomyces가 75.8%, Micromonospora가 10.7%, Nocardia가 7.1% 정도 분포하였다. 따라서 동일 지역 내에서도 동굴의 내부와 외부에 따라서 큰 차이를 나타내고 있었다. 그리고 분리된 방선균 중에서 Streptomyces속 균주의 형태적인 특징을 조사한 결과, 기균사의 색에 있어서는 회색 계열 45.7%, 적색 계열 7.8%, 황색 계열 2.3%, 녹색 계열 13.2%, 백색 계열 27.1%, 불량 3.9%의 분포를 나타내었다. 일반적으로 Streptomyces속 방선균에서 잘 분리되는 회색과 적색 계열의 분리 비율은 크게 낮아 졌으나 희소한 녹색과 백색 계열은 분리 비율이 크게 증가하였다. 그리고 성류굴에서는 황색, 녹색, 백색, 계열등 다양한 계열의 Streptomyces속 방선균이 많이 분리되었다. 포자 연쇄의 형태에 있어서는 retinaculiaperti 형태가 35.7%, spirales 형태가 12.4%, rectiflexibiles 형태가 51.9%로 나타났다. Total 276 soil actinomycete strains were isolated from 46 soil samples collected at domestic natural caves; the Kosu, Chundong, and Nodong caves at Chungbook province, the Kossi cave at Kangwon province, the Sungruye cave at Kyungbook province, the Hyupjae, Ssangyoug, and Manjang caves at Cheju province. All of these isolates were identified to the genus level based n morphological and physiological characteristics. As the result, 52.5% of those isolates were Streptomyces, 16.3% were Micromonospora, 22.8% were Nocardioform group, 1.1% were Actinomadura, 0.3% were Nocardiopsis, 0.3% were Streptosporangium, 0.3% were Nocardioides, 1.4% were Kineosporia, 4.7% wee the others. Streptomycete strains were the most abundant, but were relatively less comparing to general distribution pattern. Nocardioform and Micromonospora strains were quite abundant, and other rare actinomycete groups were somewhat abundant comparing to general distribution pattern previously reported. Especially Nocardioform strains were highly abundant at almost of the natural caves.

후방순환계 뇌동맥류의 임상분석

임동준,이훈갑,정흥섭,김봉룡,권택현,이기찬,서중근 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.11

목재가 선적된 선창에서 발생한 산소결핍에 의한 질식사

김동훈,김기권,장태정,김정란,이구,김수근,임현술 大韓法醫學會 2001 대한법의학회지 Vol.25 No.1

Oxygen deficiency has been frequent in a clouted space. Wood consumes oxygen and discharges carbon dioxide Instead of photosynthesis in closed space without light, so do some microorganisms on the surface. We experienced a case that a healthy Insect-proofer fell down and died of asphyxia on stair-board at 7 m below the hatch of the cargo-hold shipping wood Analysis of gases in cargo-hold revealed O2; 12.3%, CO; 105 ppm, CH4; 2.7%, and H2S; 1.9% at 1 m below the hatch, and then O2; 6.1%, CO; 220 ppm, CH4; 2.9%, and H2S, 2.3 ppm at 2.5 m below the hatch. Autopsy findings were unremarkable. We justiced the cause of death asphyxia due to oxygen deficiency. As seen in this case, the serious oxygen deficiency was accounted for oxygen consumption by wood and microorganisms.

신규개발된 제초제 metamifop 현탁농축액제에 대한 급성독성평가

이동연,이상훈,백경진,김태원,정두순,임종환,김명석,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Metamifop, (R)-2-[4-[(6-chloro-2-benzoxazolyloxyphenoxy]-N-(2-fluorophenyl)-N-methyl propanamide, was newly developed by Dongbu Hannong Chemicals in Korea. In the present study we conducted acute oral toxicity and acute dermal toxicity test. The values of LD_(50) of metamifop was found to be over 5,000 mg/kg for ICR mice. On the other hand, metamifop showed no acute dermal toxicity to SD rats.

Slim Patch Type을 이용한 카페인의 경피흡수에 관한 연구

김정수,권동환,임도형,김구서,강진양 한국약제학회 2006 Journal of Pharmaceutical Investigation Vol.36 No.2