논평 / 중증 지속성 천식 또는 급성 악화를 보인 천식 환자에서 기도내 호중구성 염증의 의미

남동호 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.2

N/A

증례: Mefenamic acid에 의한 고정약진 1례

남동호,서창희,박해심 대한천식알레르기학회 1996 천식 및 알레르기 Vol.16 No.3

Mefenamic acid, a nonsteroidal anti inflammatory drug, has been used for symptomatic relief of musculoskeletal pain. Fixed drug eruption due to mefenamic acid is rare, but there are about 20 reported caees in world literatures. Here, we present a case of recurrent fixed drug eruption for five years due to mefenamic acid included in the prescription for upper respiratory infection. Mefenamic acid was confirmed as a causative drug of fixed drug eruption by oral provocation test, however the patient showed no reaction to salicylic acid. It is suggested that the disturbance of arachidonic acid metabolism may not be involved in the development of fixed drug eruption by mefenamic acid.

정유연성 지배주파수를 이용한 매개변수 인식기법

남동호,박수용,최상현 한국지진공학회 2005 한국지진공학회논문집 Vol.9 No.1

This paper presents an improved system identification methodology for structural systems by applying static compliance dominant (SCD) frequencies. The existing sensitivity-based system identification technique is extended to adopt the static compliance dominant frequencies, and the performance of the additional spectral information, i.e., SCD frequencies, is compared with that of the natural frequencies only via a numerical example of a mechanical system. The results of the numerical study indicate that the additional use of the SCD frequencies improves accuracy in system identification problems. 본 논문에서는 정유연성 지배주파수를 이용한 개선된 매개변수 인식기법이 제안되었다. 정유연성 지배주파수를 이용할 경우 주파수응답함수에서 고유주파수 보다 다수의 정보를 추출할 수 있어 매개변수 인식의 성능을 향상시킬 수 있는 장점이 있다. 정유연성 지배주파수를 매개변수 인식에 이용하기 위하여 기존의 고유주파수 민감도에 기반한 구조계 인식기법이 확장되었다. 정유연성 지배주파수의 이용을 통한 매개변수 인식의 성능향상은 수치예제를 통해 증명하였다. 수치예제는 스프링과 질량으로 이루어진 간략 모델이 사용되었으며, 고유주파수 만을 이용하여 구한 인식값과 비교한 결과 보다 정확한 매개변수 값의 인식이 가능함을 알 수 있었다.

토석류 발생 예측을 위한 강우경보지수 산정

남동호,이석호,김만일,김병식 대한지질공학회 2018 지질공학 Vol.28 No.1

At present, there has been a wide range of studies on debris flow in Korea, more specifically, on rainfall characteristics that trigger debris flow including rainfall intensity, rainfall duration, and preceding rainfall. the prediction of landslide / debris flow relies on the criteria for landslide watch and warning by the Korea Forest Service (KFS, 2012). Despite this, it has been found that most incidents of debris flow were caused by rainfall above the level of landslide watch, maximum hourly rainfall, extensive damage was caused even under the watch level. Under these circumstances, we calculated a rainfall triggering index (RTI) using the main factors that trigger debris flow–rainfall, rainfall intensity, and cumulative rainfall–to design a more sophisticated watch / warning criteria than those by the KFS. The RTI was classified into attention, caution, alert, and evacuation, and was assessed through the application of two debris flow incidents that occurred in Umyeon Mountain, Seoul, and Cheongju, Inje, causing serious damage and casualties. Moreover, we reviewed the feasibility of the RTI by comparing it with the KFS’s landslide watch / warning criteria (KFS, 2012). 우리나라의 토석류에 관한 연구들을 살펴보면 강우강도 및 강우지속시간, 선행강우 등의 토석류를 유발하는 강우의 특성과 토석류 발생 등에 대한 다양한 연구가 수행되고 있으며, 현재 산사태 및 토석류 예보는 산림청에서 제시한 산사태 경보 및 주의보 기준(Korea forest service, 2012)을 사용하고 있다. 그러나산림청의 예보기준만으로 볼 때, 대부분의 피해는 주의보 기준 이상의 강우에서 발생한 것으로 나타났고, 또한 최대시강우량의 경우 주의보 이하의 강우에서도 많은 피해가 발생하였다(Hwang et al., 2013). 따라서 본 연구에서는 산림청에서 제시한 산사태 경보기준 보다 더욱 세밀한 예 · 경보 기준을 산정하기위해 토석류 발생원인 인자인 강우량, 강우강도 및 누적강우량을 이용하여 강우경보지수(rainfall triggering index, 이하 RTI)를 산정하였으며, 이를 등급화 하여 관심, 주의, 경계, 대피로 구분하여 토석류 피해가 발생했던 서울시 우면산, 청주시, 인제군 피해사례를 적용하여 평가하였다. 또한 기존에 산림청에서 제시한 산사태 경보 및 주의보 기준과 비교하여 적용성을 검토하였다.

식도 파열환자에서의 종격동비대

남동호,김성규 한국의학사 1991 診斷과治療 Vol.11 No.11

최근 제약회사 근로자에서 발견된 새로운 직업성 알레르겐 ; Lysozyme , Peptidase , Cimetidine , Amoxicillin

남동호,박해심 대한천식알레르기학회 1995 추계학술대회 초록집 Vol.1995 No.-

알레르기질환에서 면역요법의 현재와 미래

남동호 대한의사협회 2015 대한의사협회지 Vol.58 No.5

Current pharmacological therapies for allergic diseases can improve clinical symptoms but cannot change their longterm clinical course. There is an unmet need for a curative treatment for allergic diseases. Allergen immunotherapy (AIT) is the practice of administering increasing doses of clinically relevant allergens to an allergic subject to reduce the clinical symptoms associated with subsequent exposure to the allergen. AIT is clinically effective for allergic asthma, allergic rhinitis, venom-induced anaphylaxis, and atopic dermatitis. AIT can change the natural course of allergic diseases and induce allergen-specific immune tolerance. In current clinical practice, AIT is delivered either subcutaneously or sublingually. Both subcutaneous and sublingual AIT have long-term therapeutic efficacy after of 3-5 years of treatment. The development of safer and more effective AIT strategies is needed. Conclusion: AIT is a disease-modifying therapy for allergic diseases. Future development of AIT should be directed toward achieving longterm clinical remission in patients with allergic diseases by the safe and effective induction of immune tolerance.

기관지천식 환자 객담내 IgA 항체의 측정 : 객담내 호산구 증가 유무에 따른 차이

남동호,채보원,박해심,정민권,전희선,곽연식,남재현,최영화 대한천식알레르기학회 1996 천식 및 알레르기 Vol.16 No.1

To evaulate the possible association between IgA antibody and eosinophilic inflammation, we measured total IgA content, albumin, and eosinophil counts in sputa from 27 atopic asthmatics, 6 non atopic asthmatics and 13 non atopic non asthmatic controls (including 6 non atopic healthy controls, 2 patients with atopic dermatitis, 2 patients with allergic rhinitis, and 3 patients with rheumatoid arthritis.) 1) IgA antibody was predominant immunoglobulin isotype in sputum, followed by IgG and IgM. 2) IgA antibody levels in sputa were significantly higher in non atopic asthmatics than controls with no statistical significance between atopic asthmatics and controls. In atopic asthmatics with sputum eosinophilia (eosinophil counts 25% of 200 leukocytes), sputum IgA levels were significantly higher than those of atopic asthmatics without sputum eosinophilia and control,s respectively (p <0.05). 3) Albumin levels in sputa from asthmatic patients were significantly higher than controls(p<0.05). No association was found between albumin level and eosinophil counts in sputum. 4) The ratio of total IgA to albumin levels in sputum was significantly higher (about 10 100 times) than that of serum. 5) There was no significant correlation between total IgA content and albumin levels in sputum. 6) When comparing total IgA and albumin levels in both sputa and saliva from 6 asthmatic patients, minimal amount of IgA and albumin was detected in saliva(p<0.05). In conclusion, IgA antibody was the predominant immunoglobulin isotype in sputum, and apparently locally produced in bronchial mucosa, and IgA antibody levels in sputa were significantly higher in non atopic asthmatics and atopic asthmatics with sputum eosinophilia than controls.

소아에서 Der fⅠ과 Der fⅡ 에 대한 특이 IgE 의 측정

남동호,홍천수,이수영,이기영 대한천식알레르기학회 1992 추계학술대회 초록집 Vol.1992 No.-

기관지 천식 환자 혈청내 IgE 항체와 집먼지 진드기항원 (Der fl)과의 면역 복합체 검출

남동호,박중원,홍천수 대한천식알레르기학회 1994 추계학술대회 초록집 Vol.1994 No.-