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김기권,장은숙,Kim, Ki-Kwon,Chang, Eun-Sook 대한세포병리학회 1990 대한세포병리학회지 Vol.1 No.1
CT guided percutaneous fine-needle aspiration (FNA) of the liver for both cytologic and histologic examination has great value in diagnosing liver malignancy. From March, 1986 to April, 1990, 62 patients with the clinical impression of liver malignancy underwent CT guided percutaneous FNA biopsy. Of these, 43 cases were reviewed for this study, 19 were reported to be liver cell carcinoma, 2 were adenocarcinoma, 11 were reported as anaplastic cell present, and the rest (11 cases) were negative (9) or necrotic (2). Among the 11 cases of the last group, 9 were diagnosed as liver cell carcinoma and 2 were necrotic histologically. Retrospective review, in order to clarify the cause of cytologic diagnostic error, of both cytologic and histologic slides of all cases showed discordance of 23% between these diagnoses and sensitivity is 93.9% and specificity is 90.9%. The reasons were as follows ; 1) the lack of awareness of tumor cells of well differentiated liver cell carcinoma (4 cases), 2) missed tumor cells due to too scanty cellularity (1 case), 3) improper smear (2 cases) and no tumor cell In the cytologic smears (3 cases). In such cases, at the initiation of FNA, a correct diagnosis of liver malignancy could only be made by a combination of cytologic and histologic examinations. However after three years' experience we can conclude that cytomorphologic features of liver cell carcinoma are sufficiently distinctive from other liver malignancies to be diagnostic.
김기권,권건영,장은숙 啓明大學校 醫科大學 1989 계명의대학술지 Vol.8 No.2
A case of papillary and solid epithelial neoplasm of the pancreas occured iin 64-year-old woman without detectable symptoms was reported and the tumor was found incidentally on CT scanning work up for staging of known cervical carcinoma of the uters. Distal pancreatectomy with splenectomy and radical hysterectomy were done. The tumor in the pancreas was large (10.4X7.5cm) and multilobulated. and showed good encapsulation with hemorrhagic center and pale homogenous yellowish white periphery on cut surface. Microscopically, the tumor was characterized by distinct papillary and solid pattern with microcystic change in areas. Most pancreatic carcinoma is high grade malignancy with a five-year survival of less than 5%, but papillary and solid epithelial neoplasm is potentially curable by surgical resection. Ultrastructurally, neoplastic cells contained a round to ovoid or indented nuclei with eccentric nucleoli and abundant cytoplasm with many mitochondria and some electron dense secretory granules.