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장태정,김동훈 東國大學校醫學硏究所 2003 東國醫學 Vol.10 No.2
위장관의 간질성 종양은 비교적 쉽게 기원하는 세포의 종류를 알 수 있는 종양들과 기원하는 세포의 종류를 알기 힘든 종양으로 구분할 수 있다. 전자에 해당되는 종양의 병리학적 소견은 다른 부위나 장기에 발생하는 간질성 종양과 유사하다. 후자에 해당하는 종양이 위장관 간질종양(gastrointestinal stromal tumor, GIST)인데 위장관의 간질성 종양의 대부분을 차지하고 있으며 주로 위와 소장에 발생한다. 저자들은 위장관의 간질성 종양들의 병리소견과 특히 GIST에 관한 악성 및 양성에 관한 병리학적 진단기준들을 기술하고자 한다. Two broad groups of mesenchymal tumors originate within gastrointestinal tract. The first and smaller group contains tumors identical to those that arise in the somatic soft tissues. The second and far larger and mere important group avoids esophagus and arises in the stomach and intestines, which are different from typical somatic tissue tumors; that is, they are uniquely gastrointestinal tract. This tumor is called gastrointestinal stromal tumor (GIST). We describe the pathologic features of these tumors and malignant criteria of GIST.
장태정 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.5
Background : The Scribble, Par and Crumbs polarity modules are essential for establishing and maintaining apicobasal cell polarity in epithelial cells. The aim of the present study was to investigate the expression pattern of Lethal giant larvae2 (Lgl2) in normal colonic epithelium and epithelial tumors and to examine the relationship between Lgl2 expression and clinicopathological parameters. Methods : We examined Lgl2 expression in 66 primary colon cancers and 20 adenomas by immunohistochemistry. Results : In normal colonic epithelium, Lgl2 was strongly expressed at the basolateral membrane of cells in the luminal surface but was not expressed at the base of crypts. The expression pattern of E-cadherin in normal epithelium was similar to that of Lgl2. In contrast, tumors did not express Lgl2 or showed diffuse cytoplasmic staining. The Lgl2 positive rate in tumors was significantly lower than in normal epithelium, and its negative rate in tumors was higher in tumors with abnormal E-cadherin expression than in tumors with positive membranous staining. Lgl2 staining intensity was significantly lower in tumor budding sites than in tumor centers. No significant differences were observed between Lgl2 and clinicopathological parameters. Conclusions : Lgl2 expression was reduced or localized at the cytoplasm in colon epithelial tumors, suggesting that a perturbation of Lgl2 expression frequently occurs in colon epithelial tumors.
장태정 대한병리학회 2009 Journal of Pathology and Translational Medicine Vol.43 No.6
Background : Tumor budding is present in the stroma at the invasive margin of colorectal carcinomas (CRC). The disintegration of cell adhesion molecules is closely related to this process. This study investigated the role of tumor budding in the progression of CRC, and compared the expression of β-catenin and E-cadherin between tumor budding and tumor center to determine whether epithelial-to-mesenchymal transitions (EMTs) occur in tumor budding. Methods : The number of tumor budding (NTB) instances was determined in 58 cases of CRC, and immunoreactivities of E-cadherin and β-catenin were compared at the tumor center and at the tumor budding site. Immunohistochemical staining for vimentin was also done. Results : Tumor budding was seen in 52 tumors (90%). There were significant associations between NTB and cliniopathologic parameters such as tumor depth, nodal metastasis and clinical stage. Expression of cytoplasmic and nuclear β-catenin were significantly higher at tumor budding sites than in the tumor center. In contrast, expression of membranous and cytoplasmic E-cadherin were significantly higher in the tumor center than at the tumor budding sites. Vimentin was expressed at tumor budding foci of only 2 cases (3%). Conclusions : This study suggests that EMT occurs at tumor budding, and that NTB may be a good marker for predicting a poor prognosis in CRC.
The Expression of Cyclooxygenase-2 and Survivin in Urinary Bladder Transitional Cell Carcinoma
장태정,이경섭 대한병리학회 2009 Journal of Pathology and Translational Medicine Vol.43 No.3
Background : The aim of this study was to investigate the expressions of cyclooxygenase-2 (COX-2) and survivin in bladder transitional cell carcinoma (TCC) that has different clinicopathologic characteristics, and we also wanted to determine if a relation exists between the COX-2 and survivin expressions. Methods : The expressions of COX-2 and survivin were investigated in 80 bladder TCCs by performing immunohistochemistry. Results : The normal bladder mucosa did not express COX-2 and survivin. COX-2 immunopositivity and cytoplasmic survivin immunopositivity were seen in 48% and 30% of bladder tumors, respectively. The expressions of COX-2 and survivin were closely related to the differentiation, depth and recurrence of bladder TCC, and there was a significant correlation in topographic distribution of COX-2 and survivin immunopositivity. In addition, COX-2 and survivin were predominantly expressed at the invasive front of tumors. Conclusions : This data suggest that COX-2 and survivin may be involved in the progression of bladder TCC, and there is a close correlation between the expressions of COX-2 and survivin.
계획된 행위이론에 근거한 대사증후군을 진단받은 대상자의 건강행위설명모형
장태정,송라윤 한국성인간호학회 2020 성인간호학회지 Vol.32 No.1
Purpose: This study aimed to identify the factors explaining the performance of health behaviors among adults withmetabolic syndrome based on the theory of planned behavior. Methods: A total of 218 adults with metabolic syndromewere recruited for the study from September to December, 2017. Data were analyzed using SPSS/WIN 22.0and AMOS 24.0. Results: The hypothetical model appeared to fit the data with x2/df=2.65, SRMR (StandardizedRoot Mean Residual)=.07, PNFI (Parsimonious Normed Fit Index)=.67. Attitude toward health behavior, subjectivenorm and perceived behavioral control explained 32.3% of variance in intention toward health behavior. Perceivedbehavioral control showed significant direct effects and mediating effect through intention on health behavior (γ=.57,t=5.85). Family support also had significant direct effects on health behavior (γ=.38, t=4.75). Attitude toward healthbehavior, subjective norm, perceived behavioral control, and family support were the significant factors explaining56.3% of variance in the performance of health behaviors among patients with metabolic syndrome. Conclusion:Health promotion programs for behavioral modification in this population should focus on these factors to lead tobetter health outcomes. Further studies are warranted to test the health promotion strategies based on theory ofplanned behavior for long-term change toward a healthy lifestyle among individuals with metabolic syndrome.
장태정 한국융합학회 2021 한국융합학회논문지 Vol.12 No.5
본 연구는 대사증후군을 진단받은 대상자가 가지고 있는 진단지표와 건강행위간의 관련성을 파악함으로써 대사 증후군 예방과 증진을 위한 근거자료를 제공하기 위해 시행되었다. 연구대상은 2017년 7월부터 2018년 7월까지 대전 지역 1개 대학병원과 4개의 보건소에 방문한 성인 633명이었으며, 분석방법은 SPSS/WIN 22.0 program으로 독립 t-test, ANOVA, Scheffe test, Pearson’s Correlation 을 실시하였다. 연구결과 본 연구의 대상자는 연령, 종교유무, 교육수준, 진단지표의 수에 따라 건강행위의 차이를 보였다. 고혈당을 기준으로 대사증후군 유형을 구분했을 때, 진단유 형에 따라 건강행위 중 스트레스 관리에 차이를 보였고, 고혈당이 있는 그룹에서 고지질혈증이 건강행위와 통계적으로 유의한 상관관계가 있는 것으로 나타났다. 따라서 대사증후군 증진을 위해 건강중재프로그램을 제공할 때 이러한 요인 들을 고려하여 중재프로그램을 제공하는 것이 필요하다. This study conducted to provide the evidence to prevent and promote Metabolic Syndrome by figuring out the relationship between diagnostic indicators and health behavior of participants with Metabolic Syndrome. The subject included 633 participants who visited to university medical center or public health center in Daejeon from July 2017 to July 2018 for regular check-up. The data were analyzed using independent t-test, ANOVA, Scheffe test, Pearson’s correlation coefficients by SPSS/WIN 22.0 program. As a result, 633 participants showed the differences in health behaviors according to age, religion, level of education, and the number of diagnostic indicators. By types of metabolic syndrome based on “hyperglycemia”, there was a difference in stress management between groups. Moreover, in the group with hyperglycemia, hyperlipidemia was associated with stress management among health behaviors. Therefore, it is necessary to provide an interventional program that include these factors to improve Metabolic Syndrome.
Decreased Expression of 15-hydroxyprostaglandin Dehydrogenase in Gastric Carcinomas
장태정,지예섭,정기훈 연세대학교의과대학 2008 Yonsei medical journal Vol.49 No.6
Purpose: Gastric carcinoma tissues release high level of prostaglandin E2 (PGE2) when compared to non-neoplastic mucosa, and cyclooxygenase-2 (COX-2), which is the rate-limiting enzyme in prostaglandin (PG) biosynthesis, is often overexpressed in gastric carcinomas and during gastric carcinogenesis. However, little is known about the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme responsible for the biological inactivation of PG, in gastric carcinomas. Materials and Methods: We investigated the expression of 15-PGDH in 28 cases of advanced gastric carcinomas by Western blot analysis and also the relation between its expression and the gene promoter methylation. Results: 15-PGDH expression was significantly decreased in gastric carcinomas compared to corresponding non-neoplastic tissues and inversely correlated with the expression of proliferating cell nuclear antigen in gastric carcinomas. However, there was no correlation between 15-PGDH expression and pathological findings such as nodal metastasis and vascular invasion. Promoter hypermethylation of 15-PGDH gene was not detected in carcinomas, with only a negligible expression of the enzyme. Conclusion: Our results suggested that 15- PGDH has tumor suppressor activity in gastric carcinomas.
장태정 연세대학교의과대학 2002 Yonsei medical journal Vol.43 No.3
Impaired regulation of apoptosis is known to be associated with the development of various cancers, and Fas/Fas-ligand (FasL) is known to play an important role in apoptosis. CD40 is a cell surface receptor, which when ligated modulates apoptosis in some cell types. The expressions of CD40 and FasL were examined in 10 normal skins, 7 Bowen's disease skins, 10 squamous cell carcinomas (SCCs) and 12 basal cell carcinomas (BCCs) immunohistochemically. In the normal epidermis, CD40 was more highly expressed in the keratinocytes of the squamous cell and granular layers than in those of the basal layer, and FasL expression was observed in the cell membrane of keratinocytes at the basal and squamous cell layers. CD40 expression was significantly higher in SCCs than in normal or Bowen's disease skin, while FasL expression was significantly higher in Bowen's disease than in SCCs. BCCs expressed the lowest levels of CD40 and FasL. These results suggest that altered CD40 and FasL expression may be related with the progression of SCC, and the marked reduced expression of CD40 and FasL may explain the biologic behavior of BCCs.OriginalArticle