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      • KCI등재

        전이성 골암으로 인한 골질 변화와 이로 인한 골절 위험성 분석

        임도형,Lim, Dohyung 대한의용생체공학회 2012 의공학회지 Vol.33 No.4

        While much has been learned about the mechanisms of metastatic spread of cancer to bone, there has been little headway in establishing guidelines for monitoring the alteration in bone quality and estimating fracture risk. The aims of this study are, therefore, 1) to evaluate bone quality induced by metastatic bone tumor by analyzing the characteristics on bone microarchitecture and degree of bone mineralization and 2) analyze fracture risk increased secondary to the bone quality changes by metastatic bone tumor through calculating mechanical rigidities based on in-vivo micro CT images. For this study, eighteen female SD rats (12 weeks old, approximate 250 g) were randomly allocated in Sham and Tumor groups. W256 (Walker carcinosarcoma 256 malignant breast cancer cell) was inoculated in the right femur (intraosseous injection) in Tumor group, while 0.9% NaCl (saline solution) was injected in Sham group. The right hind limbs of all rats were scanned by in-vivo micro-CT to acquire structural parameters and degree of bone mineralization at 0 week, 4 weeks, 8 weeks, and 12 weeks after surgery. At the same time, urine was collected by metabolic cages for a biochemical marker test in order to evaluate bone resorption. Then, bone metastasis had been directly identified by positron emission tomography. Finally, axial, bending and torsional rigidities had been calculated based on in-vivo micro CT images for predict fracture risk. The results of this study showed that metastatic bone tumor might induce significant decrease in bone quality and increase of fracture risk. This study may be helpful to monitoring a degree of bone metastasis and predicting fracture risk due to metastatic bone tumor. In addition, this noninvasive diagnostic methodology may be utilized for evaluating other bone metabolic diseases such as osteoporosis.

      • KCI등재

        Relationship Between Dual Time Point FDG PET/CTand Clinical Prognostic Indexes in Patients with High Grade Lymphoma: a Pilot Study

        임도형,이재현 대한핵의학회 2017 핵의학 분자영상 Vol.51 No.4

        Purpose This study investigated the correlative relationship between metabolic parameters estimated from dual time point 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG) positron emission tomography/computerized tomography (PET/CT) and the clinical tools predicting the outcome of a lymphoma. We also measured metabolic and volumetric alterations between early and delayed 18F-FDG PET/CT in patients with high grade lymphoma (HGL). Methods The samples were 122 lymph nodes and extralymphatic lesions from 26 patients diagnosed with HGL. All patients were applied to the International Prognostic Index (IPI), Ann Arbor stage, and revised IPI as clinical prognostic parameters. 18F-FDG dual time point PET/ CT (DTPFP) consisted of an early scan 1 h after 18F-FDG injection and a delayed scan 2 h after the early scan. Based on an analysis of DTPFP, we estimated the standardized uptake value (SUV) of tumors from the early and delayed scans, retention index (RI) representing the percentage change between early and delayed SUV, and metabolic volume different index (MVDI) calculated using metabolic tumor volumes (MTV). Results RImax showed a multiple positive correlative relationship with stage and IPI in lesion-by-lesion analysis (p < 0.01). In the case of IPI, the high risk group exhibited higher RImax than the low risk group (p = 0.004). In the case of revised IPI, the RImax of the low risk group were significantly lower than the intermediate and high risk groups, respectively (p < 0.01). The MVDIs of the best outcome group were decreased in comparison to the moderate outcome group (p = 0.029). There was a significant negative correlative relationship between RImax and MVDI, and the inclinations for decreased MVDIs were slightly associated with increased RIs. Conclusions RImax extracted from DTPFP had a significant relationship to extranodal involvement, staging, IPI, and revised IPI. MVDI showed significant negative correlation with RImax. Further large scale studies are warranted to support and extend these preliminary results.

      • KCI등재

        Evaluation of Loads Imposed on Muscles and Joints by Repeated Vacuum Cleaning Works for Estimation of a Potentiality of Musculo-skeletal Disorder Occurrence

        임도형,김한성,조영근,최현호,황성재,한바울,우대곤,황근배,김영호,추준욱,신태민 한국정밀공학회 2012 International Journal of Precision Engineering and Vol.13 No.3

        The excessive accumulation of physical burden is known widely as one of the main factors underlying musculoskeletal disorders in the working population. The current study was performed to evaluate the loads imposed on the muscles and joints by excessive accumulation of physical burdens for the estimation of a potentiality of musculoskeletal disorder occurrence, particularly in vacuum cleaning works, the motions most commonly performed both at home and in industry. A survey, rapid entire body assessment, and experimental/ virtual three-dimensional motion analysis were performed. The results showed that latissimus dorsi and trapezius muscle strengths and elbow and shoulder joint moments were generally higher than other muscle strengths and joint moments generated during cleaning works. In addition, motions required cleaning in corners and in hard-to-reach areas generally required more muscle strengths and joint moments than other motions. These findings may be used in improvement of vacuum cleaner (a device to clean up dust and dirt usually from floors) design reducing a potentiality of musculoskeletal disorder occurrence due to repeated cleaning works, through consideration of a methodology capable of decreasing the loads imposed on the muscles and joints by repeated cleaning works. The findings can be also expanded to improvement of working environments in which pushing and pulling works (cleaning works mainly included pushing and pulling motions) frequently occur, to reduce a potentiality of musculoskeletal disorder occurrence due to pushing and pulling works.

      • 신경망을 사용한 매도/매수 주식 종목 선정

        임도형,이일병 한국경영과학회 2000 한국경영과학회 학술대회논문집 Vol.- No.1

        주가는 시계열 데이터의 일종므로 많은 변수들이 주가의 변동에 영향을 미친다. 그러나몇멸 개의 어떠한 변수가, 이렇게 영향물 미치는 지 정확히 알려져 있지 않다. 그렇기 때문에 주가를 예측하는 것은 쉽지 않으며 단지 등락을 예측하는 것 조차도 쉽지 않다. 본 논문에서는 주가를 신호와 잡음이 혼합된 것으로 가점하고 그 특성을 고려하여, 전 종목에 대한 등락물 예측하지 않고, 예측율이 높은 종목물 선정하는 것을 목표로 하였다 MLP를 BP로 학습시켰으면 밉력으로는 28개의 주가분석 지표값이 사용되었다. 여러 예측 기간므로 실험하몄으며, 예측기간이 60일일 때 77.1%의 예측뮬물 보였고 선정된 좀목의 등락 예측물은 88%였다.

      • KCI등재

        Pulmonary Complications After Hematopoietic Stem Cell Transplantation

        임도형,이지연,Hong Ghi Lee,박병배,백경란,오원섭,Sang Hoon Ji,이세훈,박준오,김기현,김원석,정철원,박영석,Young Hyuck Im,강원기,박근칠 대한의학회 2006 Journal of Korean medical science Vol.21 No.3

        Despite advanced effective prophylaxes, pulmonary complications still occur in a high proportion of all hematopoietic stem cell recipients, accounting for considerable morbidity and mortality. The aim of our study was to describe the causes, incidences and mortality rates secondary to pulmonary complications and risk factors of such complications following hematopoietic stem cell transplantation (HSCT). We reviewed the medical records of 287 patients who underwent either autologous or allogeneic HSCT for hematologic disorders from February 1996 to October 2003 at Samsung Medical Center (134 autografts, 153 allografts). The timing of pulmonary complica-tions was divided into pre-engraftment, early and late period. The spectrum of pul-monary complications included infectious and non-infectious conditions. 73 of the 287 patients (25.4%) developed pulmonary complications. Among these patients, 40 (54.8%) and 29 (39.7%) had infectious and non-infectious conditions, respectively. The overall mortality rate from pulmonary complications was 28.8%. Allogeneic trans-plant, grade II-IV acute graft-versus-host disease (GVHD) and extensive chronic GVHD were the risk factors with statistical significance for pulmonary complications after HSCT. The mortality rates from pulmonary complications following HSCT were high, especially those of viral and fungal pneumonia, diffuse alveolar hemorrhage and idiopathic pneumonia syndrome.

      • KCI등재

        Stress Analysis of Two-Dimensional Cellular Materials with Thick Cell Struts

        임도형,김한성,김영호,김윤혁,S.T.S Al-Hassani 대한기계학회 2008 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.22 No.5

        Finite element analyses (FEA) were performed to thoroughly validate the collapse criteria of cellular materials presented in our previous companion paper. The maximum stress (von-Mises stress) on the cell strut surface and the plastic collapse stress were computed for two-dimensional (2D) cellular materials with thick cell struts. The results from the FEA were compared with those from theoretical criteria of authors. The FEA results were in good agreement with the theoretical results. The results indicate that when bending moment, axial and shear forces are considered, the maximum stress on the strut surface gives significantly different values in the tensile and compressive parts of the cell wall as well as in the two loading directions. Therefore, for the initial yielding of ductile cellular materials and the fracture of brittle cellular materials, in which the maximum stress on the strut surface is evaluated, it is necessary to consider not only the bending moment but also axial and shear forces. In addition, this study shows that for regular cellular materials with the identical strut geometry for all struts, the initial yielding and the plastic collapse under a biaxial state of stress occur not only in the inclined cell struts but also in the vertical struts. These FEA results support the theoretical conclusion of our previous companion paper that the anisotropic 2D cellular material has a truncated yield surface not only on the compressive quadrant but also on the tensile quadrant.

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