서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

웹 기반의 교수자·학습자간 행동 동기화 기법을 이용한 실시간 원격 강의 시스템

이부권,박규석 경남대학교 정보통신연구소 1999 연구논문집 Vol.1 No.-

현재 다양한 환경에서 여러가지 원격 강의 기법이 있지만, 아직 면대면 강의보다 적합한 시스템은 거의 없다. 이와 같이 아직도 면대면 강의가 훨씬 효율적이라는 것은 누구도 부정할 수 없다. 하지만 컴퓨터를 이용한 원격 강의에서 면대면 강의의 효과를 그대로 적용할 수 있다면 면대면 강의의 효과를 얻을 수 있을 것이다. 본 논문에서는 면대면 강의에서 발생할 수 있는 교수자의 행동을 분석하여 학습자의 상황으로 그대로 전이시켜 면대면 강의의 효과를 제공하는 것이다. 교수자의 행동은 설명을 하기 위한 소리의 전달, 칠판이나 TP의 내용을 가리키는 포인팅, 그리고 문서의 페이지 또는 형태가 된다. 먼저 학습자가 웹 상의 홈페이지를 이용해서 문서를 검색하며, 이후에 교수자는 설명을 소리로써 하게 되며, 특정 페이지를 보게 된다. 특히 설명을 위해서 마우스를 이용해 특정 위치를 가리키게 된다. 이와 같이 모든 교수자의 행동을 감지하여 학습자로 전달시켜 주는 기능과 전달받은 의미를 분석하여 학습자에게 표현해 주는 기능으로 분류할 수 있는데 본 논문에서는 전자를 서버, 후자를 클라이언트라고 정의한다. There are many different remote lecture systems, but there is no better lecture system than face-to-face system. And, nobody can deny the face-to-face lectures are more efficient. Accordingly, if a computer assisted lecture can adapt the effect of face-to-face lecture, we could acquire the effect. In this paper, we analyze teacher's actions in face-to-face lecture, and transfer it to the student's aspects and can provide the effect of face-to-face lecture. Teacher's actions are voice delivery to explain something, pointing objects and pages or form of documents. First, students display document pages via Web. Then, the teacher gives voice to explain the contents and points to the document. The server(teacher side) captures teacher's action and transfers it to students, and the client(student side) receives and analyzes the action, then presents it on monitor or speaker.

다형홍반증에서 각질형성세포의 ICAM-1, TNF-α 및 IL-1α 발현에 관한 연구

황규왕,정현,이종석,박준홍,부태성,이성열 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

The pathogenetic mechanisms involved in the developement of erythema multiforme(EM) are still largely unknown. The histologic and immunopathologic changes in erythema appear to be due in part to cellular immune mechanisms with the cytotoxic T cell. Especially cytotoxic T cell/ICAM-1 positive-keratinocyte adherence plays an important role in the pathogenesis of EM. In this study, we investigated the expression of TNF-a, IL-1 a by immunohistochemical stain and ELISA. In skin tissue of EM, strong basal cell expression of ICAM-1, TNF-a and IL-1 a was found, and we detected more TNF-a from supernatants of cultured human keratinocytes with serum of EM patient than normal control. Our results may suggest possible relationship between the pathogenesis of EM and cytokine from keratinocyte.

골격성 제3급 부정교합환자의 하악지 시상분할 골절단술후 하안면 폭경 및 고경의 변화에 대한 두부계측 방사선학적 연구

장현석,임재석,권종진,이부규,손형민 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.3

Purpose : The purpose of this study was to analyze the lower third facial changes in frontal view after mandibular setback surgery. Materials and Methods : In this study, fifteen subjects(6 males and 9 females) with class III dental and skeletal malocclusions who were treated with BSSRO(Bilateral Sagittal Split Ramus Ostetomy) were used. Frontal cephalometric radiographs were taken preoperatively and more than 6 months postoperatively, and hard tissue(H2-Hl) and soft tissue changes (S2-S1) were measured on vertical and horizontal reference lines. In 15 cases, changes which developed more than 6 months after surgery were studied. Results : The results were as follows. 1.In the facial height, hard tissue decreased(2.46±2.76mm) with statistical significance(P<0.01), and soft tissue also decreased(1.64±3.66mm). As a result, the facial height generally becomes shorter after sagittal split ramus osteotomy. 2.In the mandibular width, hard tissue decreased(2.08±3.59mm) with statistical sgnificance(P<0.05), but soft tissue increased (2.14±5.73mm) without statistically significant difference (P>0.05) postoperatively. 3.In the facial index, hard tissue decreased(0.23±2.21%), but soft tissue increased(2.41±3.46%) with statistical significance. Conclusion : One of the main purpose of orthognathic surgery is to achieve facial esthetics and harmony. In order to fullfill this purpose, it is important to carry out a precise presurgical treatment planning by estimating the changes of frontal profile after surgery.

Temporomandibular joint disc plication with MITEK mini anchors: surgical outcome of 65 consecutive joint cases using a minimally invasive approach

Lee, Bu-Kyu,Hong, Jun Hee Korean Association of Maxillofacial Plastic and Re 2020 Maxillofacial Plastic Reconstructive Surgery Vol.42 No.-

Background: The purpose of this study is to introduce our modified disc plication technique using MITEK mini anchors and to evaluate the clinical outcome for patients with internal derangement (ID) of the temporomandibular joint (TMJ). Patients and methods: We evaluated 65 joints in 46 patients, comprised 32 women and 14 men, who first visited the Asan Medical Center from December 2012 to December 2016. The age of the patients ranged from 14 to 79 years, with a mean age of 36.6 years. The patients presented with joint problems including pain, joint noise, and mouth opening limitation (MOL). Patients who met our inclusion criteria underwent unilateral or bilateral disc repositioning surgery with our minimally invasive disc plication technique using MITEK mini anchors and No. 2-0 Ethibond^® braided polyester sutures. The variables taken into account in this study were the range of maximum mouth opening (MMO), painful symptoms (evaluated with the visual analog scale, VAS), and the type of noise (click, popping, crepitus) in the TMJ. Results: Preoperative examination revealed painful symptoms in 50.7% (n = 35) of the operated joints (n = 69) and the presence of clicks in 56.5% (n = 39). Postoperative examination revealed that 4.3% (n = 3) of the operated joints had painful symptoms with lower intensity than that in the preoperative condition. Additionally, 17.4% (n = 12) had residual noise in the TMJ, among which two were clicking and the other 10 had mild crepitus. The intensity of the postoperative residual noise was significantly decreased in all cases compared to that in the preoperative condition. Among patients with MOL below 38 mm (n = 18), the mean MMO was 31.4 mm preoperatively and 44.2 mm at 6 months postoperatively, with a mean increase of 13.8 mm. A barely visible scar at the operation site was noted during the postoperative observation period, with no significant complications such as facial palsy or permanent occlusal disharmony. Conclusion: Subjective symptoms in all patients improved following the surgery. TMJ disc plication using MITEK mini anchors with our minimally invasive approach may be a feasible and effective surgical option for treating TMJ ID patients who are not responsive to conservative treatment.

Growth factors in oral and maxillofacial surgery: potentials and challenges

Bu-Kyu Lee 대한구강악안면외과학회 2013 대한구강악안면외과학회지 Vol.39 No.6

Internet marketing in the medical industry; challenges and future

Bu-Kyu Lee,D.D.S.,M.S.D.,Ph.D. 대한구강악안면외과학회 2015 대한구강악안면외과학회지 Vol.41 No.6

Evaluation of mechanical strength and bone regeneration ability of 3D printed kagome-structure scaffold using rabbit calvarial defect model

Lee, Se-Hwan,Lee, Kang-Gon,Hwang, Jong-Hyun,Cho, Yong Sang,Lee, Kang-Sik,Jeong, Hun-Jin,Park, Sang-Hyug,Park, Yongdoo,Cho, Young-Sam,Lee, Bu-Kyu Elsevier 2019 Materials Science and Engineering C Vol.98 No.-

<P><B>Abstract</B></P> <P>In clinical conditions, the reconstructions performed in the complex and three-dimensional bone defects in the craniomaxillofacial (CMF) area are often limited in facial esthetics and jaw function. Furthermore, to regenerate a bone defect in the CMF area, the used scaffold should have unique features such as different mechanical strength or physical property suitable for complex shape and function of the CMF bones. Therefore, a three-dimensional synthetic scaffold with a patient-customized structure and mechanical properties is more suitable for the regeneration. In this study, the customized kagome-structure scaffold with complex morphology was assessed in vivo. The customized 3D kagome-structure model for the defect region was designed according to data using 3D computed tomography. The kagome-structure scaffold and the conventional grid-structure scaffold (as a control group) were fabricated using a 3D printer with a precision extruding deposition head using poly(ε-caprolactone) (PCL). The two types of 3D printed scaffolds were implanted in the 8-shaped defect model on the rabbit calvarium. To evaluate the osteoconductivity of the implanted scaffolds, new bone formation, hematoxylin and eosin staining, immunohistochemistry, and Masson's trichrome staining were evaluated for 16 weeks after implantation of the scaffolds. To assess the mechanical robustness and stability of the kagome-structure scaffold, numerical analysis considering the ‘elastic-perfectly plastic’ material properties and deformation under self-contact condition was performed by finite element analysis. As a result, the kagome-structure scaffold fabricated using 3D printing technology showed excellent mechanical robustness and enhanced osteoconductivity than the control group. Therefore, the 3D printed kagome-structure scaffold can be a better option for bone regeneration in complex and large defects than the conventional grid-type 3D printed scaffold.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The customized PCL kagome-structure scaffold was successfully fabricated by a precision extruding deposition head. </LI> <LI> The superior mechanical robustness of the kagome-structure scaffold has been demonstrated by realistic numerical analysis. </LI> <LI> The fabricated kagome-structure scaffold was showed excellent osteoconductivity and fitting ability. </LI> <LI> The kagome-structure scaffold can be suitably applied for esthetic and functional reconstruction in complex bony defects. </LI> </UL> </P>

Evidence-based practice in the treatment of temporomandibular disorders

Lee, Bu-Kyu The Korean Association of Oral and Maxillofacial S 2012 대한구강악안면외과학회지 Vol.38 No.5

백서에서 자가 구강점막세포와 혈소판 농축 혈장의 이식에 의한 점막 근 피판의 조직공학적 제작

이부규(Bu Kyu Lee),황진혁(Jin Hyuk Hwang) 대한구강악안면외과학회 2007 대한구강악안면외과학회지 Vol.33 No.4

Backgrounds: To overcome limited amount of autogenous mucosa for the reconstruction of various mucosal defect including oral mucosal defect, tissue engineered mucosa has been recently introduced. However, introduced conventional technique of tissue engineered mucosa still have serious pitfalls such as long fabrication time, fragility of the reconstructed mucosa, and complexity of the technique. Aim of the study: To examine whether the complex of preconfluent autologous keratinocytes and autologous PRP (Platelet rich plasma) can reconstruct oral mucosa on the muscular flap with easier and faster way compared to conventional mucosal tissue engineering technique. Materials and methods: One day before the operation, oral mucosa (3mm in diameter) were taken and treated for extraction of oral keratinocytes according to the routine manner. The day of operation, oral keratinocytes were prepared in the laboratory and then moved to the operating theater. Autologous PRP was also prepared and then mixed with oral keratinocytes just before grafting on the prepared muscular flap. After keratinocyte-PRP complex was seated, then a sterilized rubber sheet was placed on the graft and the elevated skin flap was replaced and sutured. Biopsies were proceeded at 3,5,7,14 and 21 days. Tissue samples were evaluated clinically, histologically, and immunohistochemically. Results: All of the oral keratinocyte-PRP complexes were successfully grafted on the recipient sites (100%). On 3 days after the operation, 1-2 continuous epithelial layer and many inflammatory cells were observed. On 5 days after the operation, increase of layers of keratinocyte was observed with less inflammatory response. Thickness of the layers was gradually increased from 7 to 21 days after the operation. Cytokeratin confirms epithelium in every specimen. Conclusions: Preconfluent graft of autogenous oral keratinocytes mixed with autogenous PRP have successfully reconstructed myo-mucosal flap. This technique could be a useful alternative for oral mucosal reconstruction in the near future.