석위의 흰쥐 신기능에 미치는 영향

정윤주,양기숙 숙명여자대학교 약학연구소 1999 약학논문집-숙명여자대학교 Vol.16 No.-

Pyrrosia lingua has been used as the diuretics in folk remedies. In order to investigate its effect on kidney function, urine volume, excretion rates of electrolyte, serum chemical parameters (BUN, creatinine, uric acid) and kidney and spleen weights of rats were measured. Hexane, EtOAc and BuOH fractions showed significant diuretic action than water fraction. Serum creatinin value induced by mercuric chloride had significantly decreased and uric acid and BUN contents was decreased by administration of fractions.

대장암 세포주 SNU C2A에서 etoposide처리에 의한 apoptosis 유도

정지연,나윤숙,정호철,오상진 Official Journal of the Korean society for immunol 2001 Immune Network Vol.1 No.3

쌍각자궁에서 4회 반복유산 후 만삭 둔위 분만 1예

홍정의,김윤숙,최승도,선우재근,배동한 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.2S

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당뇨병과 동반된 화농성 간농양의 임상상 및 예후인자

오은숙,강무일,이원영,오기원,임동준,이소영,이정민,고승현,김성래,안유배,손현식,윤건호,차봉연,이광우,손호영,강성구 대한당뇨병학회 2000 임상당뇨병 Vol.1 No.1

연구배경: 감염질환은 혈관질환과 함께 당뇨병의 중요한 사망원인의 하나이며, 혈당조절이 불량할수록 감염 빈도가 증가됨은 잘 알려져 있다. 간농양의 발생이 있어서도 당뇨병은 중요한 기저질환 중의 하나이다. 일반적으로 간농양의 가장 흔한 원인균은 Escherichi coli라고 알려져 있으나, 최근 당뇨병을 가진 간농양 환자에서 Klesiella pneumoniae의 검출이 증가되고 있다. 또 최근 연구에 의하면 K.pneumonie가 간농양의 가장 흔한 원인균이며, K. pneumoniae에 의한 간농양은 K.pneumoniae 이외의 균주에 의한 간농양보다 당뇨병과 밀접히 관련되어 있다고 보고된 바 있다. 이에 저자들은 간농양 환자를 대상으로 당뇨병환자의 빈도를 알아보고, 그 원인균 및 특징을 비당뇨병 환자들의 경우와 비교해 보고자 하였다. 방법: 1992년 1월부터 1999년 6월까지 방사선학적 검사 혹은 수술에 의해 간농양이 확인되거나, 경피적 천자나 수술을 통한 배농액 배양, 혹은 혈액 검사에서 원인균이 증명된 182명의 환자를 대상으로 후향적 임상고찰을 실시하였다. 결과: 화농성 농양을 가진 167명의 환자(남:94명, 여:73명)중 당뇨병을 가진 환자는 54명 (남:30명, 여:24명)으로 32.3%를 차지하였다. 환자의 평균나이는 당뇨군에서 62.1 ± 13.4세, 비당뇨군에서는 55.1 ±15.5세로 당뇨군에서 높았으며(p=0.0021), 남녀간의 평균나이 비교 시 두 군 모두 여성의 나이가 의미있게 높았다. 비당뇨군에 비하여 당뇨군의 경우 저알부민혈증의 빈도와 aspartate transaminase가 증가되어있었다. 원인균주는 K. pneumoniae (당뇨군54%, 비당뇨군 39.1%), E. coli(당뇨군 17.5%, 비당뇨군 18.8%), Pseudomonas aeruginosa, Streptococcus viridans, Enterococcus 순이었으며 두 군간의 의미는 차이는 없었으나 K. pneumoniae의 경우 다른 균종에 비해 단독감염의 빈도가 높았다(82.8%). 사망률은 당뇨군에서 16.7%, 비당뇨군에서 7.1%로 당뇨군에서 의미있게 높았으며(p=0.019), 당뇨군에서의 사망환자는 모두 패혈증이 동반되어 있었다. 당뇨환자의 사망군은 생존군에 비해 당뇨병 이환기간이 길고 혼합감염의 빈도가 높았다(p=0.046). 검사실 소견에서는 총 빌리루빈 및 알카리성 포스파타제의 증가가 관찰되어 있었다. 결론: E. coli가 간농양의 주된 원인균이라는 기존 보고와는 달리 당뇨군과 비당뇨군 모두 K. pneumoniae가 간농양의 주된 원인균이었다. 또한 당뇨 유병기간이 길고 당뇨조절이 불량한 환자에서 혼합감염이며 총 빌리루빈 및 알카리성 포스파타제의 증가등과 같은 위험인자가 존재할 경우 사망률이 증가될 수 있으므로 이들 군에서는 적극적인 치료가 필요할 것으로 사료된다. Background: Liver abscesses are commonly associated with underlying disease, particularly diabete mellitus. The number of the liver abscesses caused by Klebslella pneumoniae in diabetic patient has been increased in Korea nowadays. This study was conducted to clarify the clinical presentation and prognostic factors of pyogenic liver abscesses, especially in diabetic patients and to determine the proportion of K. pneunomiae as a pathogen in liver abscess in Korea. Methods: Medical records of 167 patients treated for pyogenic liver abscess from January, 1992 through June, 1999 were reviewed retrospectively in detail. Major Pathogenic organism, clinical manifestations, prognostic factors, the importance of diabetes mellilus as an underlying disease and its effect on clinical features and prognosis were analyzed. Results: Among 167 cases of pyogenic liver abscess, underlying diabetes mellitus was present in 32.3%. The mean age of patients was 62.7 13.4 years in diabetic liver abscess group and 55.1 15.5 years in non-diabetic liver abscess group. Most liver abscesses were cryptogenic in origin or secondary to the billary tree diseases. The clinical presentations among the two groups were not significantly different. When compared to patients without diabetes, patients with diabetes had significantly higher proportions of hypoalbuminemia and elevated aspartate transaminase level. The most common organism of the pyogenic abscess was K. pneumoniae in both groups. Percutaneous drainage of the abscess with appropriate antibiotics was the most commonly used therapeutic modality in liver abscess. The mortality rate of diabetic liver abscess is 16.1 % and 7.1% in nondiabetic liver abscess. Complications, especially septicemla, were found more frequently in patients with diabetes than in patients without diabetes (64.8% vs 28.3%, septicemia : 31.5% vs 9.7%). The factors influencing mortality in the diabetic liver abscess were disease duration, mixed infection, presence of septicemia, elevated bilirubin and alkaline phosphatase. Conclusions: In contrast to prior report that the E. coli was the most common pathogen in liver abscess, we found that K. pneumoniae was the most common organism cultured in liver abscess. Diabetic patients have more complications and higher mortality than patients without diabetes. Early detection and proper treatment are needed to improve the outcome for diabetic patient with liver abscess.

住居環境의 經驗的 側面에 대한 調査硏究 : 大學生의 住居經驗 事例를 中心으로

이연숙,장윤정 대한건축학회 2003 대한건축학회논문집 Vol.19 No.3

Based on the phenomenological view of housing environment, this study has investigated residents' experiences in the housing environment through the stimuli of housing environment and the residents' responses. The content analysis method was applied to 103 essays of university students. The findings indicated that typical stimuli of hosing environment were housing type, arrangement of house, and structure of indoors. Cognitive responses, followed by emotional responses, were the most frequently responded. The emotional experiences in the natural characteristics of communities and outdoors were positive, while those in arrangement of house, arrangement of rooms, and structure of indoors were negative. It was also noteworthy that social housing environment in neighbors and family, and emotional influence of housing environment on the residents were significant.

人工甘味料의 合成過程에 對한 再考

박숙자,안송자,유영자,윤정자,윤종은,이명재,정규영,황민자 梨花女子大學校 藥學硏究所 1963 梨花藥學硏究 Vol.- No.4

사회 인구학적 변인과 부모의 스포츠참여에 따른 자녀의 체육학습 태도

권윤정,김경숙 이화여자대학교 동작과학연구소 2004 이화체육논집 Vol.8 No.-

The main object of this study is to find out how socio-demographic variable and parents participation in sports affect the physical education learning attitude of students. Furthermore, this reports primary purpose is to provide new data and materials for future physical education classes. To achieve such a study aim, the subjects students(518) were chooses in the 2 grader middle schools located on Seoul, classifying in to Gangnam and Gangbuk. The statistics employed this study are the frequent analysis, t-test, One-Way ANOVA and Scheff test. In light of the above research method and process, the following are the analysis results. First, according to the socio-demographic variable(with the exemption of the age of parents) each low primary factors perception, interest, confidence, concentration, and self regulating of physical education learning attitude showed significant difference. Secondly, parents participation in sports greatly influenced the physical education learning attitude(perception, interest, confidence, concentration, and self regulating) of students showed significant difference.

전자의무기록의 충실성 검토를 통한 미비기록 개선 활동

조윤정,김경숙,이향숙,이진영,김태민,김민순 한국의료QA학회 2008 한국의료질향상학회지 Vol.14 No.1

문제: 전자의무기록(EMR) 시행 후 의무기록 정리율의 저하와 질적인 측면에서의 충실성과 정확성에 대한 문제점이제기되었다. 목적: 전자의무기록의 정리율과 충실성 검토를 통하여 문제점을 파악하고개선점 찾아 의무기록 정리율을 향상시키고 충실성을 높이고자 하였다. 의료기관: 서울시에 소재한대학병원 의무기록과 질 향상 활동: 전자의무기록의 문제점을 개선히키 위하여 사용자 편의를 위한 EMR프로그램 수정 및 보완, 진단·수술 관련 작업, 업무개선, 교육, 홍보 등의 활동을실시하였다. 개선효과: 의무기록 정리율, 전자인증미비, 경과기록 기재일수, 퇴원요약주진단적합률, 기록지별 필수항목기 재율, 충실성에서 향상이 이루어졌다.

항암화학요법 관련 오심과 구토 완화를 위한 비약물요법에 관한 연구동향

소향숙,최자윤,조인숙,김영재,김지영,김애숙,김옥미,김춘심,김현오,설영애,안정옥,이애리,이영자 성인간호학회 2003 성인간호학회지 Vol.15 No.3

Purpose: Purposes of this study were to understand the current trends on complementary therapy in relieving chemotherapy-induced nausea and vomiting and to suggest the future research direction. Method: Subjects were selected on CINAHL, MEDLINE, Korean Academy Data Base from 1980 to 2001 which used nausea, vomiting, chemotherapy and complementary therapy as key words in experimental studies. Eight korean articles and twenty-one international articles were analyzed in terms of general characteristics, research methods, and types of complementary therapy. Data were analyzed by using descriptive statistical methods. Result: Since 2000, researchers have more actively used complementary therapy. In subject characteristics, mean age was 35.5 years old, 45% of the researchers were performed with high level of incidence of chemotherapy induced vomiting, 14% of them set limit of consecutive cycle during research, and 65% of them did not comment the selecting criteria of sample. About 60% of them were designed post-test only control group: 35% used INV by Rhodes, 31% used Likert scale, and 24% used VAS for dependent variable. Muscle relaxation therapy was mostly applied for relief of nausea and vomiting. Conclusion: Further studies will be needed to control extrinsic variables affecting nausea and vomiting in research design and to accumulate evidence with studies applying various complementary therapies.

아동실 환경특성이 아동의 자아존중감에 미치는 영향에 관한 연구

이연숙,황연숙,장윤정 대한건축학회 2004 대한건축학회논문집 Vol.20 No.6

This study investigated the physical environmental characteristics of elementary school children's rooms, and assessed the extent to which environmental characteristics influence the children's self-esteem. Survey questionnaires were given to 221 elementary school children in the lower grades, and frequency analysis, t-tests, analysis of variance(ANOVA), Duncan's MRT tests, and multi regression analysis were mainly employed for data analysis. The findings of the study indicated that the most negatively ranked characteristics of children's rooms were territoriality, ability to express, and creativity. The respondents' evaluation of the rooms differed by children's grade, housing type, housing size, and children's roo m size. For example, children in the first grade were more critical about safety and privacy, while those in the third grade were negative about social interaction. Meanwhile, children's self-esteem was very dependent on the extent to which children's rooms provide convenience, order, and safety. Therefore, the results of this study can be utilized to justify the importance of physical environments to children's self-esteem.