한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

행우서옥본(杏雨書屋本)『황제내경태소(黃帝內經太素)』 권(卷)21, 권(卷)27의 출간(出刊) 의의(意義)와 그 내용에 대한 고찰(考察)

김종현 ( Jong Hyun Kim ),백유상 ( You Sang Baik ),장우창 ( Woo Chang Jang ),정창현 ( Chang Hyun Jeong ) 대한한의학원전학회(구 대한원전의사학회) 2011 대한한의학원전학회지 Vol.24 No.5

『Hwangjenaegyeong-taeso(黃帝內經太素)』 is a classic work of Yang Sang-seon(楊上善), which comprises original articles of 『Hwangjenaegyeong(黃帝內經)』 along with 『Somun(素問)』, 『Yeongchu (靈樞)』, and 『gapeul(甲乙)』, as a one of the oldest annotated publications. Therefore, its significance lies in that 『Hwangjenaegyeong-taeso(黃帝內經太素)』 is a valuable work to reconstruct the original text of 『Hwangjenaegyeong(黃帝內經)』 and comprehend its fundamental ideas. The only printed edition of 『Hwangjenaegyeong-taeso(黃帝內經太素)』 was photocopied in 1981, and is currently known as ``Orient Edition``. While ``Orient Edition`` was referred to as the draft for the latest revised edition, volume 21 and 27 were photocopied from hand-copied edition, not the original. The original publications of ``Orient Edition`` have been stocked at ``Haengwuseook(杏雨書屋)`` of Japan and were recently published. Hence, a comparative study between the two original volumes and the former ones has been conducted. Although the most of the differences were trivial, some may have led to distorted interpretation of the text. The errors of the former revised edition fall into a few specific categories, and the most significant ones were errors that were made during the hand-copying procedure. Moreover, there were errors that were made due to the low resolution of the former draft, and simple errors during the publishing. In this work, examples of such cases were presented, and the results were collected.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

종 분포 모형을 이용한 구상나무림의 지속 및 쇠퇴에 관한 연구 - 전라남도 광양시 백운산을 중심으로 -

조선희 ( Seon Hee Cho ),박종영 ( Jong Young Park ),박정호 ( Jeong Ho Park ),이양근 ( Yang Geun Lee ),문이만 ( Lee Man Mun ),강상호 ( Sang Ho Kang ),김광현 ( Gwang Hyun Kim ),윤종국 ( Jong Guk Yun ) 한국산림과학회 2015 한국산림과학회지 Vol.104 No.3

The present study investigated the habitats of Korean fir trees (Abies koreana E. H. Wilson) on Mt. Baekwun (Baekwun-san), determined the current distribution, quantified the contribution of biological and nonbiological environmental factors affecting the distribution, derived actual and potential habitats, presented a plan for the establishment of protected areas, applied RCP 8.5 climate change scenario to analyze the effects of climate change on the future distribution of Korean fir trees, and predicted future potential habitats. According to the results of the study, 3,325 Korean fir trees (DBH >= 2.5 cm) inhabited Mt. Baekwun, and their distribution area was approximately 150 ha. Populations of Korean fir trees were confirmed to exist at an altitude of 900 m above sea level and were distributed up to 1,200 m. Based on potential distribution, areas appropriate for habitation by Korean fir trees were analyzed to be 450 ha, three times the current distribution area, with a focus on Sang Peak (Sang-bong), Eokbul Peak (Eokbul-bong), Ddari Peak (Ddari-bong), and Dosol Peak (Dosol-bong). The forest stands near Sang Peak, the main peak, were evaluated as those with the most appropriate potential for the habitation of Korean fir trees, and populations of the trees tended to prefer the northern slope rather than the southern slope. When climate change scenario RCP 8.5 was applied and future potential distribution was analyzed, the habitats were expected to decrease in area to 20 ha by 2050, with a focus on Sang Peak, and areas appropriate for habitation were predicted not to exist by 2080. Judging from such results, as global warming accelerates, the habitats of Korean fir trees are clearly expected to move from lowlands to highlands.

초경합금 소재 LCU_CL 코어의 초정밀 연삭 특성에 관한 연구

정상화,차경래,김현욱,이봉주 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

As the various manufacturing technology of optical glass is developed, the aspherical lenses are applied to many fields. However, It is still very difficult to manufacture glass lens because of the high cost and the short life of core. In recent years, the demands of the aspherical glass lenses increase since it is difficult to obtain the desirable performance in the plastic lens. In the glass mold lens, it has merits of high productivity and reproductivity since lens is manufactured by the only forming with high precision mold. The fabricating conditions for glass mold lens are glass surface that does not cause fusion, viscosity of 108-1013 poise for the 0.2㎛ accuracy, and viscoelasticity for the roughness less than 100 angstrom. In this thesis, ultra-precision grinding characteristics of tungsten carbide for forming the aspherical glass lens core were studied and the result of it is applied to manufacture the tungsten carbide-base core of the glass lens used to the laser scanning unit and the camera phone.

극초정밀 다축 스테이지의 광소자 정렬에 관한 연구

정상화,차경래,김현욱,최석봉,김광호,박준호 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

In recent years, as the demands of VBNS and VDSL increase, the development of kernel parts of optical communication such as PLC(Planar Light Circuit), Coupler, and WDM elements increases. The alignment and the attachment technology are very important in the fabrication of optical elements. In this paper, the optical alignment characteristics of multi-axis ultra precision stage were studied. The alignment algorithms were studied for applying to the ultra precision multi-axis stage. The alignment algorithm is comprised of field search and peak search algorithms. The contour of optical power signals can be obtained by field search and the precise coordinate can be found out by peak search. Two kinds of alignments, such as 1ch. input vs. 1ch. output optical stack, and 1ch. input vs. 8ch. output PLC stacks were performed for investigating the alignment characteristics.

위궤양에 대한 Teprenone(Selbex^�)의 임상효과

정현용,김병호,성자원,이기천,허승식,이종선,이헌영,김영건 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

The study objective was to assess the ulcer healing effects of Teprenone, stimulator of mucus production, given in dose of 50mg tid. We reviewed 25 cases of gastric ulcer proven endoscopically and treated by Teprenone. The results were follows; 1) The healing rate of gastric ulcer was 72% after 8 weeks treatment. 2) Subjective symptoms such as epigastric pain, belching, nausea, anorexia and vomiting were subsided at 86%. 3) There were not developed any symptoms, signs and laboratory abnormality (CBC, liver funtion test, urinalysis) suggesting side effect of drugs. In conclusion, Teprenone was considered an effective and safe drug in the treatment of gastric ulcer diseases.

사회적 음주자에서 매운 맛 선호도가 급성 음주 반응에 대한 Naltrexone 효과에 미치는 영향

정희정,김성곤,김종현,박숙현,강철중 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Capsaicin과 알코올이 각각 중추신경 아편계 활성도를 증가시킨다는 선행 연구들이 있다. 이에 본 연구는 매운맛 선호도에 따라 급성 음주 반응에 차이가 있는지와 급성 음주 반응에 naltrexone이 미치는 영향에 차이가 있는지를 조사하고자 하였다. 12명의 의과대학 남학생을 대상으로 두 군으로 나눈 후 cross-over design을 사용하여, 한 군(6명)은 naltrexone 25 mg을 실험 1일째에, 50 mg을 실험 2일러에 주었고, 다른 군(6명)은 naltrexone 25 mg을 실험 8일째에, 50mg을 실험 9일째에 주었다. 실험 2일째와 9일째에 각대상자의 Biphasic Alcohol Effects Scale (BAES)로 측정한 급성 음주 반응과 음주갈망, 혈중알코을 농도 등을 음주 전, 음주(0.6 ml/kg) 후 15분, 30분, 60분에 측정하였다. 통계 분석 시 Food Preference Scale 점수에 따라 모든 대상자를 매운 맛을 선호하는 군(strong preference for hot food, SP)과 매운 맛을 덜 선호하는 군(lesser preference for hot food, LP)의 두 군으로 다시 나누어 분석하였다. 결과는 다음과 같다. 1) Naltrexone을 투여 여부에 관계없이 알코올의 급성 흥분 효과는 매운 맛 선호도에 따른 차이가 없었다. 그리고 LP에서도 naltrexone의 투여 여부에 따른 알코올의 급성 흥분 효과의 차이가 없었다. 그러나 SP에서는 알코올의 급성 흥분 효과가 naltrexone 투여 시 유의하게 억제되었다. 2) 알코올의 급성 진정 효과, 음주 갈망 및 혈중 알코올 농도는 매운 맛 선호도 혹은 naltrexone 투여 여부에 따른 차이가 없었다. 본 연구에서 매운맛을 선호하는 경우 알코올의 급성 흥분효과가 naltrexone에 의해 억제되었다. 이것으로 naltrexone이 매운맛을 선호하는 군에서 알코을 의존 재발 예방 효과가 더 클 가능성을 제시한다. Objectives : Both capsaicin, a pungent substance of hot food, and alcohol, are known to affect central opioid activity. The purpose ofthis study was to investigate the difference in the subjective acute responses to alcohol and the effect of naltrexone on them among those who prefer hot food to varying degrees. Methods : Twelve male medical students were divided into two groups using a cross-over design. One group was given naltrexone on only the first (25 mg) and the second day (50 mg), and the other group was given naltrexone on only the eighth (25 mg) and the ninth day (50 mg). On the second and the ninth day, the acute effect of alcohol was assessed in all subjects, using the Biphasic Alcohol Effects Scale (BAES) just before drinking and at 15 minutes, 30 minutes and 60 minutes after drinking (0.6 ml/kg). Alcohol craving was also measured, using Visual Analogue Scale for craving (VAS-C) and blood alcohol concentration (BAC), at the same interval. For statistical analysis, subjects of both group were re-divided into two group, those with a strong preference and those with a less preference (LP) for hot (spicy) food (SP), using the Food Preference Scale. Results : 1) Repeated measures of ANOVA (2 preference groupsX4 time blocks) on the stimulative subscale of BAES yielded no significant group by block interaction of naltrexone administration. Repeated measures of ANOVA (2 drug groupsX4 time blocks) on the stimulative subscale of BAES revealed a significant group by block interaction in SP (p=0.028), but not in LP. The paired t-test revealed that significant suppression of the stimulative subscale of BAES was observed at 15 minutes and 30 minutes after drinking when naltrexone condition was compared with no-medication condition in SP(p=0.014 ; p=0.007). 2) For the sedative subscale ofBAES, VAS-C and BAC, repeated measures of ANOVA yielded nosignificant group by block interaction by either hot food preference or naltrexone administration. Conclusion : For those who prefer hot food, the effect of stimulative acute alcohol was suppressed by naltrexone. This result strongly suggests that naltrexone could prevent relapse more effectively in those who prefer hot food.

탈력발작 유무에 따른 기면병 환자의 비교 : 임상변인, HLA-DQB1*0602, Hypocretin

정종현,홍승철,신윤경,한진희,이성필 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.1

Objectives : Narcolepsy is a sleep disorder, characterized by excessive daytime sleepiness, cataplexy, sleep paralysis and hypnagogic hallucination. Among these symptoms, cataplexy is one of the most pathognomonic symptoms in narcolepsy. This study was designed to investigate the clinical features, frequency of DQB 1 *0602 and CSF hypocretin levels in Korean narcolep-tics with cataplexy to compare with those who have not cataplexy. Methods : From August 2003 to July 2005, we selected 72 patients who have narcolepsy confirmed by nocturnal Polysomno-graphy and multiple sleep latency test (MSLT) as well as their history and clinical symptoms at Sleep Disorders Clinic of St. Vincent's Hospital, Catholic University of Korea. Patients were divided into 56 cataplexy-positive group (narcolepsy with cataplexy group) and 12 cataplexy-negative group (narcolepsy without cataplexy group). HLA typing was done in all patients for the presence of DQB 1*0602, and patients received spinal tapping to measure the level of CSF hypocretin. Clinical variables were examined by semi-structured interview for narcolepsy patients. Results : 1) In cataplexy-positive group, compared with cataplexy-negative group, the frequency ofHLA-DQB 1*0602 was found to be significantly increased (50 subjects, 89.3% vs. 8 subjects, 50.0%) (p=0.000). 2) tn 48 out of 56 cataplexy-positive patients (85.7%), hypocretin levels were decreased (≤110 pg/mI) or were below the detection limit of assay (≤40 pg/ml).However, only 6 out of 16 cataplexy-negative patients (37.5%) exhibited decreased hyopcretin level. The difference between two groups were statistically significant (p=0.000). 3) Cataplexy-positive group, compared to cataplexy-negative group, re-ported more frequent hypnagogic hallucinations (36 subjects, 64.3% vs. 4 subjects, 25.0%) (p=0.005). However, there were no significant differences in frequency or seventy of daytime sleepiness, sleep paralysis and demographic data. 4. In nocturnal polysomnography and MSLT findings, there were no significant differences in all sleep parameters between two groups. Conclusion : Higher frequency of HLA-DQB 1*0602, and lower hypocretin levels in cataplexy-positive groups than Cata-pelxy-negatives suggest that narcoleptics with cataplexy might be a etiologically different disease entity from narcoleptics without cataplexy. Additionally, Current criteria prevail for the diagnosis of narcolepsy need to be reclassified according to the presence of cataplexy or not.

Solubility of TiO2 in NaF‑CaF2‑BaF2 Melts

Jeong‑Hyun Yoo,Sung‑Wook Cho 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.6

The solubility of TiO2in NaF-CaF2-BaF2 ternary eutectic melts was investigated at the temperature range of 1025–1150 °C. The least-squares equation was obtained from the relationship between the reciprocal temperature and the natural logarithm ofthe titanium concentration in the melts saturated with TiO2. The corresponding partial molar enthalpy of dissolution of TiO2was found to be 188 kJ/mol. The titanium saturation concentration was 3.73 wt% at 1100 °C. From the titanium concentrationchange with the added amount of TiO2at different holding time after a final stirring, it was found that not only completedissolution of TiO2but also enough sedimentation of excessive TiO2should be guaranteed to obtain more reliable solubilitydata. The holding time of 10 h was found to be enough for the excessive TiO2particles to settle down in our experimentalconditions. It is noteworthy that in case of adding TiO2in excess of its solubility, the Ba1.12(Ti8O16) phase was observed atthe lower and bottom of the solidified salt ingots.