균류 분화과정의 유전적 조절기작

박범찬,이환희,박윤희,박희문 충남대학교 생물공학연구소 2003 생물공학연구지 Vol.9 No.1

Fungi are well suited for studying mechanism controlling development and cell differentiation in multicellular eukaryotes. The asexual and sexual reproductive cycles are tightly coordinated during the life cycle of Aspergillus nidulans. The asexual (mitotic) reproductive cycle involves the formation of a number of differentiated cell types. Successful formation of multicellular reproductive structures and spores (conidia) requires the establishment of spatiotemporal gradients in essential transcriptional regulators, such as brlA, abaA and wetA. Altered gene expression is coordinated with critical changes in the movement of nuclei and the regulation of the cell division cycle. Therefore, it has been proposed to define a central regulatory pathway. Several early regulatory genes involved in signal transduction pathway controlling asexual sporulation are also required for activating the central pathway. Sexual (meiotic) reproduction is more complex, requiring the differentiation of several specialized tissue types. Although technical difficulties have limited efforts to study the genetics of sexual fruiting-body formation directly, some recent progress has been made. With the recent availability of mutants blocked in sexual development, understanding the genetic interactions between genes that function primarily in determining sexual sporulation will be achieved in the near future.

간호실무에서 신봉이론(Espoused theories)에 대한 탐색적 연구

서문자,김혜숙,이은희,박영숙,조경숙,강현숙,임난영,김주현,이소우,조복희,이명하,지성애,하양숙,손영희,권성복,김희진,추진아 성인간호학회 2001 성인간호학회지 Vol.13 No.1

As a nursing practice involves nurses' actions in a specific context of health care, this study has focused on exploring the espoused theories in nursing practice within the action science perspectives, Espoused theories are the belief, principles, and rationale expressed by the practitioner as guiding her/his actions in a situation of practice. The data were analysed qualitatively and 25 elements of espoused theories of nursing action were identified and clustered into 6 categories. The 25 elements of espoused theories are as follows: The clinical nurse worked in wholistic and individual nursing, focussed on the patient's needed, comfort and supportive nursing (5 theories of nursing goal) ; excellent skills, knowledge based, assessment and data collection, explaining, educating or a scientific basis(6 theories of nursing intervention): advocacy, value oriented, treatment, account- ability and commitment(4 theories of nursing ethics) ; human respect. partnership, trust(3 theories of patient-nurse relationship) : knowledgable, accumulated clinical experiences and personally lived experiences. positive perspectives(4 theories of nurse), role of intervention. rewarding peer relationship(3 theories of situations) The above mentioned espoused theories are similar to that of nursing textbooks which students learned through basic nursing education and almost the same as the Acts ofa Nurse in Korean. However, we are doubtful whether nurses actually do as they think. Therefore. it is recommended to review the theories-in-use in order to and any discrepancies between the espoused theories and the reality of nursing actions

바이모달 트램의 위치 인식 방법 및 정밀 정차 구현

서기원(Seo Ki-Won),박주연(Park Ju-Yeon),이상남(Lee Sang-Nam),류희문(Ryu Hee-Moon),변윤섭(Byun Yeun-Sub) 한국철도학회 2009 한국철도학회 학술발표대회논문집 Vol.2009 No.5월

This paper presents a method for precisely localizing and parking of bimodal trams. In order to gain an automatically driving system for bimodal trams, precise up-to-date localization, velocity recognition, distance to next station and precise parking location estimation functions are required. This paper proposes a system consisting of control device, steering device, sensor input equipment, driving system, tachometer, vehicle-side sensors, magnetic markers and magnetic sensors. The tram recognizes the precise location via magnetic markers containing information. Parking position and precise distance calculation is embodied by a tachometer. The vehicle-side sensors are used to assure safe station approaching and parking magnetic markers provide improvement of precision while tram parking. This paper provides a system realizing localization and precise parking and afterwards the automatic drive test results are reported and analyzed.

급성 출혈성 대장염으로 오인된 궤양성 대장염 1예

문희정,장병익,김승범,이호찬,박재현,은종렬,김태년 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Ulcerative colitis (UC) is a chronic inflammatory disorder of the gastrointestinal tract that affects the large bowel, Its etiology remains controversial. However, an infectious or immunologic origin is considered the primary cause. The onset of UC is typically slow and insidious, but some patients may present acutely with symptoms mimicking infectious colitis. We report a case of ulcerative colitis mimicking acute hemorrhagic colitis at initial presentation. A 60-year-old man was referred to Yeungnam University Hospital for bloody diarrhea and abdominal pain. Sigmoidoscopy revealed mildly edematous mucosa in the rectum and hyperemic mucosa with petechiae in the sigmoid colon. The patient was treated with antibiotics for several days, and his symptoms improved. However, after one month, his bloody diarrhea relapsed. Follow-up sigmoidoscopy revealed mucosal friability in the rectum and sigmoid colon. He was diagnosed with ulcerative colitis, and his symptoms were improved with mesalazine and a steroid enema.

보우타이 패치 안테나의 초광대역화 설계

문수덕,박재일,최경,황희용 강원대학교 정보통신연구소 2005 정보통신논문지 Vol.9 No.-

In this paper, A ultra wideband antenna with electromagnetically coupled feeding is presented. The designed antenna is composed of Bow-tie patch with parasitic patch ground of a semicircular shape. The measured bandwidth of the designed antenna is from 2.5GHz to 8.3GHz for -10dB return loss (VSWR < 2). This antenna shows a similar radiation pattern of monopole and maximum gain better than ideal dipole throughout the operating frequency band.

소화기 Behcet병: 13예의 임상분석

정희원,유빈,문희범,이인철,김병식,박건춘,김진천 대한대장항문학회 1995 Annals of Coloproctolgy Vol.11 No.1

現代精神科疾患의 分類, 原因 및 精神病理에 對한 考察

朴汶熙 최신의학사 1978 最新醫學 Vol.21 No.8

이갈이 환자의 다면적 인성검사의 특성

박병욱,이희철,장문정,심주철 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.3

연구목적 : 다면적 인성검사를 통해 이갈이군의 심리적 특성을 알아보고 이갈이 환자의 성별, 가족력, 발병기간, 이갈이 유형, 동반된 통증 유무에 따른 심리적 특성의 차이를 알아보고자 하였다. 방 법 : 1998년 1월부터 8월까지 개인 치과의원을 방문한 환자들 중 46명의 이갈이군, 41명의 대조군을 대상으로, 이갈이군과 대조군의 심리적 특성, 이갈이 환자의 성별, 가족력 유무, 이갈이 기간, 이갈이 유형, 통증과 같은 동반증상유무에 따른 심리적 특성의 차이를 알아보기 위해 다면적 인성검사를 실시하였다. 결 과 : 이갈이군이 대조군보다 모든 임상척도에서 높은 점수를 나타냈으나 남성특성-여성특성 척도점수를 제외하고는 통계적 유의성이 없었다. 가족력이 있는 이갈이군이 가족력이 없는 이갈이군보다 반사회성 척도가 높았다. 이갈이군에서 남자가 여자보다 교정척도(K) 점수가 높게 나타났으며 여자는 편집증 척도점수가 높게 나타났다. 발병기간에 따른 차이는 없었으며 이갈이 종류의 비교에서는 이악물기형이 다른형보다 내향성 척도가 유의하게 높았다. 저작근 통증, 경통, 두통과 같은 동반된 통증 유무에 따른 차이는 없었다. 결 론 : 다면적 인성검사상 일부 항목에서 높은 점수를 나타낸 것으로 이갈이 환자의 심리적 특성을 규정짓기는 어려우나 이갈이군이 대조군에 비해서 다면적 인성검사상 모든 척도가 상승되어 있고, 이갈이의 성별, 가족력, 이갈이의 종류에 따라 일부 척도의 점수가 상승되어 있는 것은 이들이 서로 다른 심리적 특성을 가질 가능성을 시사한 것이라고 판단되며, 이는 치료에 있어서도 좀 더 개별화된 접근이 필요함을 시사한다. Objectives : The aim of this study was to evaluate the psychological characteristics of the patients with bruxism by Minnesota Multiphase Personality Inventory (MMPI). Methods : MMPI was administered to 87 patients(46 bruxism group and 41 control group) who had visited a local dental clinic from January to August 1998. Results : The bruxism group had a higher score than control group in Masculinity-Femininity (Mf) scale. There were no differences between bruxism group and control group on the distribution of Depression(D), Psychopatic Deviate(Pd), Paranoia(Pa), Psychasthenia(Pt) scales. The bruxism group with the family history showed higher score than the bruxism group without family history in Pd scale. Male bruxism group had a higher score than female bruxism group in Defensiveness(K) scale and female bruxism group had higher score than male bruxism group in Pa scale. The bruxism group of clenching type had a higher score than the bruxism group of mixed type in Social Introversion(Si) scale. There were no differences in MMPI score between those who had and did not have symptoms such as masticatory muscle pain, neck pain, and headache. Conclusion : It is concluded that individualized approach may be effective to the evaluation of psychological disturbances which might be related to sex, family history and, type of bruxism, while we did not find significant differences in personality characteristics between the bruxism and control groups.

영어 전치수식 형용사의 어순규칙 수립을 위한 핵어문법(HPSG)적 접근

박희문 한국현대영어영문학회 2006 현대영어영문학 Vol.50 No.1

Candida albicans의 형태변환 조절과정 규명의 최근 연구 동향

박윤희,박희문 충남대학교 생물공학연구소 2009 생물공학연구지 Vol.15 No.-

The opportunistic fungal pathogen Candida albicans can grow as yeast, pseudohyphae or true hyphae, and morphology of each cell is essential for efficient dissemination and tissue invasion. Therefore the ability to switch in C. albicans is thought to be an important virulence factor. The morphological conversion of C. albicans can be triggered in vitro by a various environmental stimuli including serum, pH, temperature, and nutrient depletion. These inducers regulate the expression of hypha-specific genes, which are involved in morphogenesis, through multiple signaling pathways such as MAPK pathway and cAMP/PKA pathway. In order to investigate Signal transduction pathways, disruption or over-expression of the component gene(s) were performed and then change(s) in morphological transition as well as the expression of hypha-specific genes are observed in general. As the approach to unravel new roles of already-known signaling pathways in fungal pathogenicity, responses toward external stimuli such as hypoxic condition and iron utilization are performed these days. The new approaches revealed that the morphological conversion in C. albicans is resulted from the consorted action of multiple signaling pathways rather than from a single pathway. Consequently, the existence of a novel Signaling pathway for dimorphic switch in C. albicans could not be excluded. In this context, it is noteworthy that the involvement of LAMMER kinase in fungal development; LAMMER kinase is known to be involved in oxidative-stress response, filamentous growth, and flocculation in fission yeast; S. cerevisiae LAMMER kinase, ScKNS1, is also reported to phosphorylate Slt2, MAPK of cell wall integrity pathway, and to interact with dual-specificity phosphatase Sdp1, which regulates the activity of Slt2. Therefore, studies on the function of LAMMER kinase in C. albicans will be helpful to reveal novel regulatory mechanisms for virulence in pathogenic fungi.