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      • 균류 분화과정의 유전적 조절기작

        박범찬,이환희,박윤희,박희문 충남대학교 생물공학연구소 2003 생물공학연구지 Vol.9 No.1

        Fungi are well suited for studying mechanism controlling development and cell differentiation in multicellular eukaryotes. The asexual and sexual reproductive cycles are tightly coordinated during the life cycle of Aspergillus nidulans. The asexual (mitotic) reproductive cycle involves the formation of a number of differentiated cell types. Successful formation of multicellular reproductive structures and spores (conidia) requires the establishment of spatiotemporal gradients in essential transcriptional regulators, such as brlA, abaA and wetA. Altered gene expression is coordinated with critical changes in the movement of nuclei and the regulation of the cell division cycle. Therefore, it has been proposed to define a central regulatory pathway. Several early regulatory genes involved in signal transduction pathway controlling asexual sporulation are also required for activating the central pathway. Sexual (meiotic) reproduction is more complex, requiring the differentiation of several specialized tissue types. Although technical difficulties have limited efforts to study the genetics of sexual fruiting-body formation directly, some recent progress has been made. With the recent availability of mutants blocked in sexual development, understanding the genetic interactions between genes that function primarily in determining sexual sporulation will be achieved in the near future.

      • KCI등재

        중의학에서 소아 설사에 적용하는 한약 보류관장요법에 대한 문헌 고찰

        박범찬,천진홍,김기봉,김희연 대한한방소아과학회 2019 대한한방소아과학회지 Vol.33 No.4

        Objectives: The purpose of this study is to analyze recent Chinese randomized controlled trials on efficacy and safety of the retention enema with herbal medicine in pediatric diarrhea. Methods: We searched recent Chinese randomized controlled trials from the China National Knowledge Infrastructure (CNKI) by using key words; ’保留灌肠’, ’小儿’, '腹泻', and '泄泻', with data range from January 1st, 2010 to March 2nd, 2019. Year of the publication, demographic information, disease, intervention, outcome measure, results, adverse events and composition of herbal medicine were analyzed for this study. Results: 19 out of 32 studies were selected and analyzed. The most commonly used herbal medicine was Galgeungeumlyeon-tang modification (葛根芩连汤加减), and the most widely used retention enema method was to retain for 15 minutes and administer twice a day for 3 days. In most of the studies, retention enema with herbal medicine in pediatric diarrhea showed significant efficacies. No adverse effects were reported from the studies. Conclusions: The results of these studies from China showed that the retention enema with herbal medicine in pediatric diarrhea may be effective and safe.

      • KCI등재

        특발성 황반부 모세혈관 확장증 II형 환자의 황반부 신경절세포- 내망상층 두께

        박범찬,정다은,김성택 한국망막학회 2022 Journal of Retina Vol.7 No.1

        Purpose: To evaluate macular ganglion cell-inner plexiform layer (mGCIPL) thickness and peripapillary retinal nerve fiber layer (pRNFL) thickness in eyes with idiopathic macular telangiectasia type II (Mactel). Methods: Retrospective cross-sectional study including 26 eyes (14 subjects) diagnosed with idiopathic macular telangiectasia type II (Mactel group) and 26 eyes of 26 healthy control subjects (control group). The pRNFL thickness and mGCIPL thickness were measured using spectral-domain optical coherence tomography. Results: Average, minimum, superotemporal, and inferotemporal mGCIPL thicknesses in the Mactel group were significantly thinner than in the control group. There was no significant difference in pRNFL thickness between the two groups. Conclusions: mGCIPL thickness decreased in the Mactel group compared with the control group. 목적: 특발성 황반부 모세혈관 확장증 II형 환자에서 빛간섭단층촬영기를 이용하여 황반부 신경절세포-내망상층과 시신경유두주위 망막신경섬유층의 두께를 평가해 보고자 하였다. 대상과 방법: 특발성 황반부 모세혈관 확장증 II형 환자 26안(14명)을 대상으로 하였으며, 정상안 26안을 대조군으로 하여 후향적으로 비교하였다. 스펙트럼영역 빛간섭단층촬영을 이용하여, 황반부 신경절세포-내망상층과 시신경유두주위 망막신경섬유층의 두께를측정하였다. 결과: 특발성 황반부 모세혈관 확장증 II형 환자군과 대조군과 비교하였을 때, 황반부 신경절세포-내망상층 두께의 평균값, 최소값과상이측, 하이측 황반부 신경절세포-내망상층의 두께가 의미 있는 차이를 보였다. 시신경유두주위 망막신경섬유층의 두께는 두 군 간의 차이를 보이지 않았다. 결론: 특발성 황반부 모세혈관 확장증 II형 환자에서 황반부 신경절세포-내망상층의 두께가 얇아져 있음을 확인하였다.

      • KCI등재

        황련감초 추출물의 상피지방장벽 생성을 통한 Th2 분화 조절

        박범찬,안상현,서일복,천진홍,김기봉 대한한방소아과학회 2020 대한한방소아과학회지 Vol.34 No.3

        Objectives: This study is conducted to evaluate Th2 skewed condition control through skin fat barrier formation from the treatment using Coptidis Rhizoma and Glycyrrhiza uralensis extract. Methods: The 6-week-old NC/Nga mice were divided into 4 groups: Control group (Ctrl), lipid barrier eliminate treatment group (LBET), Coptidis Rhizoma and Glycyrrhiza uralensis feeding treatment after lipid barrier elimination group (CGFT), dexamethasone feeding treatment after lipid barrier elimination group (DxFT). After 3 days, differences in skin condition, improvement of skin fat barrier, and control of Th2 skewed condition of each group were observed. Results: Pathologic skin damage and tissue changes were less in the CGFT group than in the LBET and DxFT groups, and Transepidermal water loss (TEWL) and pH were also significantly decreased (p < 0.05). The filaggrin intensity and positive response also increased significantly in the CGFT group (p < 0.05). Kallikrein-related peptidase (KLK) 7, Protease activated receptor (PAR)-2, Thymic stromal lymphopoietin (TSLP), Interleukin (IL)-4, and the products of the Th2 differentiation process also showed a significant decrease compared to the LBET and DxFT groups (all p < 0.05). Conclusions: The Coptidis Rhizoma and Glycyrrhiza uralensis extract causes skin barrier recovery and function recovery through the formation of skin fat barrier. This leads to the conclusion that Coptidis Rhizoma and Glycyrrhiza uralensis extract can control Th2 differentiation through the formation of skin fat barrier.

      • KCI등재

        고병원폐렴막대균 침습증후군에 의한 간농양에 동반된 내인안내염

        박범찬,임화랑,신민호 대한안과학회 2019 대한안과학회지 Vol.60 No.12

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        목적: 고병원폐렴막대균에 의한 침습증후군에 동반된 간농양에서 안내염 및 팔꿈치 농양 1예를 경험하였기에 보고하고자 한다. 증례요약: 33세 남자가 내원 4일 전부터 발생한 우안의 무통성 시력저하를 주소로 내원하였다. 일주일 전부터 우측 팔꿈치 통증, 열감, 부종이 있었다고 하였다. 외상 기왕력 및 기저질환은 없었다. 전안부검사상 전방염증, 전방축농이 관찰되었으나, 안구충혈은 관찰되지 않았다. 포도막염에 준하여, 점안 항생제, 스테로이드, 산동제를 투여하였고, 테논낭하 스테로이드주입술을 시행하였다. 정형외과에 의뢰한 후 우측 팔꿈치 농양으로 수술을 시행하였다. 수술 후 2일째, 안구 통증 및 충혈 소견과 함께 전신 발열, 오한 등의 전신 상태가 악화되어, 감염안내염 소견으로 유리체절제술을 시행하였고 술 중 망막하 및 맥락막농양이 보여 안구적출술을 시행하였다. 내과로 전과된 후 간농양도 발견되었으며, 혈액과 간, 안구 배양검사에서 고병원폐렴막대균이 검출되었다. 결론: 기저질환이 없는 젊은 환자에게도 고병원폐렴막대균에 의한 원발간농양이 발생할 수 있으며, 합병증으로 안내염 및 팔꿈치의 농양도 일으킬 수 있다. 특히 고병원폐렴막대균에 의한 안내염은 예후가 아주 불량하므로 조기에 적절한 진단과 치료가 필요할 것으로 사료된다. Purpose: To report a case of endogenous endophthalmitis with an elbow abscess spread from a liver abscess in a patient with hypervirulent Klebsiella pneumoniae (hvKP) invasive syndrome. Case summary: A 33-year-old healthy male presented with painless visual loss in his right eye. He experienced pain, a febrile sensation, and swelling in his right elbow for 1 week prior. He had no trauma history. Many inflammatory cells, hypopyons, and cyclitic membranes were present in the anterior chamber of the eye but no ocular injection was performed. With a provisional diagnosis of panuveitis, topical antibiotics, steroid, and cycloplegics were administered and subtenon triamcinolone was injected. After orthopedic consultation, an elbow abscess was suspected and surgery was performed. Two days after the surgery, the patient experienced ocular pain and an injection was performed. Fever, chill, and acute deterioration of his general condition were noted which suggested infective endophthalmitis. Emergency vitrectomy was performed but because subretinal and choroidal abscesses were observed during surgery, the surgery was changed to enucleation. A liver abscess was observed using abdominal computed tomography after transfer to the infection medical department and hvKP was positive in the blood, liver, elbow, and eye cultures. Conclusions: A primary liver abscess caused by hvKP occurred in a healthy young man and metastatic infection occurred with endogenous endophthalmitis and a rare elbow abscess. Because hvKP endogenous endophthalmitis has a poor prognosis, rapid diagnosis followed by appropriate treatment is required.

      • KCI등재

        Transcriptional Regulation of fksA, a β-1,3-Glucan Synthase Gene, by the APSES Protein StuA during Aspergillus nidulans Development

        박범찬,박윤희,이수현,최유경,강은혜,박희문 한국미생물학회 2014 The journal of microbiology Vol.52 No.11

        The temporal and spatial regulation of β-1,3-glucan synthesisplays an important role in morphogenesis during fungalgrowth and development. Northern blot analysis showedthat the transcription of fksA, the gene encoding β-1,3-glucansynthase in Aspergillus nidulans, was cell-cycle-dependentand increased steadily over the duration of the vegetative period,but its overall expression during the asexual and sexualstages was fairly constant up until the time of transcriptioncessation. In an A. nidulans strain mutated in the eukaryoticbHLH-like APSES transcription factor stuA1, the transcriptionallevel of fksA, and consequently the content ofalkali-insoluble cell wall β-glucan, significantly increased atthe conidial chain formation and maturation stage. Electrophoreticmobility shift assays revealed that StuA was boundto StREs (StuA Response Elements) on the fksA promoterregion. Promoter analysis with sGFP-fusion constructs alsoindicated the negative regulation of fksA expression by StuA,especially during asexual development. Taken together, thesedata suggest that StuA plays an important role in cell wallbiogenesis during the development of A. nidulans, by controllingthe transcription level of fksA.

      • KCI등재

        황련해독탕의 위염 치료 효과에 대한 단일비교 임상연구

        박범찬,김희연,김광연,양주혜,김경호,도현주,지선영,최준용,김영우,박광일,김기봉 대한한의학방제학회 2020 大韓韓醫學方劑學會誌 Vol.28 No.2

        Objectives : The purpose of this clinical study was to investigate the efficacy and safety of Hwangryunhaedok-tang on the gastritis treatment. Methods : A total of 20 subjects who visited Pusan National University Hospital from April 2nd, 2019 to September 2nd, 2019 were included. In this study, we evaluated the individual symptoms through questionnaires, laboratory test, BIA (Bioelectrical Impedance Analysis), and adverse reaction according to medication. Statistical analysis was performed with paired t-test and Wilcoxon Signed Rank test. Statistical significance was achieved if the probability was less than 5% (p < 0.05). Results : After medications, the total score of individual symptoms, primary outcome, was significantly decreased. In particular, individual symptoms such as upper abdominal pain, bloating, heartburn and trim showed significant improvement. However, no statistically significant differences were found in nausea/vomiting and anorexia. In additions, the laboratory test showed a statistically significant decrease in total cholesterol, but no statistically significant differences in results of BIA. In the safety evaluation, adverse reactions were not reported. Conclusions : Considering this results, we have confirmed the possibility of Hwangryunhaedok-tang to the gastritis treatment.

      • KCI등재

        태권도 품새지도자의 리더십 유형이 품새 선수들의 집단응집력과 운동만족에 미치는 영향

        박범찬 세계태권도문화학회 2011 세계태권도문화학회지 Vol.- No.3

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        The purposes of this study are to verify the correlation between the leadership styles of taekwondo poomsae master, group cohesiveness, exercising satisfaction and to investigate how the leadership styles of taekwondo poomsae master affect group cohesiveness and exercising satisfaction so that it can provide some basic information for instructing taekwondo players and managing poomsae national teams effectively. The specific topics of this study are as follow. Topic 1. Depending on the period of player's career, how the leadership styles of taekwondo poomsae master, group cohesiveness and exercising satisfaction make differences? Topic 2. How the leadership styles of poomsae master affect group cohesiveness? Topic 3. How the leadership styles of poomsae master affect exercising satisfaction? This study was conducted with the subjects who participated in national taekwondo poomsae competition in 2011 as high school taekwondo poomsae players and suggests that the leadership styles of taekwondo poomsae master have an effect on group cohesiveness and exercising satisfaction directly and indirectly. Therefore, with regard to the result of this study, although the study set a limit to player's career as background cause, it is required that more research should be conducted in relation to many kinds of personal and circumstance factors such as leadership style of leader, group cohesiveness, player's age, gender, position in a team, career as team member and these extensive factors should be considered in a subsequent study.

      • KCI등재

        Aspergillus nidulans 영양균사에서 효소전구체형 ChsC 활성의 검출

        박범찬,박윤희,박희문 한국미생물학회 2004 미생물학회지 Vol.40 No.2

        Saccharomyces cerevisiae의 class I 키틴생합성 효소인 Chsl의 활성측정법을 적용하여 Aspergillus nidulans의 영양균사에서 class I 키틴생합성 효소인 ChsC의 활성측정을 시도하였다. 그 결과, A. nidulans의 class I 키틴생합성효소도 효모류의 경우와 마찬가지로 트립신 처리에 의하여 활성화되는 효소전구체형태(zymogenic form)로 존재함을 알 수 있었다. 그리고 A. nidulans 야생형의 class I 키틴 생합성 효소활성은 트립신 처리에 의하여 6배 가량 증가되었다. 반면, chsC 유전자가 파괴된 돌연변이주는 트립신 처리에 의하여 효소활성이 증가되지 아니하였을 뿐만 아니라, 효소활성의 수준도 트립신을 처리하지 아니한 야생형의 class I 키틴생합성 효소활성과 거의 동일한 수준이었다. 따라서, 트립신을 처리하여 측정한A. nidulans 야생형의 class I 키틴생합성 효소활성 값에서 트립신을 처리하지 아니한 야생형의 class I 키틴생합성 효소활성을 제외한 값이 A. nidulans 야생형의 ChsC 효소활성임을 알았다. 이러한 조건을 토대로 영양균사 생장과정 동안 ChsC의 효소활성을 측정한 결과, chsC 유전자의 발현양상과 유사하게 액체배양상태의 영양균사가 무성분화능을 획득하는 시기로 알려진 시간대에 효소의 활성이 증가하였다. 이러한 결과는 이미 보고된 바와 같이 chs 유전자가 A. nidulans의 영양균사 생장에 관여함을 시사하고 있다. In the vegetative hyphae of Aspergillus nidulans, a zymogenic form of the class I chitin synthase activity was successfully measured by the assay condition for Saccharomyces cerevisiae class I chitin synthase, Chsl. The class I chitin synthase activity of the A. nidulans chsC wild type strain was increased about six-fold by trypsin-pretreatment, but that of the chsC disruption strain revealed no increase. Interestingly enough, level of the class I chitin synthase activity of the chsC disruption strain was almost the same as that of the chsC wild type without trypsin-pretreatment. These results indicated that the A. nidulans ChsC activity could be measured by account-ing the class I chitin synthase activity without the trypsin-pretreatment as an internal control. Consistence to the expression pattern of the chsC revealed by northern blot analysis, the activity of ChsC was increased upon reaching the culture time for acquiring developmental competence. Our results shown here also supported the previous report suggesting the possible involvement of ChsC in vegetative hyphal growth of A. nidulans.

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