http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 정희원 (검색결과 523 건)
- 무료
- 기관 내 무료
- 유료
-
-
-
-
정희원,고영초,한대희,심보성,지제근 대한신경외과학회 1979 Journal of Korean neurosurgical society Vol.8 No.1
Two case of cerebral infestation with Paragonimus westermani complicating obstructive hydrocephalus are presented. The diagnosis was aided by brain CT scan and Conray ventriculogam. Both cases showed a strong positive intradermal test with relevant histories of eating crayfishes in roast form. In simple skull X-ray, one stowed characteristic shell-like calcifications over the temporo-occipital region and the otter showed multiple round calcifications over the suboccipital region. Brain CT scan demonstrated much more characteristic calcifications with marked ventricular dilatation. Conray ventriculogram disclosed obstructive hydrocephalus in both cases, one at the level of the cerebral aqueduct and the other at the level of the fourth ventricle outlet. Both patients were subjected to ventriculoatrial shunts and concommitant Bithionol therapy with marked improvement. The case involving the cerebellum and the fourth ventricle outlet was submitted to the posterior fossa exploration to be verified as a rare cerebellar paragonimiasis.
-
시신경 손상없이 좌측 시신경공을 통과한 이물(알미늄제 젓가락)의 1예
정희원,차희중,한대희,심보성 대한신경외과학회 1976 Journal of Korean neurosurgical society Vol.5 No.2
A 20-year-old, male patient was admitted to the Department of Neurosurgery, Seoul National University Hospital, complaining- of painful swelling of the left orbit. Two days before admission, patient sustained piercing of an aluminium chopstick at his left upper eyelid by his friend accidentally. Fluttered friend tried to pull out the chopstick manually but only broke its proximal portion. On neurologic and ophthalmologic exam, he was fully conscious and free from neurologic deficits at all. His visual acuity was as usual and examination of fundi, extraocular muscle functions, visual field and pupillary light reflex were all within normal limit. Subconjuctival hemorrhage and chemosis were positive findings. Skull X-rays including optic foramen, view revealed broken distal part of the chopstick, about 7 ㎝ in length, which passed through the left lateral orbit and left optic foramen to reach sellar region across the midline. Emergency Kro¨nlein-Berke's lateral orbitotomy was performed and the chopstick was removed without difficulty. Postoperatively patient showed good recovery and presented quite normal and usual eve function.
-
정희원,한종우,김종수,정천기,전상룡,최길수 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.12
The present study investigated whether organotypic spheroids derived from human fetal brain tissue, cultured at agarose-overlay media may serve as an optimal in vitro model for multidisciplinary studies in human neurobiology, particularly in the fields of tumor invasiveness and its biochemical mechanism, using light microscopy. electron microscopy and immunohistochemical staining Eight fetal brain tissues of 8-9 weeks of gestation were minced and explanted into agarose-coated culture wells. After three to five days these human fetal brain tissue fragments emerged as spheroids and could be maintained as organotypic spheroids for up to seven weeks. Light and electron microscopic studies of spheroids demonstrated that most cells were poorly differentiated and there were no definite mature neurons or glial cells after enough culture time, but some cells showed certain evidence suggestive of differentiation to neurons or glial cells immunohistochemical staining for glial fibrillary acidic protein(GFAP) and neuron specific enolase(NSE) demonstrated that NSE-positive cells were oval or spherical cells containing abundant cytoplasm and GFAP-positive cells were fibrillary cytoplasma-containing cells which showed some evidence suggestive of differentiation to glial cells by light microscopy. In future, adding some modifications in culture, this organotypic spheroids derived from the human fetal brain may serve as an optimal in vitro model for neurobiology, especially in the field of studies on tumor invasiveness through co-culture with microtumor spheroids.
-
초점성 뇌허혈에서 재관류가 국소뇌혈류 변화에 미치는 영향에 관한 실험적 연구
정희원,고학종,김현집,조병규,김성완,민병구,한대희,심보성,최길수 대한신경외과학회 1987 Journal of Korean neurosurgical society Vol.16 No.3
Reperfusion into focal ischemia using a transorbital snare ligature was studied in 20 unanesthetized cats following middle cerebral arrtery (MCA) occlusion of 1 to 6 hours duration. Changes of a regional cerebral blood flow (rCBF) were investigated upon with a hydrogen clearance method in the center and periphery of the MCA territory, which were correlated with the size of infarct delineated by a 2% triphenyl tetrazolium chloride solution and with the occurrence of severe brain edema or hemorrhagic infarct. The results were as followings: 1) Post-ischemic hyperperfusion was usually found after 1 hour occlusion of MCA followed by 2 hours recirculation. Final rCBF, however, reached pre-occlusion value and little or no infarct was found. 2) In the 2 hours occlusion-reperfusion group, hypoperfusion after reopening of MCA was regularly found in both the center and the periphery of ischemia, which was well contrasted with hyperperfusion in the I hour occlusion group and was accompanied by evident but mild infarcts. 3) After 4 and 6 hours occlusion, there was usually evident post-ischemic hyperperfusion soon followed by development of severe hypoperfusion and a higher grade of infarct and hemispheric swelling was found. 4) Final hypoperfusion after transient MCA occlusion was observed only after ischemic periods lasting 2 hours or more irrespective of preceding post-ischemic hyperperfusion and was only related to the duration of the occlusion and not to the degree of blood flow disturbance. 5) Spontaneous hyperemia during occlusion was found in 3 of the 5 cats used in each of the 4 and 6 hours occlusion groups, in which there was marked hyperperfusion after reopening of MCA followed by severe hypoperfusion and transtentorial herniation associated with resulting extensive hemorrhagic infarct and marked hemispheric swelling. 6) Hemorrhagic infarcts were found in one cat of the 4 hour-occlusing group and two of the 6 hour-occlusion group, all of whom showed early hyperemia before reperfusion predictable of such a detrimental result. 7) These data indicate that potential hazard for surgical revascularization in the acute stage of ischemic stroke should be considered in case profound ischemia had already progressed for 4 hours or more and especially when hyperemia during the initial stage of severe ischemia is observed at the center and the periphery of the ischemic area expected.
-
후하소뇌동맥 원위부에 발생한 뇌동맥류 : 증례보고 Case Report with Review of the Literature
정희원,한대희 대한신경외과학회 1984 Journal of Korean neurosurgical society Vol.13 No.1
True congenital saccular aneurysms of distal posterior inferior cerebellar arteries are rare. We describe a 29 year-old female patient with subarachnoid hemorrhage in whom a nonmycotic saccular aneurysm arising from the tonsillomedullary segment of the left posterior cerebellar artery was demonstrated. This aneurysm was successfully clipped with good postoperative result. Brief review of the literature is also presented.
-
정희원,심기범,정천기 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.12
A retrospective analysis was performed to evaluate the prognostic factors affecting the length of survival of 86 adults(age>15 years) with newly diagnosed biopsy-proven supratentorial anaplastic astrocytomas and glioblasmas treated at the Seoul National University Hospital and Korea Cancer Center Hospital between June, 1980 and June, 1990. Of the 86 patients, 44 patients (51%) had anaplastic astrocytoma, and 42 patients(49%) had glioblastoma multiforme. The mean age was 40 years, and mean initial Karnofsky performance score(KPS) was 70. The duration of follow up ranged from 3 months to 85 months. Survival curves were generated using the Kaplan-Meier curves. Median survival times were compared using the log-rank test. Additionally, for a study of the prognostic importance of multiple factors acting simultaneously, the proportional hazards regression model of Cox was used in which survival times were modeled as a function of the important independent variables identified in the univariate analysis. Categories included biopsy, partial resection, and gross total resection. Seventeen patient(20%) who underwent a gross total resection of their tumors had median survival time and 6-, 12-, 24- month survival rates of approximately 33 months, 94%, 80% and 57% respectively, when compared to 13 months, 74%, 53%, 34% for fifty patients(60%) who had partial resection. Multivariate analysis demonstrated that the age(p=0.010), the initial KPSP(p<0.001), the histology(p<0.001) and the extent of resection (p=0.016) were significant and independent variables influencing survival. These results suggest that gross total resection of supratentorial anapalstic astrocytomas and glioblastomas is directly associated with longer survival when compared to partial resection or biopsy.
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
