http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 이인철 (검색결과 712 건)
- 무료
- 기관 내 무료
- 유료
-
-
-
-
-
-
-
-
-
Inhibitory effect of vicenin-2 and scolymoside on secretory group IIA phospholipase A2
이인철,배종섭 한국통합생물학회 2015 Animal cells and systems Vol.19 No.5
It is well known that the expression level of secretory group IIA phospholipase A2 (sPLA2-IIA) is elevated in inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Cyclopiasubternata is a medicinal plant commonly used in traditional medicine to relieve pain in biological processes. Here, two structurally related active compounds found in C. subternata, namely vicenin-2 and scolymoside, were examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mouse. Prior treatment of cells or mouse with vicenin-2 and scolymoside inhibited LPS-induced expression and activity of sPLA2-IIA. And each compound suppressed the activation of cytosolic phospholipase A2 (cPLA2) and extracellular signal-regulated kinase (ERK) 1/2 by LPS. Therefore, these results suggest that vicenin-2 and scolymoside inhibited LPS-mediated expression of sPLA2-IIA by suppression of cPLA2 and ERK 1/2.
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
