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Inhibitory effect of vicenin-2 and scolymoside on secretory group IIA phospholipase A2
이인철,배종섭 한국통합생물학회 2015 Animal cells and systems Vol.19 No.5
It is well known that the expression level of secretory group IIA phospholipase A2 (sPLA2-IIA) is elevated in inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Cyclopiasubternata is a medicinal plant commonly used in traditional medicine to relieve pain in biological processes. Here, two structurally related active compounds found in C. subternata, namely vicenin-2 and scolymoside, were examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mouse. Prior treatment of cells or mouse with vicenin-2 and scolymoside inhibited LPS-induced expression and activity of sPLA2-IIA. And each compound suppressed the activation of cytosolic phospholipase A2 (cPLA2) and extracellular signal-regulated kinase (ERK) 1/2 by LPS. Therefore, these results suggest that vicenin-2 and scolymoside inhibited LPS-mediated expression of sPLA2-IIA by suppression of cPLA2 and ERK 1/2.