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마우스 B세포에서의 Interleukin 4에 의한 IgGI 및 IgE 생산조절에 관한 연구
문희범 대한천식알레르기학회 1991 천식 및 알레르기 Vol.11 No.5
Mouse interleukin 1(IL-4) is a T cell-produced lymphokine with multiple effects on different cell types of the hematopoietic lineages. IL-4 has pronounced effects on B lymphocytes, where it induces high levels of IgG1 and IgE secretion in lipopolysaccharide (LPS)-stimulated cultures that would otherwise secrete predominantly IgG3 and IgG2b. An important question which been adked is how IL-4 exerts its effect. Two main possibilities exist; (a) 1L-4 instructs uncommitted B lymphocytes to produce IgG1 and IgE; (b) IL-4 selects and expands an already precommitted B cell. In this study, the limiting dilution analysis showed that IL-4 dramatically increased the precursor frequency of IgG1 and IgE-secreting cells with no significant effect on the clone size, and it clearly suggested that IL-4 instructs uncommitted B cells to switch to IgG1 and IgE. The characteristics of IL-4-regulated Ig isotype production in LPS-stimulated splenic B cell cultures also were studied with emphasis on the comparison between the IgG1 and IgE responses. The results showed that the kinetics for the appearance of IgG1 and IgE isotypes was similar, but the dose of IL-4 required for the induction of an IgE response is 3 to 10 times higher than that for an IgG1 response. No requircment for T cells was found for the induction of either isotype IL-4 alone was sufficient to induce an IgG1 response when cells were recultured with LPS from day 1 to day 6. However, the simultaneous presence of both IL-4 and LPS for more than 24 hours was required for a detectable IgE response. For an optimal IgE response, IL-4 needed to be present for more than 72 hours in LPS-activated cultures. The possible reasons for the,different regulation of IgG1 and IgE responses are discussed.
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문희범,김유영,강석영 대한천식알레르기학회 1985 천식 및 알레르기 Vol.5 No.2
A Case of occupational asthma due to awelding flux is presented. The patient was a welder engaged in gas welding of copper, nickel alloy, and zincplated iron, etc. in a shipyard. His astb,rnatic symptoms developed 5, yrs ago snd used to be provoked or aggravated by welding procedure. Bronchoprovocation tests were performed during which the patient welded several kinds of metals with his own hands. Interestingly, wheezing dyspnea and decreased expiratory flow rate were observed only when he used a wel:dng flux. Direct bjurning of the flux without metal also resu)ted in airway obstruction. However, the causative off- ending constituent of the flux couldnt be ide'ntified, because the patient died of acute astbmatic attack on his sbop floor and further study was impossible.
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꿀벌 ( Apis mellifera Linne ) 독 알레르기의 1례
문희범,강석영 대한천식알레르기학회 1983 천식 및 알레르기 Vol.2 No.1
A 4 7 year old w om a.n visited our Allergy Clinic in April 1981 with the chief complaints cf syncopal att acks and recurrent urticaria. S he w as an apiarists wife living I n a rural area. There w ss no remarka- ble past or farmily his.'cries. One day in June 198 0, she was stung by a hone yb e ( Apis mellifera Linne ) on the he d at home. A few minutes laier, gener alized itching urticaria, chest tightness, dizzin ess and finally s vnccpe develo- pe d. Emergency tre atment was done at a local c lin- ic, and all symptcr rs disppeared in the next mcr n ing. P revicusly she w s s tur.g by honeybees on the extremites two or three times in the spring cf that year, but there ws no systemic reacticns, Since abcut 15 days sf ier the sy nccp zl attack, re- current chronic ur ticaria develc ped svithcut att ributa- ble cause or seascn a l variaiio n. In september 1 58 0, s he w as stung g -I n on the arm with rel stiv e ly l arge loc sl re ac ticn I n April 1 981, s 4e experi enced t xv o tirr.es cf fai nt- ing att ack and vsu ! Ar ccl! Spse in the fu!1 blown stage cf gener a lize 3 urtic a ri a. She h.d no defini te memor y cf bee s.in g , On ph ysical ex amin it icr., no r em ar' ab !e nbncrm- ali t v was f -und except mi l d derm c graph I s v , On laboratory examination, CBC was normal, urine and stool exam. Negative, total serum IgE level 354 IU/ml by RlST, Skin test with 1% body extract cf Apis mellifera showed pcsitive reaction, We concluded that this patient had honeybee ven- om allergy with a typical history cf anaphyl axis, although the causes of recurrent urticaria a nd recent syncopal attacks were uncert ain.
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