Benzothiazolyl Biguanides의 항미생물작용

임철부,이인숙,임채욱 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-

The twenty benzothiazolyl biguanides synthesized were evaluated for their antimicrobial activities against Staphylococcus aureus. Bacillus subtilis, Mycobacterium phlei, Escherichia coli, Microsporium canis, Candida albicans, Sporothrix schenkii and Trichophyton mentagrophytes. The results obtained were as follow : The most active compound, 1,6-bis{N^5-(6-chlorobenzothiazol-2-yl)-N^1-biguanido} hexane·2HCI (14) showed the growth inhibitory activity against S. aureus at the concentration of 7.81ug/mL, against B.subtilis at 15.63ug/mL and against M. phlei at 31.25ug/mL. 1,6-Bis {N^5-(6-chlorobenzothiazol-2-yl)-N^1-biguanido} hexane·2HCI(14), 1,6-Bis{N^5-(6-bromobenzothiazol-2-yl)-N^1-biguanido) hexane·2HCI (15) and N-(6-chlorobenzothiazol-2-yl)-1-piperidinylamidinoamidine·HCI (24) inhibited the growth of M. phlei at the concentration of 31.25ug/mL respectively. 1,4-Bis{N^5-(6-methylbenzothiazol-2yl)-N^1-biguanido}butane·2HCI(9) and 1,4-bis{N^5-(6-bromobenzothiazol-2-yl)-N^1-biguanido}butane·2HCI(11) exhibited the antimicrobial activity against B.subtilils at the concentration of 31.25ug/mL. Twelve new biguanide compounds showed growth inhibitory activities against C. albicans at the concentration of 400ug/mL.

Benzothiazolyl Biguanides의 합성

임철부,이인숙,임채욱 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-

In order to find new antimicrobial agents, twelve new alkylene bis benzothiazolyl biguanides and eight benzothiazoly biguanides were synthesized. The treatment of alkylenediamines·2HCI with sodium dicyanamide afforded alkylene bis cyanoguanidines. Alkylene bis benzothiazolyl biguanides were synthesized by the reaction of alkylene bis cyanoguanidines with 2-aminobenzothiazole. Benzothiazolyl biguanides were obtained from N-cyanoheterocyclylamidines and 2-aminobenzothiazoles through the similar procedures.

Gilbert 증후군에서 열량 제한 시험과 Phenobarbital 자극 시험의 의의(14예)

이헌영,채경훈,정재훈,강윤세,김연수,문희석,박기오,이엄석,김선문,김석현,성재규,이병석,이강욱 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Gilbert 증후군은 인구의 7%에서까지 나타날 수 있는 매우 흔한 증후군으로서 비진행성인 양성의 만성적 경과를 치하며, 간질환의 증상과 징후가 없는 경한 비포합형 고빌리루빈혈증이 특징인 일종의 체질적인 증상으로서 혈장 빌리루빈 농도에 대한 사춘기의 영향 때문에 10대와 20대에 자주 진단이 된다. 따라서 임상적인 중요성은 미약하지만 높은 빈도가 예상되는 점에 그 중요성이 부여되어야 할 것이다. 따라서 적정한 임상적 진단법으로 기왕에 소개된 열량제한 시험과 phenobarbital 유도 시험을 시행하고 이들의 진단적 가치를 알아보기 위하여 본 연구를 시행하였다. 1990년 7월부터 1999년 4월까지 충남대학교병원에 내원하여 HBsAg, IgG anti-HBc 및 anti-HCV가 음성이고, 간 초음파 스캔에서 이상이 없으며, 혈청 AST, ALT 및 AP가 정상인 비음주자에서 경한 비포합형 고빌리루빈혈증이 있는 14예의 환자들을 대상으로 ^(99m)Tc-DISID 스캔을 시행하였으며, 기저 치 총빌리루빈 및 포합형 빌리루빈 치를 측정한 다음에 하루에 400Kcal로 48시간동안 제한한 열량 제한 시험을 시행하였고, phenobarbital을 하루 60mg씩 5일간 투여한 후에도 각각 총빌리루빈과 포합형 빌리루빈 치를 검사하여 비포합형을 구하였다. 대상 환자들은 모두 14예로서 남자가 11예(78.6%)였고 여자가 3예(21.4%)여서 3.7:1로 남자에서 많았으며, 20대가 6예(42.9%), 30대가 역시 6예(42.9%) 및 40대가 2예(14.2%)로서 2,30대가 대부분(85.8%)이었다. 열량 제한 시험 후의 총빌리루빈 치, 비포합형 및 포합형 빌리루빈 치들은 평균 각각 5.5±2.7, 4.2±2.3 및 1.3±10mg/dL 로서, 시험 전 치들인 3.0±0.8, 2.2±0.8 및 0.7±0.4mg/dL 보다 유의하게(p=0.001, p=0.001, p=0.023) 상승하였다. 포합형 빌리루빈 치도 유의하게 상승하였으나 비포합형의 상승보다는 훨씬 낮아서 주로 비포합형이 증가하였다. phenobarbital 투여 중 설사가 발생하여 중단한 1예를 제외한 13예에서 열량 제한 시험 후에 상승하였던 총, 비포합형 및 포합형 빌리루빈 치가 phenobarbital 유도 시험후에는 2.0±1.1, 1.5±0.8 및 0.5±0.4mg/dL로서 열량 제한 시험 결과보다 유의하게 낮아졌고(p=0.00, p=0.000, p=0.001), 열량 제한 시험 전의 기초치들인 3.0±0.8, 2.2±0.8 및 0.7±0.4mg.dL 보다도 더욱 낮아졌으며 유의한 차이(p=0.001, p=0.02, p=0.005)를 나타내었다. 14예에서 시행한 ^(99m)-Tc DISIDA 스캔에서 9예(64.3%)가 정상이었고, 5예(35.7%)에서는 심장 및 신장으로의 간외 섭취가 3예였고, 60분까지 소장 배출이 없는 배설 지연 예와 담낭 수축 불량 예가 각각 1예 씩 발견되었다. Phenobarbital 투여시험에서 민감도가 열량제한시험에 비해 더 높았다(92.3%와 50.0%). Gilbert 증후군에서 1일 400 Kcal로 48시간의 열량제한 시험과 1일 60mg의 phenobarbital을 5일간 투여하는 유도 시험은 편리하고 유용한 임상적인 진단법으로 이용할 수 있다고 생각된다. 그러나 열량 제한 시험에서는 증가 기준의 통일이 필요하다고 유추되며 phenobarbital 유도 시험이 민감도가 더 높은 것으로 생각된다. Gilbert's syndrome is very frequent and benign chronic process characterized by mild, intermittent, unconjugated hyperbilirubinemia without any symptom and sign of liver disease. Previously intoduced caloric restriction test and phenobarbital stimulation test as two appropriate clinical tests had been examined and their diagnostic values were reevaluated. Fourteen patients with mild, persistent, unconjugated hyperbilirubinemia were included. Subsequently caloric restriction has been applicated by 400 Kcal/day for 48 hours and phenobarbital has been prescribed by 60 mg/day for 5 days. Therafter serum levels of total and direct bilirubin were measured. Most of the patients were third and fourth decade(85.8%) and male predominant. Each basal serum levels of total, indirect and direct bilirubin were 3.0±0.8, 2.2±0.8 and 0.7±0.4 mg/dL. After caloric restriction test, each levels were increased significantly to 5.5±2.7, 4.2±2.3 and 1.3±1.0 mg/dL(p=0.001, p=0.001, p=0.023). After phenobarbital stimulation test for 13 patients had been practiced, increased levels of each bilirubin after caloric restriction test were decreased significantly to 2.0±1.0, 1.5±0.8 and 0.5±0.4 mg/dL(p=0.000, p=0.000, p=0.001) and these levels were significantly lower than basal levels(p=0.001, p=0.02, p=0.005). The sensitivities of caloric restriction test were 85.7%, 50.0%, and 71.4%, 35.7%(1.0, 1.5 mg increase of total bilirubin and 1.0, 1.5 mg/dL increase of indirect bilirubin). The sensitivities of phenobarbital stimulation test were 93.2% and 92.3% at criteria of 1.5 mg/dL increase of total bilirubin and indirect bilirubin. On the diagnosis of Gilbert syndrome, caloric restriction test and phenobarbital stimulation test are convenient and useful diagnostic tools in clinical face. And also phenobarbital stimulation test has higher sensitivity than caloric restriction test. Furthermore, standardization of bilirubin increment would be necessary in caloric restriction test.

Random Circuit Breaker Network Model for Unipolar Resistance Switching

Chae, Seung Chul,Lee, Jae Sung,Kim, Sejin,Lee, Shin Buhm,Chang, Seo Hyoung,Liu, Chunli,Kahng, Byungnam,Shin, Hyunjung,Kim, Dong-Wook,Jung, Chang Uk,Seo, Sunae,Lee, Myoung-Jae,Noh, Tae Won WILEY-VCH Verlag 2008 ADVANCED MATERIALS Vol.20 No.6

<B>Graphic Abstract</B> <P>The random circuit breaker network model is proposed for unipolar resistance switching behavior. This model describes reversible dynamic processes involving two quasi-metastable states. The formation and rupture of conducting channels (see figure) in the polycrystalline TiO<SUB>2</SUB> thin films may be analyzed by the self organized avalanche process in the random circuit breaker network model. <img src='wiley_img/09359648-2008-20-6-ADMA200702024-content.gif' alt='wiley_img/09359648-2008-20-6-ADMA200702024-content'> </P>

The moderation of resilience on the negative effect of pain on depression and post-traumatic growth in individuals with spinal cord injury

Min, Jung-Ah,Lee, Chang-Uk,Hwang, Sung-Il,Shin, Jung-In,Lee, Bum-Suk,Han, Sang-Hoon,Ju, Hye-In,Lee, Cha-Yeon,Lee, Chul,Chae, Jeong-Ho Informa UK Ltd. 2014 Disability and Rehabilitation Vol.36 No.14

<P><I>Purpose</I>: To determine the moderating effect of resilience on the negative effects of chronic pain on depression and post-traumatic growth. <I>Method</I>: Community-dwelling individuals with SCI (<I>n</I> = 37) were recruited at short-term admission for yearly regular health examination. Participants completed self-rating standardized questionnaires measuring pain, resilience, depression and post-traumatic growth. Hierarchical linear regression analysis was performed to identify the moderating effect of resilience on the relationships of pain with depression and post-traumatic growth after controlling for relevant covariates. <I>Results</I>: In the regression model of depression, the effect of pain severity on depression was decreased (β was changed from 0.47 to 0.33) after entering resilience into the model. In the final model, both pain and resilience were significant independent predictors for depression (<I>β</I> = 0.33, <I>p</I> = 0.038 and <I>β</I> = −0.47, <I>p</I> = 0.012, respectively). In the regression model of post-traumatic growth, the effect of pain severity became insignificant after entering resilience into the model. In the final model, resilience was a significant predictor (<I>β</I> = 0.51, <I>p</I> = 0.016). <I>Conclusions</I>: Resilience potentially mitigated the negative effects of pain. Moreover, it independently contributed to reduced depression and greater post-traumatic growth. Our findings suggest that resilience might provide a potential target for intervention in SCI individuals.<OL><LI><P>The majority of individuals with spinal cord injury suffer from pain that is usually refractory to treatment.</P></LI><LI><P>In a study among community-dwelling individuals with spinal cord injury, resilience mitigated the negative effects of pain on depression and post-traumatic growth.</P></LI><LI><P>Resilience might be suggested to provide a potential target for intervention in individuals with spinal cord injury.</P></LI></OL></P>

아시아 중형항공기 개발 교훈

이채욱(Chae Uk Lee),정현진(Hyun jin Jeong),유창경(Chang-Kyung Ryoo) 한국항공우주학회 2019 한국항공우주학회 학술발표회 논문집 Vol.2019 No.11

측경부 림프절 전이를 동반한 갑상선 유두상암의 임상 양상과 면역조직화학적 특성

이선욱(Seon Uk Lee),진성민(Sung Min Jin),이상혁(Sang Hyuk Lee),손진희(Jin Hee Sohn),채승완(Seung Wan Chae),김동훈(Dong Hoon Kim) 대한두경부종양학회 2011 대한두경부 종양학회지 Vol.27 No.1

Background and Objectives:Papillary thyroid carcinoma(PTC) frequently metastasize to the regional neck, however, lateral neck lymph node metastasis is less common. The aim of this study is to investigate clinical and immunohistochemical features of PTC with lateral LN metastasis, and determine the predictive factors for lateral LN metastases. Material and Methods:We undertook a retrospective study of 83 patients treated between January 2007 and December 2009 for PTC by thyroidectomy with or without lateral neck dis-section. The following criteria were used to study the clinical predictive value of lateral LN. metastases : sex, age, tumor size, multifocality, extracapsular spread(ECS) and lymphovascular emboli. Immunohistochemical staining for VEGF-A, VEGF-C, Bax, Bcl-2, Cyclin D1, Cyclin E, p27 kip1 and p57 kip2 was performed, and quantified blindly by three pathologists who had no clinical information of the patients. Immunohistochemical expression was scored as high(>50% of cells stained) or low(0-49%). Results:With use of univariate and multivariate analysis, tumor size(>2cm) and ECS were independent correlates of lateral LN metastasis in PTC. Expression of VEGF-C, Bax, and Cyclin D1 in the PTC with lateral LN metastasis was scored higher than in PTC without lateral LN metastasis(p<0.05). Conclusion:The important risk factors for lateral LN metastasis in PTC are primary tumor size and the presence of ECS. And expression of VEGF-C, Bax and cy-clin D1 may be considered of lateral LN metastatic potential in PTC.

Effect of Light Emitting Diodes Treatment on Growth and Mineral Contents of Lettuce (Lactuca sativa L. ‘Chung Chi Ma')

Shin, Yong-Seub,Lee, Mun-Jung,Lee, Eun-Sook,Ahn, Joon-Hyung,Do, Han-Woo,Choi, Don-Woo,Jeong, Jong-Do,Lee, Ji-Eun,Kim, Min-Ki,Park, Jong-Uk,Um, Young-Ghul,Park, So-Deuk,Chae, Jang-Heui 한국유기농업학회 2013 韓國有機農業學會誌 Vol.21 No.4

The objective of this study was carried out to elucidate the effect of LEDs (light emitting diodes) irradiation in relation to early growth and inorganic elements in leaf lettuce (Lactuca sativa L. ‘Chung Chi Ma’). In morphological changes of leaves, shoot elongation and hypocotyl length showed poor growth in red light irradiation, while the red+blue light irradiation induced shorter plant height and much greater leaf numbers resulting in increased fresh weight. In change of the Hunter's color and SPAD values, lettuce seedlings grown under in red+blue and fluorescent light irradiation had a higher a* value, otherwise SPAD values were not changed in these light irradiations. Interestingly, relative chlorophyll contents showed 1.8 times increased redness in the treatment of red+blue light irradiation. Inorganic element (N, Ca, Mg, Mn, and Fe) and ascorbic acid contents were increased in lettuce plants grown under LEDs light irradiation compared to those of lettuce grown under the fluorescent light which showed higher P and Mn contents. In conclusion, it is considered that red+blue light irradiation which stimulates growth and higher nutrient uptake in leaf lettuce could be employed in containers equipped with LEDs.

기관지내 전암성 병변 발견을 위한 자가 형광 기관지 내시경의 유용성

이연선 ( Yeun Seun Lee ),정미경 ( Mi Kyong Jeuong ),이유진 ( Yu Jin Lee ),장필순 ( Pill Soon Jang ),이정은 ( Jeung Eun Lee ),박희선 ( Hee Sun Park ),정재욱 ( Chae Uk Chung ),정성수 ( Sung Soo Jung ),김선영 ( Sun Young Kim ),김주옥 대한내과학회 2006 대한내과학회지 Vol.71 No.1

Background: Autofluorescence bronchoscopy (AFB), when used as an adjunct to conventional white light bronchoscopy (WLB) improves the bronchoscopist`s ability to localized small intraepithelial lesions. Current study was undertaken to evaluate prevalence of preinvasive intraepithelial lesions (dysplasia II-III & CIS) and efficacy of additional AFB system to WLB in comparison with WLB alone. Methods: In patients with suspicion of lung cancer or follow-up ones with known lung cancer, WLB (Pentax; BP 3500, Japan) and AFB (Richard Wolf, Germany) were done and all subjects with endoscopic abnormalities underwent biopsies from January 2005 to December 2005. Results: 169 patients (134 suspected to have lung cancer radiologically, 18 with known lung cancer, and 17 with initial abnormal WLB visual findings) were enrolled. Overall preinvasive intraepithelial lesions were detected in 6.5% (11 persons). Biopsy based sensitivity of WLB+AFB and WLB alone for detecting preinvasive intraepithelial lesions was 77.8% compared with 22.2% (relative ratio 3.5, 95% CI 0.93-13.24). Corresponding specificity was 56.9% compared with 89.2% (relative ratio 0.64, 95% CI 0.54-0.75). The positive predicitve value was 6% and 3%, and the negative predictive value was 94% and 87%, respectively, for WLB+AFB and WLB alone. Conclusions: WLB+AFB was superior to WLB alone in detecting preinvasive intraepithelial lesions, but general use of AFB as a screening tool seems to be limited in suspected or known lung cancer group because of low prevalence. It is necessary of further study for precise indication for AFB among the lung cancer risk groups.(Korean J Med 71:67-74, 2006)

부산·울산·경남지역 직업병 감시체계

김정일,김병권,김정원,채창호,이철호,강동묵,김지홍,김진하,김영욱,이영하,이지호,김정호,윤형렬,유철인,정백근,장태원,김운규,윤동영,강진욱,김종은,안진홍,이동준,장준호,이광영,송혜란,최영희,이용환,조병만,최홍렬,고상백,김은아,이유진,홍영습,정갑열,김정만,김준연 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.1

Objective: Occupational medicine specialists in the Busan, Ulsan and Kyung-Nam areas established an area-based occupational disease surveillance system and used this system to collected case information for the purpose of preventing occupational diseases Methods: l l hospital participated in this system. The authors selected five main diseases, which were hand-arm vibration syndrome (HAVS), work-related musculoskeletal disorder (WRMSD), occupational asthma, occupational skin disease and occupational and occupational lung cancer and established their case definitions. All cases were reported on the web, and real time analysis was conducted. Results: Between April 2001 and April 2003, 192 cases of HAVS, 118 cases of WRMSD, 33 cases of occupational asthma, 17 cases of occupational skin disease and 17 cases of occupational lung cancer (for a total of 377 cases of these five main diseases) were reported. most of the HAVS cases came from shipbuilding, and 172 of them (92.7%) were associated with grinding. Of the four main types of WRMSD, carpal tunnel syndrome (CTS) was the most prevalent with 46 cases and shipbuilding was also the main industry involved (83.9%). The ergonomic risk factors involved mainly associated with the hand. In 19 (57.6%) and 4 (12.1%) cases of occupational asthma, the agents involved. The causative agents of occupational lung cancer included Cr, welding fume, PAH, Ni, etc. 10(58.8%) of the cases were diagnosed as squamous cell carcinoma and 5(29.4%) as adenoma. Conclusion: This result showed that an area-based occupational disease surveillance system might provide an effective method of evaluating the prevalence of such diseases, however the Busan, Ulsan and Kyung-Nam provinces are too large to be treated as individual areas. Therefore, the authors suggest that each province should establish its own surveillance system.