정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

성장과 운동수행능력 향상에 도움을 주는 식이조성물의 개발

윤승원,정은희,양동식,이홍석,윤유식 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.3

We developed a dietary supplement using natural herbs and nutrients for the growth and exercise performance improvement. It called JR-22 supplement containing distilled extracts of natural herbs to remove bitterness and the addition of Vitamin B1, B6, Ca and xylitol. We investigated on the effect of JR-22 supplementation on the maximal exercise performance, IGF-1 (insulin like growth factor-1) concentration and antioxidant activity in SD rat model. In result, JR-22 supplement group was better than control group about 10% in exercise performance test and increased about 63% of IGF-1 concentration in blood. In addition, the oxidative damage induced by exercise was reduced by JR- 22 supplementation. Therefore, we suggested that JR-22 supplementation enhanced effectively exercise performance and IGF-1 concentration and reduced to oxidative stress in muscles. Also, we analysed biochemical factors in blood for the safety of JR-22 supplement. We known that there is no change of blood lactic acid, ammonia, inorganic phosphorous ion and creatine kinase activity.

고출력 펄스 레이저로 증착된 유기필름

홍진수,채희백,안성기,박해윤 순천향대학교 기초과학연구소 2001 순천향자연과학연구 논문집 Vol.7 No.2

유기발광 응용에 성공적으로 사용되어 새로운 물질을 개발할 때 기준으로 사용되는 Alq_3와 TPD필름을 기존의 증착법(열증착법과 스핀코터 기술)을 대체할 수 있는 고출력펄스레이저로 합성하였다. 펠릿 타겟은Q-스위칭 Nd:YAG 레이저의 532 nm와 355 nm를 사용하여 2&10^-6 Torr압력 하에서 용발시킨다. 슬라이드 유리 위에 증착된 필름은 유기발광 디바이스에 사용될 가능성이 있는지 알기 위해 다음과 같은 조사를 하였다: PL,AFM, 흡수 스펙트라, XRD. 355 nm 레이저로 유기필름을 증착하면 532 nm 경우의 필름보다 결합이 적고, 특히 열증착 필름보다 스트레스를 덜 받는다는 사실을 알 수 있다. 또한 타겟의 구조가 Alq_3 다를지라도 레이저 증착법으로 합성된 Alq_3 필름은 열증착과 동일한 구조를 갖는다는 사실을 알 수 있다. 어느 레이저를 사용하건 증착된 필름은 결정구조를 확인할 수 없을 정도로 비정질을 이룬다는 사실을 알 수 있다.

경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

도마 Yeo2동작에 대한 운동학적 요인 분석

윤희중,여홍철,김태삼 한국운동역학회 2001 한국운동역학회지 Vol.11 No.1

The purpose of this study was to investigate the effect of the kinematic factors about event of the Yeo2 motion on the Horse Vault. The subject in this study was 1 male gymnast to performance Yeo2 motion. Two video cameras were used to attain kinematic variables by phase. As a result, the following conclusion was drawn; 1. As the take-off time on the board was short, it appeared to increase horizontal and vertical velocity. In the motion, the flight apex height increased largely, too. 2. As the contact time on the board was short, it appeared to performance the air motion smoothly by increasing the horizontal distance and apex height. 3. The horizontal and vertical velocity in take-off on the board appeared increase horizontal distance and apex height. 4. To increase the apex height and horizontal distance, the body appeared to must be take the posture of vertical axis in take-off on the board.

有機農業의 實態와 發展에 관한 事例 硏究 : 忠南 洪城郡 洪東面 有機農家를 中心으로

尹英相,洪性贊,金成敏,具漢謨,申東一,金昌護,姜熙慶 公州大學校 資源科學硏究所 1997 資源科學硏究論文集 Vol.5 No.-

This study was carried out to improve the organic farming system about crop cultivation, compost production and application, plant diseases & pest control, weed control and marketing system of organic farming products to the case study in Chungnam Hongdong area. Agricultural technologies concerning pest & diseases control, weed control and compost production are not established due to lacks of systemized researches by the agricultural scientist, and agricultural machines profitable to this works had not developed yet. In cropping system, reasonable crop rotation had not conducted. The related cultivation of vegetables on the same ground for a long time cause a various plant disease easily. So crop rotation is a reasonable method about soil nutrient utility and soil disease control. It is a good method that introduce the barley and wheat in this field crop system. Those crop have a long root, so can use the other nutrient against the vegetable. In organic farming products, the safety and quality of products by the National Agricultural Products Inspection Center had not inspected except rice, lettus and apple. Inspection is needed for the development of organic farming and mutual confidence between producer and consumer, because the mutual confidence is a major thing to sustain the organic farming. In products marketing, it is more need for the information of organic farming products. Nowaday most products are marketed in Seoul region, but it is not a good method. To search the consumer in near region is a good method for decrease the cost of conveyance and maintain the quality of products. The varieties of distribution structure of organic farming products are required. The products are sold to department store in large city and the prices are about 30% higher than normal products. But when those are supplied in near region, the prices of those are similar to normal products. Direct transactions in near regions is a good method for decrease the cost of conveyance and strength the mutual confidence between producer and consumer.

親環境農業을 위한 有機農業의 作付體系 確立에 관한 硏究

홍성찬,강희경,윤영상 공주대학교 자원과학연구소 2000 資源科學硏究論文集 Vol.8 No.-

This study was carried out to produce safe agricultural product and to improve the soil environment of crop cultivation using the reasonable cropping system in organic farming to the case study of organic farmhouse in Chungnam Hongdong area for sustainable agriculture. In the ratio of farming forms in these organic farmhouses, paddy field-upland field-greenhouse form, paddy field-upland field form, crop-livestock form and only greenhouse form were 23.8%, 23.8%, 23.8% and 19.0% respectively. In the greenhouse area of organic farmhouse, the 50% of total greenhouse number were 600~1,000 pyung(200~330a) and the 40% of total were 1,000~1,500 pyung(330~500a). In the area of upland field, the 80% of total upland field number were 500~1,000 pyung(167~330a). In the cropping systems of surveyed farmhouses, the number of crop-combination patterns were twenty-seven and the 96.3% of those was combined with vegetable. Vegetable-vegetable pattern, cereal crops-vegetable pattern and root and tuber crop-vegetable pattern were 44.4%, 18.5% and 14.8% respectively. Leguminous crop combined pattern was 7.4%, but patterns combined with barley or wheat did not exist. Among the vegetable combined patterns, leaf vegetables combined pattern, fruit vegetables combined pattern and root vegetables combined pattern were 66.7%, 31.0% and 22.2% respectively. Among the vegetable-vegetable patterns, the portion of fruit vegetables-leaf vegetables pattern was the highest and that of root and tuber vegetables-root and tuber vegetables pattern was the lowest. Among the twenty-seven crop-combination patterns, unreasonable crop rotation pattern was 50% over and especially the almost crop-combination pattern of greenhouse was unreasonable to crop rotation pattern. The farmhouse that control the amount of compost application by means of periodical soil analysis did not exist in this area.

다발성 고무밴드 치핵 결찰술

윤완희,신흥식,송인상,이희만 최신의학사 1994 最新醫學 Vol.37 No.2

특징 형상기반의 CAIP에 관한 연구

윤길상,조명우,이홍희 한국공작기계학회 2003 한국생산제조학회지 Vol.12 No.5

A feature-based inspection planning system is proposed in this research to develop more efficient measuring mthodolog for the OMM(On-Machine Measurement) or CMM(Coordinate Measuring Machine) for complicated workpiece having man; primitive form features. This paper is proposed solution that optimum inspection sequence of the objective features. The sequences are determined by analyzing the feature information such as the nearest relationship and the possible probe-approach direction(PAD) of the features, and forming feature groups. A series of heuristic rules are developed to accomplish in Also. each feature is decomposed into its constituent geometric elements for inspection process, and then the number c sampling points, location of the measuring points, optimum probing path are determined.

대학생의 노인에 대한 태도에 관한 연구

이영희,권미경,김남선,김혜원,최미경,이규은,홍윤미 關東大學校 醫科大學 醫科學硏究所 2003 關東醫大學術誌 Vol.7 No.1

The purpose of this study is to identify the perception, the future and images, and prejudice toward old people. And to examine difference the group of gerontological education (educated group) with the non-educated group. 189 students in K university were participated in this study. The educated group was composed 101 students who enrolled liberal arts course that learned this title. Data were collected from May to June, 2002. The results are as follows; 1) Many students perceived the elderly that was started 60~64 years. 2) The perception, the future and images, and prejudice of both groups were some positively. 3) Each variables were not significantly difference. But the mean level of the educated group were more higher. 4) The educated group was found significantly related to the perception and prejudice(r=.303, p=.002). The non-educated group was found significantly related to the perception and the future and image(r=.421, p=.000), the perception and prejudice(r=.321, p=.003), the future, image and prejudice(r=.272, p=.012).