김치유래 젖산균의 균체지방산 분석을 이용한 분류학적 연구

이정숙,정민철,김우식,이근철,김홍중,박찬선,이헌주,주윤정,이근종,안종석,박완,박용하,민태익 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

표준균주를 포함한 230여개의 김치유래 젖산균에 대한 균체지방산(FAMEs)을 분석하였다. FAMEs profiles는 Euclidian Distance 17.5에 의해 7개의 Major Cluster와 1개의 Single Cluster로 나뉘어졌다. 이중 A, B, C 및 Cluster는 Leuconostoc속으로 분석되어졌고, F는 Lactobacillus속으로 분석되어졌다. 그리고 E와 G cluster는 두개의 Genus가 혼재되어 나타났으며 보충적인 연구가 필요하다. 앞으로 김치유래 젖산균의 균체지방산 분석결과를 기반으로 한 데이타베이스에 95가지 탄소원을 이용하는 수치분류학적 접근방법 및 Pyrolysis Mass Spectrometry 등의 화학적 분석 방법과 분자친화적 연구를 통한 종합적 분류정보 체계가 갖추어지면 젖산균의 신속, 정확한 동정 및 연구에 활발히 이용되어질 것이다. Two hundreds and thirty lactic acid bacteria, mostly isolated from Kimchi, including type strains were sued for analysis of cellular fatty acids. The 230 test strains were recoverd in 7 major and 1 single clusters defined a Euclidian distance of 17.5. These aggregate taxa were equivalent to the genus Leuconostoc (aggregate group A, B, C and D), and the genera Leuconostoc and Lactobacillus (aggregate group G). It is concluded as evident that FAMEs (Fatty Acid Methyl Esters) profile of cell can be used as a criterion in classification of lactic acid bacterial from kimchi. Additional comparative taxonomic studies need to be carried out on well chosen representative strains to determine the most appropriate methods of value.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

45세 이후에 초발한 망상성 정신병의 특징

정철호,박종한,하재창 최신의학사 1986 最新醫學 Vol.29 No.3

요통환자에서 경막외 주사 효과의 평가Modified Dallas Pain Questionnaire를 중심으로

김종철,김현배,김미정,이상건 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.1

Smallworld를 이용한 이동 객체 이력 관리 및 위치 예측기

정영진,배종철,안윤애,류근호 충북대학교 컴퓨터정보통신 연구소 2001 컴퓨터정보통신연구 Vol.9 No.2

시간에 따라 객체의 위치나 크기 등의 공간 속성이 연속적으로 변하는 특징을 가진 객체를 이동 객체라고 한다. 이와 같은 이동 객체를 일반적인 데이터베이스를 이용하여 관리할 경우, 단순히 이산적인 시간으로 샘플링 된 이동 객체 정보만을 저장하여, 질의를 처리할 때 저장되지 않은 이동 객체의 과거 및 미래에 대한 위치 정보를 전혀 제공하지 못하고 저장된 정보에 대한 단순 질의만을 처리 할 수 있는 단점을 가진다. 따라서, 이 논문에서는 이와 같은 단점을 해결하기 위해 이동 객체 정보를 저장 관리하고 샘플링 되지 않은 객체의 위치는 물론 가까운 미래의 위치를 예측하는 이동 객체 이력 관리 및 위치 예측기를 구현한다. 그리고 이를 위해 보간법과 이동객체의 속도와 방향을 고려한 삼각함수를 사용한다. 구현된 이동 객체 이력 관리 및 위치 예측기는 과거의 이력 질의와 현재의 위치 질의를 제공하고, 저장된 객체의 행위 정보를 시간에 대한 함수에 활용하여 가까운 미래에 대해 대략적인 향후 위치 질의를 제공하는 특징을 가진다. Moving objects are objects that have spatial attributes, such as position and/or extent are changing object data that are sampled with discrete time are stored only, the application has a following problem. When the queries are processed. past and future positions of the moving objects except saved data are not provided and, only simple query for saved data is processed. Therefore, in this paper, we implemented the history manager and location PFedictor of moving objects which are able to save and manacle the moving obiect data, predict positions of moving objects of about near future as well as presume ones which are not sampled. To do this, we use interpolation and trigonometrical function to well as query about historical and current position

노인 알코올성 정신장애의 임상적 고찰

정철호,박종한 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.3

저자들은 1969년 1월 1일부터 1983년 7월 31일까지 대구직할시 소재 계명대학교 동산의료원 신경정신과에 내원한 60세 이상 노인 알코올성 정신장애자 20례를 조사하여 그 결과를 다음과 같이 요약한다. 1. 남녀 비율에 있어서는 남자가 월등히 많았다 (남자 19례, 여자 1례). 2. DSM-Ⅲ 진단 기준에 의하면 모든 환자에서 알코올 사용장애 (alcohol use disorder)의 진단을 붙일 수 있었는데, 이 중에서 전체의 95%인 19례가 알코올 의존 (alcohol dependence)이었고, 나머지 1례만이 알코올 남용 (alcohol abuse)이었다. 또 전체의 85%인 17례에서 알코올 건망성장애 (alcohol amnestic disorder 5례), 알코올 금단섬망 (alcohol withdrawal delirium 4례), 알코올 금단증 (alcohol withdrawal 3례), 알코옥성 치매 (dementia associated with alcoholism 3례), 알코올 특이중독 (alcohol idiosyncratic intoxication 1례), 알코올 환각증 (alcohol hallucinosis 1례) 등의 알코올로 인한 기질성 정신장애 (alcohol-induced organic mental disorder)를 확인할 수 있었고 이들은 모두 알코올 의존 (alcohol dependence)을 동반하고 있었다. 3. 알코올성 정신장애의 기타 정신장애 이외는 전체의 25%인 5례에서 찾을 수 있었는데, 이들은 비특이적 기질성 정신장애 (atypical organic mental disorder 2례), 주요 우울병 (1례), 수면장애 (1례) 및 기질성 성격장애 (1례) 등이 있다. 4. 알코올성 정신장애에 동반된 신체장애는 전체의 70%인 14례에서 확인할 수 있었는데 간장장애 (6례), 고혈압 (4례)이 많았고, 그외에도 폐결핵 (2례), 영양결핍 (2례), 펠라그라 (1례), 봉와직염 (cellulitis 1례), 동상 (frostbite 1례), 청각장애 (1례) 등도 있었다. 5. 과음 시작시기는 음주력이 확인된 12례 모두가 60세 이전이었다. 덧붙여 말하면, 일반적으로 노인의 알코올성 정신장애자들은 환자 자신이나 가족 및 의료진이 가지는 노인 혐오증 (gerontophobia)이나 인구 전체에서 차지하는 노인인구의 미미함 때문에 여태까지는 큰 관심을 끌지 못했다. 그러나 현재 인구의 노령화가 급속히 진행되고, 또 앞에서 살펴본 바와 같이 노인들이 지니는 각종 장애에의 취약성이나 알코올이 미치는 신체적, 정신적 및 사회적 영향을 생각해 볼 때 앞으로는 노인 알코올성 정신장애에 대하여 보다 적극적인 연구가 요망되리라고 생각한다. The authors retrospectively reviewed 20 elderly alcoholics age over 60 who visited department of neuropsychiatry, Keimyung University Dongsan Medical Center, Taegu from January, 1969 to July, 1983. DSMⅢ- was used for diagnosis. Results were as follows : 1. The ratio of male to female alcoholics was 19:1. 2. All of the cases met the diagnosis of alcohol use disorder. 19 (95%) of them met the diagnostic criteria of alcohol dependence and only one case belonged to alcohol abuse. Alcohol-induced organic mental disorders were able to be identified in 17 (85%) of 20 cases : alcohol amnestic disorder (5), alcohol withdrawal delirium (4), alcohol withdrawal (3), dementia associated with alcoholism (3), alcohol idiosyncratic intoxication (1) and alcohol hallucinosis (1). All of these 17 alcohol-induced organic mental disorder cases had alcohol dependence. 3. Mental disorders excluding alcoholic mental disorders were found in 5 cases (25%) and they were atypical organic mental disorder (2), major depression (1), sleep disorder (1) and organic personality disorder (1). 4. Physical disorders were found in 14 cases (70%) and they had liver disease (6), hypertension (4), pulmonary tuberculosis (2), malnutrition (2), pellagra (1), cellulitis(1), frostbite (1) and hearing impairment (1). 5. The period of excessive drinking could be inferred in 12 case with age of onset below 60.

정상인 집단과 성인병 집단의 심폐기능과 혈액성분에 관한 연구

정한종,박철빈 경희대학교 체육과학연구소 1996 體育學論文集 Vol.24 No.-

To study effects of cardiorespiratory function and blood components in normal and degenerative disease groups, 36 men who aged 40-60yrs were checked by medical process and exercise stress testing. Subjects were divided into five groups that were control, activity, obesity, hypertension and diabetes group. Results of this study are following, 1.%Body fat is 19.7% in control groups, 17.4% in activity group, 30.1% in obesity group, 26.0% in hypertension group and 27.1% in diabetes group. Control and activity group are significantly leaner than obesity, hypertension and diabetes group(p〈0.05). 2.It is not significantly different in amounts of WBC and RBC between groups. But obesity group has a significantly more amount of hemoglobin than control group(p〈0.05). 3.Glucose is 164.83mg/dℓ in diabates group, which is the significantly most plentiful among groups(p〈0.05). But in Calcium and Pi, it is not significantly different between groups. 4.In serum cholesterol, total cholesterol is 179.0mg/dℓ in activity group, which is the significantly least amount among groups(p〈0.05). LDL-C(101.3mg/dℓ) and triglycerides(135.5mg/dℓ) of activity group are the significantly least amount among groups, too(p〈0.05). Amount of HDL-C of activity group is greater than obesity, hypertension and diabetes group, but not significant. 5.Resting HR is 60.6beats/min in control group and 57.1beats/min in activity group, that are significantly lower than those of hypertension and diabetes(p〈0.05). Resting SBP/IDBP is 160.7/107.9mmHg in hypertension group, which is the highest among groups(p〈0.05), but blood pressure of other groups are normal. 6.Resting rate pressure product(RPP ; myocardial oxygen consumption) is 6.60×103mmHg·bpm in activity group, which is less than those in obesity, hypertension and diabetes group(p〈0.05). Values of hypertension group, 10.91×103mmHg·bps, are the greatest among others(p〈0.05). 7.Maximal oxygen consumption(Vo2max) of activity group is 37.3㎖/kg/min, that is significantly greater than degerative groups(p〈0.05). 8.Correlation coefficients with Vo2max have significance(p〈0.001); TCH(r=-0.853), HDL-C(r=0.633), LDL-C(r=-0.813), Triglycerides(r=-0.844), TCH/HDL-C (r=-0.862), LDL-C/HDL-C (r=-0.834). 9.Correlation coefficients with resting RPP have significance; (p〈0.001) TCH(r=0.732), LDL-C (r=0.699) , Triglycerides (r=0.705), TCH/HDL- C (r=0.736) , LDL-C/HDL-C (r=0.713) ; (p〈0.001) HDL-C(r=-0.483). Results of this study indicate that improvement of cardiorespiratory function induces significant changes of serum lipids in middle and elderly men, implicate that modern degenerative diseases are decrease according to cardiorespiratory function. Conclusionally, elderly men must increase their activities in daily life for improving their cardiorespiratory function and protecting degenerative disease. This study is expected to contribute the area of exercise prescription, hereaftar more effort is required to establish the relation between serum lipids and exercise amount.

연질폴리우레탄폼의 물리적 성질 및 흡음율에 관한 연구

정종원,박남국,박선정,박종래,김영철 全南大學校 觸媒硏究所 1997 觸媒硏究 論文集 Vol.19 No.-

The effects of polyols, isocyanates. surfactants and water on the physical properties of the polyurethane foam were investigated. The resin used in this study was prepared from a variety of polyol mixtures by adding catalyst, surfactant and cross-linker. The polyurethane was foamed from the resin by adding an equivalent amount of isocyanate and was used in property measurements. The physical properties were more affected by the type of isocyanates and the amount of water than the sound absorption coefficient. The sound absorption coefficient of the polyurethane foam was superior for the polyol mixture of KE-810(40%)FA-733(40%)/FA-703(20%). The sound absorption coefficient was increased with the amount of surfactant L-5309 up to 3000Hz, but was decreased above that frequency.

디젤 乘用車輛에서 DPF 條件에 따른 極微細粒子의 排出 特性에 關한 硏究

鄭珉元,崔源鶴,柳鍾植,李海喆,車京玉 明知大學校 産業技術硏究所 2008 産業技術硏究所論文集 Vol.27 No.-

Recent1y, the nano-PM(Particulate Matters) number concentration emitted by diesel internal combustion engine has focused on attention because this nano-PM is suspected being hazardous of human health. In this study, the PM of the diesel passenger vehicles were investigated by number concentration. A condensation particle counter (CPC) system was used to measure the particle number concentration and size of diesel exhaust particles at the end of dilution tunnel during the NEDC(ECE15+EUDC) vehicle test mode using light-duty diesel passenger vehicles with DPFs. As a research result, the characteristic of DPF performance about diesel nano-particle number concentration and size distribution was investigated in this study.