정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Nuss 방법에 의한 소아 오목가슴 수술 후 정맥 통증자가조절법을 사용한 Fentanyl 과 Fentanyl-Ketorolac의 진통효과 비교

안기량,서은정,김천숙,강규식,유시현,정진헌,정지원 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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호흡기계 감염증에 대한 Jimox^� (Doxycycline Guaiacol Sulfonate/Lysozyme Chloride)의 임상적 평가

정기영,이건수,서종진,정용헌 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

Twenty three patients with respiratory tract infection wre treated with newly developed drug Doxycycline Guaiacol Sulfonate/Lysozyme Chloride; Jimox^?? capsule, including 2 with sinobronchitis, 12 with bronchits, and 9 with pneumonia. They were given a daily dosage of 2 or 4 capsules (doxycycline 100mg-200mg) of Jimox^?? divide two per oral for 8.9days(from 5 to 14days). Therapeutic effects were excellent in 8 cases (34.8%), good in 9 cases(39.1%), fair in 4 cases(17.4%), and poor in 2 cases(8.7%). Mild side effects were observed, such as nausea, vomiting, and anorexia, but immediately subsided with discontinuation of medication. These results suggest that Jimox^?? capsule is effective and tolerable tetracycline with little side effects for childhood respiratory tract infections.

갑상선 기능항진증에 병발된 주기성 마비 3예

최지훈,최경숙,김기훈,박병현,조정구 圓光大學校 醫科學硏究所 2001 圓光醫科學 Vol.16 No.1-2

Thyrotoxic periodic paralysis is characterized by intermittent flaccid paralysis of skeletal muscle, lasting several hours. The underlying pathophysiology of the syndrome is not yet to be well characterized and remains controversal, but reflects altered potassium and calcium dynamics as well as certain morphologic characteristics within the muscle unit itself. It occurs primarily in Asian populations with an overwhelming male preponderance and a higher association of specific HLA antigens. Precipitating factors include high carbohydrate ingestion, exercise, trauma, infection, alcohol ingestion, administration of epinephrine, thyroid hormone, or corticosteroid. If hypokalemia is present, potassium administration may help abort the attack, but the only definitive treatment is formation of euthyroid state. We discribed two patients with hypokalemic thyrotoxic periodic paralysis and one patient with normokalemic thyrotoxic periodic paralysis.

여가활동으로서의 볼링참여 동기 분석

이충훈,전도선,김기영 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

The purpose of this study was to investigate sport paticipation motivation of adult bowling participants and to furnish the related information to sport centers and sport for all leaders, The 292 subjects for this study were adult males and females over 18 years old in Busan. The results of this study are as follows: 1. Males showed higher scores with regard to social behavier with external displays than females, 2. Subjects aged 10~30 years showed higher scores for intrinsic motivation such as skill development than those aged 40~50. 3. Participants with boeling career 7 below 6 months, showed higher scores for intrinsic motivation such as skill development, Participants with over 6-month career scores for intrinsic motivation such as enjoyment, extrinsic motivation such as affiliation, amotivation.

단독 전이성 척추 종양의 일괄 전척추 절제술

김기택,한정수,석경수,이영호,이상훈 대한척추외과학회 2003 대한척추외과학회지 Vol.10 No.3

흰쥐에서 에스트로젠 결핍이 하악골 골밀도에 미치는 영향

김기현,신상훈,김욱규,박봉수,정인교 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.2

The relationship between systemic bone loss(osteopenia) and loss of oral bone has been of considerable recent interest. In dentistry, some investigators have studied using human subjects, but no firm conclusion due to many obstacles have yet been obtained. From these obstacles in the assessment of human subjects, the significance of investigations with overiectomized rats has been proposed recently. Also, in ovariectomized rats, quantitative data on changes in the alveolar bone of mandible and basal bone of mandible using dual-energy x-ray absorptiometry(DEXA) were far fewer. The purposes of this study were to certify systemic estrogen deficiency-induced osteopenia by biochemical markers(serum osteocalcin(OC) & urinary deoxypyridinoline(DPD)) and bone mimeral density(BMD) of femur by DEXA and examine changes in BMD of the rat mandible by DEXA with 24-week-old female Sprague-Dawley rats. Forty eight rats were used in this study and twenty four rats were ovariectomized bilaterally(OVX) to induce systemic osteopenia and remainders were subjected to sham surgery(Sham). The experimental rats were killed at different time interval(1st, 2nd, 3rd, 4th, 6th, 8th, 12th and 16th week) for histologic examination, biochemistry analysis and BMD measurement. The results obtained from this study were as follows: On histological examination, in mandible, early degeneration of periodontal ligament, early bone resorption in alveolar bone and late bone resorption in basal bone were observed. On biochemical analysis, OC and DPD were observed statistically no significancy to predict systemic osteopenia. On DEXA measurement, in OVX group, we observed statistically significant decrease from 3rd week in distal metaphysis, statistically non-significant decrease from 2nd week in alveolar bone of mandible, and statistically significant decrease at 16th week in total mandible. From these results, it could be stated that systemic osteopenia by ovariectomy was early affected in the trabecular bone of femur and alveolar bone of the mandible whereas the total mandible was affected later.

VLSI 제작에서 텅스텐 CMP 공정의 최적화

이우선,정헌상,박정기 조선대학교 에너지.자원신기술연구소 2001 에너지·자원신기술연구소 논문지 Vol.23 No.1

We have been optimized tungsten(W) CMP(chemica1 mechanical polishing) characteristics using two different kinds of component of slurry and two different kinds of pad which have different hardness. The comparison of oxide film roughness on around W after polishing has been carried out. And W plug recess for consumable sets and dishing effect at dense area according to the rate of over-polishing has been investigated. Also, the analysis of residue on surface after cleaning have been performed.

승용 디젤엔진용 가변과급기 성능에 관한 연구

진영욱,정진은,조훈기,강우,정재우 한국기술교육대학교 2006 論文集 Vol.13 No.1

A test bench which is consisted of roots blower, air flow meter, driving unit for VGT actuator, transmitters for temperature and pressure, and the rotational speed sensor was developed to evaluate the characteristics of the VGT system. Measurements using VGT of the 2.0 L diesel engine were carried out. The corrected mass flow rate and the pressure ratio for the compressor of the VGT are related directly with the rotational speed, but they are independent of the rack position of the VGT. The pressure ratio and the corrected mass flow rate of the turbine of the VGT are related directly with the rack position of the VGT, but they don't have any relation with the rotational speed. The mechanical efficiency of the VGT is higher than the conventional turbocharger in the wide range. The efficiency at the 0.03 kg/s of the mass flow rate is 4.36 times as high as that of the conventional turbocharger. These data will be used to develop the new engine equipped with the VGT system.

韓國産 靈芝 煎湯液이 Mouse의 免疫細胞 機能에 미치는 影響

崔政和,鄭憲鐸,李起男 圓光大學校 韓醫學硏究所 1991 원광한의학 Vol.1 No.1

This study was done to know the effects of Natural Ganoderma or Cultured Ganoderma on the innate immunities, tumor immunities and rosette forming capacities of spleen cells. The innate immunities were evaluated by measuring the effects of Natural or Cultured Ganoderma on the phagocytic activity and reactive oxygen intermediate(ROI) formation of macrophages. The effects of Natural or Cultured Ganoderma on the tumor immunities were evaluated by checking the antibody-dependent cellular cytotoxicity(ADCC) and natural killer(NK) cell activities. The administrations of both Natural and Cultured Ganoderma increased the phagocytic activities and the production of ROI of macrophages from the peritoneal cavities. But the effects caused by Natural Ganoderma were bigger than those by Cultured Ganoderma. Both the Natural and Cultured Ganoderma enhanced the ADCC but did not affect on the NK activity. The capacities of spleen cells to forming rosette were increased greatly bo the administration of Natural Ganoderma and slightly by the administration of Cultured Ganoderma. The results of this study showed that even though both Natural and Cultured Ganoderma enhanced the innate immunities, tumor immunity, and rosette forming capacity of spleen cells, Natural Ganoderma were better than Cultured Ganoderma in increasing the host's immune capabilities.