先天性甲狀腺 機能低下症의 원인, 병태 및 진단과 치료

徐宗振 藥業新聞社 1989 (月刊) 醫藥情報 Vol.1989 No.2

소아 갑상선종에 대한 임상적 고찰

徐宗振 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2

56 Children with goiter who visited Chungnam National Univ. Hospital from Jun. 1986 to Nov. 1987 were studied and the observed clinical data are as follows: 1) Children of more than 10 year of age were 46 cases(82.1%), and the ratio of male and female was 1 : 6. 2) Simple goiter and chronic lymphocytic thyroiditis(CLT) were about 75% of the studied cases and they were the two most important underlying diseases of goiter in childhood. 3) In classification of goiters according to function, the euthyroid goiter was 80.3% of all the studied cases. The hyperthyroid and hypothyroid goiter were 8% and 5.4% each. Among 20 cases of CLT, 14 cases (70.0%) were euthyroid CLT. The hyperthyroid and hypothyroid CLT were 3 cases(15.0%) each, but the abnormalities in thyroid function were not so severe. 4) Goiter, increased sweating, palpitation, easy fatigability and exophthalmos were the common initial symptoms and signs hyperthyroid goiters in descending order. 5) Antithyroid medication with or without thyroxine was given to hyperthyroid patients, and replacement therapy with thyroxine was done for all the hypothyroid goiters. 24.4% of euthyroid goiters were regularly followed up without medication, and the others were given thyroxine.

일본의 개정 교육기본법과 학습지도요령을 통해 본 교육정책의 변화–고등학교 역사과 학습지도요령을 중심으로–

서종진 역사교육연구회 2019 역사교육 Vol.152 No.-

This article examines the changes in Japanese education policy through the revised Basic Act on Education and Japanese High School National Curriculum. The Basic Act on Education(1947) reflected the imperial assimilation policy during the imperialist period. However, after 60 years, the Basic Act on Education was revised in 2006 to reflect the conservative values of patriotism, publicness and morality. After that, with the prolongation of the Liberal Democratic Party's Abe regime, the Japanese National Curriculum for school education were revised in 2017 and 2018, and it is expected that Japan's educational policy and textbook contents will change considerably in the future. The revised Framework of Basic Act on Education has changed significantly in terms of educational objectives and educational administration. The second revision of the Japanese National Curriculum, which was revised after the revision of Basic Act on Education, is the largest revision since World War Ⅱ. To summarize, Basic Education Law and teaching guidelines have been revised to reflect the needs of conservatives and historical revisionists. The Ministry of Education, Culture, Sports, Science and Technology has made it possible to induce influences in the textbook examination process by revising the regulations, thus increasing the possibility of leading them to Japan-based history education and textbook narrative. 이 논문은 일본 교육정책의 변화를 개정된 교육기본법과 고등학교 학습지도요령을 통해서 살펴보는 것을 과제로 하고 있다. 교육기본법이 2006년에 보수세력이 주장하는 애국심과 공공성, 도덕성을 강조하는 방향으로 60여년 만에 개정되었다. 이후 자민당 아베 정권이 장기화 되는 가운데 2017년과 2018년에 걸쳐 개정된 소·중·고 학습지도요령이 고시되어 향후 일본의 교육정책과 교과서 기술 내용 등이 상당히 변화될 것으로 예상된다. 개정된 교육기본법에서는 교육 목표와 교육 행정 관련 부분에서 규정이 대폭 변경되었다. 먼저 교육 목표로서 애국심, 公共성, 도덕심 등 20여개 덕목이 구체적으로 제시되고 강조되었다. 또 교육 행정 부분에서는 국가가 주도하여 교육 시책을 실행할 수 있도록 개정되고 새로운 조항도 신설되었다. 교육기본법 개정 이후 2번째 개정된 이번 학습지도요령은 전후 가장 큰 폭으로 개정되었다고 평가되고 있다. 특히 고등학교 역사과 학습지도요령에 나타난 역사 교과의 특징은, 첫째는 교육 현장의 자율성이 제한받고 교과서 기술 내용이 ‘위축’될 수 있고, 둘째는 애국심의 지나친 강조로 자국중심적인 역사 교육을 유도할 수 있으며, 셋째는 근린제국조항을 형해화시키는 내용이 개선되지 않고 있으며, 넷째는 근대 일본의 식민 통치와 침략전쟁에 대한 언급이 결여되어 있고, 다섯째는 정부 견해를 기술하게 함으로써 다각적이고 다면적인 학습을 강조하는 방침과 모순되어 있다는 점 등으로 정리할 수 있다. 교육기본법과 학습지도요령이 보수세력과 역사수정주의론자들의 요구를 반영하는 방향으로 개정되었다. 결과적으로 문부과학성을 중심으로 한 교육 당국은 교육 정책과 행정을 통해 교육의 중립성을 훼손하고 나아가 외부 세력의 교육정책에 개입할 수 있는 가능성이 높아졌다. 문부과학성은 개정된 규정들을 내세워 교과서 검정 과정에서 영향력을 행사하게 됨으로써 자국중심적인 역사 교육과 교과서 기술로 유도할 수 있는 가능성을 높였고 그 결과로 정부 방침에 따른 역사인식이 형성될 수 있게 되었다는 것이 문제이다.

The Study on "Reaction Classification Tables" and Database to aid the Learning of Mathematics -Using Reaction analysis on arithmetic questions and linear equations-

서종진,김태균 장전수학회 2010 Advanced Studies in Contemporary Mathematics Vol.20 No.2

This paper has researched/analyzed students' responses on arithmetic problems and linear equations. Using the analyzed data, a "Reaction Structure" showing students' individual Understanding of Math and a "Reaction Classified Table" was created. By using these "Reaction Structure" and "Reaction Classified Table" as a base, explains how the database was constructed. Nodes represent the student responses toward Understanding of Math and acts as a bridge connecting each step and paths. The existence and non-existence of nodes in between each step means the connection and severance of the math education curriculum. In the constructed database, the "Classification Symbols" according to the "Reaction Structure" explains the students' individual level of understanding of Math. Therefore the teacher can utilize these information and create a math teaching plan for individual students. The student will be acknowledged what to study on by being provided information about his/her level of understanding of Math, and consequently able to create and use study plan.

영유아의 동종 조혈모세포이식에서 주사용 Busulfan과 Cyclophosphamide 전처치의 유용성

서종진,김윤정,이미정,최은석,문형남,김태형,서을주,박찬정,지현숙 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2

연구배경: HSCT의 중요한 전처치 약제 중 하나인 경구 Bu은 위장관 흡수가 일정하지 않고 환자에 따라 약리에 크게 차이가 나는 경우가 있으며, 영유아에서는 경구 복용이 어렵고 구토하는 경우도 많아 일정한 혈장 농도를 얻기가 힘들어 간독성 및 전처치 효과가 문제가 될 수 있다. 이러한 경구 Bu의 여러가지 단점들을 극복하기 위해 그 수용성을 개선하여 최근 IV Bu이 개발되었다. 본 연구에서는 경구 약제 복용이 난이한 영유아에게 IV Bu를 사용한 전처치법을 시행한 단일기관의 HSCT 경험을 보고하고자 하였다. 방법: 울산의대 서울아산병원 소아과에서 2000년 7월부터 2002년 4월까지 IV Bu을 포함한 전처치로 HSCT를 시행한 4세 미만의 영유아 총 6예를 대상으로 후향적인 의무기록분석을 시행하였다. IV Bu는 0.8 mg/kg/dose로 6시간마다 4일간 총 16 dose를 투여하였고(D-7~D-4), 이어 Cy 60 mg/kg/dose를 24시간마다 2일간 투여하였다(D-3, D-2). 결과: 대상 질환은 급성 백혈병이 5예, CGD가 1예이었으며 HSCT 시 대상 연령의 중앙값은 2년 2개월이었다. 3예는 조직적합성일치 혈연간 HSCT이었으며, 나머지 3예는 조직적합성일치 비혈연간 HSCT이었다. 환자에 주입된 CD34+ 세포는 15.3×10^(6) (5.0~31.7×10^(6))/kg이었다. 점막염 grade 4를 보인 1예를 제외하고는 모두 경미한 점막증상을 보였으며, 간독성은 grade 1~3정도였고, 중추신경계 독성을 보인 증례는 없었으며, VOD는 경증 1예만 관찰되었다. 호중구 생착의 중앙값은 D+13일, 혈소판은 D+23일이었으며 중증으로 사망한 1예를 제외하고는 aGVHD는 없었다. 생존 환자 4명 중 백혈병 환자 3명은 추적관찰기간 각기 18, 28, 28개월로 현재 모두 완전관해 상태이며, CGD 환자 1명은 NBT 검사결과 정상화되었고 HSCT 후 이전에 반복되던 감염증이 발생되지 않았다. 결론: IV Bu는 영유아에서 HSCT 시 사용의 편이성, 높은 순응도, 부작용 감소의 가능성 및 신뢰할 수 있는 전처치 효과 등의 유용성이 있어 경구 Bu의 대체 약제로 추천된다. Background: Oral busulfan (Bu) and cyclophosphamide (Cy) is a well established pretransplant conditioning regimen, but the use of oral Bu is limited by the difficulty of oral administration in young children and by the liver toxicity following unpredictable intestinal drug absorption. Several studies on intravenous (IV) Bu (Busulfex®) showed more consistent pharmacokinetic parameters than those seen with oral Bu in children. This study was carried out to ascertain the utility of IV Bu and Cy conditioning regimen for allogeneic hematopoietic stem cell transplantation (HSCT) in young children with acute leukemia. Methods: Six patients less than 4 years of age who underwent allogeneic HSCT using IV BuCy conditioning regimen at Asan Medical Center from July 2000 to April 2002 were analyzed retrospectively with regard to the tolerability and toxicity of IV Bu and the transplant data. IV Bu was given 16 doses of 0.8 mg/kg every 6 hr, and 2 doses of 60 mg/kg Cy were daily. All the patients received short-term methotrexate and cyclosporin A as GVHD prophylaxis, and G-CSF starting at day +5. Results: The diagnosis of 6 patients were AML(3), ALL(1), acute mixed lineage leukemia(1) and chronic granulomatous disease(1). The median age at HSCT was 2 years and 2 months, and all the 5 patients with leukemia were in complete remission at the time of transplant. Three received HSC from matched sibling donor and the other 3 from unrelated donors. The mean CD34+ cell dose/kg of recipient body weight was 15.3×10^(6) (5.0~31.7×10^(6)). Median day of engraftment to >500 neutrophil/μL was day +13 (11~16), and >20,000 platelet/μL was day +23(12~30). Early transplant-related toxicities were acceptable; grade 1 mucositis (except 1 case with grade 4) and grade 1~3 hepatotoxicities in all. One case developed mild hepatic veno-occlusive disease, and there were no case with CNS toxicity. The chimerism status documented by short tandem repeats-PCR revealed complete chimerism in 5 cases and mixed chimerism in 1. There were 2 transplant-related mortalities, one due to severe acute GVHD and the other due to secondary graft failure. Conclusion: IV Bu was well tolerated, and could avoid the difficulties of oral ingestion in younger children, with moderate toxicity. It should be considered as replacement for oral busulfan in conditioning regimen of HSCT in infant and young children.

SOME IDENTITIES OF SYMMETRY FOR DAEHEE POLYNOMIALS ARISING FROM p-ADIC INVARIANT INTEGRAL ON Zp

서종진,김태균 장전수학회 2016 Proceedings of the Jangjeon mathematical society Vol.19 No.2

In this paper, we give some new and explicit symmetric iden- tities for the Daehee polynomials arising from p-adic invariant integral on Zp.

Some identities involving the degenerate Bell-Carlitz polynomials arising from differential equation

서종진,유천성 한국전산응용수학회 2020 Journal of applied mathematics & informatics Vol.38 No.5

In this paper we define a new degenerate Bell-Carlitz polynomials. It also derives the differential equations that occur in the generating function of the degenerate Bell-Carlitz polynomials. We establish some new identities for the degenerate Bell-Carlitz polynomials. Finally, we perform a survey of the distribution of zeros of the degenerate Bell-Carlitz polynomials.

소아백혈병 치료의 최신 지견

서종진,Seo, Jong Jin 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.1

Study On Equal Sign Expression of Students - Focused On Linear Equations -

서종진,김태균 장전수학회 2009 Proceedings of the Jangjeon mathematical society Vol.12 No.3

This paper has investigated on how much understanding of equal sign the 7th grade students have in the process of solving linear equations. The result of investigation are as follows. First, it was shown that most students prefer transposition while solving linear equations. And the fact is that they concentrate on calculating the answer by putting behind the proper expression of equal signs as they use the transposition method. In other words, they have an instrumental understanding of equation that the symbol changes when items on left side are moved to the right side. In the symmetrical expression of equal signs, only about 20.7% of students were shown as expressing properly in all questions while other students were shown as having difficulty in expressing equal signs properly. Second, the students making mistakes could be corrected by interviewing each students. Therefore, it would be necessary to correct mistakes on an individual basis by investigating the learning status of each student. Also, a teaching-learning method to raise the learning habit of being able to solve problems using characteristics of equality and transposition method as well as letting students gain adequate experience on various types of problems would become necessary.

Research on Convergence Based on Problem Solving in Mathematics Teaching and Learning

서종진,김태균 장전수학회 2010 Proceedings of the Jangjeon mathematical society Vol.13 No.2

In this paper, convergence was introduced in order to efficiently explain and use the results of each student's problem solving. Here convergence was defined in order to understand learning situation in school math and help math teaching and learning. This can show the results of math learning. Therefore it will help us to explain each student's math learning situation and to find a better way for math teaching and learning.