간내 담석과 동반된 간내 담도암에서의 p53과 Ki-ras의 발현

김명환,이성구,서동완,이승규,남승우,박능화,민영일,김연석,심기남,공경엽 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5

Background/Aims: Hepatolithiasis or primary intrahepatic stones may be accompanied later by intrahepatic cholangiocarcinoma. This cancerous lesion is frequently associated with atypical hyperplastic epithelium that was suspected of being precancerous. To investigate the Ki-ras or p53 mutation may play a role in carcinogenesis, and to determine whether atypical hyperplastic epithelium may be precancerous, this study was performed in intrahepatic cholangiocarcinomas associated with hepatolithiasis. Methods: We examined 12 patients with intrahepatic cholangiocarcinomas associated with hepatolithiasis. Ki-ras point mutations were assessed by direct DNA sequencing. Expressions of p53 protein were immunohistochemically assessed. The overexpression of p53 and point mutation of Ki-ras were examined in normal, hyperplastic, atypical hyperplastic, and can- cerous tissues separately. Results: The expressions of p53 protein were detected in 4 (33%) of 12 cholangiocarcinomas and Ki-ras point mutations at codon 12 were found in 2 (17%) of 12 cholangiocarcinomas. In those two carcinoma cases which contained the mutant sequence of Ki-ras, the same point mutation from wild type GGT (glycine) to GAT (aspartic acid) was. found in the associated atypical hyperplastic epithelium. However, none of the normal and hyperplastic epithelium harbored Ki-ras or p53 mutations. Conclusions: The overexpression of p53 may play a part in the carcinogenesis of some intrahepatic cholangiocarcinomas associated with hepatolithiasis, whereas the role of Ki-ras mutations in those cases is dubious. However, Ki-ras point mutation at codon 12 may be responsible for either cancer or atypical hyperplastic epithelium associated with hepatolithiasis in certain cases, suggesting atypical hyperplastic epithelium may give rise to carcinoma.

P164 : A clinical and statistical study of cutaneous premalignant lesions in Busan city and the eastern Gyeongnam province over 19 years

( Seung Hwan Choi ),( Seung Min Ha ),( Dong Yeob Ko ),( Ki Ho Kim ),( Ki Hoon Song ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Premalignant lesions has recently continuously increased in Koreans. However, there has been little research into the distribution and incidence of cutaneous premalignant lesions in the south-eastern part of korea Objectives: To analyze recent trends in incidence and clinical patterns of cutaneous premalignant lesions in Busan city and the eastern Gyeongnam province Methods: We reviewed 1,292 cases (3,651 lesions) of cutaneous premalignant lesions that include actinic keratosis (AK) and bowen’s disease (BD) at the Department of Dermatology in Dong-A University Hospital Results: The average annual incidence of cutaneous premalignant lesions among total outpatients was 1.82% and has continuously increased from 0.70% to 4.25% over the last 19 years. The most common cutaneous premalignant lesionwas AK (75.85%), followed by BD (24.15%). The mean age of onset was 68.76 years. A major skin cancer was found in 15.79% of patients with cutaneous premalignant lesions, including SCC (11.54%), BCC (6.09%), and malignant melanoma (0.64%). Additionally, 59.13% of the patients had a single lesion, while 40.87% had multiple lesions. Age, occupation-related exposure to ultraviolet radiation, and a past history of skin cancer were higher in the patients with multiple lesions than single lesion Conclusion: The incidence of cutaneous premalignant lesions has gradually increased in Busan city and the eastern Gyeongnam Province, which was relatively higher than incidence in other areas

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

인접건물에 의한 반사주광 성능에 대한 평가

최원기,이동권,안명환,서승직 대한건축학회 2004 대한건축학회논문집 Vol.20 No.6

This paper is focused on evaluation of daylight reflecting performance from the adjacent building for improvement of poor environment conditions in a metropolitan area. The numerical model developed can be used for evaluation of daylight reflecting performance. As a result comparison of our simulation programs and commercial softwares, it was verified that there was no difference between two results. In this study, the sensitivity analysis of environmental performance factors of daylight reflecting from the adjacent building were examined, analysed and presented as a solution method for improvement of building environments. The results were proved to be an effective control methods for improvement of building environment, especially in a metropolitan area.

중안면부 골절이 하악 과두 골절에 미치는 영향에 관한 임상적 연구

민승기,이동근,오승환,이은택,조이수,김종구 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

This is clinico-statistical & retrospective study of 30 patients with only unilateral mandibular condyle fracture and combined with 24 midface fracture patients who were treated with open reduction in Wonkwang University Dental Hospital during the period 1993 to 2000. The results were as follows : 1. In mandibular condyle fracture combined with midface fracture, the most incident type is associated with zygomaticomaxillary complex fracture and level Ⅳ of mandibular condyle fracture combined with ZMC fracture is the most related(33.32%). 2. In the period of intermaxillary fixation, unilateral mandibular condyle fracture group (9.8 days) is shorter than combined with midface fracture group (15.3 days), but no statistical difference between two groups(p.>0.05). 3. In the mouth opening recovery, unilateral mandibular condyle fracture group is faster than combined with midface fracture group in post-operative 1 month, but no significant difference between two-groups after 3 months postoperatively (p>0.05). 4. In two-groups, treatment method is almost open reduction with internal fixation(ORIF) and overall 25% temporary complications were shown, but little lower incidence in unilateral condylar fracture group.

소아의 하악골 골절에 관한 임상적 연구

민승기,최문기,오승환,이동근 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

The jaws of children differ from those of adults in the aspects of architectural and mechanical properties, sites, form and treatment modality. This study reviews the result of treatment of pediatric mandibular fractures between 1994 and 1998 at dept. of Oral & Maxillofacial Surgery, School of dentistry, Wonkwang University by means of the age and sex distribution, mechanism of injury, location of fractures and associated patterns, fracture management, postoperative complications, any associated injuries to other organ systems. Total number of these study was 61 facial bone fractures in 32 patients. The results were as follows. 1.The pediatric mandibular fractures predominated in the age of 6∼12, and had no sexual predilection. 2.The main cause of pediatric mandibular fractures was the traffic related accidents(56.2%) 3.The condylar fracture only was 23 cases (37.7%) in total 61 sites of mandibular fractures and the symphysis fracture was 20 (32.7%) ; the highest incidence of mandibualr fracture was the symphysis with unilateral condyle combined fracture in 61 total mandibular fracture sites. 4.The major postoperative complication was deviation during mouth opening (41.2%) and the facial asymmetry(17.7%) in second. 5.Soft tissue laceration(53%) was the most associated injury with mandibular fracture and the abdominal injury(12.5%), the head injury(12.5%), and the extrimity injury (6.2%) in order.

하악골 전돌증 수술 후 하악골 이동량에 따른 발음 양상에 관한 비교 연구

신기영,이동근,오승환,성헌모,이숙향 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.1

After performing mandibular setback surgery, we found some changes in patterns and organs of speech. This investigation was undertaken to investigate the aspect and degree of speech patterns according to the amount of surgical setback in mandibular prognathic patients. Thirteen patients with skeletal Class Ⅲ malocclusion were studied preoperative and postoperative over 6 months. They had undergone the mandible setback operation via bilateral sagittal split ramus osteotomy(BSSRO). We split the patients into two groups. Group 1 included patients whose degree of mandibular setback was 6mm or less, and Group 2 above 6mm. Control group was two adults wish normal speech patterns. A phonetician performed narrow phonetic transcriptions of tape-recorded words and sen- tences produced by each of the patients and the acoustic characteristics of the plosives, fricatives, and flaps were analyzed with a phonetic computer program (Computerized Speech Lab(CSL) Model 4300B(USA) ). The results are as fallows : 1. Genera1ly, Patients showed longer closure duration of plosives, shorter VOT(voice onset time) and higher ratio of closure duration against VOT 2. Patients showed more frequent diffuse distribution than the control group in frication noise energy of fricatives. 3. In fricatives, frequency of compact from were higher in group 1 than in group 2. 4. Generally, a short duraction of closure for /ㄹ/ was not realized in the patient's flaps. Instead, it was realized as fricatives, sonorant with a vowel-like formant structure, or trill type consonant. 5. Abnormality of the patient's articulation was reduced, but adaptation of their articulation after surgery was not perfect and the degree of adaptation was different according to the degree of surgical setback.

지면효과익선 개발을 위한 기초 실험 연구

김기은,이동환 울산대학교 1997 공학연구논문집 Vol.28 No.2

본 논문에서는 차세대 해상고속 운송체의 하나로 각국에서 개발되고 있는 WIG에 사용되고 있는 익형에 대한 공력특성을 통하여 연구하였다. NACA 계열의 익형 9종과 S-type의 익형 4종에 대해 풍동실험을 통하여 지면효과에 대한 특성을 조사 하였으며, 실험에 사용된 익형 중 구 소련에서 해면효과익선용으로 개발한 익형(DHMTU 계열 : Department of Hydromecbanics of Marin Technical University)의 2종류와 양력특성이 우수한 NACA 6409익형에 대해 보다 자세한 실험 연구를 행하였다. 모형은 가로세로비가 1.5이고 스팬(span)이 450㎜ 시위(chord)가 300㎜인 모형을 제작하여 실험에 사용하였다. 지면에 접근할 때 양항비의 경우 각 받음각에 대해 4˚ 부근에서의 값이 가장 크게 나타났고 NACA 6409의 경우 약 8에서 12정도이고 DHMTU 8에서 10정도이다. 피칭모우멘트에 있어서는 공력중심인 시위의 1/4근방에서 DHMTU계열의 익형이 NACA 6409보다 절대값이 매우 작게 나타났다. 따라서 WIG와 같은 수송체는 세로 운동특성이 매우 중요한 인자이기 때문에 세로운동자세 제어에 용이한 피칭모우멘트값이 작은 DHMTU 계열이 유리한다. In recent years, various kinds of high speed vehicle have been developing for marine transportation in many countries. A Wing-in-ground effect ship(WIG) is expected for candidate as a super high speed vehicle in the future. WIG is sustained by the aerodynamic lift generated by cambered-airfoil wing, and flies just above the sea surface. In this paper, the aerodynamic characteristics of two different type of cambered airfoils in ground effect are investigated through wind tunnel tests, to select better suitable airfoils for WIG. One is highly cambered airfoil NACA 64 series and the other is DHMTU series which have already been used to the EKRANO PLAN, a Russian WIG, developed by Department of Hydrmechanics of Marin Technical University. As result, it is shown that NACA 64 series are more effective in the lifting force, but DHMTU have smaller pitching moment about the quarter chord point, which can produce easier control of longitudinal motion

유기성자원의 퇴비원료로 활용 가능성 평가방법 개발

임동규,이승환,성기석,소규호,신중두,이정택 한국환경농학회 2006 한국환경농학회지 Vol.25 No.1

기존 트랙터 로터리날의 운동분석

이현동,김기대,김찬수,김성환 충남대학교 농업과학연구소 2004 농업과학연구 Vol.31 No.1

In this study, motion characteristics and power requirement of rotary tilling according to shape of conventional rotary blade were measured This study was performed to establish factors which needed to develop energy saving rotary blade. Starting point of edged curve of imported rotary blade was faster than that of domestic rotary blade after measuring and analyzing edged curve of rotary blade. So domestic rotary blade tills much soil than imported rotary blade. In analyzing motion of rotary blade, Rotary blade of A, D type was begun to contact at part 3. Analyzing back surface of rotary blade which contact to soil at critical λ results in contacting at e-f part. In measuring power requirement of rotary blade, specific torque and specific work of rotary blade are 160~170 kgf·m/m², 3,700 kgf·m/m³. It shows power requirement of rotary blade according to shape of rotary blade are very different.