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이승규,정지형,최은영,이성철,고형준,이준행 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.6
Purpose: To investigate the effects of resveratrol on the expression of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelialgrowth factor (VEGF) in human adult retinal pigment epithelial (ARPE-19) cells, and on experimental choroidal neovascularization(CNV) in mice. Materials and Methods: ARPE-19 cells were treated with different concentrations of resveratrol and then incubated under hypoxicconditions with subsequent evaluation of cell viability, expression of HIF-1α, and expression of VEGF. The effects of resveratrolon the synthesis and degradation of hypoxia-induced HIF-1α were evaluated using inhibitors of the PI3K/Akt/mTOR and theubiquitin proteasome pathways. In animal studies, CNV lesions were induced in C57BL/6 mice by laser photocoagulation. After 7days of oral administration of resveratrol or vehicle, which began one day after CNV induction, image analysis was used to measureCNV areas on choroidal flat mounts stained with isolectin IB4. Results: In ARPE-19 cells, resveratrol significantly inhibited HIF-1α and VEGF in a dose-dependent manner, by blocking thePI3K/Akt/mTOR signaling pathway and by promoting proteasomal HIF-1α degradation. In mice experiments, orally administeredresveratrol significantly inhibited CNV growth in a dose-dependent manner. Conclusion: Resveratrol may have therapeutic value in the management of diseases involving pathological neovascularization.
119구급대원의 개인보호장비 착용이 혈압·맥박·호흡에 미치는 영향
이승규,공하성,Yi, Seung-Ku,Kong, Ha-Sung 대한안전경영과학회 2021 대한안전경영과학회지 Vol.23 No.3
This study analyzed the physical changes in 119 paramedics transporting equipment at the emergency site and performing post-cardiopulmonary resuscitation through experiments. First, the average heart rate increased by about 25 times comparing CPR was performed without physical load and with personal protective equipment after moving equipment. In the third quartile, it increased to about 27 times. Second, when CPR was performed without physical load, and CPR was performed after moving the equipment with personal protective equipment, both the body temperature was raised and the rising body temperature was measured within normal body temperature. Third, the change in respiration rate increased by 7 times on average comparing CPR was performed without physical load and CPR was performed after moving the equipment while wearing personal protective equipment. In the third quartile, it increased to about 11 times. Finally, the change in blood pressure increased by 26.6 mmHg on average comparing CPR was performed without physical load and with wearing personal protective equipment after moving the equipment, and increased by 31.2 mmHg on average in the third quartile.
PVC-THF 용액에 비용매 첨가에 따른 PVC 박막의 표면 특성 분석
이승규,문제철,이원규 한국공업화학회 2022 공업화학 Vol.33 No.4
폴리염화비닐(polyvinylchloride, PVC)-tetrahydrofuran (THF) 용액에 PVC 비용매의 첨가와 박막 건조 공정이 PVC 박막에 미치는 영향을 분석하였다. 사용된 비용매는 알코올과 비알코올계로 구성되었으며, 첨가에 따른 PVC 박막의 표면거칠기와 표면 형상의 차별성에 따른 소수성 성질을 비교하였다. PVC-THF 용액 제조과정에 발생하는 용액 내 기포함유가 박막의 표면 구조에 미치는 영향이 큼을 확인하였다. 상대적인 고농도 PVC-THF 용액에서 코팅 박막의 정상적표면 물성을 구현하기 위하여 적절한 박막 건조법의 선택이 요구된다. 알코올계 비용매를 첨가할 경우 과립형 형상의다공성 표면을 갖는 PVC 박막이 얻어져 초소수성 특성을 보인다. 비용매에 대한 PVC-THF 용액의 부피 비는 코팅박막의 표면 형상에 영향을 주며, 비용매 첨가량이 많을수록 초소수성 PVC 박막을 형성하는 데 유리하다.
원추형(圓錐型) 탈곡기(??機)에 관(關)한 연구(硏究)
이승규,Lee, Seung Kyu 한국농업기계학회 1981 바이오시스템공학 Vol.6 No.1
The major limiting factor on the determination of combine capacity is the frequent occurence of clogging over the some parts of machine when the crop is wet in the case of Japanese self-feeding type combine. And in the case of American conventional combine having big separating parts, the great grain loss and damage occur when the machine is used for rice harvesting. This experiment was carried out to develop the new type threshing and separating equipment. Proto-type thresher which consist of a conical threshing drum and a conical separating sieve rotating around the threshing cone was constructed and tested. In the case of 800 rpm of threshing cone speed, average threshing loss was below 1 percent, separating loss was about 1 percent, grain damage was about 0.4 percent, and average total power required was about 2.6 PS. This design has some problems such as higher power required or wrapping problems under the conditions of feeding long damp straw. But, compared with the conventional combine or thresher, this machine certainly has some potentials for this approach to combine development. The crop feed rate must be increased through improvement of the feeding portion of the threshing cone. And it is required to investigate further about some parameters causing wrapping phenomena.