정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

ORiginal Article : Gastroprotective Effects of PMK-S005 against Ethanol-Induced Acute Gastric Damage in Rats

( Yoon Jeong Choi ),( Nayoung Kim ),( Ju Yup Lee ),( Ryoung Hee Nam ),( Ji Hyung Seo ),( Seonmin Lee ),( Hee Jin Kim ),( Yoon Jin Choi ),( Hye Seung Lee ),( Dong Ho Lee ) 대한간학회 2016 Gut and Liver Vol.10 No.3

Background/Aims: This study aimed to examine the gastroprotective effects of PMK-S005, which is a synthetic S-allyl-Lcysteine (SAC; a sulfur-containing amino acid), against acute ethanol-induced gastric damage in rats. Methods: Sprague- Dawley rats were divided into six groups, including a nonethanol group, groups treated with absolute ethanol 1 hour after pretreatment with various doses of PMK-S005 (1, 5, and 10 mg/kg) or rebamipide (50 mg/kg), and an absolute ethanolonly group. Ethanol-induced gross ulcer and mucus levels were measured. Myeloperoxidase, tumor necrosis factor a, interleukin 1β, PGE2, LTB4, cPLA2, COX-1, and COX-2 levels were estimated by enzyme-linked immunosorbent assay or Western blot analysis. Furthermore, the protein expression levels of antioxidant enzymes, including heme oxygenase-1 (HO-1), NAD(P)H:quinine oxidoreductase 1 (NQO-1), GCLC, and GCLM, were assessed. Results: PMK-S005 significantly attenuated the ethanol-induced gastric damage; it reduced mucosal inflammatory cytokine production and increased mucus levels. The expression levels of cPLA2, COX-1, and COX-2 were decreased by PMK-S005. PMK-S005 did not affect PGE2 synthesis, but LTB4 production was significantly suppressed. In addition, long-term administration of PMKS005 significantly increased the expression of HO-1, NQO-1, GCLC, and GCLM. Conclusions: These results strongly suggest that PMK-S005 prevents gastric mucosal damage and that these gastroprotective activities are due to anti-inflammatory effects and enhancement of the gastric defense system, including antioxidant enzymes. (Gut Liver 2016;10:348- 355)

성견 하악의 치주-치근단 실험적 복합병소에서 골조직 재생에 관한 연구

윤수한,백승호,김정혜 大韓齒科保存學會 1999 Restorative Dentistry & Endodontics Vol.24 No.2

국내산 중하(Metapenaeus joyneri) 내 주알레르겐 규명 : 가열 및 소화액에 의한 변화

윤성호,김현아,김현미,최정희,서창희,남동호,김윤근,민경업,박해심 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

산업 자동화 시스템을 위한 안정된 인터페이스 기술 개발 및 구현

윤호군,정화영 목원대학교 자연과학연구소 1999 自然科學 硏究論文集 Vol.8 No.-

In general, industrial automation systems(IASs) deals with very sensitive data about operation and production and operates at the poor environment. IASs consist of a control part and a GUI(Graphical User Interface) part. The control part mainly takes charge of controling each operational device and the GUI part takes charge of communication mode for data and controls between the user and IAS. Thus communication information between the two parts includes production, control and operation information. It is very important to make sure that the GUI correctly processes and analyses the communication information, because GUI delivers such information between the operation part and the user. There has been difficulties in implementing GUI communication part without losing such important operational data. Therefore this paper presents development and implementation of a new stable processing method of GUI communication using a combined mechanism of message interrupt and timing. Several systems with this method have been implemented and tested in various conditions, and they show us that lose of the unstable operational data can be prevented.

고속치환 영상처리를 위한 암호화 기법에 관한 연구

윤정오,이훈재,홍영호,최병진 경운대학교 산업기술연구소 1998 産業技術硏究論文誌 Vol.1 No.1(A)

In this paper, we suggest a new encryption system for high speed permutation image processing. We show how to secure attack relative to redundancy in image data. In addition, by applying the proposed permutation algorithm in image data, we show how to solve problems related to scanning sequence and scraming.

개 아토피성 피부염 장기치료 1례

박은정,윤기영,박정호,이왕희,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1

A 7-year-old male castrated Shih-tzu dog was referred to the Veterinary Medical Teaching Hospital of Chungnam National University for severe pruritus. On physical examination were confirmed systemic erythema and alopecia, crust on the neck and flank region. Tape strip test identified numerous degenerative neutrophils and severe Malassezia infection. Treatment for severe pruritus was applied with systemic antihistamine therapy and topical therapy with antimicrobial shampoos. For the finding of appropriate treatment of atopic dermatitis, it was chosen six immune-related treatments. And clinical sign scores were evaluated by investigator with CADESI-03 after each application of six treatments. Application of human immunoglobulin G and leflunomide showed the remarkable regression of lesions.

계열별 고등학생집단의 뇌기능특성화 경향에 대한 연구

윤규태,최기수,안의태,고정식,양남길,박경호 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

본 연구에서는 계열에 따른 고등학생들의 대뇌반구기능의 특성화 또는 편재화의 경향을 알아보고, 전공분야에 대한 적응력과의 상관관계를 검토하고자 했다. 일반고등학교 인문계열 학생 359명, 자연계열 학생 371명, 음악과 미술전공 학생을 포함한 예능계열 196명, 체육특기자를 포함한 체육계열 학생 151명 등 1,077명을 대상으로 각 계열별, 남녀별, 성적별 고등학생 집단들의 대뇌반구의 특성화, 편재화 경향을 시나가와(품川)질문지법을 이용하여 분석하였으며, 다음과 같은 결과를 얻었다. 1. 인문계열 고등학생의 뇌기능의 편재화 경향은 우뇌형 54.3%, 양쪽뇌형 32.6% 및 좌뇌형 13.1%였다. 남녀별로는 남학생은 우뇌형 62.9% 양쪽뇌형 27.9% 및 좌뇌형 9.5%로 나타났으며, 여학생은 각각 43.7%, 38.6% 및 17.7%로서 여학생이 남학생에 비하여 죄뇌화 경향을 보였다. 2. 자연계열 고등학생의 경우는 우뇌형 56.9%, 양쪽뇌형 29.9% 및 좌뇌형 13.2%로서 인문계열 고등학생과 비슷한 분포를 보였다 이를 남녀별로 구별하여 보면 남학생은 62.2%, 27.1% 및 10.2%, 여학생은 51.5%, 32.5%및 16.0%의 분포를 보여, 역시 여학생의 좌뇌화 경향이 뚜렷했다. 3. 예능계열 고등학생의 경우는 우뇌형 56.1%, 양쪽뇌형 35.2% 및 좌뇌형 8.7%의 분포를 보였으며, 이를 전공별로 세분해서 살펴보면 음악전공학생의 경우 53.7%, 35.5% 및 10.7%로서 전체 평균과 거의 비슷한 분포를 보였으나, 미술전공학생의 경우 60.0%, 34.7% 및 5.3%로서 , 특히 좌뇌형의 경우 음악전공에 비해 절반수준에도 못 미치는 경향을 보였다. 4. 체능계열 고등학생 집단의 경우 우뇌형 50.3%, 양쪽뇌형 37.7% 및 좌뇌형 11.9% 분포를 보였다. 5. 성적별로 보면 일반고등학교 학생 가운데 성적 우수 집단은 뚜렷하게 좌뇌형 경향(25.6% 및 25.0%)을 보였다. 6. 예능계열의 우수집단은 양쪽뇌형의 분포비율(50.0% 및 44.4%)이 특히 높았다. 7. 체육계열의 우수집단은 좌뇌형 분포(21.6%)가 높았다. According to the advanced study on differential theory of brain function, the left hemispheric functions are concerned more on the verbal, logical, sequential and arithmetic abilities, whereas the right hemisphere has characteristics of non-lingual, general, creative and aesthetic abilities. The authors compared the tendency of hemispheric specialization in high school students with different educational condition and facilities. Sinakawa's questionnaire method was the instrument for this study. The results obtained were as follows: Among 1,077 of whole subjects, right hemispheric dominant type was 55.0% (59.1% in male, 51.0% in female), bilateral type was 32.9% (10.6% in male, 35.1% in female) and left hemispheric dominant type was 12.2% (10.4% in male, 13.9% in female). 1. Of the 359 subjects in the field of humanity science, right hemispheric dominant type was 54.3% (62.9% in male, 43.7% in female), bilateral type was 32.6% (27.9% in male, 38.6% in female) and left hemispheric dominant type was 13.1% (9.5% in male, 17.7% in female). 2. Of the 371 subjects in the field of natural science, right hemispheric dominant type was 56.9% (62.2% in male, 51.5% in female), bilateral type was 29.9% (27.1% in male, 32.5% in female) and left hemispheric dominant type was 13.2% (10.2% in male, 16.0% in female). 3. Of the 196 art school students, 56.1% was regraded as right hemispheric dominant type, students majoring music was 53.7%, 35.5% and 10.7%, respectively, whereas the frequency for students majoring find art was 60.0%, 34.7% and 5.3%. 4. In students majoring physical education, 50.3% were shown in right hemispheric dominant type, 37.7% were bilateral type and 11.9% were left hemispheric dominant type. 5. Laterality patterns of students who adapt more successfully to their specific studying fields show following characteristics; Successful students of general high school show pronounced left shift in their laterality pattern, whereas successful students of art school exhibit more bilateral type. And successful students of physical education school show left shift in their laterality patterns.

불리언 질의 재구성에서 의사결정나무의 학습 성능 감도 분석

윤정미,김남호,권영식 한국경영과학회 1998 한국경영과학회지 Vol.23 No.4

One of the difficulties in using the current Boolean-based information retrieval systems is that it is hard for a user, especially a novice, to formulate an effective Boolean query. One solution to this problem is to let the system formulate a query for a user from his relevance feedback documents. In this research, an intelligent query reformulation mechanism based on ID3 is proposed and the sensitivity of its retrieval effectiveness, i.e., recall, precision, and E-measure, to various input settings is analyzed. The parameters in the input settings is the number of relevant documents. Experiments conducted on the test set of Medlars revealed that the effectiveness of the proposed system is in fact sensitive to the number of the initial relevant documents. The case with two or more initial relevant documents outperformed the case with on initial relevant document with statistical significances. It is our conclusion that formulation of an effective query in the proposed system requires at least two relevant documents in its initial input set.

스트레스 대처방식이 조혈모세포 이식 환자의 우울과 불안에 미치는 영향

윤수정,이철,임성후,채정호,전태연,김광수 한국정신신체의학회 2002 정신신체의학 Vol.10 No.1