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남동호,김명은 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.1
Purpose: The clinical efficacy of subcutaneous allergen immunotherapy (SCIT) for the treatment of patients with severe atopic dermatitis (AD) using house dust mite (HDM) extract has been reported. Cyclosporin has been regarded as an effective medication for treatment of severe AD. In this study, we investigated a clinical usefulness of combined treatment with SCIT and cyclosporin in patients with severe AD. Materials and Methods: Nine patients with severe AD and hypersensitivity to HDM were treated with a combination of SCIT using HDM extract and cyclosporin for 12 months. The primary efficacy outcome was the change in the standardized clinical severity scoring system for AD (SCORAD) values, measured at 6 and 12 months, in comparison with the values at baseline. Daily dose of cyclosporin was decreased or discontinued according to the degrees of clinical improvements in individual patients. Results: In 8 patients who completed 12 months of treatment, the SCORAD values significantly decreased from 71.5±15.5 (mean±SD) at baseline to 20.4±14.6 at 6 months and 26.3±13.6 at 12 months (Wilcoxon signed-rank test, p=0.01), and no significant systemic side effects were observed. Cyclosporin was discontinued in 4 of 8 patients within 8 months after starting the combined treatment. Conclusion: In this study, combined treatment with SCIT and cyclosporin resulted in significant clinical improvements in patients with severe AD. Further studies are needed to test the clinical usefulness of this combined treatment for patients with severe AD.
남동호,박수용,최상현 한국지진공학회 2005 한국지진공학회논문집 Vol.9 No.1
This paper presents an improved system identification methodology for structural systems by applying static compliance dominant (SCD) frequencies. The existing sensitivity-based system identification technique is extended to adopt the static compliance dominant frequencies, and the performance of the additional spectral information, i.e., SCD frequencies, is compared with that of the natural frequencies only via a numerical example of a mechanical system. The results of the numerical study indicate that the additional use of the SCD frequencies improves accuracy in system identification problems. 본 논문에서는 정유연성 지배주파수를 이용한 개선된 매개변수 인식기법이 제안되었다. 정유연성 지배주파수를 이용할 경우 주파수응답함수에서 고유주파수 보다 다수의 정보를 추출할 수 있어 매개변수 인식의 성능을 향상시킬 수 있는 장점이 있다. 정유연성 지배주파수를 매개변수 인식에 이용하기 위하여 기존의 고유주파수 민감도에 기반한 구조계 인식기법이 확장되었다. 정유연성 지배주파수의 이용을 통한 매개변수 인식의 성능향상은 수치예제를 통해 증명하였다. 수치예제는 스프링과 질량으로 이루어진 간략 모델이 사용되었으며, 고유주파수 만을 이용하여 구한 인식값과 비교한 결과 보다 정확한 매개변수 값의 인식이 가능함을 알 수 있었다.