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만니톨 투여에 의한 혈뇌장벽의 개방은 All-or-None Phenomenon인가?
윤수한,조기홍,조경기,안영민,안영환 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.9
We evaluated the effect of mannitol-induced blood-brain-barrier disruption(BBBD) in 20 rats of the routine-dose mannitol group(1.75g/㎏). 7 rats of the small-dose mannitol group(0.87g/㎏), and 10 rats of the saline control group. Radioactivity ratios of brain section to plama in the routine dose mannitol group revealed a wide variation of 0.0134 to 0.1747 which was compared to the small dose mannitol group of 0.0107-0.0275 in the plasma albumin space and to the saline control group of 0.0051-0.0174. This result suggest that mannitol-induced BBBD may not be threshold event of all-or-none phenpomenon, but progressive graded reacton with various sensitivity.
신경교종 및 교모세포종 세포와 동시배양된 혈관내막세포에서 Dexamethasone의 투여에 따른 투과도 변화
윤수한,조기홍,김세혁,안영환,안영민,조경기 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1
Even though many hypotheses have been advanced from the anatomical and functional analysis of in vivo and in vitro models of brain tumors, it is still not yet possible to explain the mechanism of peritumoral edema. Dexamethasone administration has been shown to dramatically decrease peritumoral edema, especially in patients with malignant brain tumor. We evaluated permeability changes of the endothelial monolayer co-cultured with or without glioma and glioblastoma cell lines by dexamethasone administration. All groups showed reduced permeability after dexamethasone administration: 73.6% in the endothelial monolayer culture, 83.8% in the endothelial monolayer co-cultured with C6 glioma cell line, 81.8% in the coculture with H683 astrocytoma cell line, 69.3% in the coculture with 373 MG glioblastoma cell line, and 53.0% in the coculture with 87 MG glioblastoma cell line. These results suggested that dexamethasone inhibited not only the production of some soluble factor which was secreted from the co-cultured cells to the media, but also influenced endothelial cells thus explaining the pathogenetic mechanism of peritumoral edema in malignant brain tumors.