Begonia Semperflorens의 器官分化에 미치는 몇가지 要因에 關한 硏究

李承雨,李容珠,尹洪淵 경희대학교 유전공학연구소 1989 遺傳工學論文集 Vol.1 No.-

Begonia semperflorens 줄기組織을 MS 배지를 이용하여 器內 培養時 器官分化 및 生長에 미치는 cytokinin류, Ca, Mg myo-inositol의 影響을 조사한 바 그 결과를 요약하면 아래와 같다. NAA 0.1mg/l와 BA 0.1mg/l가 혼용된 배지에서는 不定芽 形成을 촉진시켰던 反面 NAA 0.1mg/l 와 Kinetin 0.1mg/l가 혼용된 培地에서는 不定根 形成 및 伸長이 촉진되었다. Ca 처리농도에 있어서 부정아 형성은 무처리에 비하여 Ca 처리배지에서 약간 증가하는 경향을 보였던 반면, 부정근의 형성은 Ca 처리배지에서 민감하게 반응하였다. 특히 Ca 440mg/l 처리에서 부정아 및 부정근 형성이 가장 양호하였다. Mg이 첨가되지 않은 배지에서는 부정아 및 부정근이 형성되지 못했고 Mg370mg/l에서 가장 많은 부정아 및 부정근이 형성되었다. 低濃度(50, 100mg/l)의 myo-inositol이 첨가된 배지에서는 부정아 형성에 효과가 없었지만 고농도(200, 400mg/l)에서는 약간 촉진되었다. 이에 비하여 myo-inositol은 부정근 형성에 매우 민감한 반응을 보였다. Experiments were conducted to investigate the effects of cytokinins, Ca, Mg, and myo-inositol on the formation and growth of adventitious shoot and root in Begonia semperflorens stem segments cultured on MS medium. The medium containing both NAA 0.1 mg/l and BA 0.1 mg/l promoted the formation of adventitious shoot, while NAA 0.1 mg/l and kinetin 0.1 mg/l in the medium accelerated the formation and growth of adventitious root. In concentrations of Ca treatment, the formation of adventitious shoot tended to be increased on the medium containing Ca. On the other hand, the formation of adventitious root was sensitively affected with Ca treatments, the concentration of Ca 440 mg/l, especially, gave the best result for adventitious root formation and growth. No adventitious shoot and root was formed on the medium without Mg. However, the best result for the formation of both adventitious shoot and root was obtained on the medium containing Mg 370 mg/l. The formation of adventitious shoot was not effective on the medium with low concentrations of myo-inositol (50 and 100 ㎎/l), while that was slightly promoted with high myo-inositol concentrations (200 and 400 mh/l). On the other hand, myo-inositol showed the sensitive response for adventitious root formation.

GC/NPD를 이용한 다성분 잔류농약의 동시분석

김우성,이선화,김상엽,정동윤,김재이,이영자,이홍재,정성욱,박흥재 한국환경과학회 2003 한국환경과학회지 Vol.12 No.10

Pesticides were extracted from samples with 70% acetone and methylene chloride in order, and then cleaned up via open-column chromatography apparatus packed with fiorisil, and finally analyzed simultaneously the organophosphorus pesticides using GC/NPD, Ultra-2 and Ultra-1 fused silica capillary columns were used to separate and identify the products. Recovery of most analytes from soybean sample, taken from pesticide residues well, was greater than(80%) for all except(6) analytes. This method can simultaneously determine multiple pesticides with a high degree of accuracy and precision.

頭部 X-線 規格寫眞을 利用한 韓國正常成人의 眼窩部 計側學的 硏究

金雨慶,洪聖鎬,丁銓殷,金泰淵 大韓成形外科學會 1983 Archives of Plastic Surgery Vol.10 No.2

For measurements on orbit of normal Korean adults by non-rotated skull P-A roentgenogram, the author measured the interorbital distance, the distance between medial and lateral orbital walls, the depth of cribriform plate from the upper orbital margin, the thickness of the lateral orbital margin, the thickness of the lateral orbital wall at zygomatico-frontal suture, and the angle between both greater wings of sphenoid. The roentgenograms of 200 patients of adults above 20 years were reviewed. To establish original standards, the author used non-rotated posteroanterior roentgenograms of skulls obtained at a focus-film distance of 100cm and a patient-film distance of 7cm. The results are summarised as follows: 1. The interobital distances were 27.46±1.64mm in male and 25.52±1.42mm in female. 2. The distances between medial and lateral walls were 36.94±1.52mm in male and 34.54±1.04mm in female. 3. The depths of cribriform plate from the upper orbital margin were 9.83±0.41mm in male and 9.84±0.34mm in female. 4. The thicknesses of the lateral orbital wall at zygomatico-frontal suture were 5.09±0.52mm in male and 4.85±0.42mm in female. 5. The angles between both greater wings of sphenoid were 41.43±3.48 degree in male and 41.80±3.45degree in female. 6. In the above 5 measurements, there were no significant differences among the age groups above 20 years old. 7. In contrast to female, male had significantly larger interobital distance and distance between medial and lateral orbital walls.

좌심방 석회화와 관련된 반복된 좌심방 혈전 1예

김성훈,우성용,오유경,정우백,임철현,신재원,박철수,윤호중,정욱성,홍순조 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.3

항암화학요법 중 호중구감소증이 발생한 저위험군 발열 환자들을 대상으로 한 경구 항균제 요법의 임상적 유용성 및 안정성에 대한 연구

김연숙,이혁,기현균,김춘관,김신우,김성민,백경란,김원석,윤성수,이홍기,강원기,박찬형,박근칠,송재훈 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

목적 : 항암화학요법 중 호중구감소증을 동반한 발열이 발생하는 암환자들을 치료하기 위한 다양한 항균제와 여러 가지 방법들이 시도되고 있는 가운데, 합병증과 사망률의 발생가능성이 적은 저위험군 환자들을 대상으로 초기 72시간동안 정주 항균제를 투여한 이후 경구 항균제로 전환하는 요법의 유용성과 안정성을 평가해보고자 본 연구를 시행하였다. 방법 : 1998년 2월부터 1999년 9월까지 본원에서 항암화학요법 중 호중구감소증과 발열이 발생한 환자들 가운데 기저 암질환이 고형암이거나 림프종이고, 입원당시 패혈증의 증후가 없으며 입원 72시간이내에 해열되고 백혈구수치가 증가 추세인 환자들을 대상으로 하여 72시간 동안 정주 항균제를 투여한 이후 경우 ciprofloxacin 750㎎을 하루 2회씩 투여하여 총 4일간 투여하였다. 모든 환자들은 열이 떨어지고 호중구감소증이 회복될 때까지 입원하도록 하였다. 결과 : 총 38명 환자의 40예가 등록이 되었고, 환자들의 기저암 질환은 고형함이 72.5%, 림프종이 27.5%였다. 입원당시 평균 호중구치수는 156/㎕였고, 호중구수치가 100/㎕미만인 경우는 65%였으며, 호중구감소증이 지속된 기간의 평균은 2.4일이었다. 40예 중 39예가 항균제의 변형이나 추가 없이 호중구감소증과 발열로부터 회복이 되어 97.5%의 성공율(95% 신뢰구간: 86.8-99.9%)을 보였다. 부작용으로 피부발진이 있었던 경우가 한 예 있었는데, 증상이 경하여 경구 항균제를 지속할 수 있었다. 심와부의 동통으로 복용을 지속할 수 없어서 대상에서 제외된 예가 또 한 예 있었다. 결론 : 항암요법 중 호중구감소증과 발열을 동반한 환자들 가운데 저위험군 환자들에서 항균제 72시간정주 이후 경구 항균제로의 전환요법은 효과적이고도 안전한 치료방법이라고 할 수 있다. Background : Oral antibiotic therapy following empirical intravenous antibiotics may be effective and safe for febrile neutropenic patients with lowrisk for complications. Methods : We conducted a prospective clinical trial of oral antibiotic therapy in the patients with neutropenia and fever during chemotherapy for cancer. Underlying malignancies were solid tumor or lymphoma with short duration of neurtropenia and the patients had no evidence of clinically or microbiologically documented infections. Oral ciprofloxacin was given to the patients who lacked signs of sepsis on admission, had a rising tendency of neutrophil count (ANC >100 /㎕ ) at 72 hours, and were afebrile at 72 hours. All patients were hospitalized until neutropenia and fever resolved. Results : A total of 40 episodes of 38 patients were enrolled from February 1998 to September 1999. The mean neutrophil counts on admission were 156/㎕ and the mean duration of neutropenia was 2.4 days. The episodes which had neutrophil count below 100 /㎕ were 26 (65%). Treatment was successful in 39 of 40 episodes (97.5% : 95 % confidence interval, 86.8% to 99.9%). Adverse reactions of oral ciprofloxacin were skin rash and epigastric soreness in two cases, respectively. There were no deaths during the study. Conclusions : For low-risk febrile patients with neutropenia during cancer chemotherapy, switch therapy to oral ciprofloxacin at 72 hours following intravenous broad-spectrum antibiotics is effective and safe,

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

A Kinetic Study on the De-Crosslinking and Decomposition of Silane-Cross-Linked Polyethylene in Supercritical Methanol

Hong, Giyoung,Hong, Soon Man,Koo, Chong Min,Baek, Bum Ki,Lee, Hong-shik,Lee, Youn-Woo American Chemical Society 2015 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.54 No.48

<P>De-crosslinking of silane-cross-linked polyethylene (S-XLPE) in supercritical methanol was investigated. Changes in gel content and molecular weight with reaction temperature and reaction time were analyzed in a batch reactor, and kinetic parameters were calculated from the experimental data. The reaction time for de-crosslinking shortened as the reaction temperature increased and the complete de-crosslinking of S-XLPE was achieved at 320 °C and 20 min. The de-crosslinking rate of S-XLPE fit well with the first order reaction model. In addition, the molecular weight of de-cross-linked polyethylene (DXPE) decreased further as reaction temperature and reaction time increased when the reaction temperature exceeded 360 °C relative to that of the original polyethylene before being cross-linked. The decreasing molecular weight trend also fit well with the first order reaction model.</P>

ZnO-Bi2O3-Sb2O3-Mn3O4-NiO 바리스터의 소결과 입계 특성

홍연우 ( Youn Woo Hong ),이영진 ( Young Jin Lee ),김세기 ( Sei Ki Kim ),김진호 ( Jin Ho Kim ) 대한금속재료학회(구 대한금속학회) 2013 대한금속·재료학회지 Vol.51 No.5

We prepared ZnO-Bi2O3-Sb2O3-Mn3O4-NiO(Sb/Bi=0.5, 1.0, and 2.0) varistors to examine the co-doping effect of 1/6 mol% Mn3O4 and 0.5 mol% NiO (Mn:Ni = 1:1) on the reaction, microstructure, and electrical properties, such as J-E characteristics, bulk defects and grain boundary properties. The sintering and electrical properties of the ZnO-Bi2O3-Sb2O3-Mn3O4-NiO varistor were controlled by Sb/Bi ratio. Pyrochlore (Zn2Bi3Sb3O14) was decomposed and promoted densification at lower temperature in Sb/Bi = 1.0. Pyrochlore reproduced on cooling, α-spinel (Zn7Sb2O12), and β-Bi2O3 were formed in all systems above 1000℃. More homogeneous microstructure was obtained in all systems by Mn doping due to the α-spinel formation. The varistor performance was drastically improved as non-linear coefficient of α = 22~84. It was found to form Zni (0.20 eV) and V0 (0.33 eV) as dominant defects. The grain boundaries consisted of an electrically single type (0.90~0.93 eV) by the co-doping effect of Mn and Ni.

화이트칼라 노동조합원의 이중몰입에 관한 연구

윤홍우(Hong Woo Youn) 한국산학경영학회 1997 산학경영연구 Vol.10 No.-

N/A

소결온도가 ZnO-Co3O4-Cr2O3의 결함과 전기적 특성에 미치는 영향

홍연우 ( Youn Woo Hong ),김유비 ( You Bi Kim ),이영진 ( Young Jin Lee ),김세기 ( Sei Ki Kim ),백종우 ( Jong Hoo Paik ),조만호 ( Man Ho Jo ) 대한금속재료학회(구 대한금속학회) 2014 대한금속·재료학회지 Vol.52 No.12

The defects and origin of the good varistor properties in the ZnO-Co3O4-Cr2O3 system were investigated by admittance spectroscopy, I-V characteristics, and impedance and modulus spectroscopy. Two kinds of defects were detected, but (0.27 eV) was identified as a major donor level by admittance spectroscopy. The ZnO grain resistivity of ~0.4 Ωcm was calculated but somewhat increased with sintering temperature. J-E characteristics with varistor behavior was seen in this system while the nonlinear coefficient α changed from 9 to 92 with sintering temperature. The single potential barrier of 0.64-1.01 eV at the grain boundary region was confirmed by impedance and modulus spectroscopy. The origin of a good varistor behavior in ZnO-Co3O4-Cr2O3 would be due to the formation and stabilization of a double Schottky barrier by the redox reaction of Co ions and the existence of small Cr ions in the grain boundaries.