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GC/MS에 의한 뇨 중 내인성 에스트로겐의 Profiling
이선화,양윤정,김태욱,팽기정,정봉철,Lee, Seon Hwa,Yang, Yoon Jung,Kim, Tae Wook,Paeng, Ki Jung,Chung, Bong Chul 대한화학회 1997 대한화학회지 Vol.41 No.4
성 호르몬으로서의 역할과 암 성장의 잠재적 저해 효과를 지니고 있는 에스트로겐의 대사체들을 동시에 분석하기 위하여 Serdolit AD-2 수지와 효소 가수분해, 액체-액체 추출방법을 이용한 전처리 과정을 확립하였으며, MSTFA/TMSCl 혼합액에 의해 trimethylsilylether 형태로 유도체화된 에스트로겐들을 GC/MS의 SIM(selected ion monitorning) 방법으로 동시에 분석, 정량할 수 있는 조건을 설정하였다. 그 결과 회수율은 80.97~97.81%이었고, within-a-day 및 day-to-day 분석에서의 RSD값은 각각 0.24~25.35%, 1.05~23.94%이었으며, 이 방법으로는 소변 내에 존재하는 19종의 에스트로겐 대사체들을 정량하여 한국인 정상인 참고치(여자:22~35세, 남자: 39~57세)를 설정하였다. Estrogens, which play an important role in sex hormone and potential inhibitor of cancer cell proliferation were profiled for normal female and male. The nineteen endogeneous estrogens were simultaneously analyzed by selected ion monitoring method of GC/MS. Urinary estrogens were extracted by using Serdolit AD-2 resin, hydrolyzed with $\beta-glucuronidase/arylsulfatase$ from Helix pomatia, liquid-liquid extraction and quantitatively derivatized by MSTFA/TMSCl mixture in order to be detected on the GC/MS. The good quality-control data were obtained through the precision and accuracy test and the recovery range of them was 80.97∼97.81%. The Korean reference values of urinary estrogens were established and differences were found in normal female compared with normal male.
이선화 대한영상의학회 1977 대한영상의학회지 Vol.13 No.2
Splenoportography has been proved a useful method for the evaluation of circulatory disturbances in portal hypertension. Author analyzed the various aspect of these disturbances as judged by changes in collateral circulations and width of the portal vein and splenic vein in 30 cases that were studied under the clinical suspection of portal hypertension during 6 years, from 1971 to 1977, at Department of Radiology, N. M. C. The results are as follows. 1. Intrahepatic obstruction is a common cause of portal hypertension, and cirrhosis is the most frequent cause that was found in 80% of cases. 2. Chief complaint was hematemesis and melana, respectively 73% and 60% in incidence. 3. The portal pressure was more than 260mm H2O levels and the ranges were wide as 400-600mm H2O levels. 4. No definite correlation is present between the degree of portal pressure and the diameter of splenic and portal veins were mainly dilatated. At the half of cases, the diameter of splenic vein was rang d from 9 to 16mm and portal vein was ranged from 17 to 24mm. 5. The filling of collateral circulations was to be definite, though not regular, sign of increased portal pressure. In liver cirrhosis, the 97% of collateral circulations were formed via coronary vein, and then short gastric vein and inferior mesenteric vein as a order. At the extrahepatic obstruction of portal hypertension, bridging collaterals were also accompanied.
이선화 한국카운슬러협회 2004 相談과 指導 Vol.39 No.-
서양의 전통적 심리학에서는 출생 후 성장함에 따라 신체적으로 변화하는 것을 외적 성장이라고 하며, 내적 성장은 마음에서 일어나는 정서적인 성숙을 의미하는 심리적 성장과 마음을 넘어선 광범위한 수준에서 영적 성장이 있다. 동양의 관점에서는 인간은 육체와 마음과 영으로 구성되어 있다고 한다. 동양의 전통들에서는 세 가지 수준이나 영역들, 즉 신체(body), 마음(mind), 영성(spirit) 또는 거칠은(gross), 미묘한(subtle), 원인의(causal) 세 가지 영역으로 인간의 내면세계를 설명하고 있다. 서양적 의식을 가지고 동양을 바라본 관점에서는 물질(matter), 신체(body), 마음(mind), 영혼(soul), 영성(spirit) 등 다섯 가지로 설명하면서 더 상세하게 구분하였다. 이들 견해의 공통점은 마음은 심리적 영역이며, 이 모든 수준에 영성이 편재해있다고 한다. 그러므로 심리적 성장이 문제들에 대해서 마음의 영역에서 성숙하게 대처하게 되는 변화라고 한다면
이선화,김원호,이상록,이경석,채제건,고재기 한국심초음파학회 2013 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.21 No.3
Background: Stress-induced cardiomyopathy (SCM) is characterized by apical ballooning on echocardiography, but some of SCM patients show non-apical involvement and their characteristics are not well defined. Methods: We investigated 56 patients that were diagnosed as SCM and divided them into 2 groups: apical ballooning syndrome (ABS, n = 49, 87.5%) and non-apical ballooning syndrome (N-ABS, n = 7, 12.5%) groups. Patients with N-ABS were significantly younger than those of the ABS group (52 ± 11 vs. 73 ± 10 years, p < 0.001). Results: Types of preceding stressors and clinical presentation including chest pain, pulmonary edema, cardiogenic shock and in-hospital mortality were comparable between the two groups. In the N-ABS group, wall motion score index was significantly lower than in the ABS group (1.61 ± 0.35 vs. 1.93 ± 0.31, p = 0.016). On electrocardiogram (ECG), T-wave inversion (57.1% vs. 95.8%, p < 0.001) were less frequent in the N-ABS than in the ABS group. Furthermore, maximum QT and corrected QT (QTc)intervals in the N-ABS patients were significantly shorter than the ABS patients (QT, 419.9 ± 66.1 vs. 487.3 ± 79.6 ms, p = 0.038;QTc, 479.0 ± 61.9 vs. 568.0 ± 50.5 ms, p < 0.001). Conclusion: Patients with the N-ABS showed not only atypical echocardiographic findings, but also atypical clinical and ECG manifestations. Integrated consideration is needed to reach a diagnosis of the non-apical subtype of SCM.