부식산 제거율 향상을 위한 오존공정의 개선에 관한 연구

이유미,손일호,이동석 강원대학교 산업기술연구소 2007 産業技術硏究 Vol.27 No.A

Ozone alone, Ozone/GAC, Ozone/H_(2)O_(2) and Ozone/GAC/H_(2)O_(2) processes were introduced for treatment of humic acid, which is a representative refractory organic compound. H_(2)O_(2) and GAC used as catalysts for experiment. The treatment efficiencies of humic acid in each process were analyzed for pH variation, DOC removal, and UV_(254) decrease. UV_(254) decrease in Ozone/GAC and Ozone/GAC/H_(2)O_(2) processes were the highest with about 93%, and Ozone alone and Ozone/H_(2)O_(2) processes were 88%. DOC removal in Ozone/GAC/H_(2)O_(2) process was the highest with 71%. Removal by Ozone/GAC, Ozone alone, and Ozone/H_(2)O_(2) processes were 66%, 39%, and 47%, respectively.

크론병에 대한 CoPPLX의 방어효과에 대한 연구

이호학,김유림,문창기,이재일,양병윤,김종수,이정민,정재혁,안석진,박상준,김윤권,김소연,김영중,조민구,최영자,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

로타바이러스 원내 감염과 지역사회 획득 감염의 비교 연구

유재성,진현주,강호석,오지은 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Purpose: This study was performed to investigate the epidemiologic and clinical characteristics of rotaviral infection, the most common nosocomial gastroenteritis. Method: We retrospectively reviewed the records of 983 patients who were diagnosed as rotavirus gastroenteritis from January 2006 to March 2010. We divided them into two groups: group A for community-acquired rotavirus infection (N=810), group B for nosocomial infection (N=173). We investigated the characteristics of both groups. Results: The percentage of nosocomial infection among rotavirus gastroenteritis was 18% in our study. Rotaviral infection in both groups was more common in winter. The average age (±SD) of group A and B was 25.8±23.3 and 17.8±15.7 months old, respectively. The average hospital days (±SD) were 4.3±2.0 days for group A and 9.0±3.5 days for group B. Nosocomial infection symptoms of group B started at 4.6±1.7 hospital days on average. Fever, vomiting, abdominal pain, convulsion, elevation of serum CRP (C-reactive protein) or AST (Aspartate aminotransferase) were observed more common in group A than B. Conclusion: The nosocomial rotavirus infection rate did not decrease as we expected in spite of our effort of strict hygiene control. Nosocomial infection showed more favorable prognosis than community-acquired infection but demanded longer days of hospitalization and more cost.

정확한 완충기체효과가 적용된 질량분석원리에 대한 다중입자 분석 전산시늉

이유용,이원욱,오차환,김필수,송석호 한양대학교 자연과학연구소 2001 自然科學論文集 Vol.20 No.-

질량분석기로 사용되는 폴 트랩 내에서 보다 실제적인 이온운동을 예측해내기 위하여 약 2천 개의 다중입자의 궤적에 대한 계산을 실시하였다. 보다 정확한 질량 분석스펙트럼을 얻기 위하여 충돌확률에 대한 보다 정확하고 실질적인 함수 값을 도입하였다. 계산된 전산시늉의 결과들로부터 특히 작은 질량의 영역에 대한 분석을 할 경우 본 논문에서 제시된 바와 같이 매우 정확한 충돌확률이 고려되어야 함을 확인할 수 있었다. To predict the practical characteristics of ion motion in the paul trap as a mass spectrometer, the ion trajectories of the multi-particle(over than 2000 particles) were calculated. In order to expect more practical mass spectrum, the exact expressions for the collision probability was adopted. From the simulation result, we found that the exact collision probability has to be considered to analyze the materials existed in the low mass region.

Bacillus lentimorbus WJ5의 감마선유도 돌연변이체들에서 공통으로 발현되는 방사선 관련 유전자의 microarray 분석

이영근,장화형,장유신,허재호,형석원,정혜영 한국환경생물학회 2004 환경생물 : 환경생물학회지 Vol.22 No.3

본 연구에서는 감마선으로 유도된 돌연변이체들에서 공통으로 발현되는 방사선 관련 유전자들의 발현을 연구하기 위하여, B. lentimorbus WJ5의 방사선 유도 돌연변이체에서 발현되는 유전자를 DNA microarray로 동시에 탐색하였다. DNA microarray는 B. lentimorbus WJ5 genome을 무작위로 절단하여 2,000단편으로 구성하였으며, 감마선 (^(60)Co)으로 유도된 7돌연변이체의 발현을 정량적으로 관찰하였다. 클러스터 분석결과 발현된 408 유전자 중 27개가 감마선 유도 돌연변이체 모두에서 유의하게 발현이 증가되었다. 특히, 복구(mutL, mutM)에너지 대사 (acsA, sdhB, p하, yhjB, citB), protease(npr), 산화자극에 대한 환원 (HMM)관련 유전자들이 동시에 증가되었다. 이는 감마선 유도 돌연변이체들에서 자발적인 직/간접 복구 관련 유전자의 발현 증가는 방사선 노출 직후 보이는 stress response와는 다른 현상임을 나타내는 것으로 생각된다. To study the radiation related gene expression in mutants of Bacillus lentimorbus WJ5 induced by gamm radiation, the simultaneous gene expression was analyzed by DNA microarray. We constructed DNA chips including two thousand randomly digested genome spots of B. lentimorbus WJ5 and compared its quantitative aspect with seven mutants induced by gamma radiation (^(60)Co). From the cluster analysis of gene expression pattern, totally 408 genes were expressed and 27 genes were significantly upregulated by the gamma radiation in all mutants. Especially, genes involved in repair (mutL, mutM), energy metabolism (acsA, sdhB, pgk, yhjB, citB), protease (npr), and reduction response to oxidative stress (HMM) were simultaneously upregulated. It seems that the induction of the direct and/or indirect repair related genes in mutants induced by gamma radiation could be remarkably different from the adaptive responses against acute exposure to radiation.

대퇴동맥을 통한 경피적 관동맥 중재시술 환자의 천자부위 지혈을 위한 Angioseal^(�) 사용과 고식적 용수 압박법의 비교 : 전향적 연구

김용훈,권현철,김필호,안석진,유철웅,최진호,이상철,김준수,김덕경,전은석,이상훈,홍경표,박정의,서정돈 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 경피적 관동맥 중재술은 최근 양적 및 질적으로 급격한 발전을 보였지만 시술 시 천자부위의 혈관 합병증은 아직 해결해야 할 문제점이다. 저자들은 대퇴동맥을 통한 경피적 관동맥 중재술을 환자에게 천자부위 지혈을 위한 혈관폐쇄기구인 안지오실의 안전성과 유용성을 고식적인 용수 압박법과 비교 연구하고자 하였다. 방법 : 2002년 4월부터 2003년 5월 사이에 삼성서울병원 심장혈관센터에서 대퇴동맥을 통한 경피적 관동맥 중재술을 성공적으로 시행한 200명의 환자(안지오실 사용군: A군, 100명, 고식적 용수압박법 사용군 B군, 100명)를 대상으로 시술 후 주요 합병증 및 경한 합병증, 지혈 후 환자가 자리에 앉기까지의 시간, 보행개시 가능시간, 총 재원 기간과 시술 1주 후의 합병증을 전향적으로 조사하여 비교 연구하였다. 결론 : 두 군에서 연령, 성별, 기저질환, 심혈관 질환의 위험요소, 시술의 종류, 시술 중 사용한 헤파린의 양, clopidogrel의 양, ticlopidine의 양, 지혈 시 수축기와 확장기혈압, ACT (activated clotting time)는 차이가 없었다. A군이 B군에 비해 시술 후 자리에 앉기까지의 시간 (A군: 4.3±0.3시간, B군: 13.7±0.8시간, p=0.004) 및 보행개시까지의 시간(A군: 6.8±0.5시간, B군: 18.8±2.1시간, p=0.013)이 유의하게 짧았다. 시술 후 주요 합병증은 두군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 A군에서 유의하게 적었다(A군: 28명, B군: 19명, p=0.003). 반상출혈의 경우는 A군에서 유의하게 낮았지만(A군: 3명, B군: 12명, p=0.01), 혈종, 출혈의 발생은 두군간에 차이가 없었다. 총 재원기간에는 두 군간에 차이가 없었다(p=0.239). 시술 1주 후 경과관찰에서 주요합병증은 역시 두 군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 두 군에서 차이가 없었다(A군: 15명, B군: 13명 p=0.418), 반상출혈의 빈도는 차이가 없었지만 혈종의 발생은 A군에서 더 낮았다(A군: 2명, B군:6명, p=0.004). 두 군 모두에서 출혈은 발생하지 않았다. 결론 : 대퇴동맥을 통한 경피적 관동맥 중재술을 시행한 환자에서 안지오실의 사용은 고식적 용수 압박법에 비해 환자의 침상 안정시간을 줄여 조기 활동개시가 가능하게 하였으며 국소합병증의 위험도를 일부 낮추어, 시술에 따른 환자의 불편을 현저하게 감소시킬 수 있다고 할 수 있을 것으로 기대된다. Background : Although the number and the quality of percutaneous coronary intervention have been recently increased dramatically, the vascular complication at puncture site is still the major cause of patients' morbidity. We evaluated the safety and efficacy of newly of newly-developed collagen-based arterial closure device, Angioseal after transfemoral percuatenous coronary intervention. Methods : This study was designed as a prospective single center non-randomized comparative study. A total 200 patients undergoing transfemoral percutaneous coronary intervention were enrolled between April 2002 and May 2003. They were divided into two groups; Angioseal group (group A, n=100) and manual compression group (group B, n=100). The baseline clinical and angiographic characteristics were reviewed. The time to sit up, the time to ambulation, the duration of hospital stay, major and minor vascular puncture site complications were monitored. The patients were followed-up for 1 week after procedure by telephone. Results : The baseline clinical characteriwtics, clinical diagnosis, cardiocascular risk factors, typesof procedure, doses and numbers of anticoagulants were similar between two groups. The blood pressure and activated clotting time were also similar. The time to sit up (group A: 4.3±0.3 hours, group B: 13.7±0.8 hours, p=0.004) and the time to ambulation (group A: 6.8±0.5 hours, group B: 18.8±2.1 hours, p=0.013) were shorter in group A. No major vascular complications were noted. The incidence of hematoma and bleeding were not significantly different between two groups. The incidence of ecchymosis, however, was significantly lower in group A (group A:12%, group B: 3%, p=0.001) The duration of gospital stay was similar between groups. During 7 days of follow-up period incidence of hematoma was significantly lower in group A (p=0.004). Although the incidence of ecchymosis was not significantly different between two groups. Conclusion : The angioseal may be associated with earlier ambulation and less patients' morbidity with low incidence of local complication rate compared to manual compression after transfemoral percutaneous coronary intervention.

유해화학물질의 계통분석

박성우,박유신,이진훈,김남이,김유나,임미애,이상기,유재훈,진광호,신호상,노동석 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

[PB-0100] Functional Analysis of Heat-induced RING-type E3 Ligases in Sorghum: Expression Patterns, Subcellular Localizations and Interaction Partners

Yu Kyong Hu(Yu Kyong Hu),Hong-Ju Lee(Hong-Ju Lee),Jeong Ho Shin(Jeong Ho Shin),Sang Hun Kim(Sang Hun Kim),Min Seok Choi(Min Seok Choi),Hyeon Ung Seo(Hyeon Ung Seo),Cheol Seong Jang(Cheol Seong Jang),S 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

Effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients

( Yu Ho Lee ),( Yoon Soo Shin ),( So-young Lee ),( Yang Gyun Kim ),( Sang Ho Lee ),( Ju Young Moon ),( Kyung Hwan Jeong ),( Hyeon Seok Hwang ),( Shin Young Ahn ),( Hong Joo Lee ),( Dong-young Lee ),( 대한신장학회 2020 Kidney Research and Clinical Practice Vol.39 No.1

Background: Online hemodiafiltration (OL-HDF) offers considerable advantages in clearance of molecules of various sizes. However, evidence of clinical effects of OL-HDF is scarce in Korea. In this study, we investigated changes in laboratory values over more than 12 months after switching to OL-HDF. Methods: Adult patients with end-stage renal disease undergoing hemodialysis (HD) were prospectively enrolled in a K-cohort (CRIS no. KCT0003281) from 6 tertiary hospitals in South Korea. We recruited 435 patients, 339 of whom were on HD at enrollment. One hundred eighty-two patients were followed for more than 24 months. Among them, 44 were switched to OL-HDF for more than 12 months without conversion to HD. We used a paired t test to compare baseline and 24-month follow-up results. Results: The mean age of the subjects was 61.2 ± 12.2 years, and 62.6% were male. The baseline hemoglobin level was not significantly different between HD and OL-HDF group (10.61 ± 1.15 vs. 10.46 ± 1.03 g/dL, P = 0.437). However, the baseline serum protein and albumin levels were significantly lower in the OL-HDF group (6.82 ± 0.49 vs. 6.59 ± 0.48 g/dL, P = 0.006; 3.93 ± 0.28 vs. 3.73 ± 0.29 g/dL, P < 0.001). In patients switched to OL-HDF, levels of hemoglobin and serum albumin significantly increased (10.46 ± 1.03 vs. 11.08 ± 0.82 g/dL, P = 0.001; 3.73 ± 0.29 vs. 3.87 ± 0.30 g/dL, P = 0.001). The normalized protein catabolic rate decreased after 24 months, but the change was not significant (1.07 ± 0.25 vs. 1.03 ± 0.21 g/kg/day, P = 0.433). Although the dose of erythropoiesis-stimulating agent was lower in patients who converted to HDF, it was not significantly different (-115.7 ± 189.7 vs. -170.5 ± 257.1 P = 0.206). Conclusion: OL-HDF treatment over more than 12 months was associated with no harmful effects on anemia and nutritional status.

Leukemoid Reaction, a Rare Paraneoplastic Syndrome in Urothelial Cell Carcinoma

Ho Seok Chung,Bo Sung Shin,Ho Song Yu,Eu Chang Hwang,Sun-Ouck Kim,Sung Il Jung,Taek Won Kang,Dong Deuk Kwon,Kwangsung Park 대한비뇨기종양학회 2015 대한비뇨기종양학회지 Vol.13 No.3

A leukemoid reaction is usually associated with malignancies of the lung, stomach, and thyroid. In contrast, urothelial cell carcinoma is rarely associated with leukemoid reactions, with few cases reported over the past 30 years. Here, we describe a patient with urothelial cell carcinoma who exhibited a leukemoid reaction. The patient had an elevated white blood cell count and experienced a rapid and aggressive clinical course, terminating in death. For urothelial cell carcinoma patients exhibiting a leukemoid reaction, removal of the inciting tumor is the definitive treatment. However, considering the aggressive nature of these tumors, if the patient is unsuitable for radical surgical management, palliative chemotherapy should be considered.