가정용 염소 소독제에서의 소독 부산물 생성 조건 연구

신호상,임현희 한국분석과학회 2016 학술대회논문집 Vol.2016 No.11

Hermansky-Pudlak Syndrome(HPS)생쥐 모델의 폐 항산화계 활성: 방사선의 영향

신호상,양우정,최은미 환경독성보건학회 2007 환경독성보건학회지 Vol.22 No.1

Hermansky-Pudlak Syndrome (HPS) 환자에서 조기에 발생되는 폐섬유화의 원인을 알아보고자, 생쥐HPS 모델인 ep/ep,pe/pe돌연변이종의 폐 항산화계의 활성과 방사선에 대한 반응을 측정하였다. HPS 폐에서는 대조군에 비해 glutathione이 더 산화되어 있었고, catalase, glutathione S-transferase(GST) 등의 항산화효소의 활성이 저하되어 있었으며, 10Gy의 방사선을 조사하였을 때, glutathione 양이 감소하였고, 대조군 폐에서 보여 지는 방사선에 의한 γ-glutamylcysteine ligase(GCL), glutathione peroxidase(GPx) 활성의유의성 있는 증가가 관찰되지 않았다. 이 결과로부터 HPS 환자의 폐는 항산화계 활성이 저하되어 있을뿐 아니라, 산화적 스트레스가 가해 졌을 때 적응 반응이 매우 취약하여 산화적 환경에 노출된 폐의 병증을 유발할 수 있음을 추측할 수 있다.

흡연자와 간접흡연자에 대한 금연교육 효과의 평가에 관한 연구

신호상,김진구 한국환경보건학회 2002 한국환경보건학회지 Vol.28 No.3

Adolescents exposed chronically to tobaccotobacco smoke have been found to have reduced pulmonary function as well as an increased risk of lung cancer and a serious heart disease. Consequently, reducing exposure to tobacco smoke is an important public health goal. This study was conducted to develope the exact evaluation method of student smoker or heavy exposure from ETS, and the change on smoking behavior and attitude after a stop-smoking program. From the study, we concluded that the cotinine concentrations in saliva from students indicate exactly whether they are smoker or not. Also, it was found that the more and exact informations from both the cotinine analysis and the questionnaire were obtained than from only the questionnaires. The non-smokers had more positive effects on the changes of cog-nitions, behaviors and attitude about passive-smoking after a stop-smoking program than the smokers. The results of this study show that through both the accurate determination of cotinine in saliva and the questionnaires, the smoking status and the tobacco education effectiveness can be predicted.

환경성 담배연기(ETS)의 노출지표 개발

신호상 한국보건교육건강증진학회 2005 한국보건교육·건강증진학회 학술대회 발표논문집 Vol.- No.-

대사체들의 거울상체비를 이용한 불법 약물남용과 치료용 약 사용의 구별

신호상,박종세,Shin, Ho-Sang,Park, Jong-Sei 생화학분자생물학회 1993 한국생화학회지 Vol.26 No.8

Amphetamine과 methamphetamine의 거울상이성질체들을 N-MTPA [${\alpha}$-methoxy-${\alpha}$-(trifluoromethyl)phenylacetyl] 유도체들로 바꾸어 capillary gas-chromatography를 이용하여 분리하였고 levorphanol과 dextrophan은 chiral phase column을 이용하여 분리하였다. 이들 이성질체들은 비대칭 삼차원의 단백질 구조를 가진 효소들의 영향을 받게 되어 서로 다른 대사속도를 갖었다. 이들 대사체들의 거울상체간의 조성비는 대사체가 불법약물의 직접 사용에서 나왔는지 아니면 다른 치료약의 사용에서 나왔는지를 구별할 때 이용되어졌다. 또한 치료약의 독특한 대사체의 검출도 추가적인 증거가 될수 있었다. The enantiomers of amphetamine and methamphetamine were separated through conversion to the N-MTPA derivatives. Also levorphanol and dextrophan were separated by chiral phase column. The enantiomers of amphetamine and methamphetamine after oral administration of famprofazone were excreted at different rates under the influence of enzymes that were chiral three dimensional protein structures. In differentiating the use of medicines from direct use of illicit drugs, the evaluation of the enantiomeric composition of the compound was very valuable. This determination was assisted by determination of a unique metabolic product.

연속 철근콘크리트 슬래브 교량의 윤하중 분포폭에 관한 연구

신호상,오병환 한국콘크리트학회 1998 콘크리트학회지 Vol.10 No.4

The wheel load distribution width for lane load is not specified in current Korea bridge design code(KD code), not like in current AASHTO and AASHTO LRFD specifications which specity it as twice of wheel load distribution width for wheel load. In this study, the wheel load distribution width in continuous reinforced concrete slab bridge is investigated. The major variables affecting the wheel load distribution of a reinforced concrete continuous slab bridge are the span length, bridge width, existence edge beam and boundary condition. From a series of comprehensive parametric study on each variable, the formula for wheel load distribution in continuous reinforced concrete slab bridge is proposed from the nonlinear regression analysis of finite element analysis results. The proposed formulas can be used efficiently in the accurate design of continuous reinforced concrete slab bridges. 현행 AASHTO 및 AASHTO LRFD 설계기준에는 차선하중에 대한 윤하중분포폭을 차륜하중에 적용되는 윤하중분포폭의 2배를 적용하도록 규정하고 있다. 이에 반해 국내 도로교 표준시방서에는 차선하중에 대한 윤하중분포폭의 규정은 없는 실정이다. 본 연구에서는 연속 철근콘크리트 슬래브 교량에 대한 윤하중분포폭에 관한 연구를 수행하였다. 연속슬래브 교량의 윤하중분포폭에 영향을 미치는 인자들로는 지간길이, 교량폭, 단부보 및 지점조건이 있다. 이들 각 인자들에 대한 유한 요소 모델의 구성 및 해석을 통하여 연속 철근콘크리트 슬래브 교량의 합리적인 윤하중분포폭의 식을 제안하였다. 본 연구에서 제안된 윤하중분포폭의 식은 현행 도로교 표준시방서에 제시되어 있지 않은 철근콘크리트 연속 슬래브 교량의 보다 정확한 설계 및 합리적인 내하력 산정시 매우 효율적으로 사용될 것으로 사료된다.

Autodesk Korea의 FOTS 사례 연구

신호상 한국경영학회 2010 한국경영학회 통합학술발표논문집 Vol.2010 No.08

첨단기술과 국가 간의 윤리

신호상 한국융합경영학회 2019 융합경영리뷰 Vol.2 No.-

원자로시설의 경년열화 종합관리에 관한 규정개발 방향

신호상,홍진기,김진수,정연기,정명조,정해동,최영환,Shin, H.S.,Hong, J.K.,Kim, J.S.,Chung, Y.K.,Jhung, M.J.,Chung, H.D.,Choi, Y.H. 한국압력기기공학회 2011 한국압력기기공학회 논문집 Vol.7 No.4

The renewed global interest in nuclear power has arisen from the need to reduce greenhouse gas emissions and to provide sufficient electricity for a growing global population. Many countries with nuclear power plants (NPPs) are still implementing license extensions of 10~20 years, and even consideration is being given to the concept of life-beyond-60, a further period of license extension from 60 to 80 years. To solve the materials aging problem is integral to its success. A foundation for effective aging management of nuclear power plants is that aging is properly taken into account at each stage of a plant's lifetime, i.e. in design, manufacture, construction and operation including long term operation and decommissioning. To evaluate the plant aging phenomena, a lot of background information such as materials and environment of the parts of the reactor and plant systems is needed by the experts. Information on degradation mechanisms is also used. In this paper, a regulation on the integrated materials aging management for nuclear facilities is proposed. The proposed regulation identifies key elements of effective aging management for nuclear power plants and provides the requirements on aging management for nuclear facilities throughout all stages of the lifetime of the plant.

전자담배 액상 및 기체상 중 유해물질 고찰

신호상,Shin, Ho-Sang 한국환경보건학회 2013 한국환경보건학회지 Vol.39 No.6

Objectives: Electronic cigarettes are battery powered devices that convert a nicotine-containing liquid into an inhalable vapor. The device aerosolizes nicotine so that it is readily entrained into the respiratory tract, from where it enters the bloodstream. Information on the safety of E-cigarettes is required. Methods: Seventeen articles on studies analyzing toxic substances in the liquid and gas phases of electronic cigarettes were reviewed. Results: Tobacco-specific nitrosamines, bis(2-ethylhexyl) phthalate, formaldehyde and acetaldehyde, known to be carcinogenic agents in humans or animals, were detected in the liquid and gas phases. In addition, diethyl phthalate, acetone, ethanol, cresol, xylene, propylene, styrene, triethylene glycol, tetraethylene glycol, pentaethylene glycol cis-3-hexen-1-ol, methyl cinnamate and undecane were identified in the liquid and gas phases of E-cigarettes. Propylene glycol, glycerin, 1-methoxy-2-propanol, 1-hydroxy-2- propanone, acetic acid, 1-menthone, 2,3-butanediol, menthol, carvone, maple lactone, benzyl alcohol, 2-methyl-2-pentanoic acid, ethyl mantel, ethyl cinnamate, myosamine, benzoic acid, 2,3-bipyridine, cotinine, hexadecanoic acid, and 1'1-oxybis-2-propanol were detected in the vapors of E-cigarettes. Conclusion: The hazardous compounds identified in the liquid and gas phases of E-cigarettes should be controlled for the lowest concentrations in the raw materials and production procedures.