위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

마이크로 박막 유량센서의 제작

노상수,최영규,정귀상 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

Pt thin films flow sensors were fabricated by using aluminum oxide films as medium layer and their characteristics were investigated after annealing at 600 ℃ for 60min. Aluminum oxide improved adhesion of Pt thin films to SiO_(2) layer without any chemical reactions to Pt thin films under high annealing temperatures. Output voltages increased as gas flow rate and gas conductivity increased because heat loss of heater, which was integrated with a sensing resistor in the flow sensor, increased. Output voltage of flow sensor fabricated on membrane strucrure was 101mV at O_(2) flow rate of 2000sccm, heating power of 0.8W while flow sensor fabricated on Si substrate without membrane had output voltage of 78mV under the same conditions.

터빈 냉각 블레이드의 응력 및 크리프 해석

노영민,이수용 한국 항공대학교 항공산업기술연구소 2000 航空宇宙産業技術硏究所 硏究誌 Vol.10 No.-

열 하중과 고속회전에 따른 원심력을 받는 터빈 냉각 블레이드에 대한 열전달해석, 응력해석 그리고 크리프해석을 수행하였다. ANSYS 프로그램을 이용하여 터빈 블레이드의 온도, 응력, 크리프 변형률을 계산하였다. 수치해석 결과에 의하면 최대온도는 터빈 블레이드 앞전에 발생하고, 최대 응력은 firtree 부근에 발생한다. 최대크리프 변형률은 터빈 블레이드의 뒷전에 발생하고, 이 변형률은 약 4500시간 경과 후 파괴 변형률에 도달하는 것으로 예상된다. Heat transfer, stress and creep analyses are performed for a turbine cooling blade subjected to thermal loading and centrifugal force due to high-speed rotation. Temperature, stress, and creep strain in the turbine blade are calculated using the ANSYS program. The numerical results show that maximum temperature is occurred at the leading edge of the turbine blade and maximum stress near the firtree of the turbine blade. Maximum creep strain is occurred at the trailing edge of the turbine blade and expected to approach to rupture strain after 4500 hours approximately.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

豚內 副産物의 特性과 加工利用에 關한 硏究 : Ⅱ. 加熱處理가 物理的 性質과 嗜好에 미치는 영향

양철영,이상건,윤정의,허윤행,채수규,노완섭 서울保健大學 1989 論文集 Vol.9 No.1

Aflatoxin B_1과 Dexamethasone이 白鼠 肝 Kupffer 細胞와 內皮細胞에 미치는 影響에 關한 走査電子顯微鏡的 硏究

이영호,김수일,박경란,노승무,김원식 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.1

For the study on the effects of aflatoxin B_1 and corticosteroid to the Kupffer cells and endothelial cells of the liver, aflatoxin B_1(1mg/kg) and dexamethasone(4mg/kg) were administrated to the 3 groups of rats; the aflatoxin B_1-treated group, the dexamethasone-treated group, and the aflatoxin B_1 and dexamethasone-treated group. The liver tissues were fixed by perfusion with 0.5% glutraldehyde and 0.5% paraformaldehyde solution at 1, 12, and 24 hours after the administration. The fixed liver tissues were cracked and observed Kupffer cells and endothelial cells under scanning electron microscope. The results were as follows; 1. In aflatoxin B_1-treated group, the Kupffer cells were destructed severely and the endothelial cells were destructed partially. 2. In dexamethasone-treated group, the cytoplasmic processes of the Kupffer cells were shortened, but the endothelial cells showed no morphological changes. 3. Destructive changes of Kupffer cells and endothelial cells in the aflatoxin B_1-treated group were reduced after administration of dexamethasone. 4. The large Kupffer cells were destructed and disappered after administration of aflatoxin B_1, but small Kupffer cells were found until 24 hours after administration. 5. In aflatoxin B_1 and dexamethasone treated group, Kupffer cells were destructed severely but the capacity to catch foreign particles were remained. Accordingly, it is considered that aflatoxin B_1 will destruct Kupffer cells severely and the endothelial cells partially, but dexamethasone will reduce the destructive changes of the Kupffer cells and endothelial cells induced by aflatoxin B_1 respectively.

시판된장의 숙성정도 예측을 위한 전자코의 적정조건

양영민,노봉수,이택수 서울여자대학교 자연과학연구소 1997 자연과학연구논문집 Vol.9 No.-

본 연구는 된장의 숙성 정도를 6개의 metal oxide 센서가 내장된 휴대용 전자코를 이용하여 예측하고자 하였다. 15℃에서 숙성시킨 시판된 장은 60일 정도에 감도가 급격히 떨어지기 시작해 그 이후로는 거의 변화가 없으며 15℃에서 숙성하다가 33일부터 25℃로 숙성 온도를 달리 하여 숙성시킨 된장은 38일부터 감응도가 급격히 떨어지기 시작해 그 이후에는 거의 일정하였다. 센서 감응도의 기울기와 상관계수를 비교해 보면 15℃에서 숙성시킨 된장보다 25℃에서 숙성시킨 된장이 센서 감응도 변화량, 상관계수값 모두 크고, 6개의 센서 중에서는 #2, #4이 가장 민감하였다. This study is to predict fermentation time of commercial soybean paste by a electronic nose that has six metal oxide sensors. #2 and #4 sensors were more sensitive to volatile components of soybean paste than any other sensors. The sensitivity of the electronic nose to a commercial soybean paste was rapidly reduced after 60 days at 15℃ and not too much changed thereafter. It was also reduced after 38 days when temperature was changed from 15℃ to 25℃ after 33 days. The correlation between sensitivity of sensor and fermentation time was evaluated. The correlation coefficient and changes of sensitivity at 25℃ was higher than that at 15℃

Ethylenediamine 유도체가 in Vitro에서 중금속의 Rat 회장투과에 미치는 영향

문상연,노영수 한국분자생물학회 1994 분자생물학뉴스 Vol.22 No.-

고온 초전도체 Y₁Ba₂Cu₃O_7-δ(CdO)_x의 핵사중극 상호작용 연구

전인,김복수,노태호,김영훈,서용문,송승기,박영민 명지대학교 자연과학연구소 2000 자연과학논문집 Vol.19 No.-

CdO가 첨가된 고온 초전도체 Y1Ba2CU3O7-δ(CdO)x(x=0.00,0.09,0.22,0.34,0.42,0.49)를 고상 반응법으로 제작하여 상온에서 Cu 핵사중극 공명 실험을 하였다. 구리-산소 평면에 있는 63Cu(2)의 핵사중극 공명 진동수는 31.13∼31.39 MHz이고, 65Cu(2)의 공명 진동수는 28.82∼29.06 MHz이었다. 이러한 공명 진동수는 χ가 증가할수록 높은 진동수 방향으로 이동하였다. 63Cu(2)과 65Cu(2)의 NQR 공명 진동수의 비는 모든 시료가 1.08로 63Cu과 65Cu의 핵 사중극 모멘트의 비와 같았다. 구리-산소 사슬에 있는 63Cu(1)의 공명 진동수는 22.15~22.36 MHz에서 관측되었는데, χ에 따른 공명 진동수의 이동 경향은 63Cu(2)과 65Cu(2)의 경우와 비슷하였다. 선폭은 63Cu(2)과 65Cu(2)그리고 63Cu(1)의 경우 모두 약 200∼300 kHz고, 전반적으로 χ가 증가할 수록 감소하였다. 스핀-에코 방법으로 구한 스핀-스핀 이완 시간 T2는 χ가 증가함에 따라 약간씩 증가하였다. We have studied Cu-NQR in CdO-mixed high-Tc superconductor Y1Ba2Cu3O7-δ(CdO)x(x=0.00, 0.09, 0.22, 0.34, 0.42, 0.49) at room temperature prepared by solid state reaction method. In the Cu-O plane, 63Cu(2)-NQR frequencies were measured to be in the range of 31.13-31.39 MHz and those of 65Cu(2) were in the range of 28.82-29.06 MHz. The position of spectrum-peaks shifted to the higher frequency with increasing χ. The ratio of 63Cu(2) and 65Cu(2)-NQR frequencies have the value of 1.08 which is equal to the ratio of 63Cu(2) and 65Cu(2) nuclear quadrupole moment for all samples. The resonance frequencies of 63Cu(1) in the Cu-O chain have been observed in the range of 22.15-22.36 MHz and the tendency of resonance frequency behaviour with χ were nearly the same for both 63Cu(2) and 65Cu(2). The line-widths of 63Cu(2), 65Cu(2) and 63Cu(1) were observed to the value of 200∼300 kHz and they decreased with increasing χ. The spin-spin relaxation time T2 obtained by spin-echo method increased slightly with increasing χ.

창의적 문제해결을 위한 웹기반 교수-학습 모형과 학습 환경 설계 : 수학교과에서의 예시를 중심으로

구양미,김영수,노선숙,조성민 이화여자대학교 사범대학 교과교육연구소 2006 교과교육학연구 Vol.10 No.1

본 연구의 목적은 지식기반사회의 학습도구로서 그 중요성이 증대되고 있는 인터넷과 웹을 활용하여 창의성 계발을 돕는 교수-학습 모형과 웹기반 학습 환경을 설계하는 데 있다. 본 연구에서 웹은 학습도우미(learning agent)로서 문제해결 학습상황에서 의사소통도구, 발견과 탐색도구, 지식과 경험 구성의 도구로 상정되었다. 즉, 중등 수학교과를 사례로 채택, 문제해결 학습상황에서 생각 5단계 모형(생각 열기, 생각 쌓기, 생각 나누기, 생각 다지기, 생각 펼치기)을 토대로 각 단계별로 문제의 구조 유형에 따른 사고 전략과 이에 상응하는 학습자와 교수자 활동, 웹기반 활동을 포함하는 웹기반 교수-학습 모형을 설계하였다. 설계된 웹기반 교수-학습 모형에 따라 실제 교수-학습활동 계획안을 개발하고, 창의적 문제해결 환경 지원을 목적으로 한 웹사이트를 설계하였다. 본 연구의 결과물인 웹기반 교수-학습 모형과 학습 환경은 창의적 문제해결을 위한 핵심요소로 간주되는 확산적 사고, 비판적 사고 및 교과지식이 조화롭게 활용될 수 있도록 하는데 그 주안점을 두고 있다. The purpose of this study is to design a web-based teaching and learning model and learning environment for creative problem solving in Mathematics. In this study, World Wide Web is considered as a learning agent assisting learning process as communication tools, inquiry tool, and knowledge construction tools in problem solving learning environments. The web-based teaching and learning model was developed based on "Five Stage Thinking Model" that consists of uncover ideas, accumulate ideas, share ideas, ensure ideas, and unfold ideas. According to the steps of the model, a web-based lessen plan on coordinates in middle school mathematics was developed. Finally, a web-based their divergent thinking, critical thinking and subject knowledge for mathematical problem solving creatively. Some sample web pages were suggested for developing a web site based on the purposed model and the lessen plan.