Collagenase와 esterase가 상아질 접착강도와 nanoleakage에 미치는 영향

정영정,한세현,김종철,이상훈,김정욱,김영재,장기택 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.3

본 연구는 상아질 접착계면에서 collagenase와 esterase가 접착강도와 극미세누출에 미치는 영향을 살펴보기 위해 시행하였다. 발치된 치아의 교합면 상아질에 Single Bond 2(SB)와 Clearfil SE bond(SE)를 사용하여 상아질-레진 접착시편을 제작하고,시편을 인산완충용액(PBS)에 24시간(I),또는 PBS(II),collagenase 용액(III),esterase 용액(IV)에 4주간 보관 한 후 질산은 용액으로 염색하였다. 시편의 미세인장접착강도(μTBS)와 질산은 침투 면적을 측정하여 다음과 같은 결과를 얻었다. 1. SB군의 접착강도가 II∼IV군에서 SE군에 비해 낮은 값을 나타내었다(p<O.05). SB군은 II∼IV군의 접착강도가 I군에 비해 낮은 값을 보였으나(p<O.05),SE군의 접착강도는 I∼IV군간에 차이를 보이지 않았다(p>O.05). 2. SB군의 질산은 침투 면적이 SE군에 비해 높았으며(p<O.05),SB군과 SE군에서 질산은 침투 면적은 I ∼ IV군간에 차이를 보이지 않았다(p>O.05). 3. 접착강도와 질산은 침투 면적은 SE군의 I, II,III군에서 음의 상관관계를 보였다(p<O.05). The purpose of this study was to evaluate the effects of collagenase and esterase on dentin bond strength and nanoleakage. Resin composites were bonded to occlusal dentin of premolars with Single Bond 2(SB) and Clearfil SE Bond(SE). After the microtensile specimens were prepared and stored in PBS for 24 hours(I) or, PBS(II), collagenase(III), esterase(IV) solution for 4 weeks, the specimens were stained with silver nitrate solution. Microtensile bond strength(μTBS) and silver penetration area were measured and, the results were as follows: 1. For group II, III, and IV, the bond strengths of SB were lower than those of SB(p<0.05). The bond strengths of SB II, III, and IV were lower than that of SB I(p<0.05). There was no difference among the bond strengths of SE I ∼ IV groups(p>0.05). 2. Silver penetration areas of SB were higher than those of SE for all storage groups(p<0.05). In SB and SE groups, there was no significant difference of silver penetration area among I ∼ IV groups(p>0.05). 3. SE I, II, and III showed inverse relationship between the bond strengths and the silver penetration areas(p<0.05).

비복신경이식을 이용한 긴 거리의 말초신경 결손부 수복

이종호,이세영,김명진,이은진,안강민,김성민,최원재,명훈,황순정,서병무,최진영,정필훈 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.2

The surgery of oral and maxillofacial area poses the risk of cranial nerve damage such as trigeminal nerve or facial nerve. Inferior alveolar nerve is prone to damage in the third molar extraction, implant installation, orthognathic surgery, open reduction and rigid fixation, and tumor ablation surgery. On the other hands,facial nerve is likely to be damaged or sacrificed with trauma or parotidectomy. In case of inferior alveolar nerve injury, the incidence is reported to be about 1.3%. The nerve function will almost recover in minimal damage, but it won't recover at last in total damage of a part of nerve unit. In latter cases, nerve regeneration in intended by allograft as nerve substitute or various route of merve condit. But the recovery with autograft is believed to be most relialbe mrthod in the rapair of long-span(longer than 15㎜)nerve defect. We have performed autologous sural nerve graft in the repair of nerve defect, which is caused by resection of benign or malignant tumor. Hereby we report the method of nerve harvesting, recovery of defected peripheral nerve and the complications of donor site with the discussion of sural nerve anatomy.

하치조신경 및 설신경 손상 평가를 위한 한국인 정상 성인의 하순-이부 및 혀의 감각 조사

이종호,이세영,송승일,이은진,안강민,김성민,명훈,황순정,서병무,최진영,정필훈,김명진 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.2

In the head and neck area, there are so many sensory nerves, which are sometimes injuried iatrogenically or inadvertently so that involved patients complained of the loss of sensations. In such cases, it is important to judge the degree of injuries and regeneration of nerve for better diagnosis and treatment. Seddon and Sunderland's classification, which is commomly used, is focused on histological change and nerve conduction. As times goes by, it is difficult to access patient's sensory disturbance by this method. Until now, so many methods such as contract threshold, direction, two-point discrimination, pin prick, thermal discrimination and current perception threshold have been introduced for sensory evaluation. However, there hasn't been enough information regarding each methodology nor integrated standard methodology for the measurement. the purpose of this study is to get Korean adult normative sensory values of lower lip,chin and tongue using modified methods of contact thershold, ditection, two point discrimination, pin prick, thermal discrimination and assess degree of regeneration of sensory nerve damage.

뇌경색후 발생한 Cortical Spreading Depression과 뇌경색 범위에 관한 실험적 연구

박윤관,이승민,김세훈,이기찬,주정화,이훈갑 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.3

Cortical Spreading Depression(CSD) is a transient depression of neuronal activity that spreads across the cortical surface and is associated with profound changes in blood flow, extracellular ion concentration. Direct Current(DC) potentials and cell membrane potentials. One of the electrophysiological disturbance in the periinfarct surrounding is spontaneous occurrence of repeated CSD like DC shifts associated with increased energy demand. Due to restricted blood flow to the periinfarct border zone, elevated metabolic demand is potentially harzardous. So the authors designed this experiment to verify the correlation between periinfarct cortical spreading depression and ischemic volume following permanent middle cerebral artery (MCA) occlusion in rats. Sprague-Dawley rats(n=27) were anesthetized with 0.5∼1% halothane, and artificially ventilated through a tracheal cannula. Arterial pressure, blood gases and body temperature were controlled. The middle cerebral artery(MCA) was occluded distally to the lenticulostriate branches. Measurements of CSD activity were made for 4 hours in each animal. Infarct volume was determined 6 hours later in 2, 3, 5-triphenyl tetrazolium chloride(TTC)-stained sections. For 4 hours after MCA occlusion, the CSDs were found in all experimental animals with a range of 2∼9 times. Those CSDs wer of varying duration, : "small"(<1 min) and "big"(> 1 min) SDs and mean of total duration of SD was 10.5±10.3 min during 4 hours of MCA occlusion. Neuropathological evaluation of brain infarct in the rats, which had been allowed to survive for 6 hours after MCA occlusion showed a mean volume of 89.7±45.3㎣. Serial observation of duration of CSD showed progressive prolongation only in 8 rats. The rest of them(n=19) did not show any prolongation. Neither the prolongation of duration of CSD nor the frequency of CSD in the penumbral zone correlated with the volume of infarct. However total duration of CSD was slightly related with the infarct volume after 6 hours of the permanent MCA occlusion(r=0.414, p=0.0318).

Ga 함량에 따른 Cu(In<SUB>x</SUB>Ga<SUB>1-x</SUB>)Se₂ 태양전지의 특성분석

김석기(Seok Ki Kim),권세한(Se Han Kwon),이두열(Doo Yeol Lee),이정철(Jeong Churl Lee),강기환(Ki Whan Kang),윤경훈(Kyung Hoon Yoon),안병태(Byung Tae Ahn),송진수(Jinsoo Song) 대한전기학회 1998 대한전기학회 학술대회 논문집 Vol.1998 No.7

Rocuronium의 애별투여방법이 모지내전근의 이완에 미치는 영향

최영균,김승수,이원진,조광래,이상은,김영환,임세훈,이정한,이근무,정순호,김영재,신치만 인제대학교 2009 仁濟醫學 Vol.30 No.-

Objective : There are controversies in pnmmg technique of rocuronium whether it can or can't shorten the onset time. We want to compare the effects of two different priming doses and intervals of rocuronium. Materials and Methods : After giving propofol, 50 patients were randomly assigned to 5 groups. Group I received a placebo, followed 3 min later by rocuronium 0.6 mg/kg. Priming doses and intervals of Group II, Ill, N, V were 0.06 rng/kg and 2 min, 0.12 mg/kg and 2 min, 0.06 rug/kg and 3 min, 0.12 mg/kg and 3 min, respectively. Total dose of rocuronium was 0.6mg/kg. Train of four (TOF) count or ratio and 1st twitch height of TOF (T1) were monitored with 15 secondsintervals. TOF ratio of each groups just before bolus injection, duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were compared. Results : Duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were decreased in priming groups compared to Group 1 (P < 0.01) In group V, significant depression of TOF ratio just before bolus injection was seen (P < 0.05). Conclusion : Priming technique with rocuronium is effective method to shorten the onset of neuromuscular block. But priming dose of rocuronium itself could cause hypoxia and aspiration in awake patients and should be used carefully. Priming dose of rocuronium 0.06 mg/kg and 2 minutes interval maybe relatively safe method.

톨루엔 노출 근로자에서 유전자적 요인, 생활습관 및 식이가 요중 마뇨산 배설에 미치는 영향

임현우,박정일,노영만,이강숙,이정민,이원철,이세훈,정치경 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.3

목 적 : 본 연구는 생물학적 지표 특성 연구를 위한 단면조사 연구로서 톨루엔 노출과 톨루엔의 생물학적 모니터링으로 이용되는 요중 마뇨산 농도간의 양-반응 관계에서 효과 변경인자로서 작용하는 유전자 ALDH2, CYPIAI, CYP2El의 다양성 분포를 조사하고, 이들 유전자가 요중 마뇨산 배설 농도에 미치는 영향을 알아보고자 하였다. 방 법 : 연구대상자는 경인지역에 위치한 22개의 사업체에서 페인트 제조 72명, 제조업에서 도장작업 50명, 인쇄업 12명, 접착작업 12명, 벽지의 코팅작업 14명등 160명의 근로자이었다. 성, 연령, 유기용제 작업장 근무경력, 흡연습관, 음주습관, 검사일 이전 밤에 음주 여부, 시료 채취전 6시간 이내에 섭취한 식품조사, 측정일 개인보호구의 착용 여부에 대하여 설문조사를 시행하였다. 톨루엔에 대한 개인노출량은 passive air sampler로 측정하였고, 요중 마뇨산은 요중 크레아틴으로 보정하여 측정하였다. 또한 aldehyde dehydrogenase 2 (ALDH2) , cytochrome P45O IAI(CYPIAI), 그리고 cytochrome P45O 2El(CYPfEl)의 유전적 다양성은 혈액으로부터 백혈구의 DNA를 추출하여 제한 효소 절단 길이 다양성 (restiction fragment length polymorphism, RFLP)법으로 검사하여 다음의 결과를 얻었다. 결 과 : 연구대상자의 요중 마뇨산 농도의 기하평균은 0.44g/g creatinine, 기하표준편차 2.80이었다. 톨루엔 노출 농도, 개인 보호구 착용여부, 안식향산이 함유된 식품의 섭취여부중 요중 마뇨산 배설농도에 영향을 미치는 인자는 톨루엔 노출 농도뿐이었다. ALDH2, CYPIAI, CYPfEl, 연령, 흡연, 근무기간에서 회귀계수간에 차이를 보이는 경향이 있었다. 요중 마뇨산 농도에 대한 다중회귀분석에서 톨루엔, ALDH2, CYPIAI, CYP2El유전자형의 회귀계수가 통계적으로 유의하였다. 결 론 : 톨루엔 노출로 인한 요중 마뇨산 배설 농도는 ALDH2, CYPIAI, CYP2El유전자 다양성에 의해 영향을 받기 때문에, 유전자형의 대사능의 차이를 고려하여 마뇨산 기준 농도를 찾는 연구가 이루어져야 하겠다. Objectives The purpose was to investigate the distributions and the effects of genetic polymorphism of aldehyde dehydrogenase 2(ALDH2), cytochrome P45O IAI (CYPIAI), and cytochrome P45O 2El (CYPfEl) on the toluene metabolism. Methods : The subacts consisted of 160 workers who were exposed to toluene in different industries such as paint manufacturing, painting on steel and wood products, printing, bonding, and coating. The exposed toluene level was monitored by passive air sam paler, and the questionnaire variables were age, sex, smoking, drinking, previous night's drinking, use of personal protectlve equipment, work duration, and taking benzoic acid containing food. The urinary hippurric acid collected in the end of shift was corrected by urinary creatinine concentration. The genotypes of ALDH2, CYPIAI, and CYP2El were investigated using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods with DNA extracted from venous blood. Results'The geometric mean and the geometric standard deviation of urinary hippuric acid concentration were 0.44 g/g creatinine and 2.80. The urinary hippuric acid concentration was significantly related to personal exposed toluene level among personal exposed toluene level, use of personal protective equipment, and benzoic acid containing food diet. The slope differences of the regression for ALDH2, CYPIAI, and CYP2E1 genetic polymorphism, age, smoking, and work duration tended to be significant. In multiple regression analysis, the regression coefficient of toluene, ALDH2, 7YPIAl, CYP2E1 genetic polymorphism were significant. Conclusions : From the above results, urinary hippuric acid level after toluene exposure was significantly affected by the genetic polymorphism of ALDH2, CYPIAI, CYPfEl. It is needed further investigation of the urinary hippuric acid level considering the effect of genetic polymorphism.

BEZ235 (PIK3/mTOR inhibitor) Overcomes Pazopanib Resistance in Patient-Derived Refractory Soft Tissue Sarcoma Cells

Kim, Hee Kyung,Kim, Sun Young,Lee, Su Jin,Kang, Mihyeon,Kim, Seung Tae,Jang, Jiryeon,Rath, Oliver,Schueler, Julia,Lee, Dong Woo,Park, Woong Yang,Kim, Sung Joo,Park, Se Hoon,Lee, Jeeyun Neoplasia Press 2016 Translational oncology Vol.9 No.3

<P><I>BACKGROUND:</I> Although pazopanib treatment has become the standard chemotherapy in salvage setting for metastatic sarcoma patients, most patients progress after pazopanib treatment in 4 to 6 months. After failure to pazopanib, patients have limited options for treatment. Therefore, subsequent therapy in patients who failed to pazopanib is urgently needed and the use of patient derived cells or patient derived tumors for accompanying testing with various pharmacological inhibitors could offer additional treatment options for these patients. <I>METHODS:</I> Patient derived tumor cells were collected from ascites at the time of progression to pazopanib and a 13-drug panel was tested for drug sensitivity. We confirmed the results using <I>in vitro</I> cell viability assay and immunoblot assay. We also performed the genomic profiling of PDX model. <I>RESULTS:</I> The growth of patient derived tumor cells was significantly reduced by exposure to 1.0 μM AZD2014 compared with control (control versus AZD2014, mean growth = 100.0% vs 16.04%, difference = 83.96%, 95% CI = 70.01% to 97.92%, <I>P</I> = .0435). Similarly, 1.0 μM BEZ235 profoundly inhibited tumor cell growth <I>in vitro</I> when compared to control (control versus BEZ235, mean growth = 100.0% vs 7.308%, difference = 92.69%, 95% CI = 78.87% to 106.5%, <I>P</I> < .0001). Despite the presence of CDK4 amplification in the patient-derived tumor cells, LEE011 did not considerably inhibit cell proliferation when compared with control (control vs LEE011, mean growth = 100.0% vs 80.23%, difference = 19.77%, 95% CI = 1.828% to 37.72%, <I>P</I> = .0377). The immunoblot analysis showed that BEZ235 treatment decreased pAKT, pmTOR and pERK whereas AZD2014 decreased only pmTOR. <I>CONCLUSION:</I> Taken together, upregulation of mTOR/AKT pathway in sarcoma patient derived cells was considerably inhibited by the treatment of AZD2014 and BEZ235 with downregulation of AKT pathway (greater extent for BEZ235). These molecules may be considered as treatment option in STS patient who have failed to pazopanib in the context of clinical trials.</P>

상아질 접착에서 collagenase와 esterase가 미세인장결합강도에 미치는 영향

정영정,현홍근,김영재,김정욱,이상훈,김종철,한세현,장기택 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.2

상아질-레진 접착강도에 대한 collagenase와 esterase의 영향을 살펴보기 위해, 소구치의 교합면 상아질에 Single Bond 2와 Clearfil SE Bond로 접착을 시행하고 미세 시편을 제작하여 PBS, collagenase 용액, esterase 용액에 4주간 보관한 후 미세인장결합강도를 측정, 비교하여 다음과 같은 결론을 얻었다. 1. 모든 보관 용액에서 Single Bond 2의 미세인장결합강도는 Clearfil SE Bond보다 유의하게 낮았다(p<0.05). 2. Single Bond 2의 미세인장결합강도는 collagenase군이 PBS군, esterase군보다 낮았다(p>0.05). 3. Clearfil SE Bond의 미세인장결합강도는 esterase군이 PBS군에 비해 낮았으나(p>0.05), collagenase군보다는 높았다(p>0.05). Collagenase군은 PBS군에 비해 유의하게 낮은 미세인장결합강도를 보였다(p<0.05). The purpose of this study was to evaluate the effect of collagenase and esterase on the microtensile bond strength (μTBS) in dentin bonding. After resin composites were bonded to occlusal dentin, μTBS specimens were formed and stored in PBS, collagenase, or esterase solution. After 4-week storage, μTBS was determined and, the results were as follows: 1. μTBS values of Single Bond 2 were lower than those of Clearfil SE Bond for all storage medium (p<0.05). 2. In single Bond 2 group, collagenase solution lowered bond strength more than PBS and esterase solution (p>0.05). 3. In Clearfil SE Bond group, esterase solution lowered bond strength more than PBS(p>0.05). Collagenase solution lowered bond strength more than esterase solution(p>0.05) and PBS(p<0.05).

유·초등학생 장애이해 교육

이유훈,권택환,김희규,유장순,최세민 국립특수교육원 2003 연구보고서 Vol.- No.1

특수교육이 장애학생을 포함한 모든 학생의 특성과 요구에 부응하는 통합교육으로 발전하기 위해서는 무엇보다도 장애인에 대한 편견과 차별이 없어야 한다. 장애인에 대한 편견과 부정적인 태도는 결국 장애인의 사회통합에 부정적인 영향을 미치기 때문에 우선적으로 해결해야 할 과제라고 할 수 있다. 본 연구에서는 「유ㆍ초등학생 장애이해 교육」자료를 개발ㆍ보급하여 장애인에 대한 편견과 차별을 해소하는데 그 목적을 두고, 전문가 협의회, 관련 문헌 탐색, 기존 장애이해 교육 자료 분석, 현장교사 설문 및 심층면담 등을 실시하였고, 이를 통해 얻은 연구 결과를 요약 정리하면 다음과 같다 첫째, 우리의 학교현장에서는 장애이해 교육 시간확보가 어려운 실정이다. 이런 현상은 교육경력이 낮은 교사일수록 또는 학교경영자와 일반교사의 이해가 부족할수록 더욱 심각하게 나타나는데, 이러한 문제를 해결하기 위해서는 국립특수교육원이나 시ㆍ도교육청에서 장애 이해 교육에 따른 시간확보 방안을 제공할 필요가 있다. 장애이해 교육의 필요성에 대한 학교경영자 및 일반교사의 인식 부족을 해결하기 위해서는 학교경영자와 일반교사가 특수교육과 장애인에 대한 이해를 넓힐 수 있도록 하는 다양한 연수프로그램이 마련되어야 한다. 둘째, 장애이해 교육에 활용할 수 있는 자료의 양이 부족할 뿐 아니라, 기존에 개발된 자료를 활용할 수 있는 체계적인 방안이 마련되어 있지 많다는 점이다. 따라서 장애이해 교육에 활용할 수 있는 다양한 자료가 개발되어야 하고, 기존에 개발된 자료는 쉽게 활용될 수 있도록 종류별로 정리되어야 하고, 활용할 수 있는 구체적인 방법도 제시할 필요가 있다. 셋째, 장애이해 교육이 학기초나 '장애인의 날'과 같은 특정기간에 편중되어 있다는 점이다. 장애인식 개선을 위한 교육은 년 중 계획을 세워 일정기간 단위로 실시하여야 한다. 넷째, 장애이해 교육에 활용되는 모델이나 이해교육 방법이 주로 감각장애(시각장애ㆍ청각장애) 또는 지체부자유학생을 중심으로 되어 있다는 점이다. 교육현장에서는 발달장애학생도 많기 때문에 발달장애학생을 모델로 하는 장애이해 교육 프로그램이나 교수-학습방법도 지속적으로 개발되어야 한다. 다섯째, 장애이해 교육방법이 다양하지 못하다는 점이다. 장애이해 교육이 효율적으로 이루어지기 위해서는 장애인의 다양한 특성이 고려되어야 한다. 그러기 위해서는 교수활동 방법 또한 이들의 특성을 고려하여 보다 다양하게 이루어져야 할 것이다. 위에서 제시한 장애이해 교육 실태를 토대로 본 연구보고서에서는 현장교사들이 쉽게 활용할 수 있도록 하기 위해서 1부, 2부로 나누어「유ㆍ초등학생 장애이해 교육자료」를 안내하였다. 제 1부 「장애이해 교육의 개관」에서는 장애이해 교육자료 개발의 필요성, 목적, 연구방법 및 절차, 장애이해 관련 제이론, 장애이해 교육의 현황 및 문제점, 개선방안 등을 기술하여 학교현장의 교사들이 장애이해 교육에 대해 보다 폭 법은 이해를 도모하도록 하였다. 제 2부 「장애이해 프로그램 및 교육자료」에서는 장애유형별 즉, 시각장애, 청각장애, 정신지체, 정서장애, 자폐성장애, 학습장애, 지체부자유 등으로 나누어 제시하여 교사들이 장애 이해 지도를 보다 쉽게 접근할 수 있도록 하였고, 아울러 기존에 개발된 장애이해 교육자료를 도서, 방송프로그램, 영화, 인터넷 웹사이트 등으로 분류 제시하여 학교현장에서 학생의 수준과 활동 내용에 따라서 다양하게 활용할 수 있도록 하였다. 본 프로그램은 「유ㆍ초등학생 장애이해 교육자료」의 한 예에 불과하다. 학교 현장의 지도 교사는 프로그램의 수준을 상향 또는 하향 조정하여 지도할 수 있으며, 생활 주변의 다양한 소재로 프로그램의 내용을 수정 또는 대체할 수 있다. 나아가 창의적으로 새로운 상황을 전개할 수 있도록 하는 노력도 필요하겠다. 2004년에는 「중ㆍ고등학생 장애이해 교육자료」가 개발되어 학교현장에 보급될 계획이다. In order for special education to develop into an inclusive education system that meets the characteristics and needs of all children, including those who are disabled, there must be no prejudices and discriminations against children who are physically or mentally challenged. As the biases and negative attitudes toward persons with disabilities could eventually exert negative influences on their integration into society, these tasks must be effectively taken care of above all else. This study, with the aim of dissolving prejudice and discrimination against the persons with disabilities by developing and disseminating materials for the "Education for Non-disabled Preschoolers and Elementary School Children to Understand Disabilities", has had consultations with experts, researched related books and other documents, analyzed the existing educational materials for understanding individuals with disabilities and conducted surveys on and interviews with teachers in the field of education. The results of the study are summarized as follows. First, the fact remains that it is difficult to secure time to educate on how to understand the children with disabilities at the nation's schools. Such a phenomenon occurs more seriously among teachers with less educational experiences as well as school managers and general education teachers without adequate understanding of the children with disabilities. To resolve this problem, either the Korea Institute for Special Education or the municipal and provincial educational agencies need to provide ideas to secure time to educate the understanding of those who are challenged. In order to solve the lack of understanding of the children with disabilities among school managers and general education teachers, various programs must be created and implemented to train the school administrators and regular teachers to expand their understanding of the persons with disabilities. Second, not only is the amount of materials available for the education of the children with disabilities insufficient, but moreover there are no systematic measures to make the most of those materials that are already developed. Therefore, diverse resources must be developed to use for educating the understanding disabilities, and already developed materials must be classified into categories for easy use along with concrete methods for utilizing such resources. Third, education for understanding the children with disabilities is concentrated on specific periods, such as the early semester or the "Day for the Persons with Disabilities". Education to improve the perception of disabilities should be conducted in periods under an annual program. Fourth, the models or methods used to educate for understanding the persons with disabilities are centered mainly on the individuals with sensory injured (with visual or hearing impairments) or the persons with physically disabled. At educational sites, there are many children with developmentally disabled and so educational programs and teaching-learning methods to educate the understanding of the children with disabilities should be modeled after the children with developmentally challenged. Fifth, the methods to educate the understanding of the persons with disabilities are not diverse. For the efficient education of the understanding disabilities, the diverse characteristics of the persons with disabilities should be taken into account. To be successful in this matter, more diverse methods of teaching activities also need to be used by considering the characteristics of the people with disabilities. On the basis of the reality of developing an understanding and proper awareness of those who are disabled as presented above, this study report guides the "Education for non-disabled preschoolers and elementary school children to understand disabilities" in Part 1 and Part 2 for easy use by teachers on active duty. In Part 1, titled as "A General Survey of Educating the Understanding of the Children with Disabilities", I have described the necessity and purpose of educating the understanding of the children with disabilities, its study methods and procedures, various theories on educating the understanding of the children with disabilities, the current situations and problems of educating the understanding of the children with disabilities and their improvement measures to deepen the understanding about educating the understanding disabilities by teachers on active duty. In Part 2, titled the "Programs to Educate the Understanding Disabilities and Educational Materials," I have classified types of disabilities into visual impairment, hearing impairment, mental retardation, emotional disorder, autism, learning disability and the physical impairment for easy approach to educate the understanding disabilities by teachers. At the same time, I re-categorized the already developed materials to educate the understanding disabilities into books, broadcasting programs, movies, Internet web-sites and others for diverse use at schools according to the children' levels and activities. This program is just one example of the "Education for Non-disabled Preschoolers and Elementary School Children to Understand Disabilities". I have arranged it in such a way as to allow teachers to teach the children by upgrading or downgrading the program's level as well as modifying or replacing the contents of this program by using various materials that can be obtained in everyday lives. In 2004, I am planning to develop and distribute the "Education for non-disabled Middle-and High-school Students to Understand Disabilities".