풍촌 석회암의 소성에 관한 연구

이재장,노범식,장경호,정수현 강원대학교 석재복합신소재제품연구센터 1997 석재연 논문집 Vol.2 No.-

본 연구는 여러 가지 용도에 적합한 생석회를 생산하기 위하여 풍촌 석회석을 대상으로 소성시험을 하였다. 시료의 형상은 주로 정방형이나 때로는 구형을 나타내며, 배색 내지 회백색을 띈다. 소성시험에 사용한 시료의 크기는 45∼50㎜ 이며, 소화시험에서는 3.3mm(6mesh) 이하로 분쇄하여 소성하였다. 시료의 광물학적 특성을 보기위하여 편광현미경 관찰, X-ray 분석, 열분석을 하였다. 시료는 거의 순수한 CaCO₃이었으며, 600℃ 부터 열분해가 시작되어 850℃에서 완결되었다. 화학분석 결과 CaO 98.27%인 잠재적 순도를 갖는 생석회를 얻을 수 있음을 알 수 있다. 대략 50 ㎜ 정도의 석회석은 전기로의 온도가 실온에서 1,050℃에 도달하였을 때 99%이상이 소성되었다. 이 때 얻어진 생석회는 거의 순 백색이며 갈라짐이 없었다. 소화시험 결과 ASTM C-110에 의하면 반응성이 우수한 생석회인 것을 알 수 있으며, 1분 이내의 상승온도는 63℃ 이었다. In this study, the calcination characteristics of Pungchon limestone was investigated to produce the optimum quick lime for various uses. The shape of limestone sample was mainly cubic, but sometimes longish. Approximate size range for the calcination tests was from 45 to 50 mm. For the slaking test, it was crushed by cobbing method and screened by 3.3 mm(6 mesh) screen. Mineralogical studies of the sample were carried out to investigate textures, X-ray diffraction analysis and thermal analysis. The result of chemical analysis shows a very high grade limestone with a CaO potential of 98.27%. Approximate 50 mm size's of limestone, about 250 g was calcined more than 99% when the calcination temperature arrived at 1,050 ℃ from room temperature in the electric laboratory furnace. Lumpy lime in nearly white colour with nearly no cracks was observed during calcining test. and during calcination process the limestone places kept their shape. Slaking test(ASTM C-110 ) results indicate a high reactivity product. In slaking, a 63℃ temperature rise was achieved within the first one minutes.

강교량의 수요·공급 변동률과 낙찰율 변동 관계 추정모델

이정훈,김경주 중앙대학교 기술과학연구소 2003 기술과학연구소 논문집 Vol.33 No.-

1997년 외환위기(IMF)이후 강교량 발주물량은 감소하였으며, 반면 강교량 관련 제작업체의 수는 증가하였다. 이는 강교량의 수요와 공급의 불균형으로 이어져 강교량 하도급단가 하락에 영향을 미치게 되었다. 이러한 요인을 수요와 공급 측면에서 조사 분석하였으며 이를 위해 연도별 하도급단가 변화추이와 공급측면에서의 철강재설치공사업체의 등록추이, 수요측면에서의 교량용 강재소비량, 물가지수와의 관계를 각각 비교하여 이러한 요인들이 강교량 하도급 단가에 미치는 영향과 이들의 상관관계를 조사 및 분석하였다. 그 결과 강교량의 수요와 공급의 불균형은 강교량 하도급단가의 변화에 영향을 미치는 것으로 나타났다. After the Korean economic crisis in 1997, steel bridge contract quality was reduced while the number of factories related to the steel bridge production was increased. It led to the imbalance of the steel bridge supply &emand and affected to the steel bridge subcontract price. This study investigated the dffect contract price in aspect of supply &emand. For this purpose, annual subcontract price change, steel bridge production factory’ number, quantity of steel bridge construction, and the price index were compared respectively and the effect of these components to the subcontract price of steel bridge was analyzed. Analysis shows, the imbalance on supply &emand the steel bridge affects to the subcontract price change.

라덱스 혼입률에 따른 철근콘크리트의 휨파괴 거동특성

정원경,김동호,이주형,임홍범,윤경구 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.A

Reinforced concrete(R/C) is commonly used to structures because they have many merits that compressive strength, economy and so on. However, reinforced concrete has a crack at the tensile section which is due to the relatively lower tensile strength than its compressive strength. Latex modified concrete(LMC) has higher tensile and flexural strength than the ordinary portland cement, due to the interconnections of hydrated cement and aggregates by a film of latex particles. The purpose of this study was to investigate the flexural behavior of reinforced concrete beam with latex modified concrete, having the main experimental variables such as concrete types(ordinary portland cement concrete, latex modified concrete), latex contents(0%, 15%), flexural steel ratios(0.012, 0.0235), and with/without shear reinforcement. The beam of LMC showed considerably higher initial cracking loads and ductility than that of OPC, but, similar to ultimate strength and deflection. This might be attributed to the interlocking of hydrated cement and aggregates by a film of latex particles, water retention due to hydrophobic, and colloidal properties of the latexes resulting in reduced water evaporation. The beam with latex modified concrete could be adopted at field for controlling and reducing the tensile crack due to its higher tensile strength.

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

Meropenem 동시 사용으로 인한 Valproic acid의 혈중농도 감소 3예

노은경,김혜경,이명진,안보숙,송영구,김정호 대한화학요법학회 2002 대한화학요법학회지 Vol.20 No.4

서울에 위치한 일개 대학병원에서 광범위 항생제인 meropenem을 사용하기 시작한 2000년 4월부터 2001년 5월까지, valproic acid의 약동학 서비스가 의뢰된 432건 중 meropenem을 동시에 사용했던 3명의 환자에서 모두 valproic acid의 현저한 혈중농도저하를 관찰하였다. 이 급격한 혈중농도 변화기간에 3명의 환자에서 valporic acid와 동시에 사용된 공통 약물은 meropenem 뿐이었다. Meropenem을 사용하기 시작한 시점에서 7일 전후로 valproic acid의 혈중농도는 측정 한계치인 15㎍/㎖ 전후의 수준으로 급격히 감소되었으며, meropenem을 중단한지 1-2일 이내에 valproic acid의 농도는 meropenem을 사용하기 이전 수준으로 빠르게 회복되었다. 이들 환자중 1명은 meropenem을 사용하는 동안 발작을 경험하였다. Meropenem이 valproic acid의 혈중 농도를 감소시키는 기전은 아직 명확하지 않으나, 이들 두 약제의 동시 투여가 요구되는 상황에서는 valproic acid의 혈중농도 모니터링이 더 자주 필요하며, 가능한 다른 항경련제로의 일시적 교체를 고려하여야 할 것이다. Meropenem, a carbapenemn, has a broad spectrum of activity that includes β-lactamase-producing organisms, and are used frequently in treating various infections. Compared with imipenem/cilastatin, meropenem has a lower affinity for the γ-butyric acid (GABA) receptor and thus a lower potential for inducing seizures. This makes meropenern, even at higher dosages and costs, suitable for the treatment of patients with infections of the central nervous system and for the treatment of infections in patients with high risk of seizure attack. In 3 neurosurgical patients using valproic acid to control seizure, however, we experienced significant decrease of serum valproic acid concentration during concomitant use of meropenem. We report here our observations of decreases in the serum concentrations of valproic acid to sub-therapeutic levels in three adult neurosurgical patients during concomitant therapy with meropenem.

韓國産 물이끼屬의 槪括的 硏究

최두문,이경옥,이정윤 공주대학교 사범대학 과학교육연구소 1989 과학교육연구 Vol.21 No.1

This study was carried out to generalize the native sphagna of Korea in the educational aspect. The samples of the genus were collected from several areas and described the explanatory diagrams for the characteristics or prepared thire indexes. The genus of sphagna from Korea were members of the following 13 species: S. congstroemii C. Hartm. S. opiculatum Lindb. S. copillaceum(Weiss) Schr. S. jimbriatum Wilson. S. fucum (Schimp.) Klinggr. S. girgensohnii Russ. S. imbricatim(Rornson.) Russ. S. magellanicion Bridel S. microporion Warnst. ex Cardot S. palustre Linne S. roiustum (Russ.) Roell S. sguarrosum Crome S. subsecum Ness

기관골 신생증 1예

오영상,이은우,정종혁,문승원,김수현,김동한,양혁승,박정환,박경옥,강성수,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Tracheobronchopathia osteoplastica is a rare disorder of unknown cause characterized by the projection of numerous bony or cartilaginous submucosal nodules into the tracheobronchial lumen with sparing of the posterior membranous portion of tracheobronchial tree. In the past, most of the cases were diagnosed as secondary finding at autopsy. Nowaday, the key component of the evaluation is flexible fiberoptic laryngoscopy and bronchoscopy, which typically demonstrates irregular spicules of subrnucosal bone and cartilage projecting into the tracheobronchial lumen and causing various degrees of airway obstruction. A 45 years old man was visited Sunchon St. Carollo hospital due to discomfort on throat. We saw several nodules just below vocal cord via laryngoscope. The computed tomography revealed multiple small calcified nqdules on trachea and both main bronchi. Pathologic finding of bronchoscopic biopsy showed abnormal proliferation of bony and cartilagious nodules in the tracheal submucosa. These fingdings were consistent with tracheobronchopathia osteoplastica. We report here on a case of tracheobronchopathia osteoplastica with review of literature.

비정형 향정신병약물을 투여 중인 정신분열병 환자의 주관적 삶의 질 : 정신병리, 약물 부작용 및 약물에 대한 주관적 반응과의 관련성

김종훈,윤정희,이자영,노경희,홍성극,윤세창,강웅구,김용식 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : The purpose of this study was to evaluate the characteristics of psychopathology, adverse drug effects, and Subjective response to drugs that have a significant impact on the subjective quality of life in schizophrenic patients receiving atypical antipsychotics. Methods : One hundred and one schizophrenic patients, who were receiving maintenance treatment with atypical antipsychotics, were evaluated. Subjective quality of life was assessed using the standardized Korean modification of a self-rating scale to measure subjective well-being under neuroleptics (KmSWN). Patients' psychopathology was evaluated using the Positive and Negative Syndrome Scale. Adverse effects and subjective response to drug were evaluated using the Liverpool University Neuroleptic Side Effect Rating Scale and the Drug Attitude Inventory-10, respectively. Correlation analysis and stepwise multiple regression analysis were conducted. Results : In psychopathology, the severity of depression and anxiety showed the most significant correlation with the score ofKmSWN. In adverse drug effects, the severity of psychic side effect and extrapyramidal side effect showed the most significant correlation with the score ofKmSWN. Regarding subjective response to drug, significant correlation was observed between the severity of subjective negative response and the score of KmSWN. Stepwise multiple regression analysis revealed that psychic side effect, extrapyramidal side effect, and depression contributed significantly to the total score of KmSWN. These variables accounted for 59.7% of the total variance. Conclusion : The results of the present study suggest that psychic side effect, extrapyramidal side effect and depressive symptom are the clinical characteristics that are significantly associated with the subjective quality of life. An effective management strategy for these variables should be established in developing a treatment program to enhance the quality of life of patients with schizophrenia.

여고생의 건강증진생활양식 수행정도에 관한 연구

홍춘실,오경옥,이선영,차규정,김선애 충남대학교 간호과학연구소 2002 충남대 간호학술지 Vol.5 No.1

The purpose of the study was to examine the performance level of and the cognitive factors of health-promoting lifestyle in high school girls. This study was designed to provide basic data for development of nursing plan and effective intervention program for health promotion. The results were; (1) The mean score of health-promoting lifestyle profile was 2.61 (possible range 1-4) (2) Performance level of each subscale was scored as follows, interpersonal support(3.01), nutrition(2.74), self-actua!ization(2.68), stress management(2.55), health responsibility(2.35), and exercise(2.11). (3) The mean scores of the study variables (possible range 1-5) were relatively high in this sample, the mean of self-efficacy was 3.24; health locus of control was 2.97; perceived health status was 3.03. (4) The health-promoting lifestyle profile had a significant positive correlation with self-efficacy (r=.521, p<.001), health locus of control (r=.236, p<001), and perceived health status(r=.156, p<.01). The study showed the needs to intervene to improve the performance of health-promoting lifestyle of high school girls. Further study is recommended to develop and apply health improvement program especially for less performed dimensions such as exercise and health responsibility. Also, it is recommended to examine other cognitive-perceptual factors influencing health-promoting lifestyle.

한국인에서 Vancomycin의 치료적 약물농도 평가

송영구,김혜경,노은경,이서영,안보숙,김정호,박민수,윤희정,김준명 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

목적 : 상용화된 PK simulation software를 이용하여 vancomycin의 치료적 약물농도 측정(Therapeutic Drug Monitoring, 이하 TDM)이 의뢰된 환자에서, 측정된 vancomycin 혈청농도와 평균 약동학 지표를 이용하여 계산된 예측농도를 비교하고, 실측 농도와 예측 농도 사이에 차이를 나타내는 요인이 무엇인지를 알아보고자 하였다. 재료 및 방법 : 2001년 3월부터 2002년 9월까지 188명으로부터 vancomycin TDM이 의뢰된 239건의 결과를 분석하였다. Vancomycin을 투여하기 30분 전에 측정된 최저 농도로 CAPCIL^(R) (Simkin Inc.) 프로그램에서 single-point linear 방법으로 약동학 지표(분포용적 : Vd_(m), 청소율: Cl_(m), 반감기 : T_(1/2m))와 이에 따른 실측 농도(ECm, 이하 실측치)를 구하였다. 또한 CAPCIL^(R) 프로그램에서 이들 환자의 평균 약동학 지표(Vd_(p), Cl_(p), T_(1/2p))를 이용한 예측 농도(EC_(p), 이하 예측치)를 계산하였다. 먼저 전체에서 실측치와 예측치의 평균에 차이가 있는지 비교하였으며 신기능 및 체중에 따라 실측치와 예측치의 차이가 있는지 알아보았다. 다음으로 예측 최저 농도를 기준으로 실측 최저 농도와 차이(%dEC=(EC_(m)-EC_(p))/EC_(p))를 세 그룹으로 나누어서 각 그룹 간에 차이를 나타내는 요인이 무엇인지 알아보았다. 통계는 SAS 프로그램을 이용하여paired t-test, ANOVA, multiple regression 등으로 처리하였으며 P<0.05를 유의한 것으로 간주하였다. 결과 : Vancomycin TDM이 의뢰된 188명중 남자 1ll명, 여자 77명이었다. 총 239건에서 실측 최저 농도는 예측 최저 농도보다 유의하게 낮았고(11.9±9.9 ㎍/ml vs. 19.2±19.5 ㎍/ml), 약동학 지표 중 청소율과 분포용적은 예측한 값보다 유의하게 높았다. 신기능 및 체중에 따른 각각의 군에서도 비슷한 양상을 보였다. 예측 최저 농도와 실측 최저 농도의 차이에 따라 구분한 세 군간에 농도 차이를 나타낸 요인으로는 몸무게, 나이, 키, IBW, BUN, Ccr이었으며, 이중 다변량 분석에서 나이, 몸무게, BUN이 실측치와 예측치의 차이에 영향을 주는 요인으로 나타났다. 결론 : 신기능이 저하되었을 경우와 저체중, 고령인 경우 실측 농도에 비해 더 높은 농도로 예측하는 경향으로 나타나 최적의 치료 농도를 유지하기 위해서는 이와 같은 환자에서 특히 vancomycin TDM이 필요하다고 생각된다. Background : We measured plasma vancomycin concentrations as a part of therapeutic drug monitoring (TDM) consultation and compared and analyzed the estimated plasma steady-state therapeutic drug levels of vancomycin obtained on the basis of measured concentrations and by population PK parameters using a PK simulation software in Korean patients to find the factors influencing the discrepancies that lie between these estimates. Materials and Methods : We analyzed the PK parameters of the 188 patients for whom vancomycin TDM was done for 239 episodes between March, 2001 and September, 2002. The trough vancomycin plasma concentrations were measured from plasma samples that were drawn 30 minutes before a vancomycin dose. Based on the measured concentrations, we estimated the steady-state therapeutic levels (EC_(m)) and PK parameters (apparent volumes of distribution, Vd_(m); clearance, Cl_(m); and half life, T_(1/2m)) using the single-point linear method utilized in CAPCIL (Simkin, Inc.) software program. We compared these with the steady-state levels and PK parameters estimated based on population PK database supplied by the software (EC_(p), Vd_(p), Cl_(p), and T_(1/2p)). We stratified and compared the values based on the patients' renal functions, body weights relative to ideal body weights, the magnitude of differences between EC_(m) and EC_(p). Multiple logistic regression using SAS software package was done to analyze factors that significantly influence the discrepancies. Results:One hundred and eleven were males, and 77 were females. The mean ECm were significantly lower than the mean ECp (11.9±9.9 μg/ml vs. 19.2±19.5 μg/ml). Clm and Vdm were higher than Cl_(p) and Vd_(p), respectively. The same patterns could be applied to the subclasses of patients based on renal functions and body weights. The factors that contribute to the differences in EC_(m) and EC_(p) were body weight, age, height, IBW, BUN, and Clcr, of which age, body weight, and BUN were found to be most significant by multiple regression analysis. Conclusions : Significant sizes of discrepancies between the estimated plasma steady-state therapeutic drug levels of vancomycin obtained on the basis of measured concentrations and by population PK parameters using a PK simulation software in Korean patients necessitate adjustment of dosage and confirmation of steady-state levels by follow-up TDM. We emphasize the need for obtaining vancomycin population PK database in Korean patients.