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      • KCI등재

        Off-label use and designation of age groupspecific contraindications for pharmacotherapy in children in Korea

        박민수 대한임상약리학회 2014 Translational and Clinical Pharmacology Vol.22 No.2

        Children should be treated with medicines that have been tested for efficacy and safety in the given age groups. In reality the majority of drugs being used in children lack such information, inevitably leading to the “off-label use.” Over decades there have been concerns regarding risk of adverse effects with such off-label uses. However, in most countries rational application of off-label uses have not been prohibited, since it may be the only available and perhaps the best possible treatment option. In contrast, in an effort to minimize such use and per se ‘protect’ children from possible harm associated with it, Korea has launched “Drug Utilization Review” system, which included age group-specific contraindications, based on the labeling information approved by Ministry of Food and Drug Safety. The problem lies in the definition and scope of ‘contraindication.’ Lack of evidence for safety and concern for risk of serious adverse drug reactions are the basis for contraindication. This leads to branding of off-label uses as contraindications in certain age groups. This policy is restricting the already scarce treatment options and suffocating the initiative for developing better pharmacotherapy for children. We should learn from other countries that have travailed more to provide better medicines to children. Clinical trials of new drugs as well as existing drugs in pediatric populations are strongly encouraged. Simple prohibition of off-label use is not the answer, but rather systematized management of off-label use as well as conduct of clinical trials in pediatric age groups must be encouraged and supported.

      • KCI등재

        University Choice and Students’ Migration: An Application of the Heckman Model

        박민수,구찬동,오정일 서울대학교행정대학원 2010 The Korean Journal of Policy Studies Vol.25 No.2

        This study attempts to elucidate the migration patterns of Korean high school students choosing a university. Estimating a migration equation without considering sample-selection bias would yield incorrect results. Thus, this study used the Heckman model. We found that the sample selection bias would be serious in the case of students living in Seoul. We also found that students living in small towns had a 13.1 percent higher probability of migrating than those residing in Seoul, and an 8.2 percent higher probability than those living in other big cities. The differences in the migration probabilities can be interpreted as a preference for metropolitan areas. A simple policy that provides physical and financial resources to the universities would not be successful. A higher-education policy is likely to be effective only when it is implemented in coordination with the cultural and economic policies of the region.

      • KCI등재
      • KCI등재

        수평감쇠판 길이에 따른 하이브리드 부유식 구조물의 거동 특성 분석

        박민수,정연주,김영택 한국해안,해양공학회 2022 한국해안해양공학회 논문집 Vol.34 No.6

        New businesses such as marine leisure and floating construction have recently flourished on the coast. As a result, consideration is given to a floating structure appropriate for marine environments. In this study, we applied a damping plate to increase the stability of a hybrid floating structure that was expanded by vertical and horizontal stacking of mobile unit modules. In the numerical analysis using ANSYS AQWA, the behavioral characteristics of the floating structure were analyzed according to the length change of the damping plate. However, the wave forces acting on a floating structure are excessively calculated by the resonance of fluid surrounded by the structure in the numerical analysis using potential flow. Therefore, we used the damping zone option of the ANSYS AQWA in the frequency domain analysis. 최근 연안에서 해상관광레저, 플로팅 건축 등의 사업발굴이 활발히 진행 중에 있어 해상조건에 적합한 부유식 구조물의 필요성이 대두되고 있다. 본 연구에서는 육상 이동이 가능한 단위 모듈의 수직 및 수평 적층으로 확장된 하이브리드 부유식 구조물의 안정성을 향상시키기 위해 수평감쇠판을 적용하였다. 적용된 수평감쇠판의 길이변화에 따른 하이브리드 부유식 구조물의 거동 특성을 상용 프로그램인 ANSYS AQWA를 이용하여 분석하였다. 하지만 제안된 하이브리드 부유식 구조물의 경우 구조물에 의해 둘러싸인 유체영역이 존재하고 이로 인해 특정 주기에서 공진이 발생할 가능성이 있다. 따라서 구조물에 의해 둘러싸인 유체영역에 ANSYS AQWA에서 제공되는 감쇠존 효과를 고려하여 부유식 구조물의 거동 특성을 주파수 영역 수치해석을 통해 면밀하게 분석하였다.

      • KCI등재

        기존 케이슨방파제에 신규 케이슨 추가설치에 따른 불규칙파 조건에서 케이슨들의 시간응답 평가

        박민수,김영택,박상기,민지영 한국해안,해양공학회 2022 한국해안해양공학회 논문집 Vol.34 No.6

        The design and the construction were carried out by installing new caissons on the back or the front of existing caissons to increase the structural stability of caisson breakwaters. In this study, we used the ANSYS AQWA program to analyze the wave forces acting on individual caissons according to the effects of wave-structure interaction when new caissons were additionally installed on existing caisson breakwaters. The wave force characteristics acting on the individual caisson were analyzed according to the distance among caissons in frequency domain analysis. In addition, the dynamic wave force characteristics were closely examined on the basis of the frequency at which the unusual distribution of wave forces occurs in irregular wave conditions using time domain analysis. 기존 케이슨방파제의 전면 또는 후면에 추가로 케이슨을 설치하여 구조물의 안정성을 향상시키기 위한 설계 및 시공사례가 보고되고 있다. 본 연구에서는 상용프로그램인 ANSYS AQWA를 이용하여 신규 케이슨이 추가로설치되는 경우 입사하는 파랑과 케이슨들간의 상호작용 영향에 의해 개별 케이슨에 작용하는 파력 특성을 분석하였다. 앞뒤 케이슨간의 간격변화에 따른 개별 케이슨에 작용하는 파력 특성을 주파수영역에서 수치해석을 수행하였다. 그리고 특이한 파력분포 특성이 발생되는 주파수에 대해서는 불규칙파 조건에서의 시간영역 수치해석을 통해 개별케이슨에 작용하는 동적파력 특성을 면밀하게 검토하였다.

      • KCI등재

        기존 원형케이슨 후면에 신규 원형케이슨 설치에 따른 파력특성 분석

        박민수 한국해안,해양공학회 2019 한국해안해양공학회 논문집 Vol.31 No.6

        In order to increse the stability of old caissons, the design and the construction are performed by installation of new caissons on the back of or on the front of old caissons. In this study, we use the eigenfunction expasnion method to analyze the characteristics of wave forces when new circular caissons are installed on the back of old caissons. The comparison of numerical results between eigenfunction expansion method and ANSYS AQWA is made and the wave force acting on each circular caisson is calculated by considering the wave-structure interaction effect. 기존 케이슨의 안정성을 높이기 위해 신규 케이슨을 기존 케이슨 전면 또는 후면에 추가로 설치하여 보강 하는 설계 및 시공사례가 발생되고 있다. 본 연구에서는 고유함수전개법을 이용하여 원형케이슨으로 구성된 기존 방 파제 후면에 신규 원형케이슨이 설치될 경우 각 원형케이슨에 작용하는 파력특성을 분석하였다. 수치해석의 신뢰성 을 확보하기 위해 상용화 프로그램인 ANSYS AQWA의 수치 해석결과와 비교를 수행하였으며, 원형 케이슨 추가 설치에 따른 파와 구조물의 상호작용 영향을 고려하여 각 원형케이슨에 작용하는 파력을 산출하였다.

      • KCI등재

        Bi-Te계 n형 열전분말의 열전특성에 미치는 Cu 도핑의 영향

        박민수,구혜영,하국현,박용호,Park, Min Soo,Koo, Hye Young,Ha, Gook Hyun,Park, Yong Ho 한국분말야금학회 2015 한국분말재료학회지 (KPMI) Vol.22 No.4

        $Bi_2Te_3$ related compounds show the best thermoelectric properties at room temperature. However, n-type $Bi_2Te_{2.7}Se_{0.3}$ showed no improvement on ZT values. To improve the thermolectric propterties of n-type $Bi_2Te_{2.7}Se_{0.3}$, this research has Cu-doped n-type powder. This study focused on effects of Cu-doping method on the thermoelectric properties of n-type materials, and evaluated the comparison between the Cu chemical and mechanical doping. The synthesized powder was manufactured by the spark plasma sintering(SPS). The thermoelectric properties of the sintered body were evaluated by measuring their Seebeck coefficient, electrical resistivity, thermal conductivity, and hall coefficient. An introduction of a small amount of Cu reduced the thermal conductivity and improved the electrical properties with Seebeck coefficient. The authors provided the optimal concentration of $Cu_{0.1}Bi_{1.99}Se_{0.3}Te_{2.7}$. A figure of merit (ZT) value of 1.22 was obtained for $Cu_{0.1}Bi_{1.9}Se_{0.3}Te_{2.7}$ at 373K by Cu chemical doping, which was obviously higher than those of $Cu_{0.1}Bi_{1.9}Se_{0.3}Te_{2.7}$ at 373K by Cu mechanical doping (ZT=0.56) and Cu-free $Bi_2Se_{0.3}Te_{2.7}$ (ZT=0.51).

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