위선암에서 p53 단백의 과발현과 임상 및 병리학적 예후인자와의 상관관계

서병조,유항종,이주호,주미,이혜경,김진복 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

Objective: Mutations in the p53 gene, one of the most common genetic alterations in human cancer, are implicated in tumorigenesis and tumor progression. Wild-type p53 negatively regulates the cell cycle; a loss of function by mutation might be expected to result in enhanced proliferating activity and tumor progression. A large number of immunohistochemical studies have confirmed p53 accumulation to be a very common feature of human malignancy. The aim of the present study was to determine whether p53 status in gastric cancer is correlated statistically with various histopathological indicators or not. Methods and Materials: A total of 197 surgically resected gastric adenocarcinomas were examined to determine whether a correlation exited between immunohistochemical expressions of the p53 protein and other histopathological factors. Results: p53 overexpression was observed in 46.2% of the gastric cancers. Overexpression of p53 was correlated with vascular invasion of gastric cancer(p=0.004). In early gastric cancer, the p53 overexpression rate was 42.3%, and of them, a correlation was found between the intestinal type of the Lauren classifcation(p=0.013) and histologically differentiated gastric cancer(p=0.014). Conclusion: p53 overexpression was significantly correlated with vascular invasion of gastric cancer. In cases of early gastric cancer, p53 overexpression was correlated with Lauren classification and differentiation. These results suggest that p53 mutation plays an important role in carcinogenesis in gastric adenocarcinomas. Further study in needed to determine the correlation between p53 overexpression and the prognosis for the gastric cancer patient.

CVM에 의한 친환경농업의 비시장적 가치평가 : 충북 도시 소비자 조사를 중심으로

유진채,공기서 한국농업정책학회, 한국축산경영학회 2001 농업경영정책연구 Vol.28 No.2

Interests in agri-environmental farming products are increasing due to increase in national income and the aggravating effects of various kinds of pollution. Even though, currently, consumers mistrust agri-environmental farming product authenticated by farmhouses or subsidized by the government, demand for these types of products continues to increase in spite of recognition of environmental problems. Questionnaire of this study was surveyed 360 consumers in Cheongju City located in the Chungbuk Province to determine consumers' recognition of agriculture, their willingness to pay environmental pollution fees, and their awareness of the public goods value of agriculture through the CVM.

대장암 환자의 성격특성과 분노표현방식

손성은,유희정,서병선,김진천,한오수 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.3

연구목적 : 협조적이고 비주장적이며 인내심이 많고 부정적인 감정(특히 분노)을 잘 표현하지 않는 C형 성격 또는 1형 성격특성과 암 발병과의 관련성에 대해서는 일치된 결과가 없는 실정이다. 특히, 대장암 환자를 대상으로 이루어진 연구는 소수이며 분노의 억압 및 부정이 암 발생과 관련을 보였던 연구결과가 보고되었던 것과 대조적으로 공격적 적대감이 대장암 발생과 관련이 있다는 상반된 연구결과가 있다. 본 연구에서는 대장암 환자를 대상으로 1형 성격과 대장암 발병과의 관련성을 살펴보고, 분노의 경험과 표현 특성을 세분화하여 평가해서 암 발병과의 관련성을 밝혀 보고자하였다. 방 법 : 대장암 환자 35명과, 정상인 37명을 대상으로 Grossarth-Maticek의 성격-스트레스 검사 단축형중, 1형 성격을 반영하는 10문항과 Spielberger의 분노 검사 44문항을 이용하여 양군을 비교하였다. 자료 분석을 위해 환자 집단과 정상 집단 간 차이를 보고, 환자 집단과 정상 집단을 가장 잘 판별해줄 수 있는 변인을 찾기위해 판별분석을 실시하였다. 결 과 : 대장암 환자집단이 정상집단에 비해 분노 경험, 상태 분노, 분노 기질의 총점이 유의한 수준에서 높았고 그외의 다른 소척도나 1형 성격 스트레스 검사에 있어서는 유의한 차이는 나타나지 않았다. 판별분석 결과, 분노 기질 변인만 환자집단과 정상집단을 유의하게 판별하였다.(정준상관계수=.33, 판별율=65.8%). 결 론 : 평상시에 특별한 일 없이도 생리적 각성 상태를 동반하는 분노를 자주, 심하게 경험하는 특성과 대장암 발병이 관련성이 있음을 시사한다. Objectives : Although previous studies have suggested that Type 1 or Type C personality may be associated with the development of cancer, the results have not been consistent. There have been some evidences that repression, denial, or non-expression of anger are related with the incidence of colorectal cancer. However, according to the results of recent researches, aggressive hostility was related to the development of colorectal cancer. This study attempted to delineate psychological characteristics or personality patterns of the patients with colorectal cancer based on multidemensions of anger and Type 1 personality for cancer development. Method : The subjects were composed of 35 patients with colorectal cancer and 37 normal controls. Grossarth-Maticek personality questionnaire and the Spielberger state-trait anger expression inventory were administered. Results : In comparison with the normal control group, the colorectal cancer patient group showed significantly higher scores on anger experience, angry temperament and state anger but no significant differences on Type 1 personality scale and other subscales. In the discriminant analysis patients and control groups were classified by means of state anger, angry temperament, angry reaction, anger-in, anger-out and anger control variables. When angry temperament variable was selected as a discriminant variable, 65.8% of cases had been correctly classified. Conclusions : These results suggested the relationship between the disposition to experience and express anger without particular provocation and the development of cancer.

고객 파트너 십이 CRM성과에 미치는 영향에 관한 연구 : 관계시스템과 신뢰의 역할 The Role of Relational Systems and Trust

이현수,이유진,서영호 한국품질경영학회 2004 품질경영학회지 Vol.32 No.1

In recent studies, there has been much interest in the relationship between customer partnership and its effect on CRM success. Yet, there is little empirical work on it. This study empirically examines the relationship between customer partnership and CRM success in Korean companies. The findings indicate that the success of the relational systems(information technology and education/reward) is significantly related to trust to customer and customer partnership. The study also provides empirical evidence that trust and customer partnership is positively related to the new CRM success and the traditional CRM success.

무궁화 根群 分布에 관한 연구 : 2. 土壤 種類別 實生苗의 根群 分布 2. Root system of seedlings on the soil conditions.

심경구,하유미,김진춘,서병기,강호철 성균관대학교 생명과학자원연구소 1995 生命資源科學硏究 Vol.2 No.1

This study was carried out to examine the characteristics of root system for seedlings of Hibiscus syriacus L. on the different soil conditions as a basic study for the stock of top-root cultivars. The obtained results are summarized as follows; It was significantly different on soil hardness between upland soil with 13 kg f/cm2 until 60 cm depth and waste landfill soil with 5 kg f/cm2 until 5 cm depth. But it was not measured soil hardness under 30 cm of waste landfill soil because of waste base. But soil pH was not different between soil conditions. The root depth of 'SKK 91-3' growing on upland soil was 81.0 cm and it was significantly different as compared with that of 'SKK 91-3' on the waste landfill. In addition, 'SKK 91-3' growing on upland soil had more root weight, root width, root number, main root diameter, and shoot growth than that on the waste landfill. Therefore it was suggested that soil condition affect root growth of seedlings in Hibiscus syriacus L. and then induce top-root system.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

사망진단서(사체검안서) 상의 선행사인으로부터 사망통계의 원사인이 선정되는 비율 : 3개 대학병원에서 교부된 사망진단서를 중심으로

박우성,박석건,정철원,김우철,탁우택,김부연,서순원,김광환,서진숙,부유경 한국의료QA학회 2004 한국의료질향상학회지 Vol.11 No.1

Background : To exatnine the problems intolved in writing practice of death certificates, we cotnpated the determination of underlying cause of death for wital statistics using recorded underlying cause of death in issued death statistics. Methods : We collected 688 rnortality certificates issue in year of 2,000 from 3 university hospitals. And we also collected vital statistics from ministry of statistics. The causes of death were coded by experienced medical record wpecialists. And causes of death determined at ministry of statistics for national vita statistics were mapped to causes of death recorded at each death certificates. The rate that underlying causes of death for vital statistics were derived from underlying causes of death recorded at issued death certificaties sere analysed. Results : 64.5% of underlying cause of death for could be derived from underlying cause of death recorded at issued death certificates, 8.6% derived from intermediate cause of death, and 3.9% derived from direct cause of death. In 23% of cases, underlying cause of death could not be derived using issued death certificates. The rate that underlying cause of death for vital statistics could be derived from underlying cause of death recorded at death certificates was different between 3 university hospitals. Ane the rate was also different between death certificates and postmortem certificates. We classified the causes of death using 21 major categories. The rate was different between diseases or conditions tha caused death too. Conclusion : When we examined the correctness of death certificate writing practice using abpve methods, cortectness of writing could not be told as satisfactory. There was difference in correctness of writing between hospotals, between death certificates and postmortem certificates, and between diseases and conditions that caused death. With this results, we suggested some strategy to improve the correctness of death certificate writing practice.

Diagnostic model for pancreatic cancer using a multi-biomarker panel

Yoo Jin Choi,Woongchang Yoon,Areum Lee,Youngmin Han,Yoonhyeong Byun,Jae Seung Kang,Hongbeom Kim,Wooil Kwon,Young-Ah Suh,Yongkang Kim,Seungyeoun Lee,Junghyun Namkung,Sangjo Han,Yonghwan Choi,Jin Seok H 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.100 No.3

Purpose: Diagnostic biomarkers of pancreatic ductal adenocarcinoma (PDAC) have been used for early detection to reduce its dismal survival rate. However, clinically feasible biomarkers are still rare. Therefore, in this study, we developed an automated multi-marker enzyme-linked immunosorbent assay (ELISA) kit using 3 biomarkers (leucine-rich alpha-2-glycoprotein [LRG1], transthyretin [TTR], and CA 19-9) that were previously discovered and proposed a diagnostic model for PDAC based on this kit for clinical usage. Methods: Individual LRG1, TTR, and CA 19-9 panels were combined into a single automated ELISA panel and tested on 728 plasma samples, including PDAC (n = 381) and normal samples (n = 347). The consistency between individual panels of 3 biomarkers and the automated multi-panel ELISA kit were accessed by correlation. The diagnostic model was developed using logistic regression according to the automated ELISA kit to predict the risk of pancreatic cancer (high-, intermediate-, and low-risk groups). Results: The Pearson correlation coefficient of predicted values between the triple-marker automated ELISA panel and the former individual ELISA was 0.865. The proposed model provided reliable prediction results with a positive predictive value of 92.05%, negative predictive value of 90.69%, specificity of 90.69%, and sensitivity of 92.05%, which all simultaneously exceed 90% cutoff value. Conclusion: This diagnostic model based on the triple ELISA kit showed better diagnostic performance than previous markers for PDAC. In the future, it needs external validation to be used in the clinic.

Crystal Packing of Two Different Tetranuclear Iron(III) Clusters, [(tacn)₄Fe₄O₂(OH)₄]₂.8Br.9H₂O (tacn = 1,4,7-triazacyclononane)

Jin, Mi-Kyung,Kim, Yoo-Jin,Jung, Duk-Young,Heu, Min,Yoon, Seok-Won,Suh, Byoung-Jin Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.2

[$(tacn)_4Fe_4O_2(OH)_4]_2{\cdot}8Br{\cdot}9H_2O$ (tacn = 1,4,7-triazacyclononane), a tetranuclear iron(III) complex was synthesized by the hydrolysis of (tacn)FeCl3 and crystallizes in the orthorhombic space group, Pca2(1), with cell parameters, a = 37.574(3) $\AA$, b = 16.9245(12) $\AA$, c = 14.2830(11) $\AA$, V = 9082.9(12) ${\AA}^3$. [$(tacn)_4Fe_4O_2(OH)_4]^{4+}$ cations approach S4 point symmetry containing an adamantane skeleton. Four Fe(III) atoms have distorted octahedral environments with two hydroxo and an oxo bridges. Two [$(tacn)_4Fe_4O_2(OH)_4]^{4+}$ clusters having different Fe…Fe distances are connected to each other by the networked hydrogen bonds. The electrochemical behavior reveals irreversible three cathodic and two anodic peaks. Magnetic properties are characterized by antiferromagnetic (AF) interactions between Fe(III) ion spins. However, the low-lying states are still magnetic and exhibit a blocking behavior and a magnetic hysteresis at low temperatures.

Correlation between fracture surface morphology and toughness in Zr-based bulk metallic glasses

Suh, Jin-Yoo,Dale Conner, R.,Paul Kim, C.,Demetriou, Marios D.,Johnson, William L. Cambridge University Press (Materials Research Soc 2010 Journal of materials research Vol.25 No.5

<P>Fracture surfaces of Zr-based bulk metallic glasses of various compositions tested in the as-cast and annealed conditions were analyzed using scanning electron microscopy. The tougher samples have shown highly jagged patterns at the beginning stage of crack propagation, and the length and roughness of this jagged pattern correlate well with the measured fracture toughness values. These jagged patterns, the main source of energy dissipation in the sample, are attributed to the formation of shear bands inside the sample. This observation provides strong evidence of significant “plastic zone” screening at the crack tip.</P>